|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
251-868 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 573.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 251 SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKmIGCTQPRRVAAMSVAARVAEEMGVKLGNEV 330
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVGETV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 331 GYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDI-ARFRPELKLLISSATLD 409
Cdd:COG1643 88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLqPALRPDLKLLVMSATLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 410 AEKFSAFFDDAPIFRIPGRRYPVDIFYT--KAPEADYIDACCVSVLQIHATQPlGDILVFLTGQDEIETCQEVLHDRVkr 487
Cdd:COG1643 168 AERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILVFLPGEREIRRTAEALRGRL-- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 488 lgskIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPI 567
Cdd:COG1643 245 ----PPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 568 SKASANQRAGRAGRTAPGKCFRLYTAWAYkHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALE 647
Cdd:COG1643 321 SQASANQRAGRAGRLAPGICYRLWSEEDF-ARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 648 QLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVnsaifyrpkdkiihADTARknfNHM 727
Cdd:COG1643 400 LLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSE--------------RDPRR---GAA 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 728 HGDHLSLLQVYNQWAETDystqwcyENFIQYRSMKRARDVREQlvgLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARL 807
Cdd:COG1643 463 GSDLLARLNLWRRLREQQ-------REFLSYLRLREWRDLARQ---LRRLLGEGANEEPADYEAIGLLLALAYPDRIARR 532
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7298547 808 -SKGGHYKTIkHNQTVMIHPNSSLFEElpRWVLYHELVFTSKEY-MRQVIEIESKWLLEVAPH 868
Cdd:COG1643 533 rGEGGRYLLA-RGRGAALFPGSPLAKK--EWLVAAELVGGAAEArIRLAAPIDPEWLEELAAH 592
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
211-882 |
9.25e-149 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 471.95 E-value: 9.25e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 211 DQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDEtrrSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLV 290
Cdd:TIGR01967 28 DQDRAIAALAKFRERIDAACDKVEARRQAVPEIRYPD---NLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 291 EAGFTKdKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVM 370
Cdd:TIGR01967 105 ELGRGS-HGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 371 IIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFY------TKAPEADY 444
Cdd:TIGR01967 184 IIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrplveeQEDDDLDQ 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 445 IDACCVSVLQIHATQPlGDILVFLTGQDEIETCQEVLHDRvkrlgsKIRELIVIPVYANLPSDMQAKIFEPTppNARKVI 524
Cdd:TIGR01967 264 LEAILDAVDELFAEGP-GDILIFLPGEREIRDAAEILRKR------NLRHTEILPLYARLSNKEQQRVFQPH--SGRRIV 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 525 LATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEdNT 604
Cdd:TIGR01967 335 LATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPE-FT 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 605 VPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETL---VLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKML 681
Cdd:TIGR01967 414 DPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIrdgFRLLEELGALDDDEAEPQLTPIGRQLAQLPVDPRLARML 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 682 LASEKYKCSEEMVTIAAMLSVNSaIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYST------QWCYENF 755
Cdd:TIGR01967 494 LEAHRLGCLQEVLIIASALSIQD-PRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQALsanqfrNACRKQY 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 756 IQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKhNQTVMIHPNSSLFEELP 835
Cdd:TIGR01967 573 LNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGAR-GRKFHIFPGSPLFKKPP 651
|
650 660 670 680
....*....|....*....|....*....|....*....|....*..
gi 7298547 836 RWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELEDSTNKK 882
Cdd:TIGR01967 652 KWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIKKNYFEPHWEKK 698
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
189-871 |
2.94e-141 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 452.21 E-value: 2.94e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 189 SARFHfGAKDAKAEEEYELLLDdQIdfiqALTLDGSREKSSSRQ---PELTEKErkrltldetrrSLPVYPFKEDLIAAV 265
Cdd:PRK11131 24 SRRLH-GAKKIKNPDAQQAIFQ-EI----AKEIAQAAQRVLLREaarPEITYPE-----------NLPVSQKKQDILEAI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 266 KEHQVLIIEGETGSGKTTQVPQYLVEAGFTKdKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTI 345
Cdd:PRK11131 87 RDHQVVIVAGETGSGKTTQLPKICLELGRGV-KGLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 346 LKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRI 425
Cdd:PRK11131 166 VKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 426 PGRRYPVDIFYTkaPEADYIDACCVSVLQ--IHATQPL-----GDILVFLTGQDEIETCQEVLHDRvkrlgsKIRELIVI 498
Cdd:PRK11131 246 SGRTYPVEVRYR--PIVEEADDTERDQLQaiFDAVDELgregpGDILIFMSGEREIRDTADALNKL------NLRHTEIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 499 PVYANLPSDMQAKIFEPTppNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGR 578
Cdd:PRK11131 318 PLYARLSNSEQNRVFQSH--SGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGR 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 579 AGRTAPGKCFRLYTawaykhelEDN-------TVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYA 651
Cdd:PRK11131 396 CGRVSEGICIRLYS--------EDDflsrpefTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 652 LGALN-----HHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAiFYRPKDKIIHADTARKNFNH 726
Cdd:PRK11131 468 LGAITtdeqaSAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDP-RERPMDKQQASDEKHRRFAD 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 727 MHGDHLSLLQVYNQWAETD---YSTQW---CYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGY 800
Cdd:PRK11131 547 KESDFLAFVNLWNYLQEQQkalSSNQFrrlCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGL 626
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7298547 801 FYHVARLSKGGHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYK 871
Cdd:PRK11131 627 LSHIGMKDAEKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQHLIK 697
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
252-425 |
3.06e-125 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 374.92 E-value: 3.06e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAE 411
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 7298547 412 KFSAFFDDAPIFRI 425
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
252-700 |
1.75e-103 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 339.82 E-value: 1.75e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKkmIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGK--IIMLEPRRLAARSAAQRLASQLGEAVGQTVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDI-ARFRPELKLLISSATLDA 410
Cdd:TIGR01970 79 YRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVqSSLREDLKILAMSATLDG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 411 EKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYI-DACCVSVLQIHATQPlGDILVFLTGQDEIETCQEVLHDrvkRLG 489
Cdd:TIGR01970 159 ERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLeDAVSRAVEHALASET-GSILVFLPGQAEIRRVQEQLAE---RLD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 490 SkirELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISK 569
Cdd:TIGR01970 235 S---DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQ 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 570 ASANQRAGRAGRTAPGKCFRLYtAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQL 649
Cdd:TIGR01970 312 ASATQRAGRAGRLEPGVCYRLW-SEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVALAAARQLL 390
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 7298547 650 YALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAML 700
Cdd:TIGR01970 391 QRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALL 441
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
251-700 |
4.33e-94 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 314.55 E-value: 4.33e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 251 SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVP-QYLVEAGFTKDKKMIgctQPRRVAAMSVAARVAEEMGVKLGNE 329
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGINGKIIML---EPRRLAARNVAQRLAEQLGEKPGET 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 330 VGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDI-ARFRPELKLLISSATL 408
Cdd:PRK11664 80 VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqQGLRDDLKLLIMSATL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 409 DAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYID-ACCVSVLQIHATQPlGDILVFLTGQDEIETCQEVLHDRVKR 487
Cdd:PRK11664 160 DNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDeAVARATAELLRQES-GSLLLFLPGVGEIQRVQEQLASRVAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 488 lgskirELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPI 567
Cdd:PRK11664 239 ------DVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 568 SKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTvPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALE 647
Cdd:PRK11664 313 SQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSE-PEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKR 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 7298547 648 QLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYkcSEEMVTIAAML 700
Cdd:PRK11664 392 LLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAKL 442
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
247-426 |
4.93e-94 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 293.62 E-value: 4.93e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 247 ETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKdKKMIGCTQPRRVAAMSVAARVAEEMGVKL 326
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTS-RGKIGCTQPRRVAAMSVAKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 327 GNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSA 406
Cdd:cd17971 80 GQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSA 159
|
170 180
....*....|....*....|
gi 7298547 407 TLDAEKFSAFFDDAPIFRIP 426
Cdd:cd17971 160 TLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
268-425 |
1.26e-89 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 280.89 E-value: 1.26e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 268 HQVLIIEGETGSGKTTQVPQYLVEAGFTKDKK-MIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTIL 346
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGKgRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7298547 347 KYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRI 425
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
247-425 |
4.42e-88 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 278.14 E-value: 4.42e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 247 ETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKD-KKMIGCTQPRRVAAMSVAARVAEEMGVK 325
Cdd:cd17973 8 EKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQpKKLVACTQPRRVAAMSVAQRVAEEMDVK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 326 LGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISS 405
Cdd:cd17973 88 LGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMS 167
|
170 180
....*....|....*....|
gi 7298547 406 ATLDAEKFSAFFDDAPIFRI 425
Cdd:cd17973 168 ATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
252-425 |
4.23e-84 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 267.30 E-value: 4.23e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKkMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG-MIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFR-----PELKLLISSA 406
Cdd:cd17978 80 YSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSA 159
|
170
....*....|....*....
gi 7298547 407 TLDAEKFSAFFDDAPIFRI 425
Cdd:cd17978 160 TLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
252-425 |
3.14e-83 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 264.71 E-value: 3.14e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTkDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYT-DYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAE 411
Cdd:cd17983 80 YAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDAD 159
|
170
....*....|....
gi 7298547 412 KFSAFFDDAPIFRI 425
Cdd:cd17983 160 KFADFFGNVPIFTI 173
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
430-591 |
4.62e-80 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 255.92 E-value: 4.62e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 430 YPVDIFYTKAP-----------EADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKirELIVI 498
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDLG--KLLVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 499 PVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGR 578
Cdd:cd18791 79 PLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGR 158
|
170
....*....|...
gi 7298547 579 AGRTAPGKCFRLY 591
Cdd:cd18791 159 AGRTRPGKCYRLY 171
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
252-418 |
6.84e-75 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 242.76 E-value: 6.84e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSD-RTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDA 410
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*...
gi 7298547 411 EKFSAFFD 418
Cdd:cd17980 161 EKFRDFFN 168
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
252-425 |
4.77e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 226.66 E-value: 4.77e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKkMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHG-MIGVTQPRRVAAISVAQRVAEEMKCTLGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDI-----ARFRPELKLLISSA 406
Cdd:cd17984 80 YQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLfqeksPNRKEHLKVVVMSA 159
|
170
....*....|....*....
gi 7298547 407 TLDAEKFSAFFDDAPIFRI 425
Cdd:cd17984 160 TLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
252-425 |
1.59e-62 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 208.85 E-value: 1.59e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKdKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGI-RGLIGHTQPRRLAARSVAERIAEELKTELGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAE 411
Cdd:cd17989 80 YKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAE 159
|
170
....*....|....
gi 7298547 412 KFSAFFDDAPIFRI 425
Cdd:cd17989 160 RFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
252-414 |
9.35e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 201.81 E-value: 9.35e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDK----KMIGCTQPRRVAAMSVAARVAEEMGVkLG 327
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPEsdnpGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 328 NEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPE--------- 398
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170
....*....|....*..
gi 7298547 399 -LKLLISSATLDAEKFS 414
Cdd:cd17982 160 pLKLVIMSATLRVEDFT 176
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
252-425 |
4.68e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 190.73 E-value: 4.68e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKdkkmIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFESLNQYGSKVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAE 411
Cdd:cd17979 77 YQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIE 156
|
170
....*....|....
gi 7298547 412 KFSAFFDDAPIFRI 425
Cdd:cd17979 157 LFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
252-425 |
1.33e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 181.58 E-value: 1.33e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKK---MIGCTQPRRVAAMSVAARVAEEMG--VKL 326
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGsscRIVCTQPRRISAISVAERVAAERAesCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 327 GNEVGYSIRFED-CTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISS 405
Cdd:cd17981 81 GNSTGYQIRLESrKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 7298547 406 ATLDAEKFSAFFDDAPIFRI 425
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
252-425 |
2.17e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 169.71 E-value: 2.17e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE----AGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLG 327
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 328 ----NEV-GYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLL 402
Cdd:cd17975 81 pggkNSLcGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 7298547 403 ISSATLDAEKFSAFFDDAPIFRI 425
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
252-425 |
6.50e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 168.08 E-value: 6.50e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKK--MIGCTQPRRVAAMSVAARVAEEMGVKLGNE 329
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQhgVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 330 VGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLD 409
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|....*.
gi 7298547 410 AEKFSAFFDDAPIFRI 425
Cdd:cd17977 161 SSKLLSYYGNVPLIEV 176
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
252-424 |
2.97e-47 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 166.35 E-value: 2.97e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIgCTQPRRVAAMSVAARVAEEMGVKLGNEVG 331
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKII-VLEPRRVAARAAARRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 332 YSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIAR-FRPELKLLISSATLDA 410
Cdd:cd17990 80 YRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDG 159
|
170
....*....|....
gi 7298547 411 EKFSAFFDDAPIFR 424
Cdd:cd17990 160 DGLAALLPEAPVVE 173
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
252-425 |
4.60e-47 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 165.77 E-value: 4.60e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKK-MIGCTQPRRVAAMSVAARVAEEMGVKLGNEV 330
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPcRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 331 GYSIRFEDCTSDRTILKYMTDGTLHREFLS-EPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLD 409
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160
|
170
....*....|....*.
gi 7298547 410 AEKFSAFFDDAPIFRI 425
Cdd:cd17987 161 VNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
252-425 |
7.89e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 162.32 E-value: 7.89e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKM---IGCTQPRRVAAMSVAARVAEEMGVKLGN 328
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPvanIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 329 EVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATL 408
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 7298547 409 DAEKFSAFFDDAPIFRI 425
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
252-425 |
5.33e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 159.96 E-value: 5.33e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKM---IGCTQPRRVAAMSVAARVAEEMGVKLGN 328
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGArcnVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 329 EVGYSIRFEDCTSDRT-ILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSAT 407
Cdd:cd17976 81 NVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 7298547 408 LDAEKFSAFFDDAPIFRI 425
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
252-425 |
1.36e-41 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 150.05 E-value: 1.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQ-VLIIEGETGSGKTTQVPQYLVEAGFTK--DKKMIGCTQPRRVAAMSVAARVAEEMGVKLGN 328
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSRgfQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 329 EVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATL 408
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160
|
170
....*....|....*..
gi 7298547 409 DAEKFSAFFDDAPIFRI 425
Cdd:cd17986 161 LEPKLRAFWGNPPVVHV 177
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
234-425 |
5.71e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 144.98 E-value: 5.71e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 234 ELTEKERKRLTLD-------ETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAgFTKDKKMIGC--- 303
Cdd:cd17972 34 DLKNELMYQREQDhnlqqilQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDD-FIQNDRAAECniv 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 304 -TQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSD--RTILkYMTDGTLHREFlsEPDLASYSVMIIDEAHERTL 380
Cdd:cd17972 113 vTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRphASIL-FCTVGVLLRKL--EAGIRGISHVIVDEIHERDI 189
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 7298547 381 HTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRI 425
Cdd:cd17972 190 NTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
252-417 |
1.38e-36 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 136.09 E-value: 1.38e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 252 LPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKM-IGCTQPRRVAAMSVAARVAEEMGVKLGNEV 330
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCnIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 331 GYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRP-ELKLLISSATLD 409
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSrHVKIILMSATIS 160
|
....*...
gi 7298547 410 AEKFSAFF 417
Cdd:cd17988 161 CKEFADYF 168
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
645-734 |
8.40e-30 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 113.87 E-value: 8.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 645 ALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSaIFYRP------KDKIIHAD 718
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRD-PFVQPnfldprSAAKAARR 79
|
90 100
....*....|....*....|....*
gi 7298547 719 TARKNFNHMH---------GDHLSL 734
Cdd:pfam04408 80 RRRAADEKARakfarldleGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
651-735 |
8.78e-29 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 110.05 E-value: 8.78e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 651 ALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSaifYRPKDKIIHADTARKNFNHMHGD 730
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD---PRPKEKREDADAARRRFADPESD 77
|
....*
gi 7298547 731 HLSLL 735
Cdd:smart00847 78 HLTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
263-434 |
1.93e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 107.58 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 263 AAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGY------SIRF 336
Cdd:smart00487 19 ALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskREQL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 337 EDCTSDRTILKYMTDGTLHREFLSEP-DLASYSVMIIDEAHERT--LHTDILFGLVKdiaRFRPELKLLISSATL--DAE 411
Cdd:smart00487 99 RKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLK---LLPKNVQLLLLSATPpeEIE 175
|
170 180
....*....|....*....|...
gi 7298547 412 KFSAFFDDAPIFRIPGRRYPVDI 434
Cdd:smart00487 176 NLLELFLNDPVFIDVGFTPLEPI 198
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
792-869 |
5.23e-25 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 99.25 E-value: 5.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 792 VRKAATAGYFYHVARL-SKGGHYKTIKHNQTVMIHPNSSLFEEL---PRWVLYHELVFTSKEYMRQVIEIESKWLLEVAP 867
Cdd:pfam07717 1 LRAALAAGLYPNVARRdPKGKGYTTLSDNQRVFIHPSSVLFNEKtfpPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 7298547 868 HY 869
Cdd:pfam07717 81 HI 82
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
261-628 |
4.18e-13 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 73.09 E-value: 4.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 261 LIAAVKEHQVLIIEGETGSGKTTQVPQ------YLVeAGFTKDKKMIGCTQPRRVAaMSVAaRVAEemgVKL-GNEVGYS 333
Cdd:PHA02653 172 IFEAWISRKPVVLTGGTGVGKTSQVPKlllwfnYLF-GGFDNLDKIDPNFIERPIV-LSLP-RVAL---VRLhSITLLKS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 334 IRFEDCTSDRTILKY--MTDGTLHREF-----------LSEPDLASYSVMIIDEAHERTLHTDILFGLV-KDIARFRpel 399
Cdd:PHA02653 246 LGFDEIDGSPISLKYgsIPDELINTNPkpyglvfsthkLTLNKLFDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIR--- 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 400 KLLISSATL--DAEKFSAFFDDAPIFRIPG-RRYPVDIFYTKAP-----EADYIDACCVSVLQI--HATQPLG-DILVFL 468
Cdd:PHA02653 323 SLFLMTATLedDRDRIKEFFPNPAFVHIPGgTLFPISEVYVKNKynpknKRAYIEEEKKNIVTAlkKYTPPKGsSGIVFV 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 469 TgqdEIETCQEVlhdrVKRLGSKIRELIVIPVYANLPS--DMQAKIFEPTPPNarkVILATNIAETSLTIDNIIYVIDPG 546
Cdd:PHA02653 403 A---SVSQCEEY----KKYLEKRLPIYDFYIIHGKVPNidEILEKVYSSKNPS---IIISTPYLESSVTIRNATHVYDTG 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 547 FAKQNNFnsRTGMESLmvvpISKASANQRAGRAGRTAPGKCFRLYTAwaykheledNTVPEIQRIN---LGNAVLMLKAL 623
Cdd:PHA02653 473 RVYVPEP--FGGKEMF----ISKSMRTQRKGRVGRVSPGTYVYFYDL---------DLLKPIKRIDsefLHNYILYAKYF 537
|
....*...
gi 7298547 624 GI---NDL 628
Cdd:PHA02653 538 NLtlpEDL 545
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
491-581 |
6.95e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 61.84 E-value: 6.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 491 KIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFakqnnfnsrtgmeslmvvPISKA 570
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPA 69
|
90
....*....|.
gi 7298547 571 SANQRAGRAGR 581
Cdd:smart00490 70 SYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
452-581 |
9.14e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 56.84 E-value: 9.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 452 VLQIHATQPLGDILVFLTGQDEIETcqEVLHDRvkrlgskiRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAE 531
Cdd:pfam00271 6 LLELLKKERGGKVLIFSQTKKTLEA--ELLLEK--------EGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 7298547 532 TSLTIDNIIYVIdpgfakqnNFNSRTGMESLMvvpiskasanQRAGRAGR 581
Cdd:pfam00271 76 RGLDLPDVDLVI--------NYDLPWNPASYI----------QRIGRAGR 107
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
269-376 |
6.20e-07 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 49.86 E-value: 6.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 269 QVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIgctqprrVAAMSVAarVAEEMGVKL-GNEVGYSI-RFEDCTSDRTIL 346
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAIKKRLRTL-------VLAPTRV--VAAEMYEALrGLPIRYRTgAVKEEHGGNEIV 72
|
90 100 110
....*....|....*....|....*....|
gi 7298547 347 KYMTDGTLHREFLSEPDLASYSVMIIDEAH 376
Cdd:cd17931 73 DYMCHGTFTCRLLSPKRVPNYNLIIMDEAH 102
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
262-411 |
1.21e-05 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 46.47 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 262 IAAVKEHQVLIIEGETGSGKTT--QVPqYLVEAGFTKDKKMIGCTQPRRVAA---MSVAARVAEEMGVKLGNEVG----Y 332
Cdd:pfam00270 8 IPAILEGRDVLVQAPTGSGKTLafLLP-ALEALDKLDNGPQALVLAPTRELAeqiYEELKKLGKGLGLKVASLLGgdsrK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 333 SIRFEDCTSDrtILkYMTDGTLHREFLSEPDLASYSVMIIDEAHErtlHTDILFG--LVKDIARFRPELKLLISSATLDA 410
Cdd:pfam00270 87 EQLEKLKGPD--IL-VGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpdLEEILRRLPKKRQILLLSATLPR 160
|
.
gi 7298547 411 E 411
Cdd:pfam00270 161 N 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
271-407 |
2.95e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 44.70 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 271 LIIEGETGSGKTTQVPQYLVEAGFTKDKK-MIgcTQPRRVAAMSVAARVAEE--MGVKLGNEVGYS---IRFEDCTSDRT 344
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKvLV--LVPTKALALQTAERLRELfgPGIRVAVLVGGSsaeEREKNKLGDAD 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7298547 345 ILkYMTDGTLHREFLSE--PDLASYSVMIIDEAHERT-LHTDILFGLVKDIARFRPELKLLISSAT 407
Cdd:cd00046 82 II-IATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLiDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
522-591 |
2.60e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 2.60e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7298547 522 KVILATNIAETSLTIDNIIYVIDPGfakqnnfnsrtgmeslmvVPISKASANQRAGRAGRTA--PGKCFRLY 591
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFD------------------PPSSAASYIQRVGRAGRGGkdEGEVILFV 77
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
6-267 |
3.54e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.75 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 6 RKRTASSSSSGEEPDSEEESRLKDLQERDEF--ASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDRDKIVPHLR 83
Cdd:PTZ00121 1503 KKAAEAKKKADEAKKAEEAKKADEAKKAEEAkkADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK 1582
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 84 LQSRRQYLEKRKDD--KVAELEADILDDEYLFDESVLTKRE---KEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLK 158
Cdd:PTZ00121 1583 AEEAKKAEEARIEEvmKLYEEEKKMKAEEAKKAEEAKIKAEelkKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 159 KGE----------RSEYVEVDEFEKQPNSEQ--------------KKWEAEQLASARfhfgaKDAKAEEEYELLlddqid 214
Cdd:PTZ00121 1663 AAEeakkaeedkkKAEEAKKAEEDEKKAAEAlkkeaeeakkaeelKKKEAEEKKKAE-----ELKKAEEENKIK------ 1731
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 7298547 215 fIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKE 267
Cdd:PTZ00121 1732 -AEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
6-247 |
3.75e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.36 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 6 RKRTASSSSSGEEPDSEEESRLKDLQERDEFASRLKKRDDDRTRNvvdSTGGRRAIEEATKRLKLEHEDRDKIVPHLRLq 85
Cdd:PTZ00121 1591 EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKV---EQLKKKEAEEKKKAEELKKAEEENKIKAAEE- 1666
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 86 SRRQYLEKRKDDKvaeleadilddeylfdesvLTKREKEEREYKKQLLNIAKEHEKARELERI--QRYNMPQDLKKGERS 163
Cdd:PTZ00121 1667 AKKAEEDKKKAEE-------------------AKKAEEDEKKAAEALKKEAEEAKKAEELKKKeaEEKKKAEELKKAEEE 1727
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 164 EYVEVDEFEKQPNSEQKKweaeqlasarfhfgAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRL 243
Cdd:PTZ00121 1728 NKIKAEEAKKEAEEDKKK--------------AEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793
|
....
gi 7298547 244 TLDE 247
Cdd:PTZ00121 1794 MEVD 1797
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
8-203 |
1.25e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.82 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 8 RTASSSSSGEEPDSEEESRLKDLQERDEFASRLK--KRDDDRTRnvvdSTGGRRAIEEATKRLKLEHEDRDKIVPHLRLQ 85
Cdd:PTZ00121 1134 RKAEDARKAEEARKAEDAKRVEIARKAEDARKAEeaRKAEDAKK----AEAARKAEEVRKAEELRKAEDARKAEAARKAE 1209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 86 SRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKREKEERE--------------YKKQLLNIAKEHEKARELERIQRY 151
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNeeirkfeearmahfARRQAAIKAEEARKADELKKAEEK 1289
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 7298547 152 NMPQDLKKGErsEYVEVDEFEKQPNSEQKKWEAEQLA-SARFHFGAKDAKAEE 203
Cdd:PTZ00121 1290 KKADEAKKAE--EKKKADEAKKKAEEAKKADEAKKKAeEAKKKADAAKKKAEE 1340
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
7-243 |
2.54e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.67 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 7 KRTASSSSSGEEPDSEEESRLKDLQERDEFASRLKKRDDDRTRnvvdSTGGRRAIEEATK--RLKLEHEDRDKIVphlrl 84
Cdd:PTZ00121 1390 KKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK----ADEAKKKAEEAKKadEAKKKAEEAKKAE----- 1460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 85 QSRRQYLEKRKDD---KVAElEADILDDEYLFDESVLTK----REKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDL 157
Cdd:PTZ00121 1461 EAKKKAEEAKKADeakKKAE-EAKKADEAKKKAEEAKKKadeaKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA 1539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 158 KKGE---RSEYV----EVDEFEKQPNSEQKKWEAEQ--LASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSRE-K 227
Cdd:PTZ00121 1540 KKAEekkKADELkkaeELKKAEEKKKAEEAKKAEEDknMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEaK 1619
|
250
....*....|....*.
gi 7298547 228 SSSRQPELTEKERKRL 243
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKV 1635
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
58-310 |
2.65e-03 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 41.65 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 58 RRAIEEATKRLKLEHEDRDKIVPH----LRLQSRRQYLEKRKDDKVAELE--ADIlddeYLFDESVLTKREKE----ERE 127
Cdd:pfam17380 281 QKAVSERQQQEKFEKMEQERLRQEkeekAREVERRRKLEEAEKARQAEMDrqAAI----YAEQERMAMEREREleriRQE 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 128 YKKQLLN------IAKEHEKARELERIQRynmpQDLKKGER-------SEYVEVDEFEKQPNSEQKKWEAEQLASARfhf 194
Cdd:pfam17380 357 ERKRELErirqeeIAMEISRMRELERLQM----ERQQKNERvrqeleaARKVKILEEERQRKIQQQKVEMEQIRAEQ--- 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 195 gaKDAKAEEeyelllddqidfIQALTLDGSREKSSSRQPELTEK---ERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVL 271
Cdd:pfam17380 430 --EEARQRE------------VRRLEEERAREMERVRLEEQERQqqvERLRQQEEERKRKKLELEKEKRDRKRAEEQRRK 495
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 7298547 272 IIEGETGSGKTTQVPQ----YLVEAGFTKDKKMIGCTQPRRVA 310
Cdd:pfam17380 496 ILEKELEERKQAMIEEerkrKLLEKEMEERQKAIYEEERRREA 538
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
6-248 |
5.34e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.24 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 6 RKRTASSSSSGEEPDS---------EEESRLKD-----LQERDEFASRLKKRDDDRtrnvvdstggRRAIEEATKRLKLE 71
Cdd:pfam02029 20 RRQKEEEEPSGQVTESvepnehnsyEEDSELKPsgqggLDEEEAFLDRTAKREERR----------QKRLQEALERQKEF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 72 HEDRDKIVPHLRLQSRRQYLEkRKDDKVAELEADILDDEYLFDESvlTKREKEEREYK-KQLLNIAKEHEKARELERIQR 150
Cdd:pfam02029 90 DPTIADEKESVAERKENNEEE-ENSSWEKEEKRDSRLGRYKEEET--EIREKEYQENKwSTEVRQAEEEGEEEEDKSEEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7298547 151 YNMPQDLKKGERSEYVEVDEfEKQPNSEQKKWEAEQlasaRFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSS 230
Cdd:pfam02029 167 EEVPTENFAKEEVKDEKIKK-EKKVKYESKVFLDQK----RGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEAE 241
|
250 260
....*....|....*....|
gi 7298547 231 RQPElTEK--ERKRLTLDET 248
Cdd:pfam02029 242 VFLE-AEQklEELRRRRQEK 260
|
|
| |
