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Conserved domains on  [gi|14043103|gb|AAH07537|]
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CSRP2 binding protein [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 686-761 2.48e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.22  E-value: 2.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 686 AFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLYQKFGFKTEEYVLDFY 761
Cdd:COG0456   1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREDNeAAIALYEKLGFEEVGERPNYY 80
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 686-761 2.48e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.22  E-value: 2.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 686 AFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLYQKFGFKTEEYVLDFY 761
Cdd:COG0456   1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREDNeAAIALYEKLGFEEVGERPNYY 80
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 672-751 3.70e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 63.69  E-value: 3.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103   672 PDFSVVVLYKKVIIAF-GFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLY 746
Cdd:pfam00583  32 SEGFFVAEEDGELVGFaSLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGcerIFLEVAADNlAAIALY 111


                  ....*
gi 14043103   747 QKFGF 751
Cdd:pfam00583 112 EKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 675-727 2.53e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 2.53e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 14043103 675 SVVVLYKKVIIAFGFMVP-DVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTC 727
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPdGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA 54
PRK09831 PRK09831
GNAT family N-acetyltransferase;
698-766 9.61e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 40.33  E-value: 9.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14043103  698 EAYISFLFVHPEWRRAGIATFMIYHLIQTcmgkDVTLHVSASNPAMLLYQKFGFKT---------EEYVLDFYDKYYP 766
Cdd:PRK09831  72 EHYIDMLFVDPEYTRRGVASALLKPLIKS----ESELTVDASITAKPFFERYGFQTvkqqrvecrGEWFINFYMRYKP 145
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 686-761 2.48e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.22  E-value: 2.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 686 AFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLYQKFGFKTEEYVLDFY 761
Cdd:COG0456   1 GFALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGarrLRLEVREDNeAAIALYEKLGFEEVGERPNYY 80
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 672-751 3.70e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 63.69  E-value: 3.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103   672 PDFSVVVLYKKVIIAF-GFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKD---VTLHVSASN-PAMLLY 746
Cdd:pfam00583  32 SEGFFVAEEDGELVGFaSLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGcerIFLEVAADNlAAIALY 111


                  ....*
gi 14043103   747 QKFGF 751
Cdd:pfam00583 112 EKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 669-764 9.07e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 60.45  E-value: 9.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 669 LQYPDFSVVVLYKKVIIAFG--FMVPDvkyNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVT---LHVSASNP-A 742
Cdd:COG0454  30 SLAGAEFIAVDDKGEPIGFAglRRLDD---KVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTaleLDTLDGNPaA 106

                        90       100
                ....*....|....*....|...
gi 14043103 743 MLLYQKFGFK-TEEYVLDFYDKY 764
Cdd:COG0454 107 IRFYERLGFKeIERYVAYVGGEF 129
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 676-781 2.20e-10

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 59.24  E-value: 2.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 676 VVVLYKKVIIAFGFMVPDVKyNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDV-TLHVSASNPAMLLYQKFGFKte 754
Cdd:COG1246  31 WVAEEDGEIVGCAALHPLDE-DLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLkRLFLLTTSAAIHFYEKLGFE-- 107

                        90       100
                ....*....|....*....|....*..
gi 14043103 755 eyVLDFYDKYYPLESTECKHAFFLRLR 781
Cdd:COG1246 108 --EIDKEDLPYAKVWQRDSVVMEKDLE 132
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 676-752 3.16e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 57.08  E-value: 3.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14043103   676 VVVLYKKVIIAFGFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTL-HVSASNPAMLLYQKFGFK 752
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLlELETTNRAAAFYEKLGFE 83
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
684-752 1.45e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 55.30  E-value: 1.45e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14043103 684 IIAFGFMVPDVkYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCM---GKDVTLHVSASNPAML-LYQKFGFK 752
Cdd:COG3393   2 LVAMAGVRAES-PGVAEISGVYTHPEYRGRGLASALVAALAREALargARTPFLYVDADNPAARrLYERLGFR 73
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
644-762 3.25e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.86  E-value: 3.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 644 RPNHIPTINSMCQEFFWPG--IDLSECLQ---YPDFSVVVLYKKVIIAFGFMVP---DVKYNEAYISFLFVHPEWRRAGI 715
Cdd:COG3153   5 TPEDAEAIAALLRAAFGPGreAELVDRLRedpAAGLSLVAEDDGEIVGHVALSPvdiDGEGPALLLGPLAVDPEYRGQGI 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 14043103 716 ATFMIYHLIQTCMGKDVT-LHVSASNPAMLLYQKFGFK-TEEYVLDFYD 762
Cdd:COG3153  85 GRALMRAALEAARERGARaVVLLGDPSLLPFYERFGFRpAGELGLTLGP 133
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 697-753 8.96e-08

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 51.50  E-value: 8.96e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103   697 NEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLH---VSASNPAMLLYQKFGFKT 753
Cdd:pfam13673  50 DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSeltVNASPYAVPFYEKLGFRA 109
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
696-763 1.20e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 49.22  E-value: 1.20e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14043103 696 YNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVT---LHVSASNPAML-LYQKFGFKTEEYVLDFYDK 763
Cdd:COG1247  78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRrlvAVVLADNEASIaLYEKLGFEEVGTLPEVGFK 149
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 675-727 2.53e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 2.53e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 14043103 675 SVVVLYKKVIIAFGFMVP-DVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTC 727
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPdGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA 54
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
697-759 5.04e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 43.63  E-value: 5.04e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14043103 697 NEAYISFLFVHPEWRRAGIATFMIYHLIQTCM---GKDVTLHvsASNPAMLLYQKFGFKT--EEYVLD 759
Cdd:COG2153  57 GEAKIGRVAVLPEYRGQGLGRALMEAAIEEARergARRIVLS--AQAHAVGFYEKLGFVPvgEEFLEA 122
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 687-782 5.25e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 44.60  E-value: 5.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103 687 FGFMVPDVKYNEAYISFlFVHPEWRRAGIATFMIYHLIQTC---MG-KDVTLHVSASNPAML-LYQKFGFKTEEYVldfy 761
Cdd:COG1670  77 VGLYDIDRANRSAEIGY-WLAPAYWGKGYATEALRALLDYAfeeLGlHRVEAEVDPDNTASIrVLEKLGFRLEGTL---- 151

                        90       100
                ....*....|....*....|.
gi 14043103 762 DKYYPLESTECKHAFFLRLRR 782
Cdd:COG1670 152 RDALVIDGRYRDHVLYSLLRE 172
PRK09831 PRK09831
GNAT family N-acetyltransferase;
698-766 9.61e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 40.33  E-value: 9.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14043103  698 EAYISFLFVHPEWRRAGIATFMIYHLIQTcmgkDVTLHVSASNPAMLLYQKFGFKT---------EEYVLDFYDKYYP 766
Cdd:PRK09831  72 EHYIDMLFVDPEYTRRGVASALLKPLIKS----ESELTVDASITAKPFFERYGFQTvkqqrvecrGEWFINFYMRYKP 145
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 691-753 5.43e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 37.55  E-value: 5.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14043103   691 VPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVTLHV-SASNPAMllYQKFGFKT 753
Cdd:pfam13527  63 VPGKTLPAAGITGVATYPEYRGRGVMSRLLRRSLEEMRERGVPLSFlYPSSYPI--YRRFGYEI 124
PRK10514 PRK10514
putative acetyltransferase; Provisional
 688-767 8.12e-03

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 37.67  E-value: 8.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103  688 GFMVPDVKYNEAyisfLFVHPEWRRAGIATFMIYHLIQtcMGKDVTLHVSASNP-AMLLYQKFGFK-TEEYVLDFYDKYY 765
Cdd:PRK10514  63 GFMLLSGGHMEA----LFVDPDVRGCGVGRMLVEHALS--LHPELTTDVNEQNEqAVGFYKKMGFKvTGRSEVDDQGRPY 136


                 ..
gi 14043103  766 PL 767
Cdd:PRK10514 137 PL 138
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 688-766 8.92e-03

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 37.60  E-value: 8.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043103  688 GFMVPDVKYNEAYISFLFVHPEWRRAGIATFMIYHLIQTCMGKDVT---LHVSASN-PAMLLYQKFGFKTeeyvLDFYDK 763
Cdd:PRK09491  53 AFAITQVVLDEATLFNIAVDPDYQRQGLGRALLEHLIDELEKRGVAtlwLEVRASNaAAIALYESLGFNE----VTIRRN 128


                 ...
gi 14043103  764 YYP 766
Cdd:PRK09491 129 YYP 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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