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Conserved domains on  [gi|1255116|gb|AAA96033|]
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heat-responsive protein [Mus musculus]

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 44-167 2.00e-70

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 208.69  E-value: 2.00e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116     44 RKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLAD 123
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1255116    124 MNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAVQ 167
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 44-167 2.00e-70

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 208.69  E-value: 2.00e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116     44 RKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLAD 123
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1255116    124 MNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAVQ 167
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 44-166 6.40e-55

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 169.59  E-value: 6.40e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   44 RKVIsTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQlVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLAD 123
Cdd:COG0251   3 RELI-NPPAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 1255116  124 MNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAV 166
Cdd:COG0251  81 MADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAA 123
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 51-166 4.36e-54

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 167.09  E-value: 4.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116     51 KAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTV 130
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1255116    131 NEIYKTYFQG-SLPARAAYQVAALPRGSRVEIEAIAV 166
Cdd:pfam01042  81 NEVYAEYFDAdKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 59-165 1.60e-46

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 147.70  E-value: 1.60e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   59 YSQAVQVDRTIYISGQVGLDPSsGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEIYKTYF 138
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPD-GELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                        90       100
                ....*....|....*....|....*...
gi 1255116  139 QGS-LPARAAYQVAALPRGSRVEIEAIA 165
Cdd:cd00448  80 GEGpPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
43-168 1.20e-35

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 120.94  E-value: 1.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116    43 IRKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQlVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLA 122
Cdd:PRK11401   1 MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFIT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 1255116   123 DMNDFGTVNEIYKTYF---QGSLPARAAYQVAALPRGSRVEIEAIAVQG 168
Cdd:PRK11401  80 DLNDFATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAVRS 128
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 44-167 2.00e-70

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 208.69  E-value: 2.00e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116     44 RKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLAD 123
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1255116    124 MNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAVQ 167
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 44-166 6.40e-55

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 169.59  E-value: 6.40e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   44 RKVIsTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQlVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLAD 123
Cdd:COG0251   3 RELI-NPPAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 1255116  124 MNDFGTVNEIYKTYFQGSLPARAAYQVAALPRGSRVEIEAIAV 166
Cdd:COG0251  81 MADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAA 123
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 51-166 4.36e-54

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 167.09  E-value: 4.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116     51 KAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTV 130
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1255116    131 NEIYKTYFQG-SLPARAAYQVAALPRGSRVEIEAIAV 166
Cdd:pfam01042  81 NEVYAEYFDAdKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 59-165 1.60e-46

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 147.70  E-value: 1.60e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   59 YSQAVQVDRTIYISGQVGLDPSsGQLVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEIYKTYF 138
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPD-GELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                        90       100
                ....*....|....*....|....*...
gi 1255116  139 QGS-LPARAAYQVAALPRGSRVEIEAIA 165
Cdd:cd00448  80 GEGpPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
43-168 1.20e-35

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 120.94  E-value: 1.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116    43 IRKVISTTKAPAAIGPYSQAVQVDRTIYISGQVGLDPSSGQlVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLA 122
Cdd:PRK11401   1 MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFIT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 1255116   123 DMNDFGTVNEIYKTYF---QGSLPARAAYQVAALPRGSRVEIEAIAVQG 168
Cdd:PRK11401  80 DLNDFATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAVRS 128
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 54-165 6.04e-24

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 90.31  E-value: 6.04e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   54 AAIGpYSQAVQVDRTIYISGQVGLDPSSGQlVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEI 133
Cdd:cd06154   9 EQAG-YSRAVRVGNWVFVSGTTGYDYDGMV-MPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRA 86

                        90       100       110
                ....*....|....*....|....*....|...
gi 1255116  134 YKTYFQGSLPARAAYQVAALPR-GSRVEIEAIA 165
Cdd:cd06154  87 HGEVFGDIRPAATMVVVSLLVDpEMLVEIEVTA 119
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 59-166 2.36e-22

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 86.05  E-value: 2.36e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   59 YSQAVQVDRTIYISGQVGLDPSsgqlvpGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEIYKTYF 138
Cdd:cd06150   3 MSQAVVHNGTVYLAGQVADDTS------ADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                        90       100
                ....*....|....*....|....*....
gi 1255116  139 Q-GSLPARAAYQVAALPRGSRVEIEAIAV 166
Cdd:cd06150  77 PpGHAPARACVEAKLADPGYLVEIVVTAA 105
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 59-166 5.69e-21

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 82.69  E-value: 5.69e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   59 YSQAVQVDRTIYISGQVGLDPSSGqlVPGGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADM-NDFGTVNEIYKTY 137
Cdd:cd02198   3 YSPAVRVGDTLFVSGQVGSDADGS--VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDEY 80

                        90       100       110
                ....*....|....*....|....*....|
gi 1255116  138 FQGSLPARAAYQVAALPR-GSRVEIEAIAV 166
Cdd:cd02198  81 FKEPYPAWTAVGVAWLARpGLLVEIKVVAV 110
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 87-165 3.72e-17

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 72.29  E-value: 3.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   87 GGVVEEAKQALKNLGEILKAAGCDFNNVVKTTVLLADMNDFGTVNEIYKTYFQGSL-PARAAyqVAA-LPRGSRVEIEAI 164
Cdd:cd06155  22 ETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNpPSRVC--VECgLPEGCDVQLSCV 99


                .
gi 1255116  165 A 165
Cdd:cd06155 100 A 100
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 59-165 2.30e-15

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 68.12  E-value: 2.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   59 YSQAVQVDRTIYISGQVGLDPSSGQLVPGGVVEEAKQALKNLGEILKAAGCdfNNVVKTTVLLADMNDFGTVNEIYKTYF 138
Cdd:cd06156   1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQHLERVAKAMNV--QWVLAAVCYVTDESSVPIARSAWSKYC 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 1255116  139 -------------QGSLPARAAYQVAALPRGSRVEIEAIA 165
Cdd:cd06156  79 seldledesrnesDDVNPPLVIVVVPELPRGALVEWQGIA 118
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 59-166 3.91e-14

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 65.02  E-value: 3.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   59 YSQAVQVDRTIYISGQVGLDPSSGQlVPGGVVEEAKQALKNLGEILKAAGCD-FNNVVKTTVLLAD-MND--FGTVNEIY 134
Cdd:cd06152   3 YSQAVRIGDRIEISGQGGWDPDTGK-IPEDLEEEIDQAFDNVELALKAAGGKgWEQVYKVNSYHVDiKNEeaFGLMVENF 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 1255116  135 KTYFQGSLPARAAYQVAALPR-GSRVEIEAIAV 166
Cdd:cd06152  82 KKWMPNHQPIWTCVGVTALGLpGMRVEIEVDAI 114
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 60-165 1.31e-11

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 58.49  E-value: 1.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   60 SQAVQV---DRTIYISGQVG--LDPSSGQLVPGGVVEEAKQA---LKNLGEILKAAGCDFNNVVKTTVLLA------DMN 125
Cdd:cd06151   2 AQAVEVpagAATIYLSGTVPavVNASAPKGSPARYGDTETQTisvLKRIETILQSQGLTMGDVVKMRVFLVadpaldGKM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 1255116  126 DFGTVNEIYKTYF----QGSLPARAAYQVAALPR-GSRVEIEAIA 165
Cdd:cd06151  82 DFAGFMKAYRQFFgtaeQPNKPARSTLQVAGLVNpGWLVEIEVVA 126
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 52-165 3.10e-11

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 57.86  E-value: 3.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   52 APAAIGPYSQAVQVDRTIYISGQVGLDPssGQLVPGGVV------EEAKQALK----NLGEILKAAGCDFN---NVVKTT 118
Cdd:cd02199   9 APAPVGNYVPAVRTGNLLYVSGQLPRVD--GKLVYTGKVgadlsvEEGQEAARlcalNALAALKAALGDLDrvkRVVRLT 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 1255116  119 VLLADMNDFG----TVN---EIYKTYF--QGsLPARAAYQVAALPRGSRVEIEAIA 165
Cdd:cd02199  87 GFVNSAPDFTeqpkVANgasDLLVEVFgeAG-RHARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 66-165 2.40e-05

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 41.47  E-value: 2.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255116   66 DRTIYISGQVGLDPSsGQLVPGGVVEEAKQALKNLGEILKAAGC-----DFNNVVKTTVLLADMNDFGTVNEIYKTYFQG 140
Cdd:cd06153  12 RTHLFISGTASIVGH-GTVHPGDVEAQTRETLENIEALLEAAGRgggaqFLADLLRLKVYLRDREDLPAVRAILAARLGP 90

                        90       100
                ....*....|....*....|....*.
gi 1255116  141 SLParAAYQVAALPR-GSRVEIEAIA 165
Cdd:cd06153  91 AVP--AVFLQADVCRpDLLVEIEAVA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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