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Conserved domains on  [gi|13542753|gb|AAH05581|]
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Kelch domain containing 2 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 13846389)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
78-341 2.83e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.13  E-value: 2.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  78 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSAdrglQWERIDcqGIPPSSKDKLGVWVYKNKL 157
Cdd:COG3055   3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATN----TWSELA--PLPGPPRHHAAAVAQDGKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 158 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFAWSQpitTGKAPSPRAAHACATVGNKGFVFGGRY 237
Cdd:COG3055  74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 238 RDARMNDLHYLNLDTWEWNELIPqgvCPVGRSWHSLTPVSSDHLFLFGGFTT---------------------------- 289
Cdd:COG3055 132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGRNGsgfsntwttlaplptaraghaaavlggk 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13542753 290 ------EKQPLSDAWTYCISKNEWIQFNHpyVEKPRLWHTACASDeGEVIVFGGCANN 341
Cdd:COG3055 209 ilvfggESGFSDEVEAYDPATNTWTALGE--LPTPRHGHAAVLTD-GKVYVIGGETKP 263
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 29-62 9.38e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 9.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 13542753    29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFY 62
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVY 34
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
78-341 2.83e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.13  E-value: 2.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  78 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSAdrglQWERIDcqGIPPSSKDKLGVWVYKNKL 157
Cdd:COG3055   3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATN----TWSELA--PLPGPPRHHAAAVAQDGKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 158 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFAWSQpitTGKAPSPRAAHACATVGNKGFVFGGRY 237
Cdd:COG3055  74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 238 RDARMNDLHYLNLDTWEWNELIPqgvCPVGRSWHSLTPVSSDHLFLFGGFTT---------------------------- 289
Cdd:COG3055 132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGRNGsgfsntwttlaplptaraghaaavlggk 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13542753 290 ------EKQPLSDAWTYCISKNEWIQFNHpyVEKPRLWHTACASDeGEVIVFGGCANN 341
Cdd:COG3055 209 ilvfggESGFSDEVEAYDPATNTWTALGE--LPTPRHGHAAVLTD-GKVYVIGGETKP 263
PLN02193 PLN02193
nitrile-specifier protein
 29-296 6.11e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 66.90  E-value: 6.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753   29 PAERSGHVAVSDGRHMFVWGG-YKSNQvrglydfylPREE-LWIYYMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYL 105
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGeFTPNQ---------PIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  106 FGGHHSRGNTNKFYMLDSRSAdrglQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 185
Cdd:PLN02193 234 FGGRDASRQYNGFYSFDTTTN----EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  186 SHP----------------------RGWN----DHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGryrD 239
Cdd:PLN02193 310 STPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---E 386

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13542753  240 ARMNDLHY------------LNLDTWEWNELIPQGV---CPVGRSWHSLTPVSSD---HLFLFGGftteKQPLSD 296
Cdd:PLN02193 387 IAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeeeTPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
Kelch_4 pfam13418
Galactose oxidase, central domain;
267-307 2.72e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 46.84  E-value: 2.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 13542753   267 GRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEW 307
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 48-157 8.11e-05

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 43.50  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753    48 GGYKsnqVRGLYDFYLPR--EELWIYYMETGRWKKIntEGDVPPSMSGSCAVCVDRVLYLFGghhSRGNTNKFYML---D 122
Cdd:TIGR01640  53 KQYK---VLCFSDRSGNRnqSEHQVYTLGSNSWRTI--ECSPPHHPLKSRGVCINGVLYYLA---YTLKTNPDYFIvsfD 124

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 13542753   123 SRSadrglqwER----IDCQGIPPSSKDKLGVWVYKNKL 157
Cdd:TIGR01640 125 VSS-------ERfkefIPLPCGNSDSVDYLSLINYKGKL 156
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 29-62 9.38e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 9.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 13542753    29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFY 62
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVY 34
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
78-341 2.83e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.13  E-value: 2.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  78 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSAdrglQWERIDcqGIPPSSKDKLGVWVYKNKL 157
Cdd:COG3055   3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATN----TWSELA--PLPGPPRHHAAAVAQDGKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 158 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFAWSQpitTGKAPSPRAAHACATVGNKGFVFGGRY 237
Cdd:COG3055  74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 238 RDARMNDLHYLNLDTWEWNELIPqgvCPVGRSWHSLTPVSSDHLFLFGGFTT---------------------------- 289
Cdd:COG3055 132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGRNGsgfsntwttlaplptaraghaaavlggk 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13542753 290 ------EKQPLSDAWTYCISKNEWIQFNHpyVEKPRLWHTACASDeGEVIVFGGCANN 341
Cdd:COG3055 209 ilvfggESGFSDEVEAYDPATNTWTALGE--LPTPRHGHAAVLTD-GKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
204-357 1.56e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.35  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 204 AWSqpiTTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPqgvCPVGRSWHSLTPVSSDHLFL 283
Cdd:COG3055   2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP---LPGPPRHHAAAVAQDGKLYV 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13542753 284 FGGFTTEK---QPLSDAWTYCISKNEWIQfnHPYVEKPRLWHTAcASDEGEVIVFGGcannllvHHRAAHSNEVLIF 357
Cdd:COG3055  76 FGGFTGANpssTPLNDVYVYDPATNTWTK--LAPMPTPRGGATA-LLLDGKIYVVGG-------WDDGGNVAWVEVY 142
PLN02193 PLN02193
nitrile-specifier protein
 29-296 6.11e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 66.90  E-value: 6.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753   29 PAERSGHVAVSDGRHMFVWGG-YKSNQvrglydfylPREE-LWIYYMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYL 105
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGeFTPNQ---------PIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  106 FGGHHSRGNTNKFYMLDSRSAdrglQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 185
Cdd:PLN02193 234 FGGRDASRQYNGFYSFDTTTN----EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  186 SHP----------------------RGWN----DHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGryrD 239
Cdd:PLN02193 310 STPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---E 386

