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Conserved domains on  [gi|6227025|gb|AAF06061|]
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EST gb|Z17747 comes from this gene [Arabidopsis thaliana]

Protein Classification

DUF577 domain-containing protein( domain architecture ID 10517522)

DUF577 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF577 pfam04510
Family of unknown function (DUF577); This domain is found in Arabidopsis thaliana proteins, ...
 108-275 2.98e-65

Family of unknown function (DUF577); This domain is found in Arabidopsis thaliana proteins, which are specifically expressed during meiosis. Many of these members contain a repeated region.


:

Pssm-ID: 367974  Cd Length: 173  Bit Score: 202.86  E-value: 2.98e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6227025    108 HILSPILISCLEEQVVSDTSLKILSMLVNRVAFEIFTIQEETWYDLREFISSKAESEFVKVVSVFKSLSMPLDgEEFLIP 187
Cdd:pfam04510   2 REIKPLLISCLTMQETKESDFKILRRIVSHVAYEVFILQEGGWDELSDCILSLSETEPVKAFHVFQDLPMPLY-EEFIIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6227025    188 LMENLLPAILKRLGDNEEDSSGQWGLAFVGGFCAAVHLLET-TRVDLVENLANEMLKSVK----RGMELGFLGKALRDVE 262
Cdd:pfam04510  81 FLENLLPEIEKVLLPPEELDVEDWVLAFQGAFKAGIQLIESeMKADLVKEIAYKMVKSVRelveRKMEEGFVRRGLRDLE 160

                         170
                  ....*....|...
gi 6227025    263 IAVVEQLWWYCTT 275
Cdd:pfam04510 161 SFVKKQMNWYKYN 173
 
Name Accession Description Interval E-value
DUF577 pfam04510
Family of unknown function (DUF577); This domain is found in Arabidopsis thaliana proteins, ...
 108-275 2.98e-65

Family of unknown function (DUF577); This domain is found in Arabidopsis thaliana proteins, which are specifically expressed during meiosis. Many of these members contain a repeated region.


Pssm-ID: 367974  Cd Length: 173  Bit Score: 202.86  E-value: 2.98e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6227025    108 HILSPILISCLEEQVVSDTSLKILSMLVNRVAFEIFTIQEETWYDLREFISSKAESEFVKVVSVFKSLSMPLDgEEFLIP 187
Cdd:pfam04510   2 REIKPLLISCLTMQETKESDFKILRRIVSHVAYEVFILQEGGWDELSDCILSLSETEPVKAFHVFQDLPMPLY-EEFIIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6227025    188 LMENLLPAILKRLGDNEEDSSGQWGLAFVGGFCAAVHLLET-TRVDLVENLANEMLKSVK----RGMELGFLGKALRDVE 262
Cdd:pfam04510  81 FLENLLPEIEKVLLPPEELDVEDWVLAFQGAFKAGIQLIESeMKADLVKEIAYKMVKSVRelveRKMEEGFVRRGLRDLE 160

                         170
                  ....*....|...
gi 6227025    263 IAVVEQLWWYCTT 275
Cdd:pfam04510 161 SFVKKQMNWYKYN 173
HipA cd17793
type II toxin-antitoxin sytem toxin HipA and similar proteins; This family contains type II ...
 174-227 1.78e-03

type II toxin-antitoxin sytem toxin HipA and similar proteins; This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli and Shewanella oneidensis HipA, which is a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. Structures of HipAB:DNA complexes from both Escherichia coli and Shewanella oneidensis reveal distinct complex assembly.


Pssm-ID: 341492 [Multi-domain]  Cd Length: 358  Bit Score: 39.50  E-value: 1.78e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6227025  174 SLSMPLDGEEFL----IPLMENLLP------AILKRLGDNEEDSSGQwgLAFVGGFCA-AVHLLE 227
Cdd:cd17793  24 SLSLPLRAEPFGddevRPFFANLLPegdvrrLIARRLGVSRSDDFAL--LEAIGGDCAgAVSILP 86
 
Name Accession Description Interval E-value
DUF577 pfam04510
Family of unknown function (DUF577); This domain is found in Arabidopsis thaliana proteins, ...
 108-275 2.98e-65

Family of unknown function (DUF577); This domain is found in Arabidopsis thaliana proteins, which are specifically expressed during meiosis. Many of these members contain a repeated region.


Pssm-ID: 367974  Cd Length: 173  Bit Score: 202.86  E-value: 2.98e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6227025    108 HILSPILISCLEEQVVSDTSLKILSMLVNRVAFEIFTIQEETWYDLREFISSKAESEFVKVVSVFKSLSMPLDgEEFLIP 187
Cdd:pfam04510   2 REIKPLLISCLTMQETKESDFKILRRIVSHVAYEVFILQEGGWDELSDCILSLSETEPVKAFHVFQDLPMPLY-EEFIIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6227025    188 LMENLLPAILKRLGDNEEDSSGQWGLAFVGGFCAAVHLLET-TRVDLVENLANEMLKSVK----RGMELGFLGKALRDVE 262
Cdd:pfam04510  81 FLENLLPEIEKVLLPPEELDVEDWVLAFQGAFKAGIQLIESeMKADLVKEIAYKMVKSVRelveRKMEEGFVRRGLRDLE 160

                         170
                  ....*....|...
gi 6227025    263 IAVVEQLWWYCTT 275
Cdd:pfam04510 161 SFVKKQMNWYKYN 173
HipA cd17793
type II toxin-antitoxin sytem toxin HipA and similar proteins; This family contains type II ...
 174-227 1.78e-03

type II toxin-antitoxin sytem toxin HipA and similar proteins; This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli and Shewanella oneidensis HipA, which is a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. Structures of HipAB:DNA complexes from both Escherichia coli and Shewanella oneidensis reveal distinct complex assembly.


Pssm-ID: 341492 [Multi-domain]  Cd Length: 358  Bit Score: 39.50  E-value: 1.78e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6227025  174 SLSMPLDGEEFL----IPLMENLLP------AILKRLGDNEEDSSGQwgLAFVGGFCA-AVHLLE 227
Cdd:cd17793  24 SLSLPLRAEPFGddevRPFFANLLPegdvrrLIARRLGVSRSDDFAL--LEAIGGDCAgAVSILP 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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