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Conserved domains on  [gi|4874274|gb|AAD31339|]
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Similar to gb|X02844 lipase precursor from Staphylococcus hyicus. ESTs gb|AI239406 and gb|T76725 come from this gene [Arabidopsis thaliana]

Protein Classification

lipase family protein( domain architecture ID 1903390)

lipase family protein such as triacylglycerol lipase, which is an alpha/beta hydrolase that catalyzes the hydrolysis of a triacylglycerol to form the corresponding diacylglycerol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0006629|GO:0016787|GO:0016298
PubMed:  7946464|1290943
SCOP:  3000102

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
EstA super family cl43327
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 68-205 8.81e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


The actual alignment was detected with superfamily member COG1075:

Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 44.44  E-value: 8.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4874274   68 PIVLVHGIFGFGkgrlgglSYFGGAEKKDER----VLVPDLGSLT-SIYDRARELFYYLkggvvdfgEEHSEACGHSRfg 142
Cdd:COG1075   7 PVVLVHGLGGSA-------ASWAPLAPRLRAagypVYALNYPSTNgSIEDSAEQLAAFV--------DAVLAATGAEK-- 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4874274  143 rryeqgqypewdedhpIHFVGHSAGAQVVR-VLQQMLADqafegfeetneNWVLSVTSLSGAFN 205
Cdd:COG1075  70 ----------------VDLVGHSMGGLVARyYLKRLGGA-----------AKVARVVTLGTPHH 106
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 68-205 8.81e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 44.44  E-value: 8.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4874274   68 PIVLVHGIFGFGkgrlgglSYFGGAEKKDER----VLVPDLGSLT-SIYDRARELFYYLkggvvdfgEEHSEACGHSRfg 142
Cdd:COG1075   7 PVVLVHGLGGSA-------ASWAPLAPRLRAagypVYALNYPSTNgSIEDSAEQLAAFV--------DAVLAATGAEK-- 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4874274  143 rryeqgqypewdedhpIHFVGHSAGAQVVR-VLQQMLADqafegfeetneNWVLSVTSLSGAFN 205
Cdd:COG1075  70 ----------------VDLVGHSMGGLVARyYLKRLGGA-----------AKVARVVTLGTPHH 106
 
Name Accession Description Interval E-value
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 68-205 8.81e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 44.44  E-value: 8.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4874274   68 PIVLVHGIFGFGkgrlgglSYFGGAEKKDER----VLVPDLGSLT-SIYDRARELFYYLkggvvdfgEEHSEACGHSRfg 142
Cdd:COG1075   7 PVVLVHGLGGSA-------ASWAPLAPRLRAagypVYALNYPSTNgSIEDSAEQLAAFV--------DAVLAATGAEK-- 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4874274  143 rryeqgqypewdedhpIHFVGHSAGAQVVR-VLQQMLADqafegfeetneNWVLSVTSLSGAFN 205
Cdd:COG1075  70 ----------------VDLVGHSMGGLVARyYLKRLGGA-----------AKVARVVTLGTPHH 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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