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13542753  240 ARMNDLHY------------LNLDTWEWNELIPQGV---CPVGRSWHSLTPVSSD---HLFLFGGftteKQPLSD 296
Cdd:PLN02193 387 IAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeeeTPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
30-298 9.89e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.18  E-value: 9.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  30 AERSGHVAVSDGRHMFVWGGYksnqvRGLYDFYLPREELWIYYMETGRWKKInteGDVPPSMSGSCAVCVDRVLYLFGGH 109
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGF-----TGANPSSTPLNDVYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGW 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 110 HSRGNTNKFYMLDsrsaDRGLQWERIdcqGIPPSSKDKL-GVWVYKNKLIFFGGYgylpedkvlgtfefDETSFWNsshp 188
Cdd:COG3055 131 DDGGNVAWVEVYD----PATGTWTQL---APLPTPRDHLaAAVLPDGKILVIGGR--------------NGSGFSN---- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753 189 rgwndhvhildtetfAWSqpiTTGKAPSPRAAHACATVGNKGFVFGGRYrdARMNDLHYLNLDTWEWNELipqGVCPVGR 268
Cdd:COG3055 186 ---------------TWT---TLAPLPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL---GELPTPR 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 13542753 269 swHSLTPVS-SDHLFLFGGFTTEKQPLSDAW 298
Cdd:COG3055 243 --HGHAAVLtDGKVYVIGGETKPGVRTPLVT 271
PLN02153 PLN02153
epithiospecifier protein
 29-303 6.52e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 63.08  E-value: 6.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753   29 PAERSGHVAVSDGRHMFVWGG-YKSNQVRGlydfylprEELWIYYMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYLF 106
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGeLKPNEHID--------KDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  107 GGHHSRGNTNKFYMLDSRSAdrglQWE---RIDCQGIPPS------SKDKLGVWVY----KNKL--------------IF 159
Cdd:PLN02153  92 GGRDEKREFSDFYSYDTVKN----EWTfltKLDEEGGPEArtfhsmASDENHVYVFggvsKGGLmktperfrtieaynIA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  160 FGGYGYLP------EDKVLGTFEFDETSFW------NSSHPRGWNDH----VHILDTETFAWSQPITTGKAPSPRAAHAC 223
Cdd:PLN02153 168 DGKWVQLPdpgenfEKRGGAGFAVVQGKIWvvygfaTSILPGGKSDYesnaVQFFDPASGKWTEVETTGAKPSARSVFAH 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  224 ATVGNKGFVFGGR-YRDAR--------MNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSD---HLFLFGGFTTEK 291
Cdd:PLN02153 248 AVVGKYIIIFGGEvWPDLKghlgpgtlSNEGYALDTETLVWEKLGECGEPAMPRGWTAYTTATVYgknGLLMHGGKLPTN 327

                        330
                 ....*....|..
gi 13542753  292 QPLSDAWTYCIS 303
Cdd:PLN02153 328 ERTDDLYFYAVN 339
PLN02153 PLN02153
epithiospecifier protein
 212-337 1.47e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 61.93  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  212 GKAPSPRAAHACATVGNKGFVFGGRYRDARM--NDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSDHLFLFGGfTT 289
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGELKPNEHidKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG-RD 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 13542753  290 EKQPLSDAWTYCISKNEWIQFNHPYVE---KPRLWHTAcASDEGEVIVFGG 337
Cdd:PLN02153  96 EKREFSDFYSYDTVKNEWTFLTKLDEEggpEARTFHSM-ASDENHVYVFGG 145
PLN02193 PLN02193
nitrile-specifier protein
 131-313 3.85e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 61.51  E-value: 3.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  131 QWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYgYLPEDKVlgtfefdetsfwnsshprgwNDHVHILDTETFAWSQPIT 210
Cdd:PLN02193 152 KWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGE-FTPNQPI--------------------DKHLYVFDLETRTWSISPA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  211 TGKAPSPRAAHAC-ATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTpVSSDHLFLFGGFT- 288
Cdd:PLN02193 211 TGDVPHLSCLGVRmVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMA-ADEENVYVFGGVSa 289

