SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2191178  450 TTNLSMREQTMFKKALELSTLCNIDVCVIYYGRDGKLIKTWPDDQskVRDMAERFSRLHERERCKKRTN 518
Cdd:cd00266  17 AVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSE--VEGVISRFEVLSALERKKKAVD 83

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 2191178   44 IASLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYF 83
Cdd:cd22152   2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPEL 41

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2191178  450 TTNLSMREQTMFKKALELSTLCNIDVCVIYYGRDGKLIKTWPDDQskVRDMAERFSRLHERERCKKRTN 518
Cdd:cd00266  17 AVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSE--VEGVISRFEVLSALERKKKAVD 83

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 2191178   44 IASLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYF 83
Cdd:cd22152   2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPEL 41

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191178   154 YVVSRNAVLRYDSWMGTLNLRSPMIFPRKKFAIAVVSGKIYVAGGGGGSEVAAAVEEYDPELNRWEVVTQSARKRYGCIG 233
Cdd:PHA03098 306 NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCV 385

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2191178   234 AAVDGVFYVIGGLKIGNETSRAVaarayassmDLFDVESRQWLRSRSVP----GGGCVVAAcaavGYVYVLT 301
Cdd:PHA03098 386 VNVNNLIYVIGGISKNDELLKTV---------ECFSLNTNKWSKGSPLPishyGGCAIYHD----GKIYVIG 444

Kelch domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2191178     192 KIYVAGGGGGSEVAAAVEEYDPELNRWEVVTQSARKRYGCIGAAVDG 238
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2191178    180 PRKKFAIAVVSGKIYVAGGGGGSEVAAAVEEYDPELNRWEVVT 222
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2191178  450 TTNLSMREQTMFKKALELSTLCNIDVCVIYYGRDGKLIKTWPDDQskVRDMAERFSRLHERERCKKRTN 518
Cdd:cd00266  17 AVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSE--VEGVISRFEVLSALERKKKAVD 83

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191178  141 LSHARAAAIGPRVYVV-------SRNAVLRYD----SWmgtLNLRSPMIFPRKKFAIAVVSGKIYVAGGGGG----SEVA 205
Cdd:COG3055  13 RSEAAAALLDGKVYVAgglsggsASNSFEVYDpatnTW---SELAPLPGPPRHHAAAVAQDGKLYVFGGFTGanpsSTPL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191178  206 AAVEEYDPELNRWEVVTQSARKRYGCIGAAVDGVFYVIGGlkignetsraVAARAYASSMDLFDVESRQWLRSRSVPGG- 284
Cdd:COG3055  90 NDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG----------WDDGGNVAWVEVYDPATGTWTQLAPLPTPr 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191178  285 GCVVAACAAVGYVYVLtshavelsfwrfdarrrGGNSGFGEWQRLKSPPLPAQVRLDGTV 344
Cdd:COG3055 160 DHLAAAVLPDGKILVI-----------------GGRNGSGFSNTWTTLAPLPTARAGHAA 202

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 2191178  450 TTNLSMREQTMFKKALELSTLCNIDVCVIYYGRDGKLIKTWP 491
Cdd:cd00120  17 QVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFWS 58

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 2191178   44 IASLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYF 83
Cdd:cd22152   2 IPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPEL 41

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191178   154 YVVSRNAVLRYDSWMGTLNLRSPMIFPRKKFAIAVVSGKIYVAGGGGGSEVAAAVEEYDPELNRWEVVTQSARKRYGCIG 233
Cdd:PHA03098 306 NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCV 385

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2191178   234 AAVDGVFYVIGGLKIGNETSRAVaarayassmDLFDVESRQWLRSRSVP----GGGCVVAAcaavGYVYVLT 301
Cdd:PHA03098 386 VNVNNLIYVIGGISKNDELLKTV---------ECFSLNTNKWSKGSPLPishyGGCAIYHD----GKIYVIG 444

Kelch domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2191178     192 KIYVAGGGGGSEVAAAVEEYDPELNRWEVVTQSARKRYGCIGAAVDG 238
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....*....
gi 2191178   45 ASLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYF 83
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2191178    180 PRKKFAIAVVSGKIYVAGGGGGSEVAAAVEEYDPELNRWEVVT 222
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2191178  218 WEVVTQSARKRYGCIGAAVDGVFYVIGGLKIGNETSRAvaarayassmDLFDVESRQWLRSRSVPGGGCVVAACAAV-GY 296
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSF----------EVYDPATNTWSELAPLPGPPRHHAAAVAQdGK 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 2191178  297 VYVL---TSHAVEL----SFWRFDARRrggnsgfGEWQRLKSPPLP 335
Cdd:COG3055  73 LYVFggfTGANPSStplnDVYVYDPAT-------NTWTKLAPMPTP 111

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 2191178   46 SLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYF 83
Cdd:cd22151   2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESL 39

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2191178     44 IASLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHSPYF 83
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40

N-acetylneuraminate epimerase;

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2191178   180 PRKKFAIAVVSGKIYVAGGGGGSEVAAA------VEEYDPELNRWE-VVTQSARKRYGCIGAAVDG-VFYVIGG 245
Cdd:PRK14131  74 PREQAVAAFIDGKLYVFGGIGKTNSEGSpqvfddVYKYDPKTNSWQkLDTRSPVGLAGHVAVSLHNgKAYITGG 147

Kelch motif;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2191178    180 PRKKFAIAVVSGKIYVAGG-GGGSEVAAAVEEYDPELNRWEVV 221
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEEL 43

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                        10        20        30
                ....*....|....*....|....*....|....*
gi 2191178   46 SLPDDLLLECISRVPSSSIPSLAVVCRRWSRLLHS 80
Cdd:cd22114   3 SLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASD 37