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Conserved domains on  [gi|198603|gb|AAA39381|]
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Kruppel-related protein, partial [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-79 2.28e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.28e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 198603    27 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIH 79
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTH 86
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
1-41 2.06e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 35.06  E-value: 2.06e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 198603     1 CPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRS 41
Cdd:COG5048 324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-79 2.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.28e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 198603    27 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIH 79
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
43-68 9.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.11  E-value: 9.00e-04
                         10        20
                 ....*....|....*....|....*.
gi 198603     43 HLTTHIRTHTGEKPFACDYCGRKFAR 68
Cdd:pfam13465  1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-41 2.06e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 35.06  E-value: 2.06e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 198603     1 CPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRS 41
Cdd:COG5048 324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
PHA00733 PHA00733
hypothetical protein
 28-75 2.41e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 34.08  E-value: 2.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 198603     28 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDYCGRKFARSDERKRH 75
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-79 2.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.28e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 198603    27 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIH 79
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
2-65 4.49e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.49e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 198603     2 PAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMR--NFSRSDHLTTHIRTHTGEKPFACDYCGRK 65
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
6-79 4.36e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198603     6 CDRRFSRSDELTRHIR--IHTG--HKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDY--CGRKFARSDERKRHTK 77
Cdd:COG5048 295 CNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQS 374


                ..
gi 198603    78 IH 79
Cdd:COG5048 375 LQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-79 7.56e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 7.56e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 198603    27 KPFQCRICMRNFSRSDHLTTHIRT--HTGE--KPFACDY--CGRKFARSDERKRHTKIH 79
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1-77 5.26e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 36.62  E-value: 5.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198603     1 CPAEGCDRRFSRSDELTRHiRIHtGHK-----PFQCRICMRNFSRSDhltthirthtgeKPFACDYCGRKFARSDERKRH 75
Cdd:COG5189 352 CPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNGLKYH 417


                ..
gi 198603    76 TK 77
Cdd:COG5189 418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
43-68 9.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.11  E-value: 9.00e-04
                         10        20
                 ....*....|....*....|....*.
gi 198603     43 HLTTHIRTHTGEKPFACDYCGRKFAR 68
Cdd:pfam13465  1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-41 2.06e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 35.06  E-value: 2.06e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 198603     1 CPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRS 41
Cdd:COG5048 324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
PHA00733 PHA00733
hypothetical protein
 28-75 2.41e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 34.08  E-value: 2.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 198603     28 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDYCGRKFARSDERKRH 75
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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