                        170       180
                 ....*....|....*....|....*
gi 13542753  289 TEKQPLSDAwtYCISKNEWIQFNHP 313
Cdd:PLN02193 290 TARLKTLDS--YNIVDKKWFHCSTP 312
PLN02193 PLN02193
nitrile-specifier protein
 205-337 6.88e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 54.19  E-value: 6.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  205 WSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMND--LHYLNLDTWEWNELIPQGVCPvGRSWHSLTPVS-SDHL 281
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDkhLYVFDLETRTWSISPATGDVP-HLSCLGVRMVSiGSTL 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 13542753  282 FLFGGFTTEKQpLSDAWTYCISKNEWiQFNHPYVE--KPRLWHTAcASDEGEVIVFGG 337
Cdd:PLN02193 232 YVFGGRDASRQ-YNGFYSFDTTTNEW-KLLTPVEEgpTPRSFHSM-AADEENVYVFGG 286
Kelch_4 pfam13418
Galactose oxidase, central domain;
267-307 2.72e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 46.84  E-value: 2.72e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 13542753   267 GRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEW 307
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 48-157 8.11e-05

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 43.50  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753    48 GGYKsnqVRGLYDFYLPR--EELWIYYMETGRWKKIntEGDVPPSMSGSCAVCVDRVLYLFGghhSRGNTNKFYML---D 122
Cdd:TIGR01640  53 KQYK---VLCFSDRSGNRnqSEHQVYTLGSNSWRTI--ECSPPHHPLKSRGVCINGVLYYLA---YTLKTNPDYFIvsfD 124

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 13542753   123 SRSadrglqwER----IDCQGIPPSSKDKLGVWVYKNKL 157
Cdd:TIGR01640 125 VSS-------ERfkefIPLPCGNSDSVDYLSLINYKGKL 156
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 217-258 1.00e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.52  E-value: 1.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 13542753   217 PRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNEL 258
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
PLN02153 PLN02153
epithiospecifier protein
 25-247 2.46e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 42.67  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753   25 ELACPAERSGHVAVSDGRHMFVWGGYKSNqvrGLYDFYLPREELWIYYMETGRWKKINTEGDVPPSMSGS-CAVCVDRVL 103
Cdd:PLN02153 121 EEGGPEARTFHSMASDENHVYVFGGVSKG---GLMKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAgFAVVQGKIW 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753  104 YLFG-------GHHSRGNTNKFYMLDSRSAdrglQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGtfe 176
Cdd:PLN02153 198 VVYGfatsilpGGKSDYESNAVQFFDPASG----KWTEVETTGAKPSARSVFAHAVVGKYIIIFGGEVWPDLKGHLG--- 270

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13542753  177 fdetsfwnsshPRGWNDHVHILDTETFAWSQPITTGKAPSPRA--AHACATV-GNKGFVF-GGRY-RDARMNDLHY 247
Cdd:PLN02153 271 -----------PGTLSNEGYALDTETLVWEKLGECGEPAMPRGwtAYTTATVyGKNGLLMhGGKLpTNERTDDLYF 335
Kelch_3 pfam13415
Galactose oxidase, central domain;
279-326 3.28e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.04  E-value: 3.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 13542753   279 DHLFLFGGFTTEKQP-LSDAWTYCISKNEWIQfnHPYVEKPRLWHTACA 326
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQ--IGDLPPPRSGHSATY 48
Kelch_3 pfam13415
Galactose oxidase, central domain;
227-274 2.52e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 13542753   227 GNKGFVFGGRYRDA--RMNDLHYLNLDTWEWNELipqGVCPVGRSWHSLT 274
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSAT 47
PHA03098 PHA03098
kelch-like protein; Provisional
 57-187 3.02e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 39.75  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13542753   57 GLYDFYLPREELWIYYMETGRWKKINTegdVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSAdRGLQWERID 136
Cdd:PHA03098 397 GISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVESYNP-VTNKWTELS 472

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 13542753  137 CQGIPpssKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEfDETSFWNSSH 187
Cdd:PHA03098 473 SLNFP---RINASLCIFNNKIYVVGGDKYEYYINEIEVYD-DKTNTWTLFC 519
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 88-122 8.17e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 8.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 13542753    88 PPSMSGSCAVCVDRVLYLFGGHHSRGN--TNKFYMLD 122
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGqpSDDVYVLS 37
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 29-62 9.38e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 9.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 13542753    29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFY 62
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVY 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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