Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1624-1984
1.11e-180
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
:
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 550.76 E-value: 1.11e-180
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1194-1457
5.74e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 223.68 E-value: 5.74e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
91-383
7.89e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 223.30 E-value: 7.89e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
875-1112
1.74e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 179.39 E-value: 1.74e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
532-763
1.27e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 170.91 E-value: 1.27e-47
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1529-1603
8.76e-38
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
:
Pssm-ID: 462591 Cd Length: 77 Bit Score: 136.57 E-value: 8.76e-38
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1466-1519
2.14e-28
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 108.89 E-value: 2.14e-28
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1624-1984
1.11e-180
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 550.76 E-value: 1.11e-180
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1194-1457
5.74e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 223.68 E-value: 5.74e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
91-383
7.89e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 223.30 E-value: 7.89e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
875-1112
1.74e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 179.39 E-value: 1.74e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
532-763
1.27e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 170.91 E-value: 1.27e-47
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1529-1603
8.76e-38
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 462591 Cd Length: 77 Bit Score: 136.57 E-value: 8.76e-38
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1466-1519
2.14e-28
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 108.89 E-value: 2.14e-28
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1581-1611
2.28e-12
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 198130 Cd Length: 31 Bit Score: 62.62 E-value: 2.28e-12
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1624-1984
1.11e-180
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.
Pssm-ID: 465298 [Multi-domain] Cd Length: 355 Bit Score: 550.76 E-value: 1.11e-180
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1194-1457
5.74e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 223.68 E-value: 5.74e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
91-383
7.89e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 223.30 E-value: 7.89e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
875-1112
1.74e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 179.39 E-value: 1.74e-50
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
532-763
1.27e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 170.91 E-value: 1.27e-47
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1529-1603
8.76e-38
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 462591 Cd Length: 77 Bit Score: 136.57 E-value: 8.76e-38
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1466-1519
2.14e-28
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 108.89 E-value: 2.14e-28
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1581-1611
2.28e-12
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Pssm-ID: 198130 Cd Length: 31 Bit Score: 62.62 E-value: 2.28e-12
Polycystin cation channel; This family contains the cation channel region from group II of ...
1223-1450
5.30e-10
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 61.52 E-value: 5.30e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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