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Conserved domains on  [gi|6560770|gb|AAF16770|]
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F3M18.5 [Arabidopsis thaliana]

Protein Classification

OPA3 family protein( domain architecture ID 10537153)

OPA3 family protein similar to human optic atrophy 3 protein (OPA3) that may play some role in mitochondrial processes

Gene Ontology:  GO:0005739

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
6-126 2.03e-55

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


:

Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 170.38  E-value: 2.03e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560770      6 MKLGTLAVKTISKPLASQLKHQAKVHPKFRQSIINFAQRNHRITTQMQRRIYGHA-TDVEIRPLDEEKAVQAAVDLIGEI 84
Cdd:pfam07047   1 FKLGSLAIRTLSKPIANRIKRQAKEHPRFRRVCIPLAQLYHRLEMRLRMRLLGLAkPTRKIRPLNEEKAVELGADLLGEA 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6560770     85 FLFGVGGAVVVFEVQRSSRSEARKEEARKQELEELRIKDEEL 126
Cdd:pfam07047  81 FIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERIEEL 122
PilO super family cl42016
Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];
103-159 4.11e-03

Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];


The actual alignment was detected with superfamily member COG3167:

Pssm-ID: 442400 [Multi-domain]  Cd Length: 202  Bit Score: 36.46  E-value: 4.11e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6560770  103 RSEARKEEARKQELEELRIKDEELEKQ------VADLkskLEELEQLAKARGLSgIFQLKPQP 159
Cdd:COG3167  66 QAKAANLPALKAQLEELEQQLGELLKQlpskaeVPAL---LDDISQAALGSGLE-FELFKPGP 124
 
Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
6-126 2.03e-55

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 170.38  E-value: 2.03e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560770      6 MKLGTLAVKTISKPLASQLKHQAKVHPKFRQSIINFAQRNHRITTQMQRRIYGHA-TDVEIRPLDEEKAVQAAVDLIGEI 84
Cdd:pfam07047   1 FKLGSLAIRTLSKPIANRIKRQAKEHPRFRRVCIPLAQLYHRLEMRLRMRLLGLAkPTRKIRPLNEEKAVELGADLLGEA 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6560770     85 FLFGVGGAVVVFEVQRSSRSEARKEEARKQELEELRIKDEEL 126
Cdd:pfam07047  81 FIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERIEEL 122
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
110-141 1.02e-05

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 41.00  E-value: 1.02e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 6560770  110 EARKQELEELRIKDEELEKQVADLKSKLEELE 141
Cdd:cd21937  22 EALRLENEELKQKNEELEEENKELKAKLQQYE 53
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
85-162 7.15e-05

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 39.86  E-value: 7.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560770   85 FLFGVGGAVVVFEVQRssrsearKEEARKQELEELRIKDEELEKQVADLKSKLEELEQLAKAR-GLSG----IFQLKPQP 159
Cdd:COG2919  21 LWFGDGGLLAYRELRQ-------EIAELEAENAKLKARNAELEAEVADLKDGPDYIEERAREElGMVKpgetFYRVPDPE 93

                ...
gi 6560770  160 GTT 162
Cdd:COG2919  94 KAA 96
PRK12704 PRK12704
phosphodiesterase; Provisional
97-145 2.91e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.07  E-value: 2.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 6560770    97 EVQRSSRSEARKEEARKQELEELRIKDEELEKQVADLKSKLEELEQLAK 145
Cdd:PRK12704  83 ELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEE 131
PilO COG3167
Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];
103-159 4.11e-03

Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];


Pssm-ID: 442400 [Multi-domain]  Cd Length: 202  Bit Score: 36.46  E-value: 4.11e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6560770  103 RSEARKEEARKQELEELRIKDEELEKQ------VADLkskLEELEQLAKARGLSgIFQLKPQP 159
Cdd:COG3167  66 QAKAANLPALKAQLEELEQQLGELLKQlpskaeVPAL---LDDISQAALGSGLE-FELFKPGP 124
 
Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
6-126 2.03e-55

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 170.38  E-value: 2.03e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560770      6 MKLGTLAVKTISKPLASQLKHQAKVHPKFRQSIINFAQRNHRITTQMQRRIYGHA-TDVEIRPLDEEKAVQAAVDLIGEI 84
Cdd:pfam07047   1 FKLGSLAIRTLSKPIANRIKRQAKEHPRFRRVCIPLAQLYHRLEMRLRMRLLGLAkPTRKIRPLNEEKAVELGADLLGEA 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6560770     85 FLFGVGGAVVVFEVQRSSRSEARKEEARKQELEELRIKDEEL 126
Cdd:pfam07047  81 FIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERIEEL 122
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
110-141 1.02e-05

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 41.00  E-value: 1.02e-05
                        10        20        30
                ....*....|....*....|....*....|..
gi 6560770  110 EARKQELEELRIKDEELEKQVADLKSKLEELE 141
Cdd:cd21937  22 EALRLENEELKQKNEELEEENKELKAKLQQYE 53
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
85-162 7.15e-05

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 39.86  E-value: 7.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560770   85 FLFGVGGAVVVFEVQRssrsearKEEARKQELEELRIKDEELEKQVADLKSKLEELEQLAKAR-GLSG----IFQLKPQP 159
Cdd:COG2919  21 LWFGDGGLLAYRELRQ-------EIAELEAENAKLKARNAELEAEVADLKDGPDYIEERAREElGMVKpgetFYRVPDPE 93

                ...
gi 6560770  160 GTT 162
Cdd:COG2919  94 KAA 96
PRK12704 PRK12704
phosphodiesterase; Provisional
97-145 2.91e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.07  E-value: 2.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 6560770    97 EVQRSSRSEARKEEARKQELEELRIKDEELEKQVADLKSKLEELEQLAK 145
Cdd:PRK12704  83 ELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEE 131
PilO COG3167
Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];
103-159 4.11e-03

Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];


Pssm-ID: 442400 [Multi-domain]  Cd Length: 202  Bit Score: 36.46  E-value: 4.11e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6560770  103 RSEARKEEARKQELEELRIKDEELEKQ------VADLkskLEELEQLAKARGLSgIFQLKPQP 159
Cdd:COG3167  66 QAKAANLPALKAQLEELEQQLGELLKQlpskaeVPAL---LDDISQAALGSGLE-FELFKPGP 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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