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Conserved domains on  [gi|6910978|gb|AAF31328|]
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sodium dependent phosphate transporter isoform NaPi-IIb [Homo sapiens]

Protein Classification

sodium-dependent phosphate transport protein 2( domain architecture ID 11490082)

sodium-dependent phosphate transport protein 2 may be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
104-603 2.02e-169

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 492.84  E-value: 2.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    104 LGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPI 183
Cdd:TIGR01013   1 LVLLFVFVCSLAVLSAAFILLGAKVGGAIFADILITDNPWASPLLGFLGTVLLQSSSTSRSIVVGMVSAGLLLVLLAIPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    184 IMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSLLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLL 263
Cdd:TIGR01013  81 IMGANIGSSVTNAIVAIMQSGDRAWFRRAFIGATVADIFNSSLALVLLPLELTTGGIESVTLLVVLVFGANGGGDAPDLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    264 KVITKPFTKLIVQLDKKVISQIAmndeKAKNKSLVKIWCKTFTnktqinvtvpstanctspSLCWTDGiqnwtmknvtyk 343
Cdd:TIGR01013 161 NSLTAPATALIVQLDNLIIRLIG----SLLILPLIDILASTLS------------------SLPVPES------------ 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    344 eNIAKCQHIFVNfhlpdlaVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGA 423
Cdd:TIGR01013 207 -NLPIEAHIFVN-------VGLILLALPFVRLCARLILVVIPLNSLLDGQVAPVILDVINLDTPVPFLWVTGYEALLVGD 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    424 GMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYP 503
Cdd:TIGR01013 279 AMTFIIQSSSVFTSALTPLVGKGVISLERAYPLVLGSNIGTTLTAVLAALLSEDEKRRSALQIAYCHNLFNISGIVLFYP 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    504 IPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRvlP 583
Cdd:TIGR01013 359 LPCTRKPIAAARGFGDDGSKYRWFLIVYLVLNFLLAPSLLFGLDLNLARRLVGVKIPFRILELFSSLLHVLQLRCPR--P 436
                         490       500
                  ....*....|....*....|
gi 6910978    584 KKLQNWNFLPLWMRSLKPWD 603
Cdd:TIGR01013 437 QSLQTWSFLPDWLRSLKRLD 456
 
Name Accession Description Interval E-value
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
104-603 2.02e-169

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 492.84  E-value: 2.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    104 LGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPI 183
Cdd:TIGR01013   1 LVLLFVFVCSLAVLSAAFILLGAKVGGAIFADILITDNPWASPLLGFLGTVLLQSSSTSRSIVVGMVSAGLLLVLLAIPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    184 IMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSLLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLL 263
Cdd:TIGR01013  81 IMGANIGSSVTNAIVAIMQSGDRAWFRRAFIGATVADIFNSSLALVLLPLELTTGGIESVTLLVVLVFGANGGGDAPDLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    264 KVITKPFTKLIVQLDKKVISQIAmndeKAKNKSLVKIWCKTFTnktqinvtvpstanctspSLCWTDGiqnwtmknvtyk 343
Cdd:TIGR01013 161 NSLTAPATALIVQLDNLIIRLIG----SLLILPLIDILASTLS------------------SLPVPES------------ 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    344 eNIAKCQHIFVNfhlpdlaVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGA 423
Cdd:TIGR01013 207 -NLPIEAHIFVN-------VGLILLALPFVRLCARLILVVIPLNSLLDGQVAPVILDVINLDTPVPFLWVTGYEALLVGD 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    424 GMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYP 503
Cdd:TIGR01013 279 AMTFIIQSSSVFTSALTPLVGKGVISLERAYPLVLGSNIGTTLTAVLAALLSEDEKRRSALQIAYCHNLFNISGIVLFYP 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    504 IPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRvlP 583
Cdd:TIGR01013 359 LPCTRKPIAAARGFGDDGSKYRWFLIVYLVLNFLLAPSLLFGLDLNLARRLVGVKIPFRILELFSSLLHVLQLRCPR--P 436
                         490       500
                  ....*....|....*....|
gi 6910978    584 KKLQNWNFLPLWMRSLKPWD 603
Cdd:TIGR01013 437 QSLQTWSFLPDWLRSLKRLD 456
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
417-509 3.91e-20

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 440894 [Multi-domain]  Cd Length: 540  Bit Score: 94.48  E-value: 3.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978  417 LAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRsslqIALCHFFFNIS 496
Cdd:COG1283 176 LGVLVGALLTALVQSSSATVGLLLALAAQGLIPLEAALALVLGANIGTTITALLASIGANVAARR----AALAHLLFNLI 251
                        90
                ....*....|....*
gi 6910978  497 GILLWYPI--PFTRL 509
Cdd:COG1283 252 GVLIFLPLlpPFAAL 266
Na_Pi_cotrans pfam02690
Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters ...
416-473 1.47e-11

Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.


Pssm-ID: 460653 [Multi-domain]  Cd Length: 137  Bit Score: 62.42  E-value: 1.47e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6910978    416 YLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAAL 473
Cdd:pfam02690  33 LKGFLVGLLVTALLQSSSATTVMVVGFVNAGLLTLAQALGVIMGANIGTTVTAQLIAF 90
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
404-504 2.09e-10

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 62.23  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   404 TDFPFPFAWLT-----GYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPgn 478
Cdd:NF037997 148 TSLPFVHSLLEstnesLLLALLIGTVLTAIIQSSSATTGITMSFLNEGILTLPAGIAIMLGANIGTCITALLASIGSG-- 225
                         90       100
                 ....*....|....*....|....*.
gi 6910978   479 alRSSLQIALCHFFFNISGILLWYPI 504
Cdd:NF037997 226 --KEAKLTAYAHIWLNVLGVLLFLPF 249
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
91-232 1.92e-05

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 47.21  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    91 LCFFQGIGRLI----LLLGFLYFFVCSldilsSAFQLVGGKMAGQFFSNSSIMS---NPLLGLVIGVLVTVLVQSSSTST 163
Cdd:NF037997 111 LLLFLPRPALKslgmSLFGLGAIFTAM-----RGFESLAGPLTSLPFVHSLLEStneSLLLALLIGTVLTAIIQSSSATT 185
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   164 SIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVAlmqVGDRSEFRR-AFAgatvHDFFNWLSLLVLLP 232
Cdd:NF037997 186 GITMSFLNEGILTLPAGIAIMLGANIGTCITALLAS---IGSGKEAKLtAYA----HIWLNVLGVLLFLP 248
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
121-200 1.03e-03

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 41.82  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   121 FQLVGGKMAGQFfsnSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVAL 200
Cdd:NF037997  20 FNLSGHKLKTWL---LKFTDTPLKGFLTGTVITAILQSSSAVMVLTVGLVSAGILTFRQSIGIILGTNIGTTFTTEFITF 96
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
418-473 5.71e-03

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 39.51  E-value: 5.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6910978   418 AILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAAL 473
Cdd:NF037997  41 GFLTGTVITAILQSSSAVMVLTVGLVSAGILTFRQSIGIILGTNIGTTFTTEFITF 96
 
Name Accession Description Interval E-value
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
104-603 2.02e-169

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 492.84  E-value: 2.02e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    104 LGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPI 183
Cdd:TIGR01013   1 LVLLFVFVCSLAVLSAAFILLGAKVGGAIFADILITDNPWASPLLGFLGTVLLQSSSTSRSIVVGMVSAGLLLVLLAIPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    184 IMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSLLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLL 263
Cdd:TIGR01013  81 IMGANIGSSVTNAIVAIMQSGDRAWFRRAFIGATVADIFNSSLALVLLPLELTTGGIESVTLLVVLVFGANGGGDAPDLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    264 KVITKPFTKLIVQLDKKVISQIAmndeKAKNKSLVKIWCKTFTnktqinvtvpstanctspSLCWTDGiqnwtmknvtyk 343
Cdd:TIGR01013 161 NSLTAPATALIVQLDNLIIRLIG----SLLILPLIDILASTLS------------------SLPVPES------------ 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    344 eNIAKCQHIFVNfhlpdlaVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGA 423
Cdd:TIGR01013 207 -NLPIEAHIFVN-------VGLILLALPFVRLCARLILVVIPLNSLLDGQVAPVILDVINLDTPVPFLWVTGYEALLVGD 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    424 GMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYP 503
Cdd:TIGR01013 279 AMTFIIQSSSVFTSALTPLVGKGVISLERAYPLVLGSNIGTTLTAVLAALLSEDEKRRSALQIAYCHNLFNISGIVLFYP 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    504 IPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRvlP 583
Cdd:TIGR01013 359 LPCTRKPIAAARGFGDDGSKYRWFLIVYLVLNFLLAPSLLFGLDLNLARRLVGVKIPFRILELFSSLLHVLQLRCPR--P 436
                         490       500
                  ....*....|....*....|
gi 6910978    584 KKLQNWNFLPLWMRSLKPWD 603
Cdd:TIGR01013 437 QSLQTWSFLPDWLRSLKRLD 456
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
417-509 3.91e-20

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 440894 [Multi-domain]  Cd Length: 540  Bit Score: 94.48  E-value: 3.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978  417 LAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRsslqIALCHFFFNIS 496
Cdd:COG1283 176 LGVLVGALLTALVQSSSATVGLLLALAAQGLIPLEAALALVLGANIGTTITALLASIGANVAARR----AALAHLLFNLI 251
                        90
                ....*....|....*
gi 6910978  497 GILLWYPI--PFTRL 509
Cdd:COG1283 252 GVLIFLPLlpPFAAL 266
Na_Pi_cotrans pfam02690
Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters ...
416-473 1.47e-11

Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.


Pssm-ID: 460653 [Multi-domain]  Cd Length: 137  Bit Score: 62.42  E-value: 1.47e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6910978    416 YLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAAL 473
Cdd:pfam02690  33 LKGFLVGLLVTALLQSSSATTVMVVGFVNAGLLTLAQALGVIMGANIGTTVTAQLIAF 90
Na_Pi_cotrans pfam02690
Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters ...
109-200 2.27e-11

Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.


Pssm-ID: 460653 [Multi-domain]  Cd Length: 137  Bit Score: 61.65  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    109 FFVCSLDILSSAFQLVGGKMAGQFFSnsSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGAN 188
Cdd:pfam02690   1 LFLFGMKLMSDGLQKLAGGRLRRILE--KLTSNPLKGFLVGLLVTALLQSSSATTVMVVGFVNAGLLTLAQALGVIMGAN 78
                          90
                  ....*....|..
gi 6910978    189 IGTSITNTIVAL 200
Cdd:pfam02690  79 IGTTVTAQLIAF 90
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
404-504 2.09e-10

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 62.23  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   404 TDFPFPFAWLT-----GYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPgn 478
Cdd:NF037997 148 TSLPFVHSLLEstnesLLLALLIGTVLTAIIQSSSATTGITMSFLNEGILTLPAGIAIMLGANIGTCITALLASIGSG-- 225
                         90       100
                 ....*....|....*....|....*.
gi 6910978   479 alRSSLQIALCHFFFNISGILLWYPI 504
Cdd:NF037997 226 --KEAKLTAYAHIWLNVLGVLLFLPF 249
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
95-233 2.22e-09

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 440894 [Multi-domain]  Cd Length: 540  Bit Score: 60.58  E-value: 2.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   95 QGIGRLILLLGFLyFFvcSLDILSSAFQ-LVGGKMAGQFFSnsSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSS 173
Cdd:COG1283 131 RQIGRILIGFGLL-FL--GLDLMSEAMEpLRDSPAFRALLA--SLSGNPLLGVLVGALLTALVQSSSATVGLLLALAAQG 205
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978  174 LLTVRAAIPIIMGANIGTSITnTIVALMqvGDRSEFRRAfagATVHDFFNWLSLLVLLPV 233
Cdd:COG1283 206 LIPLEAALALVLGANIGTTIT-ALLASI--GANVAARRA---ALAHLLFNLIGVLIFLPL 259
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
417-473 1.74e-07

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 440894 [Multi-domain]  Cd Length: 540  Bit Score: 54.42  E-value: 1.74e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6910978  417 LAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAAL 473
Cdd:COG1283  49 KGVLAGALVTALLQSSSATTVMVVGFVNAGLMTLAQALGVILGANIGTTLTAQLIAF 105
NaPi_cotrn_rel TIGR00704
Na/Pi-cotransporter; This model describes essentially the full length of an uncharacterized ...
378-542 8.52e-07

Na/Pi-cotransporter; This model describes essentially the full length of an uncharacterized protein from Bacillus subtilis and correponding lengths of longer proteins from E. coli and Treponema pallidum. PSI-BLAST analysis converges to demonstrate homology to one other group of proteins, type II sodium/phosphate (Na/Pi) cotransporters. A well-conserved repeated domain in this family, approximately 60 residues in length, is also repeated in the Na/Pi cotransporters, although with greater spacing between the repeats. The two families share additional homology in the region after the first repeat, share the properly of having extensive hydrophobic regions, and may be similar in function. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273225 [Multi-domain]  Cd Length: 308  Bit Score: 51.46  E-value: 8.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    378 CLIMIVKILGSVLKGQVATVIKKTINTDFpfpfawltgYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLT 457
Cdd:TIGR00704 143 AIEGFSHAAGPITKAKGGADIFAHLNDDI---------LLAALIGAMFAAIIHSSLAAIGILASFMAAGIIGFPQALCLV 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    458 LGSNIGTTTTAILAALAspGNAlrSSLQIALCHFFFNISGILLWYPIpFTRLPIRMAKGLGNISAKYRWFAVFY-LIIFF 536
Cdd:TIGR00704 214 IGANIGSCILAMLAASA--AGA--AAKQTALAHLLFKLLGSAIILPF-LHAAAEFMEKLSLDKAEKIAHFHLFFnLVRAL 288

                  ....*.
gi 6910978    537 FLIPLT 542
Cdd:TIGR00704 289 LFLPFT 294
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
91-232 1.92e-05

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 47.21  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978    91 LCFFQGIGRLI----LLLGFLYFFVCSldilsSAFQLVGGKMAGQFFSNSSIMS---NPLLGLVIGVLVTVLVQSSSTST 163
Cdd:NF037997 111 LLLFLPRPALKslgmSLFGLGAIFTAM-----RGFESLAGPLTSLPFVHSLLEStneSLLLALLIGTVLTAIIQSSSATT 185
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   164 SIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVAlmqVGDRSEFRR-AFAgatvHDFFNWLSLLVLLP 232
Cdd:NF037997 186 GITMSFLNEGILTLPAGIAIMLGANIGTCITALLAS---IGSGKEAKLtAYA----HIWLNVLGVLLFLP 248
NaPi_cotrn_rel TIGR00704
Na/Pi-cotransporter; This model describes essentially the full length of an uncharacterized ...
417-468 5.81e-04

Na/Pi-cotransporter; This model describes essentially the full length of an uncharacterized protein from Bacillus subtilis and correponding lengths of longer proteins from E. coli and Treponema pallidum. PSI-BLAST analysis converges to demonstrate homology to one other group of proteins, type II sodium/phosphate (Na/Pi) cotransporters. A well-conserved repeated domain in this family, approximately 60 residues in length, is also repeated in the Na/Pi cotransporters, although with greater spacing between the repeats. The two families share additional homology in the region after the first repeat, share the properly of having extensive hydrophobic regions, and may be similar in function. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273225 [Multi-domain]  Cd Length: 308  Bit Score: 42.60  E-value: 5.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6910978    417 LAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTA 468
Cdd:TIGR00704  46 KAFCAGIGFTAILQSSNAFMMIVIGFVAADLLAFAPAIPIILGADVGSAFMA 97
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
121-200 1.03e-03

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 41.82  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6910978   121 FQLVGGKMAGQFfsnSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVAL 200
Cdd:NF037997  20 FNLSGHKLKTWL---LKFTDTPLKGFLTGTVITAILQSSSAVMVLTVGLVSAGILTFRQSIGIILGTNIGTTFTTEFITF 96
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
418-473 5.71e-03

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 39.51  E-value: 5.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6910978   418 AILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAAL 473
Cdd:NF037997  41 GFLTGTVITAILQSSSAVMVLTVGLVSAGILTFRQSIGIILGTNIGTTFTTEFITF 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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