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Conserved domains on  [gi|487785|gb|AAC50261|]
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zinc finger protein ZNF136 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.33e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.33e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 487785       3 SVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-526 1.30e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   157 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 233
Cdd:COG5048  51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   234 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 313
Cdd:COG5048 131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   314 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 390
Cdd:COG5048 205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   391 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 458
Cdd:COG5048 285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487785   459 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 526
Cdd:COG5048 365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.33e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.33e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 487785       3 SVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 8.19e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 8.19e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 487785        4 VAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 9.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.43  E-value: 9.94e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 487785     4 VAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASI 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-526 1.30e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   157 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 233
Cdd:COG5048  51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   234 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 313
Cdd:COG5048 131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   314 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 390
Cdd:COG5048 205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   391 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 458
Cdd:COG5048 285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487785   459 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 526
Cdd:COG5048 365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 487785     295 LRIHERTHTGEKPYECKQCGKAFSY 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.33e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.33e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 487785       3 SVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 8.19e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 8.19e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 487785        4 VAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 9.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.43  E-value: 9.94e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 487785     4 VAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASI 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-526 1.30e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   157 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 233
Cdd:COG5048  51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   234 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 313
Cdd:COG5048 131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   314 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 390
Cdd:COG5048 205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   391 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 458
Cdd:COG5048 285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487785   459 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 526
Cdd:COG5048 365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-507 1.25e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   194 TPYKCKVCGKAFDYPSRFRTHERSHTGEKPYEC--QECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHS-LSSFQVH 270
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   271 ERIHTGEKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLP-SLRLHERIHTGEKPfvckqcgKAFRSAS 349
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   350 TFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKC--KVCGKPFHSLSPFRIHE--RTHTGEKPYVCKHC 425
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttNSQLSPKSLLSQSPSSLssSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   426 G--KAFVSSTSIRIHERTHTG-EKPYECKQCGKAFSYLNSFRTH--EMIHTGE--KPFEC--KRCGKAFRSSSSFRLHER 496
Cdd:COG5048 265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                       330
                ....*....|.
gi 487785   497 THTGQKPYHCK 507
Cdd:COG5048 345 LHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-468 1.72e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   259 KPFHSLSSFQVHERIHTG-EKPFKCKQCGKAFSCSPTLRIHERT--HTGE--KPYEC--KQCGKAFSYLPSLRLHERIHT 331
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   332 GEKPFVCK--QCGKAFRSASTFQIHERT--HTGEKPYECKECGEAFSCIPSMRRHmikhtgegpykckvcgkpfhslsPF 407
Cdd:COG5048 348 SISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS-----------------------NL 404

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487785   408 RIHERTHTGEKPYVCK--HCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEM 468
Cdd:COG5048 405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
35-355 4.81e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785    35 ETMRNLASIGKKWKDQNIKDHYKHRGRNL---RSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKL-CESIVYGEV 110
Cdd:COG5048 160 NTPQSNSLHPPLPANSLSKDPSSNLSLLIssnVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLtTNSQLSPKS 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   111 SMGQSSLNRHIKDHSGHEPKEYQEYGekpDTRNQCWKPFSSHHSfrtheiihtgeklydckecgktffsLKRIRRhiith 190
Cdd:COG5048 240 LLSQSPSSLSSSDSSSSASESPRSSL---PTASSQSSSPNESDS-------------------------SSEKGF----- 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   191 sgYTPYKCKVCGKAFDYPSRFRTHERS--HTGE--KPYEC--QECGKAFTCITSVRRHMIKHTGDGPYKCK--VCGKPFH 262
Cdd:COG5048 287 --SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   263 SLS-----SFQVHERIHTGEKPFKC--KQCGKAFSCSPTLRIHERTHTGEKPYECK--QCGKAFSYLPSLRLHERIHTGE 333
Cdd:COG5048 365 PLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNH 444

                       330       340
                ....*....|....*....|..
gi 487785   334 KPFVCKQCGKAFRSASTFQIHE 355
Cdd:COG5048 445 APLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-494 1.56e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   334 KPFVCKQCGKAFRSASTFQIHERT--HTGE--KPYECKE--CGEAFSCIPSMRRHMIKHTGEGPYKCK--VCGKPFHSLS 405
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487785   406 PFRIHERTH-----TGEKPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFSYLNSFRTHEMIHTGEKPF 476
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 487785   477 ECkRCGKAFRSSSSFRLH 494
Cdd:COG5048 448 LC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-319 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 487785     295 LRIHERTHTGEKPYECKQCGKAFSY 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-291 6.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 487785     266 SFQVHERIHTGEKPFKCKQCGKAFSC 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 9.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 487785     322 SLRLHERIHTGEKPFVCKQCGKAFRS 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 487785     210 RFRTHERSHTGEKPYECQECGKAFTC 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-459 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....
gi 487785     436 RIHERTHTGEKPYECKQCGKAFSY 459
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-375 3.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*
gi 487785     351 FQIHERTHTGEKPYECKECGEAFSC 375
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-431 3.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.56e-03
                          10        20
                  ....*....|....*....|....*
gi 487785     407 FRIHERTHTGEKPYVCKHCGKAFVS 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 4.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 487785     490 SFRLHERTHTGQKPYHCKECGKAYSC 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-399 7.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.82e-03
                          10        20
                  ....*....|....*....|..
gi 487785     378 SMRRHMIKHTGEGPYKCKVCGK 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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