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Conserved domains on  [gi|1916842|gb|AAB51242|]
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sialyltransferase X [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467715  Cd Length: 278  Bit Score: 616.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSG 170
Cdd:cd23987   1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  171 CGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKE 250
Cdd:cd23987  81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987 161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 1916842  331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987 241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 616.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSG 170
Cdd:cd23987   1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  171 CGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKE 250
Cdd:cd23987  81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987 161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 1916842  331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987 241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 111-363 1.84e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 300.29  E-value: 1.84e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842    111 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQ 190
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842    191 EYARDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLHSLNG--SILWIPAFMARGGKERVEWVNELILKHHVNV- 266
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842    267 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 343
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 1916842    344 SPHTMPLEFKALKSLHEQGA 363
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 616.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSG 170
Cdd:cd23987   1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  171 CGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKE 250
Cdd:cd23987  81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23987 161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 1916842  331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23987 241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 91-368 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 518.89  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSG 170
Cdd:cd23969   1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  171 CGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKE 250
Cdd:cd23969  81 CGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKFVERLRQLGDSILWIPAFVSKGGEE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23969 161 HVQWTNEIILKHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 1916842  331 YYDSLKYGYtsQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23969 241 YYDNRKYLT--TARPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 91-367 3.95e-174

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 485.61  E-value: 3.95e-174
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   91 TLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSG 170
Cdd:cd23988   1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  171 CGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKE 250
Cdd:cd23988  81 CGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  251 RVEWVNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYH 330
Cdd:cd23988 161 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 1916842  331 YYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKLT 367
Cdd:cd23988 241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLT 277
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 95-368 1.47e-112

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 329.22  E-value: 1.47e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   95 RIRKQILKFLDAEKDISVLKGTlKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQE 174
Cdd:cd23963   5 KFRKELERLLNTRKLFLTQKNT-PLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  175 IDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARGGKERVEW 254
Cdd:cd23963  84 IDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLK 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  255 VNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVhIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDS 334
Cdd:cd23963 164 AARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDD 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 1916842  335 LKYGYTSqaSPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23963 243 LSPSTKN--KVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 111-363 1.84e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 300.29  E-value: 1.84e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842    111 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQ 190
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842    191 EYARDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLHSLNG--SILWIPAFMARGGKERVEWVNELILKHHVNV- 266
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842    267 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 343
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 1916842    344 SPHTMPLEFKALKSLHEQGA 363
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 89-368 3.89e-97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 290.45  E-value: 3.89e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   89 NQTLSLRIRKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMN-VSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLL 167
Cdd:cd23970   2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  168 NSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLHSLNGSILWIPAFMARG 247
Cdd:cd23970  82 NSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHT 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  248 GKERVEWVNELILKH--HVNVRTAYPSlRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQN 325
Cdd:cd23970 162 SATVTRTLVDFFVEHrgQLKVQLAWPG-NIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGT 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 1916842  326 PVKYHYYDSL--KYGYTSQASpHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23970 241 PLPYHYYDKKgtKFTTKWQES-HQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 120-366 3.69e-71

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 223.67  E-value: 3.69e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  120 GDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVqEYARDVGLK 199
Cdd:cd23971  30 GSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSK 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  200 TDLVTMNPSVIQRAFEDLVNatWREKLLQRLHSLNGSILWIPAFMARGGKE---RVEWVNELIlKHHVNVRTAYPS-LRL 275
Cdd:cd23971 109 TNLVTANPSILREKFHNLKK--RRRPFVERMKVYGNALLLLPAFSYTSNTEpslRALYTLEDF-GSPQKVLFFNPEyLRN 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  276 LHAvrgYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 355
Cdd:cd23971 186 LSR---YWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL----PKKGVHAMPEEFLRY 258

                       250
                ....*....|.
gi 1916842  356 KSLHEQGALKL 366
Cdd:cd23971 259 LKLHSQGVLRL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 97-368 4.01e-59

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 192.74  E-value: 4.01e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842   97 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKnKHFGTCAIVGNSGVLLNSGCGQEID 176
Cdd:cd23989   7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  177 AHSFVIRCNLAPV-QEYARDVGLKTDLVTMNPSVIQRAFEDLVnatW-REKLLQRLHSLNGSILWIPAFMARGGKERVEW 254
Cdd:cd23989  86 RADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNLL---WsRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  255 VNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDS 334
Cdd:cd23989 163 VYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDN 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 1916842  335 LkygyTSQASPHTMPLEFKALKSLHEQGALKLTV 368
Cdd:cd23989 243 V----LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 120-366 6.40e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 171.56  E-value: 6.40e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  120 GDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPV-QEYARDVGL 198
Cdd:cd23990  30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGV 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  199 KTDLVTMNPSVIQRAFEDLvnATWREKLLQRLHSLNGSILWIPAFMARGGKE---RVEWVNElILKHHVNVRTAYPslRL 275
Cdd:cd23990 110 KTDVVTINPSIITERFHKL--EKWRRPFYEVLQVYENASVVLPAFYNTRNTDvsiRVKYVLD-DFESQQAVYYFHP--QY 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  276 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 355
Cdd:cd23990 185 LLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVK----PRPGFHAMPSEIFNF 260

                       250
                ....*....|.
gi 1916842  356 KSLHEQGALKL 366
Cdd:cd23990 261 LHMHSRGILRV 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 132-366 7.85e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 168.39  E-value: 7.85e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  132 TMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQ-EYARDVGLKTDLVTMNPSVI 210
Cdd:cd23991  42 KILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGgNISKDVGSKTNLVTANPSII 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  211 QRAFEDLVNAtwREKLLQRLHSLNGSILWIPAFMAR----------------GGKERVEWVNELILKHhvnvrtaypslr 274
Cdd:cd23991 122 SIKYAKLNER--RKPFLETVSVYGDAFLLLPAFSYRsntalsfkvyytledfKAKQKVIFFHPIYLKH------------ 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  275 LLHavrgYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFWPFPLDQNQNPVKYHYYDSL--KYGYtsqaspHTMPLEF 352
Cdd:cd23991 188 LAQ----FWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQlpKPGF------HSMPKEF 257

                       250
                ....*....|....
gi 1916842  353 KALKSLHEQGALKL 366
Cdd:cd23991 258 YQLLQLHSKGILKL 271
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 157-358 2.54e-37

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 133.26  E-value: 2.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLlqrlhsLNGS 236
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPL------EEEV 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  237 ILWIPAFMARGGKERV-----EWVNELILKHHVNvrtaypslRLLHAVRGYW----LTNKVHIKRPTTGLLMYTLATRFC 307
Cdd:cd19952  75 VLILSRAAAADFKRLKrrkkrHDNAVLLLTDPAP--------DLLSYVRKRLeklgLKSFFGGNAPSSGLLAVLLALQLC 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 1916842  308 KQIYLYGFWPFPLDQNQNPvkYHYYDslKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd19952 147 DSVDLYGFGVDSGHAPKVP--YHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 156-366 2.91e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 106.57  E-value: 2.91e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  156 TCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNP-SVIQRAFEDLV---NATWrekLL---- 227
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPeSLHNSLLKHVPqdkDTKY---LFipfk 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  228 QR-LHSLNGSILW--IPAFMARGGKERvewvneLILKHHVNVRTaypsLRLLHA-----VRGYWLtNKVHIKRPTTGLLM 299
Cdd:cd23964 161 IRdYDYLDAVLSGkpVPDGCDKGKRPP------PLFGPKLNATN----VRLLHPdfiryLFNRWL-NSSTSYRPTTGALM 229

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  300 YTLATRFCKQIYLYGF---WPFPLdqnqnpvkyHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23964 230 LLTALHTCDQVSVYGFgydPRFSL---------HYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 125-336 4.11e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 102.73  E-value: 4.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  125 YIFDRDST-MNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLV 203
Cdd:cd23968  15 STLRKTTSpFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLR 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  204 TMNpSVI----QRAFEDlvnatwrekllqRLHSLNGSIL-WIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRL-LH 277
Cdd:cd23968  95 LIN-SQIlskpEFNFLT------------DPLYRNVTLLvWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFyLI 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1916842  278 AVRGYW-------LTNKVHIKR--PTTGLLMYTLATRFCKQIYLYGFWPfPLDQNQnpvKYHYYDSLK 336
Cdd:cd23968 162 DPRFLWrlwdilqEYTPEKIKPnpPSSGFIGIVLMLHLCDWVDVYEYVP-SVRQTD---RCHYYDVEK 225
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 157-358 6.23e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 84.27  E-value: 6.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNP-SVIQRAFEDLVNAT------------WR 223
Cdd:cd23967   5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPeSAFRDPEEYDSDWLlvlvpfksmdllWL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  224 EKLLQRlHSLNGSILWI--PAFMARGGKERVEWVNELILKhhvnvRTAYPSLRLLHAvrgywltNKVHIKRPTTGLLMYT 301
Cdd:cd23967  85 QAVIKG-KKPNGKGGFWkkIATSVPKPPKKIRILNPYILQ-----EAAFDLIGLPMN-------GKQGKNVPTTGIIAIV 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 1916842  302 LATRFCKQIYLYGFwPFPLDQNQNPvkYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23967 152 MALHYCDEVDIAGF-GYDPSDPNAP--LHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 156-366 1.70e-18

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 84.25  E-value: 1.70e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  156 TCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSviqrAFEDLVNAT-------------W 222
Cdd:cd23966  79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPE----SAVDLDPGVhlvlvpfkvldlqW 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  223 rekLLQRLHslNGSILW----IPAFMaRGGKERVEWVNELILKHhvnvrtaypslrllhaVRGYWLTNkvHIKRPTTGLL 298
Cdd:cd23966 155 ---LISALT--TGEITRtytpVKRFI-KADKDKVLVINPAFIKY----------------VHDNWTEH--HGRYPSTGFL 210

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1916842  299 MYTLATRFCKQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23966 211 ALIFALHICDEVSVFGFGA---DSKGN--WHHYWEKNRSaGAFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 148-335 2.61e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 83.38  E-value: 2.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  148 PLKnKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDlvnatwREKLL 227
Cdd:cd23976  10 PLK-MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRN------RNELL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  228 QRLHSlNGSILWIPA-FMARGGKERVewVNELILKHHVnvrtaYPSLRLLHAVRGYWLTNKVHIKRPT------------ 294
Cdd:cd23976  83 NVSQG-TVFIFWGPSnYMRRDGKGLV--YNNLQLMNQI-----LPKLKVYTITRHKMLQFDELFKRETgkdrkisntwls 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 1916842  295 TGLLMYTLATRFCKQIYLYGFWP--FPLDQNQNPVKYHYYDSL 335
Cdd:cd23976 155 TGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 156-358 3.88e-18

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 82.02  E-value: 3.88e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  156 TCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPsviQRAFEDLVNATWREKLLQRLHSLNG 235
Cdd:cd23982   4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYP---ESAQFDPGIENDPDTLLVLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  236 SILWIPAFMARGGKERVEWVNELILKHHVN---VRTAYP------SLRLLHaVRGywltNKVHIKRPTTGLLMYTLATRF 306
Cdd:cd23982  81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANpkqIRILNPyytyvaATKLLQ-VPG----QRKKKQKPTTGLLAITLALHL 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 1916842  307 CKQIYLYGFwPFPLDQNQN-PVkyHYYDslkyGYTS---QASPHTMPLEFKALKSL 358
Cdd:cd23982 156 CDEVHIAGF-GYPDNGNSNqPI--HYYN----QITLksmANSGHNLNAEAQAIQRL 204
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 152-334 2.59e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 77.82  E-value: 2.59e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  152 KHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVI---QRAFedLVNATWREKLLq 228
Cdd:cd23985  43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQLVtteKHKF--LKDSLYNEGIL- 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  229 rlhslngsILWIPAFMArggKERVEWVNelilKHHVNVRTAYPSLRLLHAVRGYWLTNKV---------------HIKR- 292
Cdd:cd23985 120 --------IVWDPAPYH---SDIPEWYK----NPDYNFFENYKTYRRLNPNQPFYILHPQmqwelwdiiqenspeEIQPn 184

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 1916842  293 -PTTGLLMYTLATRFCKQIYLYGFWPfplDQNQNPVkYHYYDS 334
Cdd:cd23985 185 pPSSGMLGIILMMTLCDQVDVYEFLP---SKRKTDV-CHYYQK 223
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 155-337 2.27e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 71.50  E-value: 2.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  155 GTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDlvnatwREKLLQRLHSLN 234
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRN------AILLLAGTRAPT 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  235 GSILWIPAF-MARGGKERVEWVNELILKH-HVNVRTAYPSlRLLHAVR-------------GYWLtnkvhikrpTTGLLM 299
Cdd:cd23965  76 VVVFWGPETkMNKDGAGKYNLLRSLSKKYpDVEFYSLTPE-KMDYADElfeketgksriksGTWL---------STGWFT 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 1916842  300 YTLATRFCKQIYLYGFWP------FPLDQnqnpVKYHYYDSLKY 337
Cdd:cd23965 146 MLLALDVCDEIKVYGMVPenycreHPNSK----VPYHYYEPGGL 185
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 157-366 4.22e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.16  E-value: 4.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLV-----TMNPSVIqrAFEDL-VNATWREKLLQRL 230
Cdd:cd23972  85 CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvnTMKNSLI--SYWNLgFTRTPQGQDLQYI 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  231 H---------SLNGSILWIPafMARGGKERVEWVNELILKHHVN-VRTAYPSlrLLHAVRGYWLTNKV------HIKRPT 294
Cdd:cd23972 163 FipsdirdyvMLRSAILGVP--VPEGLDKGDRPHKYFGPEASAKkFKLLHPD--FISYLTDRFLKSKLlnthygHLYMPS 238

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1916842  295 TGLLMYTLATRFCKQIYLYGFwpfpLDQNQNPVKYHYYDSLKYGYTSQASpHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23972 239 TGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKKKPLVFYAN-HDMLLEAALWRRLHKAGILQL 305
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 127-366 1.62e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 70.29  E-value: 1.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  127 FDRDSTMNVSQNLYELLPRTSPLKNK---HFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLV 203
Cdd:cd23979  50 FKPHNTKEVLSKLFQIIPGENPYRSWdpsRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHH 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  204 TMNPsviQRAFEDLVNATWrekLLQRLHSLNgsILWIPAFMARG---------------GKERVEWVNELILKHhvnvrt 268
Cdd:cd23979 130 FMYP---ESAKNLPANVSF---VLVPFKTLD--LLWITSALSTGqirftyapvkqflrvDKDKVQIYNPAFFKY------ 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  269 aypslrllhaVRGYWLTNkvHIKRPTTGLLMYTLATRFCKQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHT 347
Cdd:cd23979 196 ----------IHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGFGA---DSRGN--WHHYWENNRYaGEFRKTGVHD 258

                       250
                ....*....|....*....
gi 1916842  348 MPLEFKALKSLHEQGALKL 366
Cdd:cd23979 259 ADFEAHIIDMLAKAGKIKV 277
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 131-366 2.11e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 70.17  E-value: 2.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  131 STMNVSQNLYELLPRTSPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVT------ 204
Cdd:cd23974  61 NLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTfstntl 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  205 MN------------PSVIQRAFEDLVNATWREKLLQRLHSLNGSIlwipafmARG---GKERVEWVNELILKHHVNVR-- 267
Cdd:cd23974 141 MNslrayagvgfngPPQSKETRYIFLPDHDRDYLLVKAALTHTPI-------DRGrdkSKRPSKYFGKDVTAEKFKIYhp 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  268 --TAYPSLRLLHAvrGYWLTNKVHIKRPTTGLLMYTLATRFCKQIYLYGFwpfpLDQNQNPVKYHYYDSlKYGYTSQASP 345
Cdd:cd23974 214 dfIRYLRNRFLWS--PILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDK-TYHKVVFYAN 286

                       250       260
                ....*....|....*....|.
gi 1916842  346 HTMPLEFKALKSLHEQGALKL 366
Cdd:cd23974 287 HDLRLEMQLWQKLHKAGLIKL 307
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 156-358 2.55e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 68.23  E-value: 2.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  156 TCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIqraFEDlvnatwrekllqRLHSLNG 235
Cdd:cd23984   4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI---FSD------------PSHYDPN 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  236 SILWIPAFMARGgkerVEWVNELILKHHVNVRTAY--PSLRLL---HAVR----------GYWLTN--KVHIKR-----P 293
Cdd:cd23984  69 TTVVLIPFKPHD----LRWLLDLLMGKKVSAKGFWkkPALNLIykpNQIRilnpfilriaAYELLHfpKRFPKEkkpkhP 144

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1916842  294 TTGLLMYTLATRFCKQIYLYGFwPFPLDQNQNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23984 145 TTGIIAITLALHICNEVHIAGF-KYDFSNLNSTL--HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 156-366 2.67e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.78  E-value: 2.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  156 TCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTdlvtmnpSVIQRAFEDLVNATW--REKLLQRLHSL 233
Cdd:cd23973  85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRT-------SFYVHTAHSITSSLMilQKRGFKNIPQD 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  234 NGsilwIPAFMARGGKERVEWVNELILKHHVN---VRTAYP-----------SLRLLHA-----VRGYWLTNKV------ 288
Cdd:cd23973 158 KD----IKYILFPEGPRDYQWLEALLKNKTIPsgaYYGRRPrsyfsgdftedKYLVLHPdflryVKNRFLRSKTlkgkyw 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  289 HIKRPTTGLLMYTLATRFCKQIYLYGFwpfpldQNQNPVKY--HYYDsLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 366
Cdd:cd23973 234 AIYRPTTGAFLLLTALHLCDTVSAYGF------ITEDYRKYpdHYYD-KKKTKLVFYINHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 157-358 8.42e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 66.87  E-value: 8.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLvtmnpsviqrafedlvNATWREKLLQRLHSLNGS 236
Cdd:cd23981   5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTL----------------RITYPEGAIQKPEQYEKD 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  237 ILWIPAfmarGGK-ERVEWVNELILKHHVN--------VRTAYP----SLRLLHAvrgYWL-----------TNKVHIKR 292
Cdd:cd23981  69 SLFVLA----GFKwQDFKWLKYIVYKEKVSasdgfwksVATRVPrephEIRILNP---YFIqeaafsfiglpFNNGLMGR 141

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1916842  293 ---PTTGLLMYTLATRFCKQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23981 142 gniPTLGSVAITMALHNCDEVAVAG---FGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 157-358 1.17e-12

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 66.30  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLvTMN-----PSVIQRAFEDLVNAT---------W 222
Cdd:cd23983   5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTI-RMTypegaPKSEQEYDPTSLFVAvlfksvdfaW 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  223 REKLLQRLHSLNGSILW--------IPAfmargGKERVEWVNELILKHHVNVRTAYPSLRllhavRGYWLTNKVHikrPT 294
Cdd:cd23983  84 LKAMVKKEPLSFWSRLFfwkevadsIPL-----KPSQFRILNPLIIKETALDILQYPEPQ-----SRLWGWDKNV---PT 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1916842  295 TGLLMYTLATRFCKQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 358
Cdd:cd23983 151 LGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 147-334 3.22e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 66.01  E-value: 3.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  147 SPLKNKHFGTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLV-NATWREK 225
Cdd:cd23986  42 SKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIdSSLYKDV 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  226 LLqrlhslngsILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPS--LRLLHAvRGYW---------LTNKVHIKRPT 294
Cdd:cd23986 122 IL---------VAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNqpFYILHP-KFIWqlwdiiqenTQEKIQPNPPS 191

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 1916842  295 TGLLMYTLATRFCKQIYLYGFwpFPLDQNQNPVKYH--YYDS 334
Cdd:cd23986 192 SGFIGILIMMSMCREVHVYEY--IPSVRQTDLCHYHerYYDA 231
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 156-315 2.40e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 63.75  E-value: 2.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  156 TCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFED--LVNATWREKLLQRLHS- 232
Cdd:cd23980  83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNvsMILVPFKTLDLEWVISa 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  233 -----LNGSILWIPAfmarggKERVEwvNELILKHHvnvrtayPSlrLLHAVRGYWLTNkvHIKRPTTGLLMYTLATRFC 307
Cdd:cd23980 163 tttgtISHTYVPVPR------KIKVK--KEKILIYH-------PA--FIKYVFDRWLQG--HGRYPSTGILSVIFSLHVC 223


                ....*...
gi 1916842  308 KQIYLYGF 315
Cdd:cd23980 224 DEVDLYGF 231
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 157-333 3.39e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 53.71  E-value: 3.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  157 CAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEdlvnatwREKLLQRLHSLNGS 236
Cdd:cd23978   4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLR-------RPQEFLNRTPETTL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  237 ILW-IPAFMARGGKERVEWVNELILKHHVNVRTAYPSLR-------LLHAVRGY-------WLtnkvhikrpTTGLLMYT 301
Cdd:cd23978  77 IFWgPPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRrmrqfddLFRGETGRdrkkshsWL---------STGWFTMV 147

                       170       180       190
                ....*....|....*....|....*....|....*
gi 1916842  302 LATRFCKQIYLYGFWPFP-LDQNQNPVK--YHYYD 333
Cdd:cd23978 148 IAVELCDNVHVYGMVPPNyCSKRPTPKKmpYHYYE 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 155-336 4.42e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 53.33  E-value: 4.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  155 GTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDL-VTMNPSViqrafedlvnatwreKLLQRLHSL 233
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLrVVSHTSV---------------PLLLRNQGY 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916842  234 -------NGSILWIPA-FMARGGKERVewvnelilkHHVNVRTA--YPSLRLLHAVRGYWL---------TNKVHIKRPT 294
Cdd:cd23977  67 ffqqsrdTKYVIWGPErNMDRDGGGKT---------YRALLTLAkmYPHLQVYTLTEEKMAycdgvfqneTGKNRMKSGS 137

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 1916842  295 ---TGLLMYTLATRFCKQIYLYGFW--PFPLDQNQNPVKYHYYDSLK 336
Cdd:cd23977 138 flsTGWFTMILALELCEEILVYGMVsdSYCRNKNHSSVPYHYYEKGR 184
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 155-202 1.63e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 48.78  E-value: 1.63e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 1916842  155 GTCAIVGNSGVLLNSGCGQEIDAHSFVIRCNLAPVQEYARDVGLKTDL 202
Cdd:cd23975   2 DLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTI 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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