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Conserved domains on  [gi|11545417|gb|AAG37834|]
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folate transporter/carrier [Homo sapiens]

Protein Classification

ADP/ATP carrier family protein( domain architecture ID 1000309)

ADP/ATP carrier family protein may provide transport for nucleotides, amino acids, carboxylic acids, fatty acids, cofactors, or inorganic ions across a membrane; similar to mitochondrial adenine nucleotide carriers

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
 26-307 3.64e-23

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 96.76  E-value: 3.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   26 LIAGVSGGVlSNLALHPLDLVKIRFAVSDGLE-----LRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYF 100
Cdd:PTZ00169  12 LMGGISAAI-SKTAVAPIERVKMLIQTQDSIPeiksgKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  101 FFYNAIKS----YKTEGRAEHLEATEyLVSAAEAGAMTLCITNPLWVTKTRLMLQydaVVNSPHRQYKGMFDTLVKIYKY 176
Cdd:PTZ00169  91 AFKDYFKNmfpkYNQKTDFWKFFGVN-ILSGGLAGASSLLIVYPLDFARTRLASD---IGKGGDREFTGLFDCLMKISKQ 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  177 EGVRGLYKGF---VPGLFgtSHGALQFMAYELLK-LKYNqhinrlPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARL 252
Cdd:PTZ00169 167 TGFLSLYQGFgvsVQGII--VYRGAYFGLYDSAKaLLFG------NDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRM 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 11545417  253 -------QDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPAcCITFVVYENVSHFL 307
Cdd:PTZ00169 239 mmmsgrkAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGG-ALVLVFYDELQKLL 299
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 26-307 3.64e-23

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 96.76  E-value: 3.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   26 LIAGVSGGVlSNLALHPLDLVKIRFAVSDGLE-----LRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYF 100
Cdd:PTZ00169  12 LMGGISAAI-SKTAVAPIERVKMLIQTQDSIPeiksgKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  101 FFYNAIKS----YKTEGRAEHLEATEyLVSAAEAGAMTLCITNPLWVTKTRLMLQydaVVNSPHRQYKGMFDTLVKIYKY 176
Cdd:PTZ00169  91 AFKDYFKNmfpkYNQKTDFWKFFGVN-ILSGGLAGASSLLIVYPLDFARTRLASD---IGKGGDREFTGLFDCLMKISKQ 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  177 EGVRGLYKGF---VPGLFgtSHGALQFMAYELLK-LKYNqhinrlPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARL 252
Cdd:PTZ00169 167 TGFLSLYQGFgvsVQGII--VYRGAYFGLYDSAKaLLFG------NDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRM 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 11545417  253 -------QDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPAcCITFVVYENVSHFL 307
Cdd:PTZ00169 239 mmmsgrkAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGG-ALVLVFYDELQKLL 299
Mito_carr pfam00153
Mitochondrial carrier protein;
116-213 1.08e-22

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 90.02  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   116 EHLEATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQydavVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTS- 194
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ----GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAp 76

                          90
                  ....*....|....*....
gi 11545417   195 HGALQFMAYELLKLKYNQH 213
Cdd:pfam00153  77 AAAIYFGTYETLKRLLLKK 95
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 26-307 3.64e-23

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 96.76  E-value: 3.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   26 LIAGVSGGVlSNLALHPLDLVKIRFAVSDGLE-----LRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYF 100
Cdd:PTZ00169  12 LMGGISAAI-SKTAVAPIERVKMLIQTQDSIPeiksgKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  101 FFYNAIKS----YKTEGRAEHLEATEyLVSAAEAGAMTLCITNPLWVTKTRLMLQydaVVNSPHRQYKGMFDTLVKIYKY 176
Cdd:PTZ00169  91 AFKDYFKNmfpkYNQKTDFWKFFGVN-ILSGGLAGASSLLIVYPLDFARTRLASD---IGKGGDREFTGLFDCLMKISKQ 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  177 EGVRGLYKGF---VPGLFgtSHGALQFMAYELLK-LKYNqhinrlPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARL 252
Cdd:PTZ00169 167 TGFLSLYQGFgvsVQGII--VYRGAYFGLYDSAKaLLFG------NDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRM 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 11545417  253 -------QDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPAcCITFVVYENVSHFL 307
Cdd:PTZ00169 239 mmmsgrkAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGG-ALVLVFYDELQKLL 299
Mito_carr pfam00153
Mitochondrial carrier protein;
116-213 1.08e-22

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 90.02  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   116 EHLEATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQydavVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTS- 194
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQ----GGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAp 76

                          90
                  ....*....|....*....
gi 11545417   195 HGALQFMAYELLKLKYNQH 213
Cdd:pfam00153  77 AAAIYFGTYETLKRLLLKK 95
Mito_carr pfam00153
Mitochondrial carrier protein;
221-309 1.13e-22

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 90.02  E-value: 1.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   221 QLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMFY----SGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCIT 296
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGkskgRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIY 81

                          90
                  ....*....|...
gi 11545417   297 FVVYENVSHFLLD 309
Cdd:pfam00153  82 FGTYETLKRLLLK 94
Mito_carr pfam00153
Mitochondrial carrier protein;
23-109 1.05e-21

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 87.71  E-value: 1.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417    23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLeLRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFF 102
Cdd:pfam00153   6 LASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS-GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84


                  ....*..
gi 11545417   103 YNAIKSY 109
Cdd:pfam00153  85 YETLKRL 91
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 25-207 3.49e-14

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 71.72  E-value: 3.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   25 NLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYN 104
Cdd:PTZ00169 116 NILSGGLAGASSLLIVYPLDFARTRLASDIGKGGDREFTGLFDCLMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYD 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  105 AIKS--YKTEGRAEHLeateYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGL 182
Cdd:PTZ00169 196 SAKAllFGNDKNTNIL----YKWAVAQTVTILAGLISYPFDTVRRRMMMMSGRKAKSEIQYTGTLDCWKKILKNEGLGGF 271

                        170       180
                 ....*....|....*....|....*
gi 11545417  183 YKGFVPGLFGTSHGALQFMAYELLK 207
Cdd:PTZ00169 272 FKGAWANVLRGAGGALVLVFYDELQ 296
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 23-281 1.98e-06

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 48.38  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417   23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELrpkyngilhclttiwklDGLRGLYQGVTPNIWGAGLSWGLYFFF 102
Cdd:PTZ00168   4 FHNLVTGALSGVIVDAVLYPIDSIKTNIQAKKSFSF-----------------SDIKKLYSGILPTLVGTVPASAFFYCF 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  103 YNAIKSYKTEGRAEHLEATEYLVSAAEAGAMTLCITNPLWVTKTRLmlqydavvnsphrQYKGMFDTLVKIYKYEGVRGL 182
Cdd:PTZ00168  67 YELSKKLLTEYRENISKTNLYLISTSIAEITACIVRLPFEIVKQNM-------------QVSGNISVLKTIYEITQREGL 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  183 ykgfvPGLFGTSH----------GALQFMAYELLKLKYNQHINRLPEAQLSTVEYIsVAALSKIFAVAATYPYQVVRARl 252
Cdd:PTZ00168 134 -----PSFLGKSYfvmivreipfDCIQYFLWETLKEKAKKDFGKFSKKYPSITSAI-CGGLAGGIAGFLTTPVDVIKSR- 206

                        250       260
                 ....*....|....*....|....*....
gi 11545417  253 qdQHMFYSGVIDVITKTwRKEGVGGFYKG 281
Cdd:PTZ00168 207 --QIIYGKSYIETVTEI-AEEGYLTFYKG 232
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 116-315 1.75e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 39.14  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  116 EHLEAteyLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVkiykyegvrglykGFVPGlfgtsh 195
Cdd:PTZ00168   2 EHFHN---LVTGALSGVIVDAVLYPIDSIKTNIQAKKSFSFSDIKKLYSGILPTLV-------------GTVPA------ 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11545417  196 GALQFMAYELLK---LKYNQHINRlpeaqlsTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMfySGVIDVITKTWRK 272
Cdd:PTZ00168  60 SAFFYCFYELSKkllTEYRENISK-------TNLYLISTSIAEITACIVRLPFEIVKQNMQVSGN--ISVLKTIYEITQR 130

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 11545417  273 EGVGGFY-KGIAPNLIRVTPACCITFVVYENvshflldLREKRK 315
Cdd:PTZ00168 131 EGLPSFLgKSYFVMIVREIPFDCIQYFLWET-------LKEKAK 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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