NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9971945|gb|AAG10506|]
View 

2P domain K+ channel TWIK-2 [Homo sapiens]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 180-256 2.07e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 61.51  E-value: 2.07e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9971945    180 VVTVCFLVPAVIFAHLEEAW--SFLDAFYFCFISLSTIGLGDYVPGEAPGqpyralyKVLVTVYLFLGLVAMVLVLQTF 256
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAG-------RLFTIFYILIGIPLFAIFLAVL 72
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 75-146 2.31e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 61.51  E-value: 2.31e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9971945     75 VVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLS 146
Cdd:pfam07885   6 VLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 180-256 2.07e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 61.51  E-value: 2.07e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9971945    180 VVTVCFLVPAVIFAHLEEAW--SFLDAFYFCFISLSTIGLGDYVPGEAPGqpyralyKVLVTVYLFLGLVAMVLVLQTF 256
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAG-------RLFTIFYILIGIPLFAIFLAVL 72
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 75-146 2.31e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 61.51  E-value: 2.31e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9971945     75 VVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLS 146
Cdd:pfam07885   6 VLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 180-256 2.07e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 61.51  E-value: 2.07e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9971945    180 VVTVCFLVPAVIFAHLEEAW--SFLDAFYFCFISLSTIGLGDYVPGEAPGqpyralyKVLVTVYLFLGLVAMVLVLQTF 256
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAG-------RLFTIFYILIGIPLFAIFLAVL 72
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 75-146 2.31e-12

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 61.51  E-value: 2.31e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9971945     75 VVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLS 146
Cdd:pfam07885   6 VLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLT 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH