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Conserved domains on  [gi|3766136|gb|AAC72013|]
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Ig-like membrane protein [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 707-804 2.27e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136     707 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 786
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 3766136     787 LTVQRAEVSDSGSYYCHV 804
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 152-251 6.01e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 6.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   152 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 231
Cdd:cd00099    5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                         90       100
                 ....*....|....*....|
gi 3766136   232 TIFHLQPSDQGEFYCEAAEW 251
Cdd:cd00099   76 TISNLQPEDSGTYYCAVSES 95
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 32-132 1.36e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 45.40  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136    32 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 102
Cdd:cd00099   10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 3766136   103 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 132
Cdd:cd00099   73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 294-386 1.46e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05775:

Pssm-ID: 472250  Cd Length: 98  Bit Score: 39.25  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   294 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 373
Cdd:cd05775    9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                         90
                 ....*....|...
gi 3766136   374 YNCRVTEREKTVT 386
Cdd:cd05775   77 YELEITSTNGKVL 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 441-534 6.72e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 6.72e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      441 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 520
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 3766136      521 SRKEDEGQYECHVT 534
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 707-804 2.27e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136     707 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 786
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 3766136     787 LTVQRAEVSDSGSYYCHV 804
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 152-251 6.01e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 6.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   152 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 231
Cdd:cd00099    5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                         90       100
                 ....*....|....*....|
gi 3766136   232 TIFHLQPSDQGEFYCEAAEW 251
Cdd:cd00099   76 TISNLQPEDSGTYYCAVSES 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 709-831 7.12e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 51.89  E-value: 7.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   709 LTLVENKPIQLNCSVKSQTSQNshfaVLWYVHKPSDADGKLILKTTHNSAFEYGtyaeeeglRARLQFERhvSGGLFSLT 788
Cdd:cd04983    8 LSVQEGENVTLNCNYSTSTFYY----LFWYRQYPGQGPQFLIYISSDSGNKKKG--------RFSATLDK--SRKSSSLH 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 3766136   789 VQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTVK 831
Cdd:cd04983   74 ISAAQLSDSAVYFC-----ALSESGGTGKL---TFGKgTRLTVE 109
IGv smart00406
Immunoglobulin V-Type;
163-247 1.20e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.38  E-value: 1.20e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      163 LELTCEVASETIqhSHLSVAWLRQKVGeKPVEVISLSRDfmlhSSSEYAQRQSLGEVRLDK-LGRTTFRLTIFHLQPSDQ 241
Cdd:smart00406    2 VTLSCKFSGSTF--SSYYVSWVRQPPG-KGLEWLGYIGS----NGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDT 74


                    ....*.
gi 3766136      242 GEFYCE 247
Cdd:smart00406   75 GTYYCA 80
IGv smart00406
Immunoglobulin V-Type;
719-802 5.87e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.45  E-value: 5.87e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      719 LNCSVKsqTSQNSHFAVLWYVHKPSDAdgkliLKTTHNSAFEYGTYAEEeGLRARLQFERHVSGGLFSLTVQRAEVSDSG 798
Cdd:smart00406    4 LSCKFS--GSTFSSYYVSWVRQPPGKG-----LEWLGYIGSNGSSYYQE-SYKGRFTISKDTSKNDVSLTISNLRVEDTG 75


                    ....
gi 3766136      799 SYYC 802
Cdd:smart00406   76 TYYC 79
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 32-132 1.36e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.40  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136    32 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 102
Cdd:cd00099   10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 3766136   103 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 132
Cdd:cd00099   73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-141 3.08e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 3.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      34 EGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTmdSSFPYAIYTQRVRGGKIFIErvqgNSTLLHITDLQAR 113
Cdd:pfam07686   10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYS--NGSEEGVKKGRFSGRGDPSN----GDGSLTIQNLTLS 83

                           90       100
                   ....*....|....*....|....*...
gi 3766136     114 DAGEYECHTPSTDKQYFGSysaKMNLVV 141
Cdd:pfam07686   84 DSGTYTCAVIPSGEGVFGK---GTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 152-246 1.22e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136     152 PQTLHRVEQDPLELTCEVASETIQHsHLSVAWLRQKVGEKPVEVISLSrdfmlHSSSEYAQRQSLGEVRLDKlGRTTFRL 231
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLIAYY-----SNGSEEGVKKGRFSGRGDP-SNGDGSL 75

                           90
                   ....*....|....*
gi 3766136     232 TIFHLQPSDQGEFYC 246
Cdd:pfam07686   76 TIQNLTLSDSGTYTC 90
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 294-386 1.46e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 39.25  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   294 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 373
Cdd:cd05775    9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                         90
                 ....*....|...
gi 3766136   374 YNCRVTEREKTVT 386
Cdd:cd05775   77 YELEITSTNGKVL 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 293-389 1.63e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 1.63e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      293 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 372
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 3766136      373 KYNCRVTEREKTVTGEF 389
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 441-534 6.72e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 6.72e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      441 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 520
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 3766136      521 SRKEDEGQYECHVT 534
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 707-804 2.27e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136     707 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 786
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 3766136     787 LTVQRAEVSDSGSYYCHV 804
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 152-251 6.01e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 6.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   152 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 231
Cdd:cd00099    5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                         90       100
                 ....*....|....*....|
gi 3766136   232 TIFHLQPSDQGEFYCEAAEW 251
Cdd:cd00099   76 TISNLQPEDSGTYYCAVSES 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 709-831 7.12e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 51.89  E-value: 7.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   709 LTLVENKPIQLNCSVKSQTSQNshfaVLWYVHKPSDADGKLILKTTHNSAFEYGtyaeeeglRARLQFERhvSGGLFSLT 788
Cdd:cd04983    8 LSVQEGENVTLNCNYSTSTFYY----LFWYRQYPGQGPQFLIYISSDSGNKKKG--------RFSATLDK--SRKSSSLH 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 3766136   789 VQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTVK 831
Cdd:cd04983   74 ISAAQLSDSAVYFC-----ALSESGGTGKL---TFGKgTRLTVE 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 705-830 2.82e-07

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 50.03  E-value: 2.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   705 SKRTLTLVENKPIQLNCSVksqTSQNSHFAVLWYVHKPSDADgKLILKTTHNSAFEygtyaeEEGLRARLQFERHvSGGL 784
Cdd:cd00099    4 SPRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGP-EFLIYLSSSKGKT------KGGVPGRFSGSRD-GTSS 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 3766136   785 FSLTVQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTV 830
Cdd:cd00099   73 FSLTISNLQPEDSGTYYC-----AVSESGGTDKL---TFGSgTRLTV 111
IGv smart00406
Immunoglobulin V-Type;
163-247 1.20e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.38  E-value: 1.20e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      163 LELTCEVASETIqhSHLSVAWLRQKVGeKPVEVISLSRDfmlhSSSEYAQRQSLGEVRLDK-LGRTTFRLTIFHLQPSDQ 241
Cdd:smart00406    2 VTLSCKFSGSTF--SSYYVSWVRQPPG-KGLEWLGYIGS----NGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDT 74


                    ....*.
gi 3766136      242 GEFYCE 247
Cdd:smart00406   75 GTYYCA 80
IGv smart00406
Immunoglobulin V-Type;
719-802 5.87e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.45  E-value: 5.87e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      719 LNCSVKsqTSQNSHFAVLWYVHKPSDAdgkliLKTTHNSAFEYGTYAEEeGLRARLQFERHVSGGLFSLTVQRAEVSDSG 798
Cdd:smart00406    4 LSCKFS--GSTFSSYYVSWVRQPPGKG-----LEWLGYIGSNGSSYYQE-SYKGRFTISKDTSKNDVSLTISNLRVEDTG 75


                    ....
gi 3766136      799 SYYC 802
Cdd:smart00406   76 TYYC 79
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 32-132 1.36e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.40  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136    32 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 102
Cdd:cd00099   10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 3766136   103 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 132
Cdd:cd00099   73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-141 3.08e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 3.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      34 EGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTmdSSFPYAIYTQRVRGGKIFIErvqgNSTLLHITDLQAR 113
Cdd:pfam07686   10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYS--NGSEEGVKKGRFSGRGDPSN----GDGSLTIQNLTLS 83

                           90       100
                   ....*....|....*....|....*...
gi 3766136     114 DAGEYECHTPSTDKQYFGSysaKMNLVV 141
Cdd:pfam07686   84 DSGTYTCAVIPSGEGVFGK---GTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 152-248 9.24e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 9.24e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      152 PQTLHRVEQDPLELTCEVASEtiqhSHLSVAWLRQKVgekpvEVISLSRDFMLHSSSeyaqrqslgevrldklgrTTFRL 231
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGG-----KLLAESGRFSVSRSG------------------STSTL 53

                            90
                    ....*....|....*..
gi 3766136      232 TIFHLQPSDQGEFYCEA 248
Cdd:smart00410   54 TISNVTPEDSGTYTCAA 70
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 702-802 1.16e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 42.65  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   702 VSKSKRTLTLVENKPIQLNCSVKSQtsqnsHFAVLWYVHKPsdadGK-LILKTTHNSAFEYgtyaEEEGL-RARLQFERH 779
Cdd:cd05899    1 VTQSPRYLIKRRGQSVTLRCSQKSG-----HDNMYWYRQDP----GKgLQLLFYSYGGGLN----EEGDLpGDRFSASRP 67

                         90       100
                 ....*....|....*....|...
gi 3766136   780 vSGGLFSLTVQRAEVSDSGSYYC 802
Cdd:cd05899   68 -SLTRSSLTIKSAEPEDSAVYLC 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 152-246 1.22e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136     152 PQTLHRVEQDPLELTCEVASETIQHsHLSVAWLRQKVGEKPVEVISLSrdfmlHSSSEYAQRQSLGEVRLDKlGRTTFRL 231
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLIAYY-----SNGSEEGVKKGRFSGRGDP-SNGDGSL 75

                           90
                   ....*....|....*
gi 3766136     232 TIFHLQPSDQGEFYC 246
Cdd:pfam07686   76 TIQNLTLSDSGTYTC 90
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 713-818 1.31e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 42.74  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   713 ENKPIQLNCSVKSQTsqNSHFAVLWYVHKPSDADGKLI-LKTTHNSAFEYGTYAEEegLRARLQFERHVSgglfSLTVQR 791
Cdd:cd04982   12 ESKSVTISCKVSGID--FSTTYIHWYRQKPGQALERLLyVSSTSAVRKDSGKTKNK--FEARKDVGKSTS----TLTITN 83

                         90       100
                 ....*....|....*....|....*..
gi 3766136   792 AEVSDSGSYYCHVeeWLLSPNYaWYKL 818
Cdd:cd04982   84 LEKEDSATYYCAY--WESGSGY-YIKV 107
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 22-120 1.60e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.40  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      22 QVTVQEGPLYRTEGSHITIWCNVSGYQGPSeqnFQWsiYLPSSPEREVQIVSTMDSsfpyaiytqrvrggkifiervqGN 101
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSPPPT---ITW--YKNGEPISSGSTRSRSLS----------------------GS 55

                           90
                   ....*....|....*....
gi 3766136     102 STLLHITDLQARDAGEYEC 120
Cdd:pfam13927   56 NSTLTISNVTRSDAGTYTC 74
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 28-132 8.82e-04

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 40.24  E-value: 8.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136    28 GPLYRTeGSHITIWCNVSGYQGPSEQnFQWSIYLPS-SPerevQIVSTMDSSFpyaiytQRVRGGKIFIERVQGNSTL-L 105
Cdd:cd16095    9 GGSHPA-GKTLSLKCQTSGFQFNTSQ-LSWYLWVPGhAP----LWLTSLDHIS------TKVSEDRITSSREDTNSQIfL 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 3766136   106 HITDLQARDAGEYEC-----HTPSTDKQYFGS 132
Cdd:cd16095   77 QIKGLGLRDSGQYHCarrvgYGDDTDKLIFGP 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 707-830 1.04e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 1.04e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      707 RTLTLVENKPIQLNCSVksqtSQNSHFAVLWYVHKPsdadgKLILKTTHnsafeygtyaeeeglrarlqFERHVSGGLFS 786
Cdd:smart00410    2 PSVTVKEGESVTLSCEA----SGSPPPEVTWYKQGG-----KLLAESGR--------------------FSVSRSGSTST 52

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 3766136      787 LTVQRAEVSDSGSYYCHVEewllspNYAWyklaeEVSGRTEVTV 830
Cdd:smart00410   53 LTISNVTPEDSGTYTCAAT------NSSG-----SASSGTTLTV 85
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 294-386 1.46e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 39.25  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   294 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 373
Cdd:cd05775    9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                         90
                 ....*....|...
gi 3766136   374 YNCRVTEREKTVT 386
Cdd:cd05775   77 YELEITSTNGKVL 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 293-389 1.63e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.64  E-value: 1.63e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      293 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 372
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 3766136      373 KYNCRVTEREKTVTGEF 389
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 157-251 3.53e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 38.50  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   157 RVEQDPLELTCEVASETIQHShlSVAWLRQKVGEKPVEVIS-LSRDFMLHSSSEYAQRQslgEVRLDKlGRTTFRLTIFH 235
Cdd:cd04982   10 REESKSVTISCKVSGIDFSTT--YIHWYRQKPGQALERLLYvSSTSAVRKDSGKTKNKF---EARKDV-GKSTSTLTITN 83

                         90
                 ....*....|....*.
gi 3766136   236 LQPSDQGEFYCeaAEW 251
Cdd:cd04982   84 LEKEDSATYYC--AYW 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 441-534 6.72e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 6.72e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136      441 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 520
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 3766136      521 SRKEDEGQYECHVT 534
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 146-252 7.79e-03

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 37.37  E-value: 7.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3766136   146 LQTTAMPQTLHRVEQDPLELTCEvASETIQHSHLsvAWLRQKVGEKPVEVISLSrdfmlhssseyAQRQSLGEVRLDKLG 225
Cdd:cd04980    1 IVMTQSPASLSVSPGERVTISCK-ASQSISSNYL--AWYQQKPGQAPKLLIYYA-----------STLHSGVPSRFSGSG 66

                         90       100
                 ....*....|....*....|....*...
gi 3766136   226 -RTTFRLTIFHLQPSDQGEFYCEAAEWI 252
Cdd:cd04980   67 sGTDFTLTISSVEPEDAAVYYCQQGYTF 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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