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Conserved domains on  [gi|3821927|gb|AAC69705|]
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ATP-specific succinyl-CoA synthetase beta subunit, partial [Columba livia]

Protein Classification

succinate--CoA ligase subunit beta( domain architecture ID 11414565)

ADP/GDP-forming succinate--CoA ligase subunit beta provides nucleotide specificity and binds the succinate substrate for the succinate--CoA ligase enzyme, which functions in the citric acid cycle (TCA) by coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

CATH:  3.40.50.261
EC:  6.2.1.-
Gene Ontology:  GO:0004774|GO:0000287|GO:0000166|GO:0006099|GO:0042709
PubMed:  3332988

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 5-393 0e+00

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 568.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:COG0045   3 LHEYQAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVVVKAQVHAGGRGKA-------GGVKLAKSPEEAREAAEE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:COG0045  76 ILGMTLVTHQTGPKGKPVNKVLVEEGVDIAKELYLSILLDRATRRPVIMASTEGGMDIEEVAEETPEKIIKVPIDPLVGL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927  165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:COG0045 156 QPYQARELAFALGLPGKQVKQFAKILKKLYRAFVEKDASLVEINPLVVTKDGRLVALDAKVNFDDNALFRHPELAALRDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927  245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:COG0045 236 SEEDPLEVEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGATAERVAEAFKIILSDPNVKAIL 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3821927  325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKL 393
Cdd:COG0045 316 VNIFGGITRCDVVAEGIVAALKEVGLKVPVVVRLEGTNVEEGRKILAESGLNIIAADTLEEAAKKAVEL 384
 
Name Accession Description Interval E-value
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 5-393 0e+00

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 568.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:COG0045   3 LHEYQAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVVVKAQVHAGGRGKA-------GGVKLAKSPEEAREAAEE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:COG0045  76 ILGMTLVTHQTGPKGKPVNKVLVEEGVDIAKELYLSILLDRATRRPVIMASTEGGMDIEEVAEETPEKIIKVPIDPLVGL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927  165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:COG0045 156 QPYQARELAFALGLPGKQVKQFAKILKKLYRAFVEKDASLVEINPLVVTKDGRLVALDAKVNFDDNALFRHPELAALRDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927  245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:COG0045 236 SEEDPLEVEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGATAERVAEAFKIILSDPNVKAIL 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3821927  325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKL 393
Cdd:COG0045 316 VNIFGGITRCDVVAEGIVAALKEVGLKVPVVVRLEGTNVEEGRKILAESGLNIIAADTLEEAAKKAVEL 384
sucC PRK00696
ADP-forming succinate--CoA ligase subunit beta;
5-395 0e+00

ADP-forming succinate--CoA ligase subunit beta;


Pssm-ID: 234813 [Multi-domain]  Cd Length: 388  Bit Score: 535.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:PRK00696   3 LHEYQAKELFAKYGVPVPRGIVATTPEEAVEAAEELGGGVWVVKAQVHAGGRGKA-------GGVKLAKSPEEAREFAKQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:PRK00696  76 ILGMTLVTHQTGPKGQPVNKVLVEEGADIAKEYYLSIVLDRATRRVVFMASTEGGMDIEEVAEETPEKIHKVAIDPLTGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:PRK00696 156 QPFQAREIAFKLGLPGEQVKQFAKILMGLYKAFVEKDASLVEINPLVVTKDGDLIALDAKINFDDNALFRHPDLAELRDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:PRK00696 236 SEEDPLEAEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAERVAEAFKIILSDPNVKAIL 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3821927   325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKLSE 395
Cdd:PRK00696 316 VNIFGGITRCDVIAEGIIAAVKEVGVTVPLVVRLEGTNVELGKKILAESGLNIIAADTLDDAAQKAVEAAK 386
sucCoAbeta TIGR01016
succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not ...
 5-395 2.48e-159

succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC 6.2.1.5) from the GDP_forming (EC 6.2.1.4) enzyme. The N-terminal half is described by the CoA-ligases model (pfam00549). The C-terminal half is described by the ATP-grasp model (pfam02222). This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G [Energy metabolism, TCA cycle]


Pssm-ID: 273396 [Multi-domain]  Cd Length: 386  Bit Score: 453.76  E-value: 2.48e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927      5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:TIGR01016   3 LHEYQAKQIFAKYGIPVPRGYVATSVEEAEEIAAKLGAGPVVVKAQVHAGGRGKA-------GGVKVAKSKEEARAAAEK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:TIGR01016  76 LLGKELVTNQTDPLGQPVNKILIEEATDIDKEYYLSIVIDRSARCPVIMASTEGGVDIEEVAEKSPEKIIKYAIDPLTGL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:TIGR01016 156 LPYQAREIAKKLGLEGELVKQVADIIKKLYQIFLEYDASLVEINPLVITKDGNLIALDAKLTIDDNALFRHPDLEEMRDY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:TIGR01016 236 SQEDPREVLAKQWGLNYVALDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGASAERVREALKLVLSDKSVKVVF 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3821927    325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKLSE 395
Cdd:TIGR01016 316 INIFGGITRCDLVAKGLVEALKEVGVNVPVVVRLEGTNVEEGKKILAESGLNIIFATSMEEAAEKAVEAAE 386
ATP-grasp_2 pfam08442
ATP-grasp domain;
4-212 3.74e-91

ATP-grasp domain;


Pssm-ID: 400651 [Multi-domain]  Cd Length: 202  Bit Score: 273.37  E-value: 3.74e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927      4 SLHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSS 83
Cdd:pfam08442   1 NLHEYQAKEIFAKYGIPVPRGEVATSPEEAEEIAKKLGGKVYVVKAQVLAGGRGKA-------GGVKLAKSPEEAKEVAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     84 RMIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEG 163
Cdd:pfam08442  74 EMLGKNLVTKQTGPDGQPVNKVLVEEALDIKKEYYLSIVLDRASKGPVIIASTEGGVDIEEVAAKNPEKIHKFPIDPLKG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 3821927    164 IKKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVE 212
Cdd:pfam08442 154 LTPYQAREIAFKLGLPGELIKQAADIIKKLYKLFVEYDATLVEINPLVE 202
 
Name Accession Description Interval E-value
SucC COG0045
Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA ...
 5-393 0e+00

Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Succinyl-CoA synthetase, beta subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439815 [Multi-domain]  Cd Length: 388  Bit Score: 568.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:COG0045   3 LHEYQAKELLAKYGVPVPRGIVATTPEEAVAAAEELGGPPVVVKAQVHAGGRGKA-------GGVKLAKSPEEAREAAEE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:COG0045  76 ILGMTLVTHQTGPKGKPVNKVLVEEGVDIAKELYLSILLDRATRRPVIMASTEGGMDIEEVAEETPEKIIKVPIDPLVGL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927  165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:COG0045 156 QPYQARELAFALGLPGKQVKQFAKILKKLYRAFVEKDASLVEINPLVVTKDGRLVALDAKVNFDDNALFRHPELAALRDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927  245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:COG0045 236 SEEDPLEVEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLAGGEPANFLDVGGGATAERVAEAFKIILSDPNVKAIL 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3821927  325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKL 393
Cdd:COG0045 316 VNIFGGITRCDVVAEGIVAALKEVGLKVPVVVRLEGTNVEEGRKILAESGLNIIAADTLEEAAKKAVEL 384
sucC PRK00696
ADP-forming succinate--CoA ligase subunit beta;
5-395 0e+00

ADP-forming succinate--CoA ligase subunit beta;


Pssm-ID: 234813 [Multi-domain]  Cd Length: 388  Bit Score: 535.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:PRK00696   3 LHEYQAKELFAKYGVPVPRGIVATTPEEAVEAAEELGGGVWVVKAQVHAGGRGKA-------GGVKLAKSPEEAREFAKQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:PRK00696  76 ILGMTLVTHQTGPKGQPVNKVLVEEGADIAKEYYLSIVLDRATRRVVFMASTEGGMDIEEVAEETPEKIHKVAIDPLTGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:PRK00696 156 QPFQAREIAFKLGLPGEQVKQFAKILMGLYKAFVEKDASLVEINPLVVTKDGDLIALDAKINFDDNALFRHPDLAELRDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:PRK00696 236 SEEDPLEAEASKYGLNYVKLDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAERVAEAFKIILSDPNVKAIL 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3821927   325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKLSE 395
Cdd:PRK00696 316 VNIFGGITRCDVIAEGIIAAVKEVGVTVPLVVRLEGTNVELGKKILAESGLNIIAADTLDDAAQKAVEAAK 386
PLN00124 PLN00124
succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
 1-396 0e+00

succinyl-CoA ligase [GDP-forming] subunit beta; Provisional


Pssm-ID: 177736 [Multi-domain]  Cd Length: 422  Bit Score: 535.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     1 RRLSLHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEI--GSKDLVIKAQVLAGGRGKGTFEGGLKGGVKIVfSPEEA 78
Cdd:PLN00124  26 RRLNIHEYQGAELMSKYGVNVPKGAAASSLDEVKKALEKMfpDEGEVVVKSQILAGGRGLGTFKNGLKGGVHIV-KKDKA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    79 KAVSSRMIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPI 158
Cdd:PLN00124 105 EELAGKMLGQILVTKQTGPAGKPVNKVYLCEKMSLVNEMYFAILLDRASAGPLIIACSKGGTSIEDLAEKFPEKIIKVPI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   159 DIVEGIKKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKI 238
Cdd:PLN00124 185 DIFKGITDEDAAKVVDGLAPKVADRNDAIEQVKKLYKLFCKCDCTMVEINPLAETADGQLVAADAKLNFDDNAAFRQKEI 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   239 FDMQDWTQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDK 318
Cdd:PLN00124 265 FALRDTSQEDPREVAAAKADLNYIGLDGEIGCMVNGAGLAMATMDIIKLHGGSPANFLDVGGNASEQQVVEAFKILTSDD 344

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3821927   319 KVLAILVNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKLSEI 396
Cdd:PLN00124 345 KVKAILVNIFGGIMKCDVIASGIVNAAKQVGLKVPLVVRLEGTNVDQGKRILKESGMTLITAEDLDDAAEKAVKALAI 422
sucCoAbeta TIGR01016
succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not ...
 5-395 2.48e-159

succinyl-CoA synthetase, beta subunit; This model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC 6.2.1.5) from the GDP_forming (EC 6.2.1.4) enzyme. The N-terminal half is described by the CoA-ligases model (pfam00549). The C-terminal half is described by the ATP-grasp model (pfam02222). This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G [Energy metabolism, TCA cycle]


Pssm-ID: 273396 [Multi-domain]  Cd Length: 386  Bit Score: 453.76  E-value: 2.48e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927      5 LHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSSR 84
Cdd:TIGR01016   3 LHEYQAKQIFAKYGIPVPRGYVATSVEEAEEIAAKLGAGPVVVKAQVHAGGRGKA-------GGVKVAKSKEEARAAAEK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     85 MIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEGI 164
Cdd:TIGR01016  76 LLGKELVTNQTDPLGQPVNKILIEEATDIDKEYYLSIVIDRSARCPVIMASTEGGVDIEEVAEKSPEKIIKYAIDPLTGL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    165 KKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQDW 244
Cdd:TIGR01016 156 LPYQAREIAKKLGLEGELVKQVADIIKKLYQIFLEYDASLVEINPLVITKDGNLIALDAKLTIDDNALFRHPDLEEMRDY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    245 TQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAIL 324
Cdd:TIGR01016 236 SQEDPREVLAKQWGLNYVALDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGASAERVREALKLVLSDKSVKVVF 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3821927    325 VNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVVKLSE 395
Cdd:TIGR01016 316 INIFGGITRCDLVAKGLVEALKEVGVNVPVVVRLEGTNVEEGKKILAESGLNIIFATSMEEAAEKAVEAAE 386
PRK14046 PRK14046
malate--CoA ligase subunit beta; Provisional
 3-391 3.89e-138

malate--CoA ligase subunit beta; Provisional


Pssm-ID: 237594 [Multi-domain]  Cd Length: 392  Bit Score: 400.24  E-value: 3.89e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     3 LSLHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVS 82
Cdd:PRK14046   1 MDIHEYQAKELLASFGVAVPRGALAYSPEQAVYRARELGGWHWVVKAQIHSGARGKA-------GGIKLCRTYNEVRDAA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    83 SRMIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVE 162
Cdd:PRK14046  74 EDLLGKKLVTHQTGPEGKPVQRVYVETADPIERELYLGFVLDRKSERVRVIASARGGMEIEEIAAKEPEAIIQVVVEPAV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   163 GIKKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEDASGVVMCMDAKINFDSNSAYRQKKIFDMQ 242
Cdd:PRK14046 154 GLQQFQAREIAFGLGLDIKQVSRAVKTIMGCYRAFRDLDATMLEINPLVVTKDDRVLALDAKMSFDDNALFRRPNIAEMR 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   243 DWTQEDERDRQAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLA 322
Cdd:PRK14046 234 DPSQEDPREAQAAEHGLSYVGLDGDIGCIVNGAGLAMATMDMIKLAGGEPANFLDVGGGASPERVAKAFRLVLSDRNVKA 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3821927   323 ILVNIFGGIMRCDVIAQGIVVAVKDLDLKIPVVVRLQGTRVDDAKALITASGLKILACDDLDEAAKMVV 391
Cdd:PRK14046 314 ILVNIFAGINRCDWVAEGVVQAAREVGIDVPLVVRLAGTNVEEGRKILAESGLPIITADTLAEAAEKAV 382
ATP-grasp_2 pfam08442
ATP-grasp domain;
4-212 3.74e-91

ATP-grasp domain;


Pssm-ID: 400651 [Multi-domain]  Cd Length: 202  Bit Score: 273.37  E-value: 3.74e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927      4 SLHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRGKGtfegglkGGVKIVFSPEEAKAVSS 83
Cdd:pfam08442   1 NLHEYQAKEIFAKYGIPVPRGEVATSPEEAEEIAKKLGGKVYVVKAQVLAGGRGKA-------GGVKLAKSPEEAKEVAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     84 RMIGKKLFTKQTGEKGRICNQVFVCERRYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPDAIIKEPIDIVEG 163
Cdd:pfam08442  74 EMLGKNLVTKQTGPDGQPVNKVLVEEALDIKKEYYLSIVLDRASKGPVIIASTEGGVDIEEVAAKNPEKIHKFPIDPLKG 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 3821927    164 IKKEQAVRLAQKMGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVE 212
Cdd:pfam08442 154 LTPYQAREIAFKLGLPGELIKQAADIIKKLYKLFVEYDATLVEINPLVE 202
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 271-391 6.09e-35

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 125.45  E-value: 6.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    271 LVNGAGLAMATMDIIKLHGGTPANFLDVGGGA-TVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVVAVKDL- 348
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAfTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDPAGGLLKAIKEAr 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 3821927    349 DLKIPVVVRLQGTRVD-----DAKALITASGLKILACDDLDEAAKMVV 391
Cdd:pfam00549  81 ARELPVVARVCGTEADpqgrsGQAKALAESGVLIASSNNQALRAAGAV 128
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 13-117 1.01e-05

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 46.79  E-value: 1.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   13 LLQEAGISVPHGVVARTPDEAYKIAKEIGSkDLVIKAQVLAGGRgkgtfegglkgGVKIVFSPEEAKAVSSRMIGKKlft 92
Cdd:COG0439  61 ALAAAGVPVPGFALVDSPEEALAFAEEIGY-PVVVKPADGAGSR-----------GVRVVRDEEELEAALAEARAEA--- 125

                        90       100
                ....*....|....*....|....*
gi 3821927   93 kqtgeKGRICNQVFVCERRYPRREY 117
Cdd:COG0439 126 -----KAGSPNGEVLVEEFLEGREY 145
ATP-grasp_5 pfam13549
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 1-80 5.53e-05

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 463918 [Multi-domain]  Cd Length: 221  Bit Score: 44.00  E-value: 5.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927      1 RRLSLHEYLSMGLLQEAGISVPHGVVARTPDEAYKIAKEIG--------SKDLVIKAQVlaggrgkgtfegglkGGVKI- 71
Cdd:pfam13549   6 GRTVLTEPEAKALLAAYGIPVVPTRLARSPEEAVAAAEEIGypvvlkivSPDILHKSDV---------------GGVRLn 70


                  ....*....
gi 3821927     72 VFSPEEAKA 80
Cdd:pfam13549  71 LRSAEAVRA 79
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 13-61 3.84e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 42.84  E-value: 3.84e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 3821927    13 LLQEAGISVPHGVVARTPDEAYKIAKEIGSKdLVIKAQvlAGGRGKGTF 61
Cdd:PRK14016 221 LLAAAGVPVPEGRVVTSAEDAWEAAEEIGYP-VVVKPL--DGNHGRGVT 266
carB PRK05294
carbamoyl-phosphate synthase large subunit;
13-77 4.48e-04

carbamoyl-phosphate synthase large subunit;


Pssm-ID: 235393 [Multi-domain]  Cd Length: 1066  Bit Score: 42.78  E-value: 4.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3821927     13 LLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLaGGRgkgtfegglkgGVKIVFSPEE 77
Cdd:PRK05294  676 LLEKLGIPQPPNGTATSVEEALEVAEEIGYPVLVRPSYVL-GGR-----------AMEIVYDEEE 728
PLN02235 PLN02235
ATP citrate (pro-S)-lyase
 2-237 1.20e-03

ATP citrate (pro-S)-lyase


Pssm-ID: 177879 [Multi-domain]  Cd Length: 423  Bit Score: 40.91  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     2 RLSLHEYLSMGLLQE-----AGISVPHGV--VARTPDEAYKIAKE--IGSKDLVIKAQVLAGGRGKgtfeGGLKgGVKIV 72
Cdd:PLN02235   3 RKKIREYDSKRLLKEhlkrlAGIDLPIRSaqVTESTDFNELANKEpwLSSTKLVVKPDMLFGKRGK----SGLV-ALNLD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    73 FSpEEAKAVSSRMiGKKLftKQTGEKGRIcnQVFVCERRYP-RREYYFAITMER-----SFqgpvligSSQGGVNIEdva 146
Cdd:PLN02235  78 LA-QVATFVKERL-GKEV--EMGGCKGPI--TTFIVEPFVPhDQEFYLSIVSDRlgcsiSF-------SECGGIEIE--- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927   147 aENPDAIIKEPIDIVEGIKKEQAVRLAQkmGFPSNLVDEAAENMIKLYNLFLKYDATMIEINPMVEdASGVVMCMDAKIN 226
Cdd:PLN02235 142 -ENWDKVKTIFLPTEAPLTSEICAPLIA--TLPLEIRGKIEEFIKGVFAVFQDLDFTFLEMNPFTL-VDGEPYPLDMRGE 217

                        250
                 ....*....|.
gi 3821927   227 FDSNSAYRQKK 237
Cdd:PLN02235 218 LDDTAAFKNFK 228
PRK08654 PRK08654
acetyl-CoA carboxylase biotin carboxylase subunit;
13-91 1.77e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236325 [Multi-domain]  Cd Length: 499  Bit Score: 40.35  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927    13 LLQEAGISV----PHGVvaRTPDEAYKIAKEIGSKdLVIKAQvlAGGrgkgtfeGGLkgGVKIVFSPEE-AKAV-SSRMI 86
Cdd:PRK08654 122 LMKKAGVPVlpgtEEGI--EDIEEAKEIAEEIGYP-VIIKAS--AGG-------GGI--GMRVVYSEEElEDAIeSTQSI 187


                 ....*
gi 3821927    87 GKKLF 91
Cdd:PRK08654 188 AQSAF 192
PurD COG0151
Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; ...
 13-91 2.01e-03

Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Phosphoribosylamine-glycine ligase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439921 [Multi-domain]  Cd Length: 422  Bit Score: 40.00  E-value: 2.01e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3821927   13 LLQEAGISVPHGVVARTPDEAYKIAKEIGsKDLVIKAQVLAGGRGkgtfegglkggVKIVFSPEEAKAVSSRMIGKKLF 91
Cdd:COG0151 109 FMARYGIPTAAYRVFTDLEEALAYLEEQG-APIVVKADGLAAGKG-----------VVVAETLEEALAAVDDMLADGKF 175
CarB COG0458
Carbamoylphosphate synthase large subunit [Amino acid transport and metabolism, Nucleotide ...
 13-41 2.19e-03

Carbamoylphosphate synthase large subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Carbamoylphosphate synthase large subunit is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440226 [Multi-domain]  Cd Length: 536  Bit Score: 40.25  E-value: 2.19e-03
                        10        20
                ....*....|....*....|....*....
gi 3821927   13 LLQEAGISVPHGVVARTPDEAYKIAKEIG 41
Cdd:COG0458 121 LLDKLGIPQPKSGTATSVEEALAIAEEIG 149
GARS_A pfam01071
Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide ...
 13-110 9.32e-03

Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase catalyzes the second step in the de novo biosynthesis of purine. The reaction catalyzed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam02786).


Pssm-ID: 395851 [Multi-domain]  Cd Length: 194  Bit Score: 37.26  E-value: 9.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3821927     13 LLQEAGISVPHGVVARTPDEAYKIAKEIGSKDLVIKAQVLAGGRgkgtfegglkgGVKIVFSPEEAKAVSSRMIGKKLFt 92
Cdd:pfam01071   9 FMKRYGIPTAEYETFTDPEEAKSYIQEAGFPAIVVKADGLAAGK-----------GVIVASSNEEAIKAVDEILEQKKF- 76

                          90
                  ....*....|....*...
gi 3821927     93 kqtGEKGricNQVFVCER 110
Cdd:pfam01071  77 ---GEAG---ETVVIEEF 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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