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Conserved domains on  [gi|1297188|gb|AAA98915|]
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Theoretical protein with similarity to Swiss-Prot Accession Number P41838 poly A+ RNA export protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-243 4.77e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 4.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   26 DSISSLSFSPRADILVATSWDNQVRCWEIsRSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGG 105
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLT----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  106 QPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPDKC-YTLSVkHP---LMVVGTADRNLIVFN 181
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAF-SPdgrLLASGSADGTVRLWD 274

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1297188  182 LQNpqtefKRIQSPLKYQTRCVTAfpdqqgfleLACSLDAYIL-----DGAFNFWDKDSKQRLKVFS 243
Cdd:COG2319 275 LAT-----GELLRTLTGHSGGVNS---------VAFSPDGKLLasgsdDGTVRLWDLATGKLLRTLT 327
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-243 4.77e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 4.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   26 DSISSLSFSPRADILVATSWDNQVRCWEIsRSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGG 105
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLT----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  106 QPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPDKC-YTLSVkHP---LMVVGTADRNLIVFN 181
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAF-SPdgrLLASGSADGTVRLWD 274

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1297188  182 LQNpqtefKRIQSPLKYQTRCVTAfpdqqgfleLACSLDAYIL-----DGAFNFWDKDSKQRLKVFS 243
Cdd:COG2319 275 LAT-----GELLRTLTGHSGGVNS---------VAFSPDGKLLasgsdDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-243 1.84e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   25 ADSISSLSFSPRADILVATSWDNQVRCWEISrSGASLASApkasISHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSG 104
Cdd:cd00200  51 TGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECVRTL----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  105 GQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPDKCYTLSVKHP---LMVVGTADRNLIVFN 181
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdgeKLLSSSSDGTIKLWD 205

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1297188  182 LQNPQTeFKRIQSPLKYqTRCVTAFPDQQgfleLACSLDAyilDGAFNFWDKDSKQRLKVFS 243
Cdd:cd00200 206 LSTGKC-LGTLRGHENG-VNSVAFSPDGY----LLASGSE---DGTIRVWDLRTGECVQTLS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-142 4.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1297188     109 TVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWD 142
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
113-142 2.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.23e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1297188    113 HEGPIAAMAWIPGMNLLATGSWDKTLKYWD 142
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-243 4.77e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 4.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   26 DSISSLSFSPRADILVATSWDNQVRCWEIsRSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGG 105
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDL-ATGKLLRTLT----GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  106 QPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPDKC-YTLSVkHP---LMVVGTADRNLIVFN 181
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAF-SPdgrLLASGSADGTVRLWD 274

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1297188  182 LQNpqtefKRIQSPLKYQTRCVTAfpdqqgfleLACSLDAYIL-----DGAFNFWDKDSKQRLKVFS 243
Cdd:COG2319 275 LAT-----GELLRTLTGHSGGVNS---------VAFSPDGKLLasgsdDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-243 1.84e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   25 ADSISSLSFSPRADILVATSWDNQVRCWEISrSGASLASApkasISHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSG 104
Cdd:cd00200  51 TGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECVRTL----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  105 GQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPDKCYTLSVKHP---LMVVGTADRNLIVFN 181
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdgeKLLSSSSDGTIKLWD 205

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1297188  182 LQNPQTeFKRIQSPLKYqTRCVTAFPDQQgfleLACSLDAyilDGAFNFWDKDSKQRLKVFS 243
Cdd:cd00200 206 LSTGKC-LGTLRGHENG-VNSVAFSPDGY----LLASGSE---DGTIRVWDLRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-251 3.81e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 3.81e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   26 DSISSLSFSPRADILVATSWDNQVRCWEISRSgaslaSAPKASISHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGG 105
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-----ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  106 QPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPD---KCYTLSVKHPLMVVGTADRNLIVFNL 182
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTdwvNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1297188  183 QN--PQTEFKRIQSPLkyqtRCVTAFPDQQGFleLACSldayiLDGAFNFWDKDSKQRLKVFSSCIDFLFC 251
Cdd:cd00200 165 RTgkCVATLTGHTGEV----NSVAFSPDGEKL--LSSS-----SDGTIKLWDLSTGKCLGTLRGHENGVNS 224
WD40 COG2319
WD40 repeat [General function prediction only];
26-186 4.65e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 4.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   26 DSISSLSFSPRADILVATSWDNQVRCWEIsRSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGG 105
Cdd:COG2319 205 GAVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLT----GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  106 QPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQ-LPDKCYTLSVkHP---LMVVGTADRNLIVFN 181
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAF-SPdgkTLASGSDDGTVRLWD 358


                ....*
gi 1297188  182 LQNPQ 186
Cdd:COG2319 359 LATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
24-144 7.93e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 7.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   24 PADSISSLSFSPRADILVATSWDNQVRCWEISrSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLS 103
Cdd:COG2319 287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLT----GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 1297188  104 GGQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTR 144
Cdd:COG2319 362 GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
24-243 1.89e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.89e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   24 PADSISSLSFSPRADILVATSWDNQVRCWEIsRSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLS 103
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  104 GGQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHT-QQLPDKCYTLSVkHP---LMVVGTADRNLIV 179
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAF-SPdgkLLASGSDDGTVRL 314

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1297188  180 FNLQNPQTefKRIQSPLKYQTRCVTAFPDQQgflELACSLDayilDGAFNFWDKDSKQRLKVFS 243
Cdd:COG2319 315 WDLATGKL--LRTLTGHTGAVRSVAFSPDGK---TLASGSD----DGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
20-243 5.94e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 5.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   20 VTPSPADSISSLSFSPRADILVATSWDNQVRCWEISRSGaslasAPKASISHDQPVLCSAWKDDGTTVFSGGCDKQAKMW 99
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL-----LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  100 PLLSGGQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHT-QQLPDKCYTLSVkHP---LMVVGTADR 175
Cdd:COG2319 148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAF-SPdgkLLASGSADG 226

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1297188  176 NLIVFNLQNPQtefkrIQSPLKYQTRCVTAfpdqqgfleLACSLDAYIL-----DGAFNFWDKDSKQRLKVFS 243
Cdd:COG2319 227 TVRLWDLATGK-----LLRTLTGHSGSVRS---------VAFSPDGRLLasgsaDGTVRLWDLATGELLRTLT 285
WD40 COG2319
WD40 repeat [General function prediction only];
22-151 2.91e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.91e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   22 PSPADSISSLSFSPRADILVATSWDNQVRCWEISrSGASLASAPkasiSHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPL 101
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLT----GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 1297188  102 LSGGQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHT 151
Cdd:COG2319 318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-142 5.12e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 5.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   26 DSISSLSFSPRADILVATSWDNQVRCWEIsRSGASLASApkasISHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGG 105
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTL----RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 1297188  106 QPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWD 142
Cdd:cd00200 253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 70-243 1.56e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 1.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   70 SHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGGQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPV 149
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  150 HTQQlPDKCYTLSV----KHPLMVVGTADRNLIVFNLQNPQ--TEFKRIQSPlkyqTRCVtAFPDQQGFLeLACSLDAYI 223
Cdd:cd00200  87 RTLT-GHTSYVSSVafspDGRILSSSSRDKTIKVWDVETGKclTTLRGHTDW----VNSV-AFSPDGTFV-ASSSQDGTI 159

                       170       180
                ....*....|....*....|
gi 1297188  224 LdgafnFWDKDSKQRLKVFS 243
Cdd:cd00200 160 K-----LWDLRTGKCVATLT 174
WD40 COG2319
WD40 repeat [General function prediction only];
25-186 6.12e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 6.12e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   25 ADSISSLSFSPRADILVATSWDNQVRCWEISRSGAslasaPKASISHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSG 104
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL-----LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  105 GQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLP-DKCYTLSVkHP---LMVVGTADRNLIVF 180
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHsGAVTSVAF-SPdgkLLASGSDDGTVRLW 189


                ....*.
gi 1297188  181 NLQNPQ 186
Cdd:COG2319 190 DLATGK 195
WD40 COG2319
WD40 repeat [General function prediction only];
32-243 1.25e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188   32 SFSPRADILVATSWDNQVRCWEISRSGASLASAPkasisHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGGQPVTVA 111
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLG-----LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297188  112 MHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQ-LPDKCYTLSVkHP---LMVVGTADRNLIVFNLQNPqt 187
Cdd:COG2319  76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAF-SPdgkTLASGSADGTVRLWDLATG-- 152

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1297188  188 efkRIQSPLKYQTRCVTAfpdqqgfleLACSLDAYIL-----DGAFNFWDKDSKQRLKVFS 243
Cdd:COG2319 153 ---KLLRTLTGHSGAVTS---------VAFSPDGKLLasgsdDGTVRLWDLATGKLLRTLT 201
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-142 4.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1297188     109 TVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWD 142
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
113-142 2.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.23e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1297188    113 HEGPIAAMAWIPGMNLLATGSWDKTLKYWD 142
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 26-53 2.72e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 2.72e-03
                           10        20
                   ....*....|....*....|....*...
gi 1297188      26 DSISSLSFSPRADILVATSWDNQVRCWE 53
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
71-99 4.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 1297188     71 HDQPVLCSAWKDDGTTVFSGGCDKQAKMW 99
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 71-99 4.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 4.50e-03
                           10        20
                   ....*....|....*....|....*....
gi 1297188      71 HDQPVLCSAWKDDGTTVFSGGCDKQAKMW 99
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
26-53 4.85e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 4.85e-03
                          10        20
                  ....*....|....*....|....*...
gi 1297188     26 DSISSLSFSPRADILVATSWDNQVRCWE 53
Cdd:pfam00400  12 GSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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