BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   24 WVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNV 103
Cdd:cd18312   2 WFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNV 81

                        90       100
                ....*....|....*....|....
gi 1946367  104 AALHCAAEFLQMTDKYCDNNLAGR 127
Cdd:cd18312  82 VGLRCAAEYLEMTESGNLGNLIDK 105

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   24 WVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNV 103
Cdd:cd18312   2 WFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNV 81

                        90       100
                ....*....|....*....|....
gi 1946367  104 AALHCAAEFLQMTDKYCDNNLAGR 127
Cdd:cd18312  82 VGLRCAAEYLEMTESGNLGNLIDK 105

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367     26 FSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPggPEIFEKAAKFCYGVNFeITVQNVA 104
Cdd:pfam00651   5 REQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSgQESESSVSEITLDDVS--PEDFEALLEFMYTGKL-ISEENVD 81

                          90
                  ....*....|...
gi 1946367    105 ALHCAAEFLQMTD 117
Cdd:pfam00651  82 DLLAAADKLQIPS 94

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   24 WVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNV 103
Cdd:cd18312   2 WFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNV 81

                        90       100
                ....*....|....*....|....
gi 1946367  104 AALHCAAEFLQMTDKYCDNNLAGR 127
Cdd:cd18312  82 VGLRCAAEYLEMTESGNLGNLIDK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   32 TDVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPggPEIFEKAAKFCYGVNFEITVQNVAALHCAA 110
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSsGMKESSSSEIELDDVS--PEAFEALLDYIYTGELELSEENVEELLAAA 79

                ...
gi 1946367  111 EFL 113
Cdd:cd18186  80 DKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367     26 FSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPggPEIFEKAAKFCYGVNFeITVQNVA 104
Cdd:pfam00651   5 REQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSgQESESSVSEITLDDVS--PEDFEALLEFMYTGKL-ISEENVD 81

                          90
                  ....*....|...
gi 1946367    105 ALHCAAEFLQMTD 117
Cdd:pfam00651  82 DLLAAADKLQIPS 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   34 VVVEVGEANFSLHKFMLVAKSNYIRKLI-MESKDSDVTRINLSDIpgGPEIFEKAAKFCYGVNFEITVQNVAALHCAAEF 112
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFrGGFRESGQAEINLRDI--SPEDFRALLEFLYGGKRDLDASNLLELLEAANF 78

                .
gi 1946367  113 L 113
Cdd:cd01165  79 L 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLI---MESKDSDVTRINLSDipggPEIFEKAAKFCYGVNFEITVQNVAALHCA 109
Cdd:cd18256  22 DVQLQVGMELFSVHRLVLAASSPYFAALFaggMSESSKDVVQIHGVE----PDIFHILLDFIYTGVVEVTVSNVQELLVA 97

                ....*...
gi 1946367  110 AEFLQMTD 117
Cdd:cd18256  98 ADMLQLTE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPggPEIFEKAAKFCYGVNFEITVQNVAALHCAAE 111
Cdd:cd18250  23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAgELRESRADRVVLHGVS--AEILGLLLDFSYTGRVTVTQDNVEALLRAAD 100

                ...
gi 1946367  112 FLQ 114
Cdd:cd18250 101 LFQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   27 SQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLImesKDSDVTRINLSDIPGG--PEIFEKAAKFCYGVNFEITVQNVA 104
Cdd:cd18215  15 SRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF---TDQLKNNVSVINLDPEiePEGFRILLDFMYTSRLNLREGNIM 91

                        90       100
                ....*....|....*....|
gi 1946367  105 ALHCAAEFLQM---TDkYCD 121
Cdd:cd18215  92 AVMATAMYLQMehvVD-TCR 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPggPEIFEKAAKFCYGVNFEITVQNVAALHCAAE 111
Cdd:cd18242  23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTsEMSEKGKSEVELQGLT--ASTMEILLDFVYTETVHVTVENVQELLPAAC 100

                ....*
gi 1946367  112 FLQMT 116
Cdd:cd18242 101 LLQLK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKlimESKDSDVTRINLSDIPGgPEIFEKAAKFCYGVNFEITVQNVAALHCAAEF 112
Cdd:cd18220  27 DIIVHIQGQPFRAHKAVLAASSPYFRD---HSALSTMSGLSISVIKN-PNVFEQLLSFCYTGRMSLQLKDVVSFLTAASF 102

                ...
gi 1946367  113 LQM 115
Cdd:cd18220 103 LQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367    6 KNPINMNSMSSSLARTgQWVFSQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMES-KDSDVTRINLSDIpgGPEIF 84
Cdd:cd18270   2 ERQINTEYAVSLLEQL-KFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGlSESKQTHVHLRNV--DAATL 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 1946367   85 EKAAKFCYGVNFEITVQNVAALHCAAEFLQMTD 117
Cdd:cd18270  79 QIIITYAYTGNLAINDSTVEQLYETACFLQVED 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   30 IPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIME----SKDSDVTRINLSDIPGgpeiFEKAAKFCYGVNFEITVQNVAA 105
Cdd:cd18230  20 ILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQvqktSDQATVTHLDIVTAQG----FKAIIDFMYSAHLALTSKNVIE 95

                        90
                ....*....|..
gi 1946367  106 LHCAAEFLQMTD 117
Cdd:cd18230  96 VMSAASYLQMTD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIMES-KDSDVTRINLSDIPggPEIFEKAAKFCYGVNFEITVQNVAALHCAAE 111
Cdd:cd18340  29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDlEESKKREIVLEDVD--PDVMGKILHYIYTSEIEITEQNVQDIFAAAN 106

                ....
gi 1946367  112 FLQM 115
Cdd:cd18340 107 MFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   28 QDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVtrinlsDIPGG--PEIFEKAAKFCYGVNFEITVQNVAA 105
Cdd:cd18290  24 QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVV------ELPAAvqPQSFQQILSFCYTGRLSMNVGDQFL 97

                        90
                ....*....|
gi 1946367  106 LHCAAEFLQM 115
Cdd:cd18290  98 LMYTAGFLQI 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   27 SQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPGgpEIFEKAAKFCYGVNFEITVQNVAA 105
Cdd:cd18235  17 KQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTgDLSESRANRVTLQDVDG--KALLLLIDYVYTAEIQVTEENVQV 94

                        90
                ....*....|..
gi 1946367  106 LHCAAEFLQMTD 117
Cdd:cd18235  95 LLPAANLLQLTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   32 TDVVVEVGEANFSLHKFMLVAKSNYIRKL----IMESKDSDVtriNLSDiPGGPEIFEKAAKFCYGVNFEITVQNVAALH 107
Cdd:cd18254  23 TDVTLWAGNRSFPCHRAVLAACSRYFEAMfsngLRESLDSTV---NFHD-SLHPEVLELLLDFAYSSRIIINEENAESLL 98

                        90
                ....*....|
gi 1946367  108 CAAEFLQMTD 117
Cdd:cd18254  99 EAGDMLQFHD 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   28 QDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKL----IMESKDSDVtriNLSDIPggPEIFEKAAKFCYGVNFEITVQNV 103
Cdd:cd18237  18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMftsnMTESKSSEV---ELKDAE--PDIIELLVEFAYTARISVNSNNV 92

                        90
                ....*....|...
gi 1946367  104 AALHCAAEFLQMT 116
Cdd:cd18237  93 QSLLDAANQYQIE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   32 TDVVVEVGEANFSLHKFMLVAKSNYIRKLiMESKDSDVTRINLsDIPG-GPEIFEKAAKFCYGVNFEITVQNVAALHCAA 110
Cdd:cd18240  18 CDVVIRVNGVEFPAHRNILCACSPYFRAL-FTNGWNETEKKVY-KIPGvSPEMMELIIEYAYTRTVPITAENVEELLPAA 95

                .
gi 1946367  111 E 111
Cdd:cd18240  96 D 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   28 QDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIM----ESKD-SDVTRINLSDIPGgpeiFEKAAKFCYGVNFEITVQN 102
Cdd:cd18201  18 KGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCftnkESCDqTTVTHLDVVAVQG----FSVILDFMYSGNLVLTSQN 93

                        90
                ....*....|....*
gi 1946367  103 VAALHCAAEFLQMTD 117
Cdd:cd18201  94 AIEVMSVASYLQMTE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTR-INLSDIPggPEIFEKAAKFCYGVNFEITVQNVAALHCAAE 111
Cdd:cd18269  29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKeVVLEDVD--PDVMGMILKYLYTSEIDLNDQNVQDIFALAS 106

                ....
gi 1946367  112 FLQM 115
Cdd:cd18269 107 RFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDS-DVTRINlSDIPGGPEiFEKAAKFCYGVNFEITVQNVAALHCAAE 111
Cdd:cd18325  25 DCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKrDIVHLN-SDIVTAPA-FSLLLEFMYEGKLEFSSLPVEDVLAAAS 102

                        90
                ....*....|....*
gi 1946367  112 FLQMTD--KYCDNNL 124
Cdd:cd18325 103 YLHMYDivKVCKGKL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   32 TDVVVEVGEANFSLHKFMLVAKSNYIRKliMESKDSDVTRINLSDIPG-GPEIFEKAAKFCYGVNFEITVQNVAALHCAA 110
Cdd:cd18253  19 TDVIICVEGREFPCHRAILSACSSYFRA--MFCNDHRESREMLVEINGiLAEAMDCFLQYVYTGKVKITTENVQYLFETS 96

                ....*.
gi 1946367  111 EFLQMT 116
Cdd:cd18253  97 SLFQIS 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNVAALHCAAEF 112
Cdd:cd18207  29 DVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKF 108

                ...
gi 1946367  113 LQM 115
Cdd:cd18207 109 LLM 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   27 SQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIPGGpeIFEKAAKFCYGVNFEITVQNVAA 105
Cdd:cd18338  17 SQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTgEMSESRAKRVRIKEVDGW--TLKMLIDYVYTAEIQVTEENVQV 94

                        90
                ....*....|....*..
gi 1946367  106 LHCAAEFLQMTD--KYC 120
Cdd:cd18338  95 LLPAAGLLQLQDvkKTC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   27 SQDIPTDVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSDVTRINLsDIPGGPEIFEKAAKFCYGVNFEITVQNVAAL 106
Cdd:cd18331  20 SRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINL-DPEINPEGFNILLDFMYTSRLNLREGNIMAV 98

                ....*....
gi 1946367  107 HCAAEFLQM 115
Cdd:cd18331  99 MATAMYLQM 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1946367   32 TDVVVEVGEANFSLHKFMLVAKSNYIRKLI-MESKDSDVTRINLSDIpgGPEIFEKAAKFCY 92
Cdd:cd18279  19 TDCCLCVGGQEFQAHKAILAARSPVFSAMFeHEMEESKKNRVEINDV--DPEVFKEMMRFIY 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIMESKDSdVTRINLSDIPGGPEIFEKAAKFCYGVNFEITVQNVAALHCAAEF 112
Cdd:cd18192  23 DCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHT-TAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDFEQLKVAMNY 101

                ...
gi 1946367  113 LQM 115
Cdd:cd18192 102 LQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIM-ESKDSDVTRINLSDIpgGPEIFEKAAKFCYGVNFEITVQNVAALHCAAE 111
Cdd:cd18246  41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTnEMSESRQTHVTLHDI--DPQALEQLVQYAYTAEIVVGEGNVQTLLPAAS 118

                ....
gi 1946367  112 FLQM 115
Cdd:cd18246 119 LLQL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1946367   33 DVVVEVGEANFSLHKFMLVAKSNYIRKLIMeSKDSDvtRINLSDIPGgPEIFEKAAKFCYGVNFEITVQNVAALHCAAEF 112
Cdd:cd18227  27 DISVVVQGHLFRAHKAVLAASSPYFCDQVL-LKNSR--RIVLPDVMN-PRVFENILLSCYTGRLVLPAPEIVSYLTAASF 102

                ...
gi 1946367  113 LQM 115
Cdd:cd18227 103 LQM 105