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Conserved domains on  [gi|9295337|gb|AAF86949|]
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GL004 [Homo sapiens]

Protein Classification

Miff domain-containing protein( domain architecture ID 10529072)

Miff domain-containing protein such as Homo sapiens mitochondrial fission factor (Miff) which plays a role in mitochondrial and peroxisomal fission, and which promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Miff pfam05644
Mitochondrial and peroxisomal fission factor Mff; This protein has a role in mitochondrial and ...
 1-218 1.22e-123

Mitochondrial and peroxisomal fission factor Mff; This protein has a role in mitochondrial and peroxisomal fission.


:

Pssm-ID: 461701  Cd Length: 292  Bit Score: 351.82  E-value: 1.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337      1 MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVPNASVIMQVPERIVVAGNNEDVSFSRPADLDLIQST 80
Cdd:pfam05644   1 MAEDNRIQYELEYTEGISQRMRVPEKLKVAPENSDEPKLLQNNIPSHSVMMQVPERIVVAGDDQDLGFSRPRDLDLIQST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337     81 PFKP-LALKTPPRVLTLSERPLDFLDLErPPTTPQNEEIRAVGRLKRERSMSEN-AVRQNGQLVRNDSL----------- 147
Cdd:pfam05644  81 PDEGfLALKTPPRVLTLSEHPLDFLELE-PSATPEPEEVRSAGRLRRERSASENdAPRHNGQIVRNDSIptpsappvrlc 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337    148 --------------------------------------------------------------YGISNIDTTIEGTSDDLT 165
Cdd:pfam05644 160 pplmspedginlysargdlssiqsttrrayqqvlevldenrrslrggsaskrssfpkhdsfrEGLPTLDSTLDLTPDDMT 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 9295337    166 VVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR 218
Cdd:pfam05644 240 LVDATSLRRQIIKLNRRLQLLEEENKERQKREMIMYSVTVAFWLLNTWIWLRR 292
 
Name Accession Description Interval E-value
Miff pfam05644
Mitochondrial and peroxisomal fission factor Mff; This protein has a role in mitochondrial and ...
 1-218 1.22e-123

Mitochondrial and peroxisomal fission factor Mff; This protein has a role in mitochondrial and peroxisomal fission.


Pssm-ID: 461701  Cd Length: 292  Bit Score: 351.82  E-value: 1.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337      1 MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVPNASVIMQVPERIVVAGNNEDVSFSRPADLDLIQST 80
Cdd:pfam05644   1 MAEDNRIQYELEYTEGISQRMRVPEKLKVAPENSDEPKLLQNNIPSHSVMMQVPERIVVAGDDQDLGFSRPRDLDLIQST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337     81 PFKP-LALKTPPRVLTLSERPLDFLDLErPPTTPQNEEIRAVGRLKRERSMSEN-AVRQNGQLVRNDSL----------- 147
Cdd:pfam05644  81 PDEGfLALKTPPRVLTLSEHPLDFLELE-PSATPEPEEVRSAGRLRRERSASENdAPRHNGQIVRNDSIptpsappvrlc 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337    148 --------------------------------------------------------------YGISNIDTTIEGTSDDLT 165
Cdd:pfam05644 160 pplmspedginlysargdlssiqsttrrayqqvlevldenrrslrggsaskrssfpkhdsfrEGLPTLDSTLDLTPDDMT 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 9295337    166 VVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR 218
Cdd:pfam05644 240 LVDATSLRRQIIKLNRRLQLLEEENKERQKREMIMYSVTVAFWLLNTWIWLRR 292
 
Name Accession Description Interval E-value
Miff pfam05644
Mitochondrial and peroxisomal fission factor Mff; This protein has a role in mitochondrial and ...
 1-218 1.22e-123

Mitochondrial and peroxisomal fission factor Mff; This protein has a role in mitochondrial and peroxisomal fission.


Pssm-ID: 461701  Cd Length: 292  Bit Score: 351.82  E-value: 1.22e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337      1 MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVPNASVIMQVPERIVVAGNNEDVSFSRPADLDLIQST 80
Cdd:pfam05644   1 MAEDNRIQYELEYTEGISQRMRVPEKLKVAPENSDEPKLLQNNIPSHSVMMQVPERIVVAGDDQDLGFSRPRDLDLIQST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337     81 PFKP-LALKTPPRVLTLSERPLDFLDLErPPTTPQNEEIRAVGRLKRERSMSEN-AVRQNGQLVRNDSL----------- 147
Cdd:pfam05644  81 PDEGfLALKTPPRVLTLSEHPLDFLELE-PSATPEPEEVRSAGRLRRERSASENdAPRHNGQIVRNDSIptpsappvrlc 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9295337    148 --------------------------------------------------------------YGISNIDTTIEGTSDDLT 165
Cdd:pfam05644 160 pplmspedginlysargdlssiqsttrrayqqvlevldenrrslrggsaskrssfpkhdsfrEGLPTLDSTLDLTPDDMT 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 9295337    166 VVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR 218
Cdd:pfam05644 240 LVDATSLRRQIIKLNRRLQLLEEENKERQKREMIMYSVTVAFWLLNTWIWLRR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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