|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
25-413 |
1.08e-129 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 378.87 E-value: 1.08e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYL 104
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331 81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331 156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 265 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 344
Cdd:cd17331 234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3158349 345 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17331 314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-413 |
7.74e-53 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 180.08 E-value: 7.74e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 30 YVLAATELTCLFMQFSIVPYLSR---KLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLL 106
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 107 AAasspALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAIL 186
Cdd:cd17330 82 GL----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 187 AalatllgavlsftcipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISM 266
Cdd:cd17330 158 A-----------------------------------AALALLNLVLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLK 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 267 DFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLN 346
Cdd:cd17330 203 DRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3158349 347 VVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17330 283 PALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
30-415 |
3.41e-28 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 113.86 E-value: 3.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 30 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAAA 109
Cdd:cd17390 2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 110 SSpalpgVYLLFASRLP-GALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGiqcpailaa 188
Cdd:cd17390 82 TS-----LALLFLSRIPlGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG--------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 189 latlLGAVLSFTCipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDF 268
Cdd:cd17390 148 ----GFYYVALLC---------------------SAIFILNAGLVWFLLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEER 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 269 FQLEAAQAGYLMSFFGLLQMVTQGLV--IGQLSSHFSEEVLLRASVLVFIVVgLAMAWMSSVFHFCLLVPGLVFSLCTLN 346
Cdd:cd17390 203 FDLSPKTIGYLISYSGVLGALSGFLVgrILKLYKNNEYLLLLHSFILLALSL-LGLALAPSIWLLVLCLTPLSISSAVLR 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3158349 347 VVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYrSFGVPVFGHVQVAINTLVLLVLWRKP 415
Cdd:cd17390 282 TCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ-EFSVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-394 |
3.70e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.40 E-value: 3.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 42 MQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAAASSPALpgvyLLF 121
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ----LLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 122 ASRLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFT 200
Cdd:cd17325 90 ARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 201 CIPASTKGAKTdaqaplpgGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLM 280
Cdd:cd17325 170 LLPEPRPPPNK--------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 281 SFFGLLQMVTQGLViGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS 360
Cdd:cd17325 242 GAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350
....*....|....*....|....*....|....
gi 3158349 361 DTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVP 394
Cdd:cd17325 321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-373 |
8.88e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.95 E-value: 8.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 18 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFL 97
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 98 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 175
Cdd:COG2814 84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 176 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 255
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 256 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLV 335
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
|
330 340 350
....*....|....*....|....*....|....*...
gi 3158349 336 PGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 373
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
25-416 |
1.18e-13 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 71.90 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 25 VILLTYVLAATELTcLFMqfSIVPYLSRKLGLDSIA----FGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAAL 100
Cdd:cd17388 3 FILVTVLLDAMGIG-LIM--PVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 101 ALYLLLAAAsspalPGVYLLFASRLPGALM-HTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGtLVSAYG 179
Cdd:cd17388 80 LDYLLMAFA-----PTLWWLYLGRIIAGITgATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEIS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 180 IQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVprIFLVKVASNCPtglfMV 259
Cdd:cd17388 154 PRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAV--FFLIQLIGQVP----AT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 260 MFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLR----ASVLVFIVVGLA-MAWMSsvfhFCLL 334
Cdd:cd17388 228 TWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILlglaADALGFLLLAFAtQGWMV----FPIL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 335 VPGLVFSLCTlnVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQV--AINTLVLLVLW 412
Cdd:cd17388 304 ILLALGGIAG--PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIigAALYLICLVLA 381
|
....
gi 3158349 413 RKPM 416
Cdd:cd17388 382 YRFF 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-381 |
2.34e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.83 E-value: 2.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 26 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLL 105
Cdd:pfam07690 1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 106 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 183
Cdd:pfam07690 79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 184 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 263
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 264 isMDFFQLEAAQAGYLMSFFGLLqMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLV---F 340
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgF 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 3158349 341 SLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGP 381
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-388 |
4.43e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.98 E-value: 4.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 30 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAAa 109
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 110 sspaLPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpaILA 187
Cdd:cd06174 81 ----APSFWLLLLGRFLLGLGSGLidPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 188 ALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMD 267
Cdd:cd06174 153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 268 FFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNV 347
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 3158349 348 VTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLY 388
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
46-420 |
9.29e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.73 E-value: 9.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 46 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAAasspaLPGVYLLFASRL 125
Cdd:COG2223 27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL-----AVSYWLLLLLGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 126 PGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIP 203
Cdd:COG2223 102 LLGIGGggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 204 ASTKGAKTDAQAPlpggprasvfdLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFF 283
Cdd:COG2223 182 DPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 284 GLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTL-NVVTDSMLIKAVSTSDT 362
Cdd:COG2223 251 ALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGgNGAVFALVPDIFPTKNA 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 3158349 363 GTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG-HVQVAINTLVLLVLWRKPMPQRK 420
Cdd:COG2223 330 GAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
134-414 |
3.65e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 3.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 134 PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPastkgakTDA 213
Cdd:cd06173 111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRR-------PPP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 214 QAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGlLQMVTQGL 293
Cdd:cd06173 184 AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG-VGALLGAL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 294 VIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 373
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 3158349 374 PLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRK 414
Cdd:cd06173 343 SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
46-420 |
9.18e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 9.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 46 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAAAsspalPGVYLLFASRL 125
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 126 PGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpailaalatllgavlsftcip 203
Cdd:COG2271 107 LLGLGEagFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW----------------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 204 astkgaktdaqaplpggpRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFF 283
Cdd:COG2271 164 ------------------RAAFLILGLPGLLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 284 GLLQMVTqGLVIGQLSSHFSEE--VLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSD 361
Cdd:COG2271 226 FLAGIVG-SLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 3158349 362 TGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRK 420
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
243-424 |
1.31e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 243 IFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAM 322
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 323 AWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVA 402
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180
....*....|....*....|..
gi 3158349 403 INTLVLLVLWRKPMPQRKDKVR 424
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK 181
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
133-413 |
1.51e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.79 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 133 LPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsAYGIQCPAILAALATLLGAVLSFTCIPastkgaktd 212
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLP--------- 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 213 aqAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQG 292
Cdd:cd17474 175 --EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 293 LVIGQLSSHFSEEVLLRASVLVFivvGLAMAWMSSVFHFCLLVPGLVFS---LCTLNVVTDSMLIKAVSTSDTGTMLGLC 369
Cdd:cd17474 253 FVGRLLKKRFGARRILVIGLLLY---ALSLLLLGFVPSLALLLIAIVLFglgLGLNLPLLTTLVTELAPEEERGTASSLY 329
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 3158349 370 ASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17474 330 NFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
254-413 |
8.03e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 254 TGLFMVMFSIISMDFfQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCL 333
Cdd:COG2814 26 IGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 334 LVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:COG2814 104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
25-414 |
9.51e-05 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 44.12 E-value: 9.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 25 VILLTYVLAATELTCLFMqfSIVPYLSrKLGLDSIA--FGYLQTTFGVLQLLGGPVFGRFANQRG-ARAALTLSFLAALA 101
Cdd:cd17326 3 VMYLTMFLSSLQFSIVLT--SIWPYLQ-KIDPTATAsfFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 102 LYLLLAAASSPALPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsaygi 180
Cdd:cd17326 80 GNILYALAEYFPSNRKYVMLVARfLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 181 qcpailaalatllgavlsftciPASTKGAKTDAQAPL-----PGGPRASVFDLKAIASLLRLPDVPRIFlVKVASNCPTG 255
Cdd:cd17326 155 ----------------------PIGYPGYVIGIKLRFnmytaPAWLMAILGIINIILILFFFKEVVCIF-LFFVVLFIFA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 256 LFMVMFSIISMDFFQLEAAQA----GYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLamawMSSVFHF 331
Cdd:cd17326 212 NLETIGTPLTMDMYGWTREEAvlynGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFV----VTLPWGI 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 332 CL-LVPGLVFSLCtlNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG-VPVFGH--VQVAINTLV 407
Cdd:cd17326 288 TGvILFGLGYPIG--NVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGpRWTWIItlGLLLLAIIL 365
|
....*..
gi 3158349 408 LLVLWRK 414
Cdd:cd17326 366 LIVFYKR 372
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-392 |
2.08e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 49 YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrLPGA 128
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG-FGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 129 LMHtlPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsAYGIQCPAILAALATLLGAVLSFTCIPASTKG 208
Cdd:cd17329 104 LFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 209 AKTDAQAPLPGGPRASVFDlkaiasllrlpdvpRIFLvkvasncptgLFMVMFSIISMDFFQLE--------------AA 274
Cdd:cd17329 181 RRAAEKTEILRGYKIVLRD--------------RAFL----------LFLLASFLISLIYFQLEstlpvyvveilglgES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 275 QAGYLMSFFGLLQMVTQGLVIGqLSSHFSEEVLLRASVLV----FIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTD 350
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVAR-LVERFRLRKILMIGILLfaigFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 3158349 351 SMLIKAvstsDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG 392
Cdd:cd17329 316 ALAPPD----KRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-163 |
3.98e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 7 PRDQGQSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVP-YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQ 85
Cdd:COG2814 190 PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3158349 86 RGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVG 163
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG---FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
32-396 |
4.28e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 4.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 32 LAATELTCLFMQ---FSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALYLLLAA 108
Cdd:cd17504 1 LALAALAVMLVEtmlSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 109 AsspalPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcpaila 187
Cdd:cd17504 81 A-----PNLPVLIAGRaLQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWR------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 188 alatllgaVLSFTCIPASTKGAktdAQAPLpggprasvFDLKaiasLLRLPDVPRIFLVKVASNcpTGLFMVMFSIISM- 266
Cdd:cd17504 150 --------WIFWTAAPVAVLLA---ALVPL--------IDLR----LLRRRNVLLANITALLAG--FGMFMVFQLLPQLl 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 267 -----DFFQLEAAQAGYLMSFFGLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMA---WMSSVFHFCLLVPGL 338
Cdd:cd17504 205 qlptpTGFGLGITEAGLLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLAllhSSLWALVVALLLIGI 283
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 3158349 339 VFSLCTLNVVTdsMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVF 396
Cdd:cd17504 284 GLGLAFASLPN--IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSIT 339
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-181 |
5.95e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 24 SVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALTLSFLAALALY 103
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3158349 104 LLLAAASSPALPGVYLLFAsrLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQ 181
Cdd:COG2271 261 ALLLLALLPSPALAIALLF--LAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-179 |
7.71e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.38 E-value: 7.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 15 GRMSALGRSSVILLTYVLAATELTCLFMQFS-IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAALT 93
Cdd:cd17324 189 SSLLLLLRNPRLRLAYLITFLLFGGFFALYTyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 94 LSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLsAPEERPAALGRLGLCFGVGVILGSLLGGT 173
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWG---LGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGL 344
|
....*.
gi 3158349 174 LVSAYG 179
Cdd:cd17324 345 VLDHGG 350
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-295 |
2.00e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 13 SPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAAL 92
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 93 TLSFLAALALYLLLAaasspALPGVYLLFASR----LPGALMhtLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGS 168
Cdd:COG0477 83 LIGLLLFGLASLLCG-----LAPSPELLIAARalqgIGAGGL--MPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 169 LLGGTLVSAYGIQCPAILAALATLLGAVLSFTcIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKV 248
Cdd:COG0477 156 LLGGLLVAALGWRWIFLINAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 3158349 249 ASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVI 295
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLL 281
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
146-412 |
4.94e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 4.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 146 PEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcPAILAALATLLGAVLSFTCIPASTKGAKtdaQAPLPGGPRASV 225
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGD-AALGYRLTALIFAVLGLLAFLLTFFGTK---ERPVPEEEKVSL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 226 FDlkAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEE 305
Cdd:COG2211 218 KE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPRLAKRFGKK 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 306 VLLRASVLVFIVVGLAMAWM--SSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAV-------STSDTGTMLGLCASVQPLL 376
Cdd:COG2211 295 KAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLG 374
|
250 260 270
....*....|....*....|....*....|....*..
gi 3158349 377 RTLGPTVGGLLYRSFG-VPVFGHVQVAINTLVLLVLW 412
Cdd:COG2211 375 QALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFL 411
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
115-340 |
9.97e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 37.92 E-value: 9.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 115 PGVYLLFASR----LPGALMhtLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcpailaala 190
Cdd:cd17321 82 PSLAFLIAARalqgIGAAAI--MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR--------- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3158349 191 tllgavlsftcipastkgaktdaqaplpggpraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIIS---MD 267
Cdd:cd17321 151 ---------------------------------WIFLINVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPlylQG 197
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3158349 268 FFQLEAAQAGYLMSFFGLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVF 340
Cdd:cd17321 198 VLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVL 269
|
|
| |
