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Conserved domains on  [gi|6979313|gb|AAF34410|]
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cysteine-rich repeat-containing protein CRIM1, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRIM1_C super family cl44859
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 898-1028 6.10e-69

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


The actual alignment was detected with superfamily member pfam19442:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 225.89  E-value: 6.10e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6979313     898 ENDIIHLPRDMGHLQVDYRDNNRLHPGEDSSLDSIVSVVVPIIICLSIIIAFLLINQKKQWVPLLCwYRTPTKPSSLNNQ 977
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6979313     978 LVSVDCKKGTRVQVDGPQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1028
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
30-81 1.78e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.48  E-value: 1.78e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6979313      30 PCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAYGLhgaCDRGLRC 81
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 810-864 1.41e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 46.26  E-value: 1.41e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6979313     810 CHFSGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--IKVEGSCCPMC 864
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 674-725 3.70e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.11  E-value: 3.70e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6979313     674 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 725
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
394-447 8.22e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 8.22e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      394 CYANGQIRAHGDRWREDDCTFCQCINGEP-HCVATAC--GQSCMHP--VKVPGECCPVC 447
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
327-381 8.89e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 8.89e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      327 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSI-CFTAQCGE-LNCERYY--VPEGECCPVC 381
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 558-583 3.30e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 6979313     558 CPELPCSKICPLGFQQDSHGCLICKC 583
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 749-799 5.34e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 38.94  E-value: 5.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6979313     749 GDIFLAAESWKPDACTSCVCVDSAISCYSESCPSVACERPVLRK--GQCCPYC 799
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 530-555 8.10e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.84  E-value: 8.10e-03
                           10        20
                   ....*....|....*....|....*.
gi 6979313     530 CRPTMCDKFCPLGFLKNKHGCDICRC 555
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 898-1028 6.10e-69

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 225.89  E-value: 6.10e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6979313     898 ENDIIHLPRDMGHLQVDYRDNNRLHPGEDSSLDSIVSVVVPIIICLSIIIAFLLINQKKQWVPLLCwYRTPTKPSSLNNQ 977
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6979313     978 LVSVDCKKGTRVQVDGPQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1028
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
30-81 1.78e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.48  E-value: 1.78e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6979313      30 PCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAYGLhgaCDRGLRC 81
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 810-864 1.41e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 46.26  E-value: 1.41e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6979313     810 CHFSGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--IKVEGSCCPMC 864
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 674-725 3.70e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.70e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6979313     674 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 725
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
810-864 2.68e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.68e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      810 CHFSGKTYADEERWDIDSCTHCYCLQGQT-LCSTVSCPPLPC---AEPIKVEGSCCPMC 864
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDcpnPERVKPPGECCPRC 59
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-86 5.31e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 42.45  E-value: 5.31e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6979313       28 CLPCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAyglHGACDRGLRCVIRPP 86
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVY---TPRCAPGLRCQPPPG 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
394-447 8.22e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 8.22e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      394 CYANGQIRAHGDRWREDDCTFCQCINGEP-HCVATAC--GQSCMHP--VKVPGECCPVC 447
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
327-381 8.89e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 8.89e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      327 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSI-CFTAQCGE-LNCERYY--VPEGECCPVC 381
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 327-381 1.22e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 1.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6979313     327 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSICFTAQCGELNCE--RYYVPEGECCPVC 381
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
674-725 1.25e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.25e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 6979313      674 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 725
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 558-583 3.30e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 6979313     558 CPELPCSKICPLGFQQDSHGCLICKC 583
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 749-799 5.34e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.94  E-value: 5.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6979313     749 GDIFLAAESWKPDACTSCVCVDSAISCYSESCPSVACERPVLRK--GQCCPYC 799
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
749-799 1.47e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.47e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 6979313      749 GDIFLAAESWKPDACTSCVCVDSA-ISCYSESCPSV-ACERPVLRK--GQCCPYC 799
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 530-555 8.10e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.84  E-value: 8.10e-03
                           10        20
                   ....*....|....*....|....*.
gi 6979313     530 CRPTMCDKFCPLGFLKNKHGCDICRC 555
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 398-447 9.15e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 39.68  E-value: 9.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6979313     398 GQIRAHGD---RWRED---DCTFCQCINGEPH---C--VATACGQ-SCMHPVKVPGECCPVC 447
Cdd:pfam14828  174 GQLQFHGAgalRVGPEacsDPSGCGCGNDENLeriCanVLQRCPPpHCLSPLRPEGHCCDVC 235
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 898-1028 6.10e-69

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 225.89  E-value: 6.10e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6979313     898 ENDIIHLPRDMGHLQVDYRDNNRLHPGEDSSLDSIVSVVVPIIICLSIIIAFLLINQKKQWVPLLCwYRTPTKPSSLNNQ 977
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREGSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6979313     978 LVSVDCKKGTRVQVDGPQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1028
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
30-81 1.78e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 48.48  E-value: 1.78e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6979313      30 PCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAYGLhgaCDRGLRC 81
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPP---CGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 810-864 1.41e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 46.26  E-value: 1.41e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6979313     810 CHFSGKTYADEERWDIDSCTHCYCLQGQTLCSTVSCPPLPCAEP--IKVEGSCCPMC 864
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 674-725 3.70e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.70e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6979313     674 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 725
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
810-864 2.68e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 2.68e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      810 CHFSGKTYADEERWDIDSCTHCYCLQGQT-LCSTVSCPPLPC---AEPIKVEGSCCPMC 864
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDcpnPERVKPPGECCPRC 59
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-86 5.31e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 42.45  E-value: 5.31e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6979313       28 CLPCDESKC-EEPRSCPGSIVQGVCGCCYMCARQRNESCGGAyglHGACDRGLRCVIRPP 86
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVY---TPRCAPGLRCQPPPG 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
394-447 8.22e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 8.22e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      394 CYANGQIRAHGDRWREDDCTFCQCINGEP-HCVATAC--GQSCMHP--VKVPGECCPVC 447
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
327-381 8.89e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 41.35  E-value: 8.89e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 6979313      327 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSI-CFTAQCGE-LNCERYY--VPEGECCPVC 381
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 327-381 1.22e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 1.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6979313     327 CVFNSVEYYDGDMFRMDNCRFCRCQGGVSICFTAQCGELNCE--RYYVPEGECCPVC 381
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
674-725 1.25e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.25e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 6979313      674 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 725
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 558-583 3.30e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 6979313     558 CPELPCSKICPLGFQQDSHGCLICKC 583
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 749-799 5.34e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.94  E-value: 5.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 6979313     749 GDIFLAAESWKPDACTSCVCVDSAISCYSESCPSVACERPVLRK--GQCCPYC 799
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 818-864 1.45e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.38  E-value: 1.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 6979313     818 ADEERWDIDSCTH---CYC---LQGQTLCSTVS--CPPLPCAEPIKVEGSCCPMC 864
Cdd:pfam14828  181 AGALRVGPEACSDpsgCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC smart00214
von Willebrand factor (vWF) type C domain;
749-799 1.47e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.88  E-value: 1.47e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 6979313      749 GDIFLAAESWKPDACTSCVCVDSA-ISCYSESCPSV-ACERPVLRK--GQCCPYC 799
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 530-555 8.10e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 34.84  E-value: 8.10e-03
                           10        20
                   ....*....|....*....|....*.
gi 6979313     530 CRPTMCDKFCPLGFLKNKHGCDICRC 555
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 398-447 9.15e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 39.68  E-value: 9.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6979313     398 GQIRAHGD---RWRED---DCTFCQCINGEPH---C--VATACGQ-SCMHPVKVPGECCPVC 447
Cdd:pfam14828  174 GQLQFHGAgalRVGPEacsDPSGCGCGNDENLeriCanVLQRCPPpHCLSPLRPEGHCCDVC 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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