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Conserved domains on  [gi|20197211|gb|AAC28530|]
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E3 ubiquitin ligase SCF complex subunit SKP1/ASK1-related [Arabidopsis thaliana]

Protein Classification

SKP1-like protein( domain architecture ID 10649839)

SKP1-like protein is a component of E3 ubiquitin ligase SCF complex involved in ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 15-116 5.67e-26

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


:

Pssm-ID: 214704  Cd Length: 104  Bit Score: 96.98  E-value: 5.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211     15 KSYIWLQTADGSIQQVEQEVAMFCPMICQEVIQKGVGSSKNHAISLPQrVNPAMFSLILDYCRFHQLPGRSNKE---RKT 91
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNNPIPLPN-VTSKILSKVIEYCEHHVDDPPSVADkddIPT 79

                           90       100
                   ....*....|....*....|....*
gi 20197211     92 YDERFIRMDTKRLCELTSAADSLQL 116
Cdd:smart00512  80 WDAEFLKIDQETLFELILAANYLDI 104
Skp1 pfam01466
Skp1 family, dimerization domain;
117-156 3.17e-10

Skp1 family, dimerization domain;


:

Pssm-ID: 460222  Cd Length: 48  Bit Score: 54.04  E-value: 3.17e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20197211   117 KPLVDLTSRALARIIEGKNPEEIREIFHLPDDLTEEEKLE 156
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEEE 40
 
Name Accession Description Interval E-value
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 15-116 5.67e-26

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 96.98  E-value: 5.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211     15 KSYIWLQTADGSIQQVEQEVAMFCPMICQEVIQKGVGSSKNHAISLPQrVNPAMFSLILDYCRFHQLPGRSNKE---RKT 91
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNNPIPLPN-VTSKILSKVIEYCEHHVDDPPSVADkddIPT 79

                           90       100
                   ....*....|....*....|....*
gi 20197211     92 YDERFIRMDTKRLCELTSAADSLQL 116
Cdd:smart00512  80 WDAEFLKIDQETLFELILAANYLDI 104
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 16-153 9.76e-14

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 66.51  E-value: 9.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211  16 SYIWLQTADGSIQQVEQEVAMFCPMICQEViqkgvgsSKNHAISLPQ---RVNPAMFSLILDYCRFHQ---------LPG 83
Cdd:COG5201   2 SMIELESIDGEIFRVDENIAERSILIKNML-------CDSTACNYPIpapNVRSSVLMKVQEWMEHHTsslsedendLEI 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211  84 RSNKERKTYDERFIRMDTKRLCELTSAADSLQLKPLVDLTSRALARIIEGKNPEEIREIFHLPDDLTEEE 153
Cdd:COG5201  75 RKSKPSDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVAEMIRGKSPEEIRETFNIENDFTPEE 144
Skp1 pfam01466
Skp1 family, dimerization domain;
117-156 3.17e-10

Skp1 family, dimerization domain;


Pssm-ID: 460222  Cd Length: 48  Bit Score: 54.04  E-value: 3.17e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20197211   117 KPLVDLTSRALARIIEGKNPEEIREIFHLPDDLTEEEKLE 156
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEEE 40
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 17-131 2.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 53.36  E-value: 2.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211  17 YIWLQTADGSIQQVEQEVAMFCPMICQEVIQKGVgssKNHAISLPQrVNPAMFSLILDYCRFHQ---------LPGRSNK 87
Cdd:cd18322   1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGY---DDDPIPLPN-VTSKILKKVIEWCEHHKddpppeidlDSEKRTD 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 20197211  88 ERKTYDERFIRMDTKRLCELTSAADSLQLKPLVDLTSRALARII 131
Cdd:cd18322  77 DIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
 
Name Accession Description Interval E-value
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 15-116 5.67e-26

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 96.98  E-value: 5.67e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211     15 KSYIWLQTADGSIQQVEQEVAMFCPMICQEVIQKGVGSSKNHAISLPQrVNPAMFSLILDYCRFHQLPGRSNKE---RKT 91
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNNPIPLPN-VTSKILSKVIEYCEHHVDDPPSVADkddIPT 79

                           90       100
                   ....*....|....*....|....*
gi 20197211     92 YDERFIRMDTKRLCELTSAADSLQL 116
Cdd:smart00512  80 WDAEFLKIDQETLFELILAANYLDI 104
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 16-153 9.76e-14

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 66.51  E-value: 9.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211  16 SYIWLQTADGSIQQVEQEVAMFCPMICQEViqkgvgsSKNHAISLPQ---RVNPAMFSLILDYCRFHQ---------LPG 83
Cdd:COG5201   2 SMIELESIDGEIFRVDENIAERSILIKNML-------CDSTACNYPIpapNVRSSVLMKVQEWMEHHTsslsedendLEI 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211  84 RSNKERKTYDERFIRMDTKRLCELTSAADSLQLKPLVDLTSRALARIIEGKNPEEIREIFHLPDDLTEEE 153
Cdd:COG5201  75 RKSKPSDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVAEMIRGKSPEEIRETFNIENDFTPEE 144
Skp1 pfam01466
Skp1 family, dimerization domain;
117-156 3.17e-10

Skp1 family, dimerization domain;


Pssm-ID: 460222  Cd Length: 48  Bit Score: 54.04  E-value: 3.17e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20197211   117 KPLVDLTSRALARIIEGKNPEEIREIFHLPDDLTEEEKLE 156
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEEE 40
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 17-131 2.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 53.36  E-value: 2.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20197211  17 YIWLQTADGSIQQVEQEVAMFCPMICQEVIQKGVgssKNHAISLPQrVNPAMFSLILDYCRFHQ---------LPGRSNK 87
Cdd:cd18322   1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGY---DDDPIPLPN-VTSKILKKVIEWCEHHKddpppeidlDSEKRTD 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 20197211  88 ERKTYDERFIRMDTKRLCELTSAADSLQLKPLVDLTSRALARII 131
Cdd:cd18322  77 DIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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