NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2228246|gb|AAB63009|]
View 

matrix metalloproteinase RASI-1 [Homo sapiens]

Protein Classification

HX domain-containing protein( domain architecture ID 10056662)

HX domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 15-186 2.46e-63

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 195.22  E-value: 2.46e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2228246   15 RGKTYAFKGDYVWTVSD-SGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLN----- 88
Cdd:cd00094  16 RGELYFFKGRYFWRLSPgKPPGSPFLISSFWPSLPSPVDAAFERPDTGKIYFFKGDKYWVYTGKNLEPGYPKPISdlgfp 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2228246   89 RVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQ 168
Cdd:cd00094  96 PTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDGYYYFFKGDQYWRFDPR 175

                       170
                ....*....|....*....
gi 2228246  169 LR-VEKGYPRNISHNWMHC 186
Cdd:cd00094 176 SKeVRVGYPLKISSDWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 15-186 2.46e-63

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 195.22  E-value: 2.46e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2228246   15 RGKTYAFKGDYVWTVSD-SGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLN----- 88
Cdd:cd00094  16 RGELYFFKGRYFWRLSPgKPPGSPFLISSFWPSLPSPVDAAFERPDTGKIYFFKGDKYWVYTGKNLEPGYPKPISdlgfp 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2228246   89 RVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQ 168
Cdd:cd00094  96 PTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDGYYYFFKGDQYWRFDPR 175

                       170
                ....*....|....*....
gi 2228246  169 LR-VEKGYPRNISHNWMHC 186
Cdd:cd00094 176 SKeVRVGYPLKISSDWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 145-183 3.13e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.09  E-value: 3.13e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2228246     145 AAMSWQDGRVYFFKGKVYWRLNQQlRVEKGYPRNISHNW 183
Cdd:smart00120   3 AAFELRDGKTYFFKGDKYWRFDPK-RVDPGYPKLISSFF 40
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 145-186 1.70e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 46.41  E-value: 1.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2228246    145 AAMSWQDGRVYFFKGKVYWRLNQQlRVEKGYPRNISH-NWMHC 186
Cdd:pfam00045   3 AAFEDRDGKTYFFKGRKYWRFDPQ-RVEPGYPKLISDfPGLPC 44
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 15-186 2.46e-63

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 195.22  E-value: 2.46e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2228246   15 RGKTYAFKGDYVWTVSD-SGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLN----- 88
Cdd:cd00094  16 RGELYFFKGRYFWRLSPgKPPGSPFLISSFWPSLPSPVDAAFERPDTGKIYFFKGDKYWVYTGKNLEPGYPKPISdlgfp 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2228246   89 RVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQ 168
Cdd:cd00094  96 PTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDGYYYFFKGDQYWRFDPR 175

                       170
                ....*....|....*....
gi 2228246  169 LR-VEKGYPRNISHNWMHC 186
Cdd:cd00094 176 SKeVRVGYPLKISSDWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 145-183 3.13e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 51.09  E-value: 3.13e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2228246     145 AAMSWQDGRVYFFKGKVYWRLNQQlRVEKGYPRNISHNW 183
Cdd:smart00120   3 AAFELRDGKTYFFKGDKYWRFDPK-RVDPGYPKLISSFF 40
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 51-94 1.67e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 49.16  E-value: 1.67e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2228246      51 LDAAVYSPRTQwIHFFKGDKVWRYINFKMSPGFPKKLNRVEPNL 94
Cdd:smart00120   1 IDAAFELRDGK-TYFFKGDKYWRFDPKRVDPGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 145-186 1.70e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 46.41  E-value: 1.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2228246    145 AAMSWQDGRVYFFKGKVYWRLNQQlRVEKGYPRNISH-NWMHC 186
Cdd:pfam00045   3 AAFEDRDGKTYFFKGRKYWRFDPQ-RVEPGYPKLISDfPGLPC 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 51-85 3.28e-04

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 37.16  E-value: 3.28e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2228246     51 LDAAVYSPRTQwIHFFKGDKVWRYINFKMSPGFPK 85
Cdd:pfam00045   1 IDAAFEDRDGK-TYFFKGRKYWRFDPQRVEPGYPK 34
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 94-140 8.01e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 36.07  E-value: 8.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2228246      94 LDAALYWPlNQKVFLFKGSGYWQWDElaRTDFSSYPKPIKGLFTGVP 140
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDP--KRVDPGYPKLISSFFPGLP 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 14-49 8.42e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 36.07  E-value: 8.42e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2228246      14 PRGKTYAFKGDYVWTVSDS--GPGPLFRVSALWEGLPG 49
Cdd:smart00120   8 RDGKTYFFKGDKYWRFDPKrvDPGYPKLISSFFPGLPC 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH