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Conserved domains on  [gi|8567783|gb|AAF76355|]
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hypothetical protein [Arabidopsis thaliana]

Protein Classification

WDR46/Utp7 family WD40 repeat domain-containing protein( domain architecture ID 11457065)

WDR46/Utp7 family WD40 repeat domain-containing protein similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA, and Canis lupus familiaris WD repeat-containing protein 46, a scaffold component of the nucleolar structure

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 360-439 7.73e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 198101  Cd Length: 80  Bit Score: 157.77  E-value: 7.73e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783     360 YMNHSMvKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVANPFETSKQRREKEVHSLLDKLPPETIMLDP 439
Cdd:smart01033   2 YMTHGL-PGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 COG2319
WD40 repeat [General function prediction only];
123-340 2.33e-19

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 2.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQV-RETVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------EL 191
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASG--------SDDGTvrlwdlatgkLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  192 HCLKE-RGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTS 270
Cdd:COG2319 198 RTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8567783  271 QAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKG-LLAAGTG 340
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtgHTGAVRSVAFSPDGkTLASGSD 350
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 360-439 7.73e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 157.77  E-value: 7.73e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783     360 YMNHSMvKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVANPFETSKQRREKEVHSLLDKLPPETIMLDP 439
Cdd:smart01033   2 YMTHGL-PGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 360-438 2.12e-45

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 153.76  E-value: 2.12e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8567783    360 YMNHsMVKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVANPFETSKQRREKEVHSLLDKLPPETIMLD 438
Cdd:pfam08149   2 YLTH-LLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
123-340 2.33e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 2.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQV-RETVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------EL 191
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASG--------SDDGTvrlwdlatgkLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  192 HCLKE-RGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTS 270
Cdd:COG2319 198 RTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8567783  271 QAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKG-LLAAGTG 340
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtgHTGAVRSVAFSPDGkTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-342 2.60e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 2.60e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  122 KLDFTASGRHMLAGGRKGHLALLDMMNMSLIKEI-QVRETVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------E 190
Cdd:cd00200  56 DVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSPDGRILSSS--------SRDKTikvwdvetgkC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  191 LHCLKE-RGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGmvaSIRTGKGRTDvmEVN-----PYNSVVGLGHSGGTVT 264
Cdd:cd00200 128 LTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK---CVATLTGHTG--EVNsvafsPDGEKLLSSSSDGTIK 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  265 MWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKGLLAAgTGSF 342
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLsgHTNSVTSLAWSPDGKRLA-SGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-309 4.74e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.74e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8567783     270 SQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWD 309
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
273-309 8.34e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.34e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 8567783    273 PLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWD 309
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 243-335 1.82e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783   243 DVMEV--NPYNSVVGLGHS-GGTVTMW-------KPTSQAPLVQMQCHPGPVSSVAFHPNG-HLMATSGKERKIKIWDLR 311
Cdd:PTZ00421  77 PIIDVafNPFDPQKLFTASeDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVE 156

                         90       100
                 ....*....|....*....|....*.
gi 8567783   312 KFEEVQTI--HSFHAKTLSFSQKGLL 335
Cdd:PTZ00421 157 RGKAVEVIkcHSDQITSLEWNLDGSL 182
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 360-439 7.73e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 157.77  E-value: 7.73e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783     360 YMNHSMvKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVANPFETSKQRREKEVHSLLDKLPPETIMLDP 439
Cdd:smart01033   2 YMTHGL-PGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 360-438 2.12e-45

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 153.76  E-value: 2.12e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8567783    360 YMNHsMVKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVANPFETSKQRREKEVHSLLDKLPPETIMLD 438
Cdd:pfam08149   2 YLTH-LLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
123-340 2.33e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 2.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQV-RETVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------EL 191
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASG--------SDDGTvrlwdlatgkLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  192 HCLKE-RGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTS 270
Cdd:COG2319 198 RTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8567783  271 QAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKG-LLAAGTG 340
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtgHTGAVRSVAFSPDGkTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
123-338 3.43e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 3.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQV-RETVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------EL 191
Cdd:COG2319 168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASG--------SADGTvrlwdlatgkLL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  192 HCLK-ERGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTS 270
Cdd:COG2319 240 RTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8567783  271 QAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKG-LLAAG 338
Cdd:COG2319 320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGAVTSVAFSPDGrTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-342 2.60e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 2.60e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  122 KLDFTASGRHMLAGGRKGHLALLDMMNMSLIKEI-QVRETVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------E 190
Cdd:cd00200  56 DVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSPDGRILSSS--------SRDKTikvwdvetgkC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  191 LHCLKE-RGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGmvaSIRTGKGRTDvmEVN-----PYNSVVGLGHSGGTVT 264
Cdd:cd00200 128 LTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK---CVATLTGHTG--EVNsvafsPDGEKLLSSSSDGTIK 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  265 MWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKGLLAAgTGSF 342
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLsgHTNSVTSLAWSPDGKRLA-SGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
123-311 2.72e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 2.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQVRE-TVRDVAFLHNDQFFAAAqkkyayiyGRDGT----------EL 191
Cdd:COG2319 210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGRLLASG--------SADGTvrlwdlatgeLL 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  192 HCLK-ERGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTS 270
Cdd:COG2319 282 RTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 8567783  271 QAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLR 311
Cdd:COG2319 362 GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
123-352 8.53e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 8.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQVRE-TVRDVAFLHNDQFFAAA-QKKYAYIYGRDGTELHCLKE--RG 198
Cdd:COG2319  42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTaAVLSVAFSPDGRLLASAsADGTVRLWDLATGLLLRTLTghTG 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  199 PVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQAPLVQMQ 278
Cdd:COG2319 122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  279 CHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKG-LLAAG------------TGSFV 343
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLtgHSGSVRSVAFSPDGrLLASGsadgtvrlwdlaTGELL 281


                ....*....
gi 8567783  344 QILGDSSGG 352
Cdd:COG2319 282 RTLTGHSGG 290
WD40 COG2319
WD40 repeat [General function prediction only];
197-338 3.28e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 3.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  197 RGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQAPLVQ 276
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8567783  277 MQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKG-LLAAG 338
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtgHSGAVTSVAFSPDGkLLASG 180
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 234-341 3.00e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 3.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  234 SIRTGKGRTD---VMEVNPYNSVVGLGHSGGTVTMWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDL 310
Cdd:cd00200   1 LRRTLKGHTGgvtCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 8567783  311 RKFEEVQTIHSfHAK---TLSFSQKGLLAAGTGS 341
Cdd:cd00200  81 ETGECVRTLTG-HTSyvsSVAFSPDGRILSSSSR 113
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-309 2.06e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 2.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  123 LDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQ-VRETVRDVAFLHNDQF-FAAAQKKYAYIYgrDGTELHCLKE---- 196
Cdd:cd00200  99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFvASSSQDGTIKLW--DLRTGKCVATltgh 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  197 RGPVARLRFLKN--HFLLASVNMS--------GQLHYQDVTHGGMVASIRtgkgrtdvmeVNPYNSVVGLGHSGGTVTMW 266
Cdd:cd00200 177 TGEVNSVAFSPDgeKLLSSSSDGTiklwdlstGKCLGTLRGHENGVNSVA----------FSPDGYLLASGSEDGTIRVW 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 8567783  267 KPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWD 309
Cdd:cd00200 247 DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-309 4.74e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.74e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8567783     270 SQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWD 309
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
273-309 8.34e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.34e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 8567783    273 PLVQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWD 309
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
211-345 3.60e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  211 LLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQAPLVQMQCHPGPVSSVAFH 290
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 8567783  291 PNGHLMATSGKERKIKIWDL--RKFEEVQTIHSFHAKTLSFSQKG--LLAAGTGSFVQI 345
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLatGLLLRTLTGHTGAVRSVAFSPDGktLASGSADGTVRL 146
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 218-325 1.13e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.06  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  218 SGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYnsvVGL----GH-----SGGTVTMWKP-----TSQAPLVQMqCHPGP 283
Cdd:cd22857  53 NGTVEVLDPENGDLLASFSDSEPATKLSEEDHF---VGLhlfsGTlltctSKGSLRSTKLpddstASSSPTAWV-CLGGN 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 8567783  284 VSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVqtIhsFHAK 325
Cdd:cd22857 129 LLCMRVDPNENYFAFGGKEVELNVWDLEEKPGK--I--WRAK 166
PTZ00421 PTZ00421
coronin; Provisional
 243-335 1.82e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783   243 DVMEV--NPYNSVVGLGHS-GGTVTMW-------KPTSQAPLVQMQCHPGPVSSVAFHPNG-HLMATSGKERKIKIWDLR 311
Cdd:PTZ00421  77 PIIDVafNPFDPQKLFTASeDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVE 156

                         90       100
                 ....*....|....*....|....*.
gi 8567783   312 KFEEVQTI--HSFHAKTLSFSQKGLL 335
Cdd:PTZ00421 157 RGKAVEVIkcHSDQITSLEWNLDGSL 182
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 207-325 2.42e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 40.31  E-value: 2.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  207 KNHFLLASVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYnsvVGLGH-----------SGGTVTMWKP------- 268
Cdd:cd22850  47 DPLLLVARRNGNGEVYVLSPVDGELFELLSSIEGLTRSKEEDKF---VGLHLlrslglltcatKSGLLHIIDLedskkds 123

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8567783  269 -TSQAPLVQmqchPGPVSSVAFHP-NGHLMATSGKERKIKIWDL-RKFEEVQTIhsFHAK 325
Cdd:cd22850 124 lEVKAPLTL----PGFLSAFRVNPtDEGVFAYGGKENDLKLWDLeKDFLKLKQI--WKAK 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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