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Conserved domains on  [gi|5031195|gb|AAD38108|]
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IkBL protein [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-138 2.69e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 2.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195   43 AGRLVRAQALLQRhpGLDVDA---GQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLP 119
Cdd:COG0666 130 NGNLEIVKLLLEA--GADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG---HLEIVKL 204

                        90       100
                ....*....|....*....|...
gi 5031195  120 LLSRcpsamG----IKNKDGETP 138
Cdd:COG0666 205 LLEA-----GadvnAKDNDGKTA 222
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-138 2.69e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 2.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195   43 AGRLVRAQALLQRhpGLDVDA---GQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLP 119
Cdd:COG0666 130 NGNLEIVKLLLEA--GADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG---HLEIVKL 204

                        90       100
                ....*....|....*....|...
gi 5031195  120 LLSRcpsamG----IKNKDGETP 138
Cdd:COG0666 205 LLEA-----GadvnAKDNDGKTA 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-109 2.01e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 2.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 5031195     69 LHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 109
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG 41
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-132 6.67e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195    58 GLDVDA----GQPPpLHRAcARHDAPALCL-LLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLPLLSRCPSAMGIKN 132
Cdd:PHA03095 247 GISINArnryGQTP-LHYA-AVFNNPRACRrLIALGADINAVSSDGNTPLSLMVRNN---NGRAVRAALAKNPSAETVAA 321
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-138 2.69e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 2.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195   43 AGRLVRAQALLQRhpGLDVDA---GQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLP 119
Cdd:COG0666 130 NGNLEIVKLLLEA--GADVNAqdnDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG---HLEIVKL 204

                        90       100
                ....*....|....*....|...
gi 5031195  120 LLSRcpsamG----IKNKDGETP 138
Cdd:COG0666 205 LLEA-----GadvnAKDNDGKTA 222
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-138 2.87e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 2.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195   44 GRLVRAQALLQRhpGLDV---DAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLPL 120
Cdd:COG0666  98 GDLEIVKLLLEA--GADVnarDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---NLEIVKLL 172

                        90       100
                ....*....|....*....|..
gi 5031195  121 LSRcpsamG----IKNKDGETP 138
Cdd:COG0666 173 LEA-----GadvnARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
46-138 6.74e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 6.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195   46 LVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLpllsrcp 125
Cdd:COG0666  68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL------- 140

                        90
                ....*....|....*..
gi 5031195  126 sAMG----IKNKDGETP 138
Cdd:COG0666 141 -EAGadvnAQDNDGNTP 156
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
49-109 7.12e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 7.12e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5031195   49 AQALLQRhpGLDVDAGQP---PPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 109
Cdd:COG0666 169 VKLLLEA--GADVNARDNdgeTPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-109 2.01e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 2.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 5031195     69 LHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 109
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
67-109 2.10e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 2.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 5031195     67 PPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQG 109
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG 45
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-105 2.77e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 2.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 5031195     68 PLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAA 105
Cdd:pfam13857  19 PLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-132 6.67e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031195    58 GLDVDA----GQPPpLHRAcARHDAPALCL-LLRLGADPAHQDRHGDTALHAAARQGpdaYTDFFLPLLSRCPSAMGIKN 132
Cdd:PHA03095 247 GISINArnryGQTP-LHYA-AVFNNPRACRrLIALGADINAVSSDGNTPLSLMVRNN---NGRAVRAALAKNPSAETVAA 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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