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Conserved domains on  [gi|160012365|sp|A5WUL3|]
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RecName: Full=Mediator of RNA polymerase II transcription subunit 22; AltName: Full=Mediator complex subunit 22; AltName: Full=Surfeit locus protein 5

Protein Classification

mediator of RNA polymerase II transcription subunit 22( domain architecture ID 10533081)

mediator of RNA polymerase II transcription subunit 22 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med22 pfam06179
Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several ...
 20-121 3.67e-43

Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.


:

Pssm-ID: 461845  Cd Length: 101  Bit Score: 139.63  E-value: 3.67e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160012365   20 KRLKDDIRSILDNFTEIIKTAKVEDETQVSRATQAeQDHFEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIS 99
Cdd:pfam06179   1 KRLDDDIESILDNFRELIKLAKVNDEGQRNNSTQA-QEGYEMEVRAANLVRAIESLLKLTRELKELWILNDFPSLNEAIK 79

                          90       100
                  ....*....|....*....|..
gi 160012365  100 LRNQQLRTLQEECDKKLISLRD 121
Cdd:pfam06179  80 QREEQLDADVEELDSLLNKLRD 101
 
Name Accession Description Interval E-value
Med22 pfam06179
Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several ...
 20-121 3.67e-43

Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.


Pssm-ID: 461845  Cd Length: 101  Bit Score: 139.63  E-value: 3.67e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160012365   20 KRLKDDIRSILDNFTEIIKTAKVEDETQVSRATQAeQDHFEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIS 99
Cdd:pfam06179   1 KRLDDDIESILDNFRELIKLAKVNDEGQRNNSTQA-QEGYEMEVRAANLVRAIESLLKLTRELKELWILNDFPSLNEAIK 79

                          90       100
                  ....*....|....*....|..
gi 160012365  100 LRNQQLRTLQEECDKKLISLRD 121
Cdd:pfam06179  80 QREEQLDADVEELDSLLNKLRD 101
BAR_RhoGAP_Rich-like cd07595
The Bin/Amphiphysin/Rvs (BAR) domain of Rich-like Rho GTPase Activating Proteins; BAR domains ...
 61-134 5.41e-03

The Bin/Amphiphysin/Rvs (BAR) domain of Rich-like Rho GTPase Activating Proteins; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. This subfamily is composed of Rho and Rac GTPase activating proteins (GAPs) with similarity to GAP interacting with CIP4 homologs proteins (Rich). Members contain an N-terminal BAR domain, followed by a Rho GAP domain, and a C-terminal prolin-rich region. Vertebrates harbor at least three Rho GAPs in this subfamily including Rich1, Rich2, and SH3-domain binding protein 1 (SH3BP1). Rich1 and Rich2 play complementary roles in the establishment and maintenance of cell polarity. Rich1 is a Cdc42- and Rac-specific GAP that binds to polarity proteins through the scaffold protein angiomotin and plays a role in maintaining the integrity of tight junctions. Rich2 is a Rac GAP that interacts with CD317 and plays a role in actin cytoskeleton organization and the maintenance of microvilli in polarized epithelial cells. SH3BP1 is a Rac GAP that inhibits Rac-mediated platelet-derived growth factor (PDGF)-induced membrane ruffling. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of Rich1 has been shown to form oligomers, bind membranes and induce membrane tubulation.


Pssm-ID: 153279 [Multi-domain]  Cd Length: 244  Bit Score: 36.54  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160012365  61 MHVRAANIVRAGESLMKLVSDL------KQFLILNDFPSVNEAislRNQQLRTLQEECDKKLISLRDEIAIDLYEL---E 131
Cdd:cd07595  116 LEVEIPNIQKQKKRLSKLVLDMdsarsrYNAAHKSSGGQGAAA---KVDALKDEYEEAELKLEQCRDALATDMYEFlakE 192


                 ...
gi 160012365 132 EEY 134
Cdd:cd07595  193 AEI 195
 
Name Accession Description Interval E-value
Med22 pfam06179
Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several ...
 20-121 3.67e-43

Surfeit locus protein 5 subunit 22 of Mediator complex; This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organization is similar in human, mouse and chicken Surfeit locus. The Med22 subunit of Mediator complex is part of the essential core head region.


Pssm-ID: 461845  Cd Length: 101  Bit Score: 139.63  E-value: 3.67e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160012365   20 KRLKDDIRSILDNFTEIIKTAKVEDETQVSRATQAeQDHFEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIS 99
Cdd:pfam06179   1 KRLDDDIESILDNFRELIKLAKVNDEGQRNNSTQA-QEGYEMEVRAANLVRAIESLLKLTRELKELWILNDFPSLNEAIK 79

                          90       100
                  ....*....|....*....|..
gi 160012365  100 LRNQQLRTLQEECDKKLISLRD 121
Cdd:pfam06179  80 QREEQLDADVEELDSLLNKLRD 101
BAR_RhoGAP_Rich-like cd07595
The Bin/Amphiphysin/Rvs (BAR) domain of Rich-like Rho GTPase Activating Proteins; BAR domains ...
 61-134 5.41e-03

The Bin/Amphiphysin/Rvs (BAR) domain of Rich-like Rho GTPase Activating Proteins; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. This subfamily is composed of Rho and Rac GTPase activating proteins (GAPs) with similarity to GAP interacting with CIP4 homologs proteins (Rich). Members contain an N-terminal BAR domain, followed by a Rho GAP domain, and a C-terminal prolin-rich region. Vertebrates harbor at least three Rho GAPs in this subfamily including Rich1, Rich2, and SH3-domain binding protein 1 (SH3BP1). Rich1 and Rich2 play complementary roles in the establishment and maintenance of cell polarity. Rich1 is a Cdc42- and Rac-specific GAP that binds to polarity proteins through the scaffold protein angiomotin and plays a role in maintaining the integrity of tight junctions. Rich2 is a Rac GAP that interacts with CD317 and plays a role in actin cytoskeleton organization and the maintenance of microvilli in polarized epithelial cells. SH3BP1 is a Rac GAP that inhibits Rac-mediated platelet-derived growth factor (PDGF)-induced membrane ruffling. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of Rich1 has been shown to form oligomers, bind membranes and induce membrane tubulation.


Pssm-ID: 153279 [Multi-domain]  Cd Length: 244  Bit Score: 36.54  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160012365  61 MHVRAANIVRAGESLMKLVSDL------KQFLILNDFPSVNEAislRNQQLRTLQEECDKKLISLRDEIAIDLYEL---E 131
Cdd:cd07595  116 LEVEIPNIQKQKKRLSKLVLDMdsarsrYNAAHKSSGGQGAAA---KVDALKDEYEEAELKLEQCRDALATDMYEFlakE 192


                 ...
gi 160012365 132 EEY 134
Cdd:cd07595  193 AEI 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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