V-type ATPase 116kDa subunit a family protein such as vertebrate V-type proton ATPase 116 kDa subunit a and plant/yeast V-type proton ATPase subunit a, an essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-829
0e+00
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.
:
Pssm-ID: 460232 [Multi-domain] Cd Length: 748 Bit Score: 1275.49 E-value: 0e+00
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-829
0e+00
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.
Pssm-ID: 460232 [Multi-domain] Cd Length: 748 Bit Score: 1275.49 E-value: 0e+00
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-830
1.35e-43
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase
Pssm-ID: 440880 [Multi-domain] Cd Length: 645 Bit Score: 168.16 E-value: 1.35e-43
non-canonical GAT domain found in metazoan signal transducing adapter molecules (STAMs) and ...
59-151
5.24e-03
non-canonical GAT domain found in metazoan signal transducing adapter molecules (STAMs) and similar proteins; STAMs are Hrs-binding proteins involved in intracellular signal transduction mediated by cytokines and growth factors. They are components of the ESCRT-0 complex that binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them for further sequential lysosomal sorting/trafficking processes. Members of this family contain a non-canonical GAT (GGA and Tom1) domain consisting of two helices. A canonical GAT domain is a monomeric three-helix bundle that bind to ubiquitin. STAM, together with another GAT domain-containing protein Hrs, forms a Hrs/STAM core complex that consists of two intertwined GAT domains, each consisting of two helices from one subunit, and one from the other subunit. The two GAT domains are connected by a two-stranded coiled-coil. The Hrs/STAM complex, an intertwined GAT heterodimer, is a scaffold for binding of ubiquitinated cargo proteins and coordinating ubiquitination and deubiquitination reactions that regulate sorting.
Pssm-ID: 410593 Cd Length: 77 Bit Score: 36.51 E-value: 5.24e-03
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-829
0e+00
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.
Pssm-ID: 460232 [Multi-domain] Cd Length: 748 Bit Score: 1275.49 E-value: 0e+00
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-830
1.35e-43
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase
Pssm-ID: 440880 [Multi-domain] Cd Length: 645 Bit Score: 168.16 E-value: 1.35e-43
non-canonical GAT domain found in metazoan signal transducing adapter molecules (STAMs) and ...
59-151
5.24e-03
non-canonical GAT domain found in metazoan signal transducing adapter molecules (STAMs) and similar proteins; STAMs are Hrs-binding proteins involved in intracellular signal transduction mediated by cytokines and growth factors. They are components of the ESCRT-0 complex that binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them for further sequential lysosomal sorting/trafficking processes. Members of this family contain a non-canonical GAT (GGA and Tom1) domain consisting of two helices. A canonical GAT domain is a monomeric three-helix bundle that bind to ubiquitin. STAM, together with another GAT domain-containing protein Hrs, forms a Hrs/STAM core complex that consists of two intertwined GAT domains, each consisting of two helices from one subunit, and one from the other subunit. The two GAT domains are connected by a two-stranded coiled-coil. The Hrs/STAM complex, an intertwined GAT heterodimer, is a scaffold for binding of ubiquitinated cargo proteins and coordinating ubiquitination and deubiquitination reactions that regulate sorting.
Pssm-ID: 410593 Cd Length: 77 Bit Score: 36.51 E-value: 5.24e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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