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Conserved domains on  [gi|7299137|gb|AAF54336|]
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beag [Drosophila melanogaster]

Protein Classification

RED_N and RED_C domain-containing protein( domain architecture ID 10544693)

RED_N and RED_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RED_N pfam07808
RED-like protein N-terminal region; This family contains sequences that are similar to the ...
 88-315 2.04e-99

RED-like protein N-terminal region; This family contains sequences that are similar to the N-terminal region of Red protein. This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, suggesting that these proteins are expressed in the nucleus. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently.


:

Pssm-ID: 462273  Cd Length: 227  Bit Score: 300.39  E-value: 2.04e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137     88 LKKQEDVKLQELSEKYRDRARERRDGANPDYVNVSTPghgSSTNAYRAVAPDMKSGIDAQERRRRIIQESKFLGGDIQHT 167
Cdd:pfam07808   1 LKKQEEDKLAELAPKYRDRAKERREGANPDYQNEDPV---STTSAYRAVAPDAKSGLDAAERRKQMIQESKFLGGDMEHT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137    168 HLVKGLDYALLQKVRSELHSKeaeeeEIAAAVAREKLAEAAAAAEQLEAERRESEDINAINGALARNIYNLVQaRRSKEV 247
Cdd:pfam07808  78 HLVKGLDYALLQKVRSEITKK-----EDEQEEEEEKLLEQKAEAKLQKEKEKKEEEEIKFKTRLAKSIYRQIL-FKQKKP 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7299137    248 PRNELFAPGRMAYVIDLDDELGESDIPTTLKRSKFEVPVSqEDVATLTTNDIVINKLSQILSYLRAGG 315
Cdd:pfam07808 152 ERNELFLPGRMAYVIDLEDEYADSDIPTTLIRSKADCPNA-ESTTTLTTNDIVINKLAQILSYLRQGS 218
RED_C pfam07807
RED-like protein C-terminal region; This family contains sequences that are similar to the ...
 434-539 6.61e-67

RED-like protein C-terminal region; This family contains sequences that are similar to the C-terminal region of Red protein. This and related proteins are thought to be localized to the nucleus, and contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated or that the protein self-aggregates extremely efficiently.


:

Pssm-ID: 462272  Cd Length: 112  Bit Score: 212.24  E-value: 6.61e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137    434 YAECYPGLEEMNDAIDDSDDEVDYTKMDLGNKKGPIGRWDFDTQEEYSDYMSTKEALPKAAFQYGVKMQDGRKTRKnKTE 513
Cdd:pfam07807   1 YAECYPGMAEYNDALVDSDDEADYSKMDMGNKKGPVGRWDFDTQEEYSSYMEKKEALPKAAFQYGVKMADGRKTRR-QGE 79

                          90       100
                  ....*....|....*....|....*.
gi 7299137    514 KNEKAELDREWQKIQTIIQKRKLPKD 539
Cdd:pfam07807  80 KDEKAKLDRELQKIQNIIQKRKGGGG 105
 
Name Accession Description Interval E-value
RED_N pfam07808
RED-like protein N-terminal region; This family contains sequences that are similar to the ...
 88-315 2.04e-99

RED-like protein N-terminal region; This family contains sequences that are similar to the N-terminal region of Red protein. This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, suggesting that these proteins are expressed in the nucleus. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently.


Pssm-ID: 462273  Cd Length: 227  Bit Score: 300.39  E-value: 2.04e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137     88 LKKQEDVKLQELSEKYRDRARERRDGANPDYVNVSTPghgSSTNAYRAVAPDMKSGIDAQERRRRIIQESKFLGGDIQHT 167
Cdd:pfam07808   1 LKKQEEDKLAELAPKYRDRAKERREGANPDYQNEDPV---STTSAYRAVAPDAKSGLDAAERRKQMIQESKFLGGDMEHT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137    168 HLVKGLDYALLQKVRSELHSKeaeeeEIAAAVAREKLAEAAAAAEQLEAERRESEDINAINGALARNIYNLVQaRRSKEV 247
Cdd:pfam07808  78 HLVKGLDYALLQKVRSEITKK-----EDEQEEEEEKLLEQKAEAKLQKEKEKKEEEEIKFKTRLAKSIYRQIL-FKQKKP 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7299137    248 PRNELFAPGRMAYVIDLDDELGESDIPTTLKRSKFEVPVSqEDVATLTTNDIVINKLSQILSYLRAGG 315
Cdd:pfam07808 152 ERNELFLPGRMAYVIDLEDEYADSDIPTTLIRSKADCPNA-ESTTTLTTNDIVINKLAQILSYLRQGS 218
RED_C pfam07807
RED-like protein C-terminal region; This family contains sequences that are similar to the ...
 434-539 6.61e-67

RED-like protein C-terminal region; This family contains sequences that are similar to the C-terminal region of Red protein. This and related proteins are thought to be localized to the nucleus, and contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated or that the protein self-aggregates extremely efficiently.


Pssm-ID: 462272  Cd Length: 112  Bit Score: 212.24  E-value: 6.61e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137    434 YAECYPGLEEMNDAIDDSDDEVDYTKMDLGNKKGPIGRWDFDTQEEYSDYMSTKEALPKAAFQYGVKMQDGRKTRKnKTE 513
Cdd:pfam07807   1 YAECYPGMAEYNDALVDSDDEADYSKMDMGNKKGPVGRWDFDTQEEYSSYMEKKEALPKAAFQYGVKMADGRKTRR-QGE 79

                          90       100
                  ....*....|....*....|....*.
gi 7299137    514 KNEKAELDREWQKIQTIIQKRKLPKD 539
Cdd:pfam07807  80 KDEKAKLDRELQKIQNIIQKRKGGGG 105
 
Name Accession Description Interval E-value
RED_N pfam07808
RED-like protein N-terminal region; This family contains sequences that are similar to the ...
 88-315 2.04e-99

RED-like protein N-terminal region; This family contains sequences that are similar to the N-terminal region of Red protein. This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, suggesting that these proteins are expressed in the nucleus. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently.


Pssm-ID: 462273  Cd Length: 227  Bit Score: 300.39  E-value: 2.04e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137     88 LKKQEDVKLQELSEKYRDRARERRDGANPDYVNVSTPghgSSTNAYRAVAPDMKSGIDAQERRRRIIQESKFLGGDIQHT 167
Cdd:pfam07808   1 LKKQEEDKLAELAPKYRDRAKERREGANPDYQNEDPV---STTSAYRAVAPDAKSGLDAAERRKQMIQESKFLGGDMEHT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137    168 HLVKGLDYALLQKVRSELHSKeaeeeEIAAAVAREKLAEAAAAAEQLEAERRESEDINAINGALARNIYNLVQaRRSKEV 247
Cdd:pfam07808  78 HLVKGLDYALLQKVRSEITKK-----EDEQEEEEEKLLEQKAEAKLQKEKEKKEEEEIKFKTRLAKSIYRQIL-FKQKKP 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7299137    248 PRNELFAPGRMAYVIDLDDELGESDIPTTLKRSKFEVPVSqEDVATLTTNDIVINKLSQILSYLRAGG 315
Cdd:pfam07808 152 ERNELFLPGRMAYVIDLEDEYADSDIPTTLIRSKADCPNA-ESTTTLTTNDIVINKLAQILSYLRQGS 218
RED_C pfam07807
RED-like protein C-terminal region; This family contains sequences that are similar to the ...
 434-539 6.61e-67

RED-like protein C-terminal region; This family contains sequences that are similar to the C-terminal region of Red protein. This and related proteins are thought to be localized to the nucleus, and contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated or that the protein self-aggregates extremely efficiently.


Pssm-ID: 462272  Cd Length: 112  Bit Score: 212.24  E-value: 6.61e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7299137    434 YAECYPGLEEMNDAIDDSDDEVDYTKMDLGNKKGPIGRWDFDTQEEYSDYMSTKEALPKAAFQYGVKMQDGRKTRKnKTE 513
Cdd:pfam07807   1 YAECYPGMAEYNDALVDSDDEADYSKMDMGNKKGPVGRWDFDTQEEYSSYMEKKEALPKAAFQYGVKMADGRKTRR-QGE 79

                          90       100
                  ....*....|....*....|....*.
gi 7299137    514 KNEKAELDREWQKIQTIIQKRKLPKD 539
Cdd:pfam07807  80 KDEKAKLDRELQKIQNIIQKRKGGGG 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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