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Conserved domains on  [gi|229889506|sp|A5W6K7|]
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RecName: Full=Ribosomal RNA large subunit methyltransferase K/L; Includes: RecName: Full=23S rRNA m2G2445 methyltransferase; AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmL; Includes: RecName: Full=23S rRNA m7G2069 methyltransferase; AltName: Full=rRNA (guanine-N(7)-)-methyltransferase RlmK

Protein Classification

23S rRNA (guanine(2445)-N(2))/(guanine(2069)-N(7))-methyltransferase( domain architecture ID 11485505)

ribosomal RNA large subunit methyltransferase K/L is a class I SAM-dependent rRNA methyltransferase that methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of the 23S rRNA

EC:  2.1.1.173|2.1.1.264
Gene Ontology:  GO:0070043|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 4-728 0e+00

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


:

Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 1280.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   4 RFELYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVD 83
Cdd:PRK11783   1 MNSLFASCAKGLEELLKDELEALGASECKVVQGGVHFEGDLELAYRSCLWSRLASRILLPLAEFKVYSDLDLYLGVQAID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  84 WADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNREGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSGHSLH 163
Cdd:PRK11783  81 WTEHFSPDKTFAVDFSGTNDEIRNTQFGALKVKDAIVDRFRRKGGPRPSVDKEQPDIRINARLNKGEATISLDLSGESLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 164 QRGYRLQQGAAPLKENLAAAVLIRAGWPRiaaEGGALADPMCGVGTFLVEAAMIAADIAPNLKRERWGFSAWLGHVPALW 243
Cdd:PRK11783 161 QRGYRQATGEAPLKENLAAAILLRSGWPQ---EGTPLLDPMCGSGTLLIEAAMMAADIAPGLHRERWGFSGWLGHDEALW 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 244 RKVHDEAQARAQAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNQKGLVISNPPYGERL 323
Cdd:PRK11783 238 QELLEEAQERARAGLAELPSKFYGSDIDPRVIQAARKNARRAGVAELITFEVKDVADLKNPLPKGPTGLVISNPPYGERL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 324 GDEASLLYLYQNLGERLRQACMGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPCKLLLFKVQPDQFVTGerreaqpeg 403
Cdd:PRK11783 318 GEEPALIALYSQLGRRLKQQFGGWNAALFSSSPELLSCLGLRADKQYKLKNGALECVLKNYTIAEESTSSD--------- 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 404 tearqqvpqaseparlSEGAQMFANRLQKNLKQLGKWARREQIDCYRLYDADMPEYALAVDLYQDWVHVQEYAAPRSVDP 483
Cdd:PRK11783 389 ----------------AEGAQDFANRLRKNLKKLKKWAKQEGIECYRLYDADLPEYNVAVDRYGDWVVVQEYAAPKTIDE 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 484 DKAQARLLDALAAIPQALGISPQRVVLKRRERQSGTRQYERQATEGRFQEVNEGGVKLLVNLTDYLDTGLFLDHRPMRMR 563
Cdd:PRK11783 453 EKARQRLFDALAATPEVLGIPPNKVVLKTRERQKGKNQYQKLAEKGEFLEVTEYGAKLLVNLTDYLDTGLFLDHRPTRRM 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 564 IQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSER-NRLEQSDVMAWLEGNRDSYDLI 642
Cdd:PRK11783 533 IGQMAKGKDFLNLFAYTGTASVHAALGGAKSTTTVDMSNTYLEWAERNFALNGLSGRqHRLIQADCLAWLKEAREQFDLI 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 643 FIDPPTFSNSKRMEGVFDVQRDHVQLLDLAMARLAPGGVLYFSNNFRKFQLDEHLMAR--YVVEEISAQTLDPDFARNNR 720
Cdd:PRK11783 613 FIDPPTFSNSKRMEDSFDVQRDHVALIKDAKRLLRPGGTLYFSNNKRGFKMDEEGLAKlgLKAEEITAKTLPPDFARNPK 692


                 ....*...
gi 229889506 721 IHRAWRLQ 728
Cdd:PRK11783 693 IHNCWLIT 700
 
Name Accession Description Interval E-value
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 4-728 0e+00

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 1280.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   4 RFELYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVD 83
Cdd:PRK11783   1 MNSLFASCAKGLEELLKDELEALGASECKVVQGGVHFEGDLELAYRSCLWSRLASRILLPLAEFKVYSDLDLYLGVQAID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  84 WADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNREGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSGHSLH 163
Cdd:PRK11783  81 WTEHFSPDKTFAVDFSGTNDEIRNTQFGALKVKDAIVDRFRRKGGPRPSVDKEQPDIRINARLNKGEATISLDLSGESLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 164 QRGYRLQQGAAPLKENLAAAVLIRAGWPRiaaEGGALADPMCGVGTFLVEAAMIAADIAPNLKRERWGFSAWLGHVPALW 243
Cdd:PRK11783 161 QRGYRQATGEAPLKENLAAAILLRSGWPQ---EGTPLLDPMCGSGTLLIEAAMMAADIAPGLHRERWGFSGWLGHDEALW 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 244 RKVHDEAQARAQAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNQKGLVISNPPYGERL 323
Cdd:PRK11783 238 QELLEEAQERARAGLAELPSKFYGSDIDPRVIQAARKNARRAGVAELITFEVKDVADLKNPLPKGPTGLVISNPPYGERL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 324 GDEASLLYLYQNLGERLRQACMGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPCKLLLFKVQPDQFVTGerreaqpeg 403
Cdd:PRK11783 318 GEEPALIALYSQLGRRLKQQFGGWNAALFSSSPELLSCLGLRADKQYKLKNGALECVLKNYTIAEESTSSD--------- 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 404 tearqqvpqaseparlSEGAQMFANRLQKNLKQLGKWARREQIDCYRLYDADMPEYALAVDLYQDWVHVQEYAAPRSVDP 483
Cdd:PRK11783 389 ----------------AEGAQDFANRLRKNLKKLKKWAKQEGIECYRLYDADLPEYNVAVDRYGDWVVVQEYAAPKTIDE 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 484 DKAQARLLDALAAIPQALGISPQRVVLKRRERQSGTRQYERQATEGRFQEVNEGGVKLLVNLTDYLDTGLFLDHRPMRMR 563
Cdd:PRK11783 453 EKARQRLFDALAATPEVLGIPPNKVVLKTRERQKGKNQYQKLAEKGEFLEVTEYGAKLLVNLTDYLDTGLFLDHRPTRRM 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 564 IQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSER-NRLEQSDVMAWLEGNRDSYDLI 642
Cdd:PRK11783 533 IGQMAKGKDFLNLFAYTGTASVHAALGGAKSTTTVDMSNTYLEWAERNFALNGLSGRqHRLIQADCLAWLKEAREQFDLI 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 643 FIDPPTFSNSKRMEGVFDVQRDHVQLLDLAMARLAPGGVLYFSNNFRKFQLDEHLMAR--YVVEEISAQTLDPDFARNNR 720
Cdd:PRK11783 613 FIDPPTFSNSKRMEDSFDVQRDHVALIKDAKRLLRPGGTLYFSNNKRGFKMDEEGLAKlgLKAEEITAKTLPPDFARNPK 692


                 ....*...
gi 229889506 721 IHRAWRLQ 728
Cdd:PRK11783 693 IHNCWLIT 700
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 5-384 5.22e-177

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 510.41  E-value: 5.22e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   5 FELYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVDW 84
Cdd:COG0116    1 FELFATCARGLEALLADELKELGAEDVKVENGGVSFEGDLEDIYRANLWLRTASRVLLPLAEFKARTFDDLYEGAKAIPW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  85 ADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNREGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSGHSLHQ 164
Cdd:COG0116   81 EEYLPPDGTFAVDATSVKSKLFHSQFAALRVKDAIVDRFREKYGARPSVDEDGPDVRIHVHLLKDRATLSLDTSGESLHK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 165 RGYRLQQGAAPLKENLAAAVLIRAGWPRiaaeGGALADPMCGVGTFLVEAAMIAADIAPNLKReRWGFSAWLGHVPALWR 244
Cdd:COG0116  161 RGYREAQGEAPLKETLAAALLLLSGWDG----DRPLVDPMCGSGTILIEAALIAANIAPGLNR-DFAFEKWPDFDAELWQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 245 KVHDEAQARAQaglAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDqnqKGLVISNPPYGERLG 324
Cdd:COG0116  236 ELREEAEARIK---RDPPLPIFGSDIDPRAIEAARENAERAGVADLIEFEQADFRDLEPPAE---PGLIITNPPYGERLG 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 325 DEASLLYLYQNLGERLRQACMGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPCKLLLF 384
Cdd:COG0116  310 EEEELEALYRELGDVLKQRFKGWSAYILTSDPELEKAIGLKASKRRKLYNGGLECRLLQY 369
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
 7-159 2.24e-55

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212584  Cd Length: 152  Bit Score: 186.25  E-value: 2.24e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   7 LYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVDWAD 86
Cdd:cd11715    1 FFATCPPGLEELLAAELKALGAEDVEVGPGGVSFEGDLEDAYRANLWLRTAHRVLLLLAEFEAEDFDDLYELAKAIDWED 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 229889506  87 HLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNReGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSG 159
Cdd:cd11715   81 YLDPDGTFAVRATRVGSKLFHSQFAALRVKDAIVDRFREK-GKRPSVDLDNPDVRIRVHLSKDRATLSLDLSG 152
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 165-379 1.70e-34

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 129.78  E-value: 1.70e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  165 RGYRLQQGAAPLKENLAAAVLIRAGWpriaAEGGALADPMCGVGTFLVEAAMIAADIAPnlkrerwgfsawlghvpalwr 244
Cdd:pfam01170   1 RGYRPFNGPAPLKETLAAAMVNLAGW----KPGDPLLDPMCGSGTILIEAALMGANIAP--------------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  245 kvhdeaqaraQAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNqkGLVISNPPYGERLG 324
Cdd:pfam01170  56 ----------GKFDARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAADLPLLEGSV--DVIVTNPPYGIRLG 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 229889506  325 DEASLLYLYQNLGERLRQAC--MGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPC 379
Cdd:pfam01170 124 SKGALEALYPEFLREAKRVLrgGGWLVLLTAENKDFEKAARERAWRKKKEFNVHIGG 180
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 71-156 5.62e-15

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 70.38  E-value: 5.62e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506    71 NADDLYDGVHA-VDWADHLAADGTLAVEFSGHGsgiDNTHFGALKVKDAIVDKLRNREGLRPsVEKIDPDVRVHLRLDRG 149
Cdd:smart00981   1 DLEDLYETALElIRWEKIFKEGKTFAVRAKRRG---KNHEFTSLEVKRAIGDKLLEKTGGRK-VDLKNPDVVIRVELRKD 76


                   ....*..
gi 229889506   150 EAILSLD 156
Cdd:smart00981  77 KAYLSID 83
 
Name Accession Description Interval E-value
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 4-728 0e+00

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 1280.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   4 RFELYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVD 83
Cdd:PRK11783   1 MNSLFASCAKGLEELLKDELEALGASECKVVQGGVHFEGDLELAYRSCLWSRLASRILLPLAEFKVYSDLDLYLGVQAID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  84 WADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNREGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSGHSLH 163
Cdd:PRK11783  81 WTEHFSPDKTFAVDFSGTNDEIRNTQFGALKVKDAIVDRFRRKGGPRPSVDKEQPDIRINARLNKGEATISLDLSGESLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 164 QRGYRLQQGAAPLKENLAAAVLIRAGWPRiaaEGGALADPMCGVGTFLVEAAMIAADIAPNLKRERWGFSAWLGHVPALW 243
Cdd:PRK11783 161 QRGYRQATGEAPLKENLAAAILLRSGWPQ---EGTPLLDPMCGSGTLLIEAAMMAADIAPGLHRERWGFSGWLGHDEALW 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 244 RKVHDEAQARAQAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNQKGLVISNPPYGERL 323
Cdd:PRK11783 238 QELLEEAQERARAGLAELPSKFYGSDIDPRVIQAARKNARRAGVAELITFEVKDVADLKNPLPKGPTGLVISNPPYGERL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 324 GDEASLLYLYQNLGERLRQACMGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPCKLLLFKVQPDQFVTGerreaqpeg 403
Cdd:PRK11783 318 GEEPALIALYSQLGRRLKQQFGGWNAALFSSSPELLSCLGLRADKQYKLKNGALECVLKNYTIAEESTSSD--------- 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 404 tearqqvpqaseparlSEGAQMFANRLQKNLKQLGKWARREQIDCYRLYDADMPEYALAVDLYQDWVHVQEYAAPRSVDP 483
Cdd:PRK11783 389 ----------------AEGAQDFANRLRKNLKKLKKWAKQEGIECYRLYDADLPEYNVAVDRYGDWVVVQEYAAPKTIDE 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 484 DKAQARLLDALAAIPQALGISPQRVVLKRRERQSGTRQYERQATEGRFQEVNEGGVKLLVNLTDYLDTGLFLDHRPMRMR 563
Cdd:PRK11783 453 EKARQRLFDALAATPEVLGIPPNKVVLKTRERQKGKNQYQKLAEKGEFLEVTEYGAKLLVNLTDYLDTGLFLDHRPTRRM 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 564 IQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSER-NRLEQSDVMAWLEGNRDSYDLI 642
Cdd:PRK11783 533 IGQMAKGKDFLNLFAYTGTASVHAALGGAKSTTTVDMSNTYLEWAERNFALNGLSGRqHRLIQADCLAWLKEAREQFDLI 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 643 FIDPPTFSNSKRMEGVFDVQRDHVQLLDLAMARLAPGGVLYFSNNFRKFQLDEHLMAR--YVVEEISAQTLDPDFARNNR 720
Cdd:PRK11783 613 FIDPPTFSNSKRMEDSFDVQRDHVALIKDAKRLLRPGGTLYFSNNKRGFKMDEEGLAKlgLKAEEITAKTLPPDFARNPK 692


                 ....*...
gi 229889506 721 IHRAWRLQ 728
Cdd:PRK11783 693 IHNCWLIT 700
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 5-384 5.22e-177

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 510.41  E-value: 5.22e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   5 FELYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVDW 84
Cdd:COG0116    1 FELFATCARGLEALLADELKELGAEDVKVENGGVSFEGDLEDIYRANLWLRTASRVLLPLAEFKARTFDDLYEGAKAIPW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  85 ADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNREGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSGHSLHQ 164
Cdd:COG0116   81 EEYLPPDGTFAVDATSVKSKLFHSQFAALRVKDAIVDRFREKYGARPSVDEDGPDVRIHVHLLKDRATLSLDTSGESLHK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 165 RGYRLQQGAAPLKENLAAAVLIRAGWPRiaaeGGALADPMCGVGTFLVEAAMIAADIAPNLKReRWGFSAWLGHVPALWR 244
Cdd:COG0116  161 RGYREAQGEAPLKETLAAALLLLSGWDG----DRPLVDPMCGSGTILIEAALIAANIAPGLNR-DFAFEKWPDFDAELWQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 245 KVHDEAQARAQaglAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDqnqKGLVISNPPYGERLG 324
Cdd:COG0116  236 ELREEAEARIK---RDPPLPIFGSDIDPRAIEAARENAERAGVADLIEFEQADFRDLEPPAE---PGLIITNPPYGERLG 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 325 DEASLLYLYQNLGERLRQACMGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPCKLLLF 384
Cdd:COG0116  310 EEEELEALYRELGDVLKQRFKGWSAYILTSDPELEKAIGLKASKRRKLYNGGLECRLLQY 369
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 423-718 4.08e-118

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 360.27  E-value: 4.08e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 423 AQMFANRLQKNLKQLGKWARREQIDCYRLYDAD---MPeyALAVDLYQDWVHVQEYAAPRSVdpdkaqaRLLDALAAIPQ 499
Cdd:COG1092   73 AAFFANRLRKALALRRKLAKREGTNAYRLVHGEadgLP--GLIVDRYGDVLVVQEYSAGMER-------RRDEILEALVE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 500 ALGisPQRVVLKRRER---QSGTRQYERQA--TEGRFQEVNEGGVKLLVNLTDYLDTGLFLDHRPMRMRIQREAAGKRFL 574
Cdd:COG1092  144 VLG--PEGIYLRSDVRvrqLEGLPQYEGVLygEAPEEVEVEENGLKFLVDLTDGQKTGLFLDQRENRARVAELAKGKRVL 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 575 NLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLE---GNRDSYDLIFIDPPTFSN 651
Cdd:COG1092  222 NLFSYTGGFSVHAAAGGAKSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFDWLRelaREGERFDLIILDPPAFAK 301

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 229889506 652 SKRmeGVFDVQRDHVQLLDLAMARLAPGGVLYFSNNFRKFQLDE--------HLMARYVVEEISAQTLDPDFARN 718
Cdd:COG1092  302 SKK--DLFDAQRDYKDLNRLALKLLAPGGILVTSSCSRHFSLDLfleilaraARDAGRRVRIIERLTQPPDHPVL 374
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
 7-159 2.24e-55

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212584  Cd Length: 152  Bit Score: 186.25  E-value: 2.24e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   7 LYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAADMETAYRLCVWSRLANRVLLVLKRFSMKNADDLYDGVHAVDWAD 86
Cdd:cd11715    1 FFATCPPGLEELLAAELKALGAEDVEVGPGGVSFEGDLEDAYRANLWLRTAHRVLLLLAEFEAEDFDDLYELAKAIDWED 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 229889506  87 HLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRNReGLRPSVEKIDPDVRVHLRLDRGEAILSLDLSG 159
Cdd:cd11715   81 YLDPDGTFAVRATRVGSKLFHSQFAALRVKDAIVDRFREK-GKRPSVDLDNPDVRIRVHLSKDRATLSLDLSG 152
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 165-379 1.70e-34

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 129.78  E-value: 1.70e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  165 RGYRLQQGAAPLKENLAAAVLIRAGWpriaAEGGALADPMCGVGTFLVEAAMIAADIAPnlkrerwgfsawlghvpalwr 244
Cdd:pfam01170   1 RGYRPFNGPAPLKETLAAAMVNLAGW----KPGDPLLDPMCGSGTILIEAALMGANIAP--------------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  245 kvhdeaqaraQAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNqkGLVISNPPYGERLG 324
Cdd:pfam01170  56 ----------GKFDARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAADLPLLEGSV--DVIVTNPPYGIRLG 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 229889506  325 DEASLLYLYQNLGERLRQAC--MGWEAAVFTGAPQLGKRMGIRSHKQYAFWNGALPC 379
Cdd:pfam01170 124 SKGALEALYPEFLREAKRVLrgGGWLVLLTAENKDFEKAARERAWRKKKEFNVHIGG 180
PRK15128 PRK15128
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
426-682 8.55e-22

23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;


Pssm-ID: 185082 [Multi-domain]  Cd Length: 396  Bit Score: 98.37  E-value: 8.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 426 FANRLQKnLKQLGKW-ARREQIDCYRLYDAD---MPeyALAVDLYQDWVHVQEYAAprsvDPDKAQARLLDALAAI-PQA 500
Cdd:PRK15128  79 FTRRLQQ-AQKWRDWlAQKDGLDSYRLIAGEsdgLP--GITIDRFGNFLVLQLLSA----GAEYQRAALISALQTLyPEC 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 501 LGISPQRVVLKRRERQSGTRQYERQATEGRFQEVNEGGVKLLVNLTDYLDTGLFLDHRPMRMRIQREAAGKRFLNLFCYT 580
Cdd:PRK15128 152 AIYDRSDVAVRKKEGMELTQGPVTGELPPALLPIEEHGMKLLVDIQGGHKTGYYLDQRDSRLATRRYVENKRVLNCFSYT 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 581 ATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYS-ERNRLEQSDVMAWLEGNRDS---YDLIFIDPPTF-SNSKRM 655
Cdd:PRK15128 232 GGFAVSALMGGCSQVVSVDTSQEALDIARQNVELNKLDlSKAEFVRDDVFKLLRTYRDRgekFDVIVMDPPKFvENKSQL 311

                        250       260
                 ....*....|....*....|....*..
gi 229889506 656 EGVFdvqRDHVQLLDLAMARLAPGGVL 682
Cdd:PRK15128 312 MGAC---RGYKDINMLAIQLLNPGGIL 335
Methyltrans_SAM pfam10672
S-adenosylmethionine-dependent methyltransferase; Members of this family are ...
 534-682 4.79e-18

S-adenosylmethionine-dependent methyltransferase; Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyze the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalyzed by the S-adenosylmethionine-dependent methyltransferases.


Pssm-ID: 287624 [Multi-domain]  Cd Length: 286  Bit Score: 85.32  E-value: 4.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  534 VNEGGVKLLVNLTDYLDTGLFLDHRPMRMRIQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLA 613
Cdd:pfam10672  88 VVENGLKYQLDIGRNQNFGLFLDMRLGRRWVQENAKGKNVLNLFAYTCGFSVAAIAGGASQVVNVDMARGSLNKGRDNHR 167

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 229889506  614 LNGYSER--NRLEQSDVMAWLEGNRDS-YDLIFIDPPTFSnskrmEGVFDVQRDHVQLLDLAMARLAPGGVL 682
Cdd:pfam10672 168 LNGHDLGrvSFLGHDIFKSWGKIKKLGpYDLVIIDPPSFQ-----KGSFALTKDYKKILRRLPELLVEGGTV 234
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 71-156 5.62e-15

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 70.38  E-value: 5.62e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506    71 NADDLYDGVHA-VDWADHLAADGTLAVEFSGHGsgiDNTHFGALKVKDAIVDKLRNREGLRPsVEKIDPDVRVHLRLDRG 149
Cdd:smart00981   1 DLEDLYETALElIRWEKIFKEGKTFAVRAKRRG---KNHEFTSLEVKRAIGDKLLEKTGGRK-VDLKNPDVVIRVELRKD 76


                   ....*..
gi 229889506   150 EAILSLD 156
Cdd:smart00981  77 KAYLSID 83
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 43-157 3.31e-10

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 58.99  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   43 DMETAYRLCVWSRLANRVLLVlkRFSMKNADDLYDGVHAVDWADHLAADGTLAVEFSGHGsgiDNTHFGALKVKDAIVDK 122
Cdd:pfam02926  36 DRELLKEALEKAPGIERFPVA--ETCEADLEDILELAKEIIKDKFKKEGETFAVRVKRRG---KNHEFTSLEINREVGKA 110

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 229889506  123 LRNREGLRpsVEKIDPDVRVHLRLDRGEAILSLDL 157
Cdd:pfam02926 111 IVEKTGLK--VDLENPDIVVHVEIIKDKAYISIDR 143
THUMP cd11688
THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, ...
 7-151 4.55e-10

THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, RNA Methyltransferases and Pseudo-uridine synthases. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212583  Cd Length: 148  Bit Score: 58.65  E-value: 4.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506   7 LYLTCPKGLESLLAEEAKGLGLDEVREHTSAIRGAA-------DMETAYRLCVWSRLANRVLLVLkrFSMK-NADDLYDG 78
Cdd:cd11688    1 VFATTGKGLEEILAAELYELLEVRGFDAEIQVVPHGrvhfktdTDEAVYQLVMWSRLISRIMPPL--GECKaDLEDLYET 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 229889506  79 VHAVDWADHLAADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDkLRNREglrpsVEKIDPDVRVHLRLDRGEA 151
Cdd:cd11688   79 ALEINEPEMGNEGAKFAVRARRRNKTILNSQEIAMKVGDAIVD-AFNPE-----VDLDNPDIVVNVEVHKEIA 145
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 572-685 2.03e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 572 RFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYsERNRLEQSDVMAWLEGNRDSYDLIFIDPPTFSn 651
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLA-DNVEVLKGDAEELPPEADESFDVIISDPPLHH- 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 229889506 652 skrmegvfdVQRDHVQLLDLAMARLAPGGVLYFS 685
Cdd:cd02440   79 ---------LVEDLARFLEEARRLLKPGGVLVLT 103
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 167-335 2.99e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 51.10  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 167 YRLQQGAapLKENLAAAVLIRAGwpriAAEGGALADPMCGVGTFLVEAAMIAADIApnlkrerwgfsawlghvpalwrkv 246
Cdd:COG1041    3 YFFYPGS--LDPRLARALVNLAG----AKEGDTVLDPFCGTGTILIEAGLLGRRVI------------------------ 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 247 hdeaqaraqaglakpplwirGYEADPRLIQPGRNNVERAGLGDWvKIYQGEVSTFEPRPDQNQkgLVISNPPYGERLGDE 326
Cdd:COG1041   53 --------------------GSDIDPKMVEGARENLEHYGYEDA-DVIRGDARDLPLADESVD--AIVTDPPYGRSSKIS 109

                        170
                 ....*....|
gi 229889506 327 A-SLLYLYQN 335
Cdd:COG1041  110 GeELLELYEK 119
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 558-683 5.66e-07

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 50.47  E-value: 5.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 558 RPMRMRIqREA---------AGKRFLNLFCytatatvhaakG-----------GARSTTSVDLSKTYLDWARRNLALNGY 617
Cdd:COG0742   22 RPTTDRV-REAlfnilgpdiEGARVLDLFA-----------GsgalglealsrGAASVVFVEKDRKAAAVIRKNLEKLGL 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 229889506 618 SERNRLEQSDVMAWLEGNRD-SYDLIFIDPPtfsnskrmegvFDVQrDHVQLLDLAMAR--LAPGGVLY 683
Cdd:COG0742   90 EDRARVIRGDALRFLKRLAGePFDLVFLDPP-----------YAKG-LLEKALELLAENglLAPGGLIV 146
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 596-686 1.61e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 48.64  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 596 TSVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLEGNRD-SYDLIFIdpptfsnskrmegvfDVQRDH-VQLLDLAM 673
Cdd:COG4122   45 TTIEIDPERAAIARENFARAGLADRIRLILGDALEVLPRLADgPFDLVFI---------------DADKSNyPDYLELAL 109

                         90
                 ....*....|...
gi 229889506 674 ARLAPGGVLYFSN 686
Cdd:COG4122  110 PLLRPGGLIVADN 122
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 587-701 8.44e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 47.83  E-value: 8.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 587 AAKGGARSTTSVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLEGNR-DSYDLIFIDPPTFS--------NSKRMEG 657
Cdd:COG4123   56 AQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAAELPpGSFDLVVSNPPYFKagsgrkspDEARAIA 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 229889506 658 VFDVQRDHVQLLDLAMARLAPGGVLYFSnnFRKFQLDE--HLMARY 701
Cdd:COG4123  136 RHEDALTLEDLIRAAARLLKPGGRFALI--HPAERLAEilAALRKY 179
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 568-685 1.06e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.39  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 568 AAGKRFLNLFCYTATATVHAAKGGARsTTSVDLSKTYLDWARRNLAlngySERNRLEQSDVMAwLEGNRDSYDLIFidpp 647
Cdd:COG2227   23 PAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIARERAA----ELNVDFVQGDLED-LPLEDGSFDLVI---- 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 229889506 648 tfsnskrMEGVFDVQRDHVQLLDLAMARLAPGGVLYFS 685
Cdd:COG2227   93 -------CSEVLEHLPDPAALLRELARLLKPGGLLLLS 123
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 583-684 6.72e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 45.53  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 583 ATVHAakggarsttsVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLEGNRdSYDLIFIDPP--TFSNSKRMEGvfD 660
Cdd:COG2890  137 ARVTA----------VDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGDG-RFDLIVSNPPyiPEDEIALLPP--E 203

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 229889506 661 VqRDH----------------VQLLDLAMARLAPGGVLYF 684
Cdd:COG2890  204 V-RDHeprlaldggedgldfyRRIIAQAPRLLKPGGWLLL 242
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 561-699 8.74e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 44.14  E-value: 8.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 561 RMRIQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSeRNRLEQSDVMAWLEGNRDSYD 640
Cdd:COG0500   18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLG-NVEFLVADLAELDPLPAESFD 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 229889506 641 LIFidpptfsnskrMEGVFDVQRDHV--QLLDLAMARLAPGGVLYFSNNFRKFQLDEHLMA 699
Cdd:COG0500   97 LVV-----------AFGVLHHLPPEEreALLRELARALKPGGVLLLSASDAAAALSLARLL 146
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 561-684 2.65e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 43.70  E-value: 2.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 561 RMRIQREA-AGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLEGNRDSY 639
Cdd:COG2520  171 RLRIAELVkPGERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGDAREVAPELEGKA 250

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 229889506 640 DLIFIDPPTFSnskrmegvfdvqrdhVQLLDLAMARLAPGGVLYF 684
Cdd:COG2520  251 DRIIMNLPHSA---------------DEFLDAALRALKPGGVIHY 280
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
558-647 3.54e-04

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 42.23  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  558 RPM--RMR------IQREAAGKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYSERnRLEQSDVM 629
Cdd:pfam03602  22 RPTtdRVRealfnwLAPYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQILKENLQLLGLPGA-VLVMDALL 100

                          90       100
                  ....*....|....*....|
gi 229889506  630 AWL--EGNRDSYDLIFIDPP 647
Cdd:pfam03602 101 ALLrlAGKGPVFDIVFLDPP 120
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 578-680 1.40e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  578 CYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYseRNRLEQSDVMAWLEGNrDSYDLIFidpptfsnskrMEG 657
Cdd:pfam13649   6 CGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPD-GSFDLVV-----------SSG 71

                          90       100
                  ....*....|....*....|....*
gi 229889506  658 VFDV--QRDHVQLLDLAMARLAPGG 680
Cdd:pfam13649  72 VLHHlpDPDLEAALREIARVLKPGG 96
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 269-319 1.69e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.51  E-value: 1.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 229889506 269 EADPRLIQPGRNNVERAGLGDWVKIYQGEVSTFEPRPDQNQKGLVISNPPY 319
Cdd:COG4123   68 EIQPEAAELARRNVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVSNPPY 118
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 587-684 2.26e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 38.06  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506  587 AAKGGARSTTSVDLSKTYLDwARRNLALNGYSERNRLEQSDVMAWLEGNRD-SYDLIFID-PPTFSnskrmegvfDVQRD 664
Cdd:pfam13578  18 LRDNGLGRLTAVDPDPGAEE-AGALLRKAGLDDRVRLIVGDSREALPSLADgPIDLLFIDgDHTYE---------AVLND 87

                          90       100
                  ....*....|....*....|
gi 229889506  665 hvqlLDLAMARLAPGGVLYF 684
Cdd:pfam13578  88 ----LELWLPRLAPGGVILF 103
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 567-683 2.26e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 40.93  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 567 EAAGKRFLNLFCYTATATVHAAKGGARsTTSVDLSKTYLDWARRNLALNGYSerN-RLEQSDVMAWL--EGNRDSYDLIF 643
Cdd:COG2265  231 LTGGERVLDLYCGVGTFALPLARRAKK-VIGVEIVPEAVEDARENARLNGLK--NvEFVAGDLEEVLpeLLWGGRPDVVV 307

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 229889506 644 IDPPtfsnskrmegvfdvqRD--HVQLLDlAMARLAPGGVLY 683
Cdd:COG2265  308 LDPP---------------RAgaGPEVLE-ALAALGPRRIVY 333
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
 593-684 2.92e-03

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 40.62  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 593 RSTTSVDLSKTYLDWARRN---LALNGYS---ERNRLEQSDVMAWLEGNRDSYDLIFIDPPTFSNskrmegvFDVQR--- 663
Cdd:COG4262  311 ESVTLVDLDPEVTDLAKTNpflRELNGGAlndPRVTVVNADAFQFLRETDEKYDVIIVDLPDPSN-------FSLGKlys 383

                         90       100
                 ....*....|....*....|..
gi 229889506 664 -DHVQLLDlamARLAPGGVLYF 684
Cdd:COG4262  384 vEFYRLVR---RHLAPGGVLVV 402
PRK14967 PRK14967
putative methyltransferase; Provisional
 570-647 3.26e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.65  E-value: 3.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 229889506 570 GKRFLNLFCYTATATVHAAKGGARSTTSVDLSKTYLDWARRNLALNGYseRNRLEQSDVMAWLEGNRdsYDLIFIDPP 647
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGV--DVDVRRGDWARAVEFRP--FDVVVSNPP 110
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 569-684 4.26e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 569 AGKRFLNLFCYTATATVHAAK-GGARSTTsVDLSKTYLDWARRNLALNGYSERNRLEQSDVMAWLEGNRdsYDLIFidpp 647
Cdd:COG2230   51 PGMRVLDIGCGWGGLALYLARrYGVRVTG-VTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQ--FDAIV---- 123

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229889506 648 tfsnskrMEGVFD-VQRDHVQ-LLDLAMARLAPGGVLYF 684
Cdd:COG2230  124 -------SIGMFEhVGPENYPaYFAKVARLLKPGGRLLL 155
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 569-647 6.39e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 38.39  E-value: 6.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 229889506 569 AGKRFLNLFCYTATATVHAAKGGARSTtSVDLSKTYLDWARRNLALNGYsERNRLEQSDVMAwLEGNRDSYDLIFIDPP 647
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLGRRVI-GSDIDPKMVEGARENLