NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1743860|gb|AAC23702|]
View 

BRCA2 [Mus musculus]

Protein Classification

single-stranded DNA-binding protein( domain architecture ID 11101627)

single-stranded DNA (ssDNA)-binding protein plays a key role in DNA replication, recombination, and repair

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2725-2973 4.53e-127

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


:

Pssm-ID: 239940  Cd Length: 251  Bit Score: 400.29  E-value: 4.53e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2725 PLSSLFSDGGNVGCVDIIVQRVYPLQWVEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTEFKDHEEDTTQR 2804
Cdd:cd04494    1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2805 CVLSRTLTRHQVHALQDGAELYPAVQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQSEFRKALESAEKEEGL-S 2883
Cdd:cd04494   81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLsK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2884 RDVTTVWKLRVTSYK-KKEKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERASIQLTATKRTQYQQLPVSSE 2962
Cdd:cd04494  161 RDVTPVWKLRVTDYRsKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                        250
                 ....*....|.
gi 1743860  2963 TLLQVYQPRES 2973
Cdd:cd04494  241 ELFQPFQPRKA 251
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2402-2588 4.01e-108

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462700  Cd Length: 187  Bit Score: 343.17  E-value: 4.01e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2402 MSSLQSARDLQDMRIKNKERRHLRLQPGSLYLTKSSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNAEYF 2481
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2482 QFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVWKLAAMEFAFPK 2561
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 1743860    2562 EFANRCLNPERVLLQLKYRYDVEIDNS 2588
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2591-2717 2.09e-61

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462678  Cd Length: 123  Bit Score: 206.65  E-value: 2.09e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2591 SALKKILERDDTAAQTLVLCISDIISPSTKVSETSGGKTSGEDAnkvdTIELTDGWYPVRAQLDPPLMALVKSGKLTVGQ 2670
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGSGTVDNTKA----ILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1743860    2671 KIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSRLGFFR 2717
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 2971-3102 1.68e-50

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


:

Pssm-ID: 462679  Cd Length: 139  Bit Score: 175.93  E-value: 1.68e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2971 RESLHFSRLSDPAFQPPCSEVDVVGVVVSVVKPIGLAPLVYLSDECLNLLVVKFGIDLN----EDI-KPRVLIAASNLQC 3045
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIvKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1743860    3046 QPESTSGVPTLFGGHFSIFSASPKEGYFQEKVNNLEHAIENIDSFYKEAEKKLIHVL 3102
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLL 137
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1927-1955 1.96e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 49.37  E-value: 1.96e-07
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1927 TYGIFSTASGKAIQVSDASLEKARQVFSE 1955
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1397-1423 1.06e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 47.06  E-value: 1.06e-06
                           10        20
                   ....*....|....*....|....*..
gi 1743860    1397 FNISFQTASGKNTRVSKESLNKSVNIF 1423
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLF 27
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1626-1654 1.12e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 1.12e-05
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1626 SALAYYTEDSRKTCVRESSLSKGRKWLRE 1654
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1195-1223 2.93e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.21  E-value: 2.93e-05
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1195 EFGRICSALGTKLSVSNEALRKAMKLFSD 1223
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 984-1012 2.00e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.89  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*....
gi 1743860     984 FGGSFRTASNKEIKLSEHNVKKSKMFFKD 1012
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2008-2035 4.26e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 39.74  E-value: 4.26e-04
                           10        20
                   ....*....|....*....|....*...
gi 1743860    2008 FSGFSTAGGKLVTVSESALHKVKGMLEE 2035
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 super family cl02912
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1496-1522 3.70e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


The actual alignment was detected with superfamily member pfam00634:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 37.04  E-value: 3.70e-03
                           10        20
                   ....*....|....*....|....*..
gi 1743860    1496 LSFHTASGKKVKIMQESLDKVKNLCGE 1522
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2725-2973 4.53e-127

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 400.29  E-value: 4.53e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2725 PLSSLFSDGGNVGCVDIIVQRVYPLQWVEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTEFKDHEEDTTQR 2804
Cdd:cd04494    1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2805 CVLSRTLTRHQVHALQDGAELYPAVQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQSEFRKALESAEKEEGL-S 2883
Cdd:cd04494   81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLsK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2884 RDVTTVWKLRVTSYK-KKEKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERASIQLTATKRTQYQQLPVSSE 2962
Cdd:cd04494  161 RDVTPVWKLRVTDYRsKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                        250
                 ....*....|.
gi 1743860  2963 TLLQVYQPRES 2973
Cdd:cd04494  241 ELFQPFQPRKA 251
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2402-2588 4.01e-108

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 343.17  E-value: 4.01e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2402 MSSLQSARDLQDMRIKNKERRHLRLQPGSLYLTKSSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNAEYF 2481
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2482 QFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVWKLAAMEFAFPK 2561
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 1743860    2562 EFANRCLNPERVLLQLKYRYDVEIDNS 2588
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2591-2717 2.09e-61

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 206.65  E-value: 2.09e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2591 SALKKILERDDTAAQTLVLCISDIISPSTKVSETSGGKTSGEDAnkvdTIELTDGWYPVRAQLDPPLMALVKSGKLTVGQ 2670
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGSGTVDNTKA----ILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1743860    2671 KIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSRLGFFR 2717
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 2971-3102 1.68e-50

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 175.93  E-value: 1.68e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2971 RESLHFSRLSDPAFQPPCSEVDVVGVVVSVVKPIGLAPLVYLSDECLNLLVVKFGIDLN----EDI-KPRVLIAASNLQC 3045
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIvKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1743860    3046 QPESTSGVPTLFGGHFSIFSASPKEGYFQEKVNNLEHAIENIDSFYKEAEKKLIHVL 3102
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLL 137
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2603-2715 2.16e-46

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 162.78  E-value: 2.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2603 AAQTLVLCISDIISPSTkvsetsggktsgeDANKVDTIELTDGWYPVRAQLDPPLMALVKSGKLTVGQKIITQGAELVGS 2682
Cdd:cd04493    1 ASRLMVLCVSGINSEER-------------LSPHMPIIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 1743860  2683 PDACAPLEAPDSLRLKISANSTRPARWHSRLGF 2715
Cdd:cd04493   68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 3003-3085 3.80e-35

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 130.60  E-value: 3.80e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  3003 PIGLAPLVYLSDECLNLLVVKFGIDL----NEDI-KPRVLIAASNLQCQPESTSGVPTLFGGHFSIFSASPKEGYFQEKV 3077
Cdd:cd04495   13 IEGKFPAVYLADECLNLLCVKFWSSLeqyaYEDVvKRRVLLAASNLQWRTESTSGVPTLFAGEYSTFSANPKESHLQEEF 92


                 ....*...
gi 1743860  3078 NNLEHAIE 3085
Cdd:cd04495   93 NNLKHLIE 100
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2752-2793 1.58e-15

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 72.78  E-value: 1.58e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1743860    2752 VEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTE 2793
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQAE 42
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1927-1955 1.96e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 49.37  E-value: 1.96e-07
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1927 TYGIFSTASGKAIQVSDASLEKARQVFSE 1955
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1397-1423 1.06e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 47.06  E-value: 1.06e-06
                           10        20
                   ....*....|....*....|....*..
gi 1743860    1397 FNISFQTASGKNTRVSKESLNKSVNIF 1423
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLF 27
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1626-1654 1.12e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 1.12e-05
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1626 SALAYYTEDSRKTCVRESSLSKGRKWLRE 1654
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1195-1223 2.93e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.21  E-value: 2.93e-05
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1195 EFGRICSALGTKLSVSNEALRKAMKLFSD 1223
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 984-1012 2.00e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.89  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*....
gi 1743860     984 FGGSFRTASNKEIKLSEHNVKKSKMFFKD 1012
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2008-2035 4.26e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 39.74  E-value: 4.26e-04
                           10        20
                   ....*....|....*....|....*...
gi 1743860    2008 FSGFSTAGGKLVTVSESALHKVKGMLEE 2035
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1496-1522 3.70e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 37.04  E-value: 3.70e-03
                           10        20
                   ....*....|....*....|....*..
gi 1743860    1496 LSFHTASGKKVKIMQESLDKVKNLCGE 1522
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2725-2973 4.53e-127

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 400.29  E-value: 4.53e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2725 PLSSLFSDGGNVGCVDIIVQRVYPLQWVEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTEFKDHEEDTTQR 2804
Cdd:cd04494    1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2805 CVLSRTLTRHQVHALQDGAELYPAVQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQSEFRKALESAEKEEGL-S 2883
Cdd:cd04494   81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLsK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2884 RDVTTVWKLRVTSYK-KKEKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERASIQLTATKRTQYQQLPVSSE 2962
Cdd:cd04494  161 RDVTPVWKLRVTDYRsKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                        250
                 ....*....|.
gi 1743860  2963 TLLQVYQPRES 2973
Cdd:cd04494  241 ELFQPFQPRKA 251
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2402-2588 4.01e-108

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 343.17  E-value: 4.01e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2402 MSSLQSARDLQDMRIKNKERRHLRLQPGSLYLTKSSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNAEYF 2481
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2482 QFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVWKLAAMEFAFPK 2561
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 1743860    2562 EFANRCLNPERVLLQLKYRYDVEIDNS 2588
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2591-2717 2.09e-61

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 206.65  E-value: 2.09e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2591 SALKKILERDDTAAQTLVLCISDIISPSTKVSETSGGKTSGEDAnkvdTIELTDGWYPVRAQLDPPLMALVKSGKLTVGQ 2670
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGSGTVDNTKA----ILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1743860    2671 KIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSRLGFFR 2717
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 2971-3102 1.68e-50

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 175.93  E-value: 1.68e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860    2971 RESLHFSRLSDPAFQPPCSEVDVVGVVVSVVKPIGLAPLVYLSDECLNLLVVKFGIDLN----EDI-KPRVLIAASNLQC 3045
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIvKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1743860    3046 QPESTSGVPTLFGGHFSIFSASPKEGYFQEKVNNLEHAIENIDSFYKEAEKKLIHVL 3102
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLL 137
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2603-2715 2.16e-46

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 162.78  E-value: 2.16e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  2603 AAQTLVLCISDIISPSTkvsetsggktsgeDANKVDTIELTDGWYPVRAQLDPPLMALVKSGKLTVGQKIITQGAELVGS 2682
Cdd:cd04493    1 ASRLMVLCVSGINSEER-------------LSPHMPIIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 1743860  2683 PDACAPLEAPDSLRLKISANSTRPARWHSRLGF 2715
Cdd:cd04493   68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 3003-3085 3.80e-35

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 130.60  E-value: 3.80e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743860  3003 PIGLAPLVYLSDECLNLLVVKFGIDL----NEDI-KPRVLIAASNLQCQPESTSGVPTLFGGHFSIFSASPKEGYFQEKV 3077
Cdd:cd04495   13 IEGKFPAVYLADECLNLLCVKFWSSLeqyaYEDVvKRRVLLAASNLQWRTESTSGVPTLFAGEYSTFSANPKESHLQEEF 92


                 ....*...
gi 1743860  3078 NNLEHAIE 3085
Cdd:cd04495   93 NNLKHLIE 100
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2752-2793 1.58e-15

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 72.78  E-value: 1.58e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1743860    2752 VEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTE 2793
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQAE 42
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1927-1955 1.96e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 49.37  E-value: 1.96e-07
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1927 TYGIFSTASGKAIQVSDASLEKARQVFSE 1955
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1397-1423 1.06e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 47.06  E-value: 1.06e-06
                           10        20
                   ....*....|....*....|....*..
gi 1743860    1397 FNISFQTASGKNTRVSKESLNKSVNIF 1423
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLF 27
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1626-1654 1.12e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 1.12e-05
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1626 SALAYYTEDSRKTCVRESSLSKGRKWLRE 1654
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1195-1223 2.93e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.21  E-value: 2.93e-05
                           10        20
                   ....*....|....*....|....*....
gi 1743860    1195 EFGRICSALGTKLSVSNEALRKAMKLFSD 1223
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 984-1012 2.00e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.89  E-value: 2.00e-04
                           10        20
                   ....*....|....*....|....*....
gi 1743860     984 FGGSFRTASNKEIKLSEHNVKKSKMFFKD 1012
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2008-2035 4.26e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 39.74  E-value: 4.26e-04
                           10        20
                   ....*....|....*....|....*...
gi 1743860    2008 FSGFSTAGGKLVTVSESALHKVKGMLEE 2035
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1496-1522 3.70e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 37.04  E-value: 3.70e-03
                           10        20
                   ....*....|....*....|....*..
gi 1743860    1496 LSFHTASGKKVKIMQESLDKVKNLCGE 1522
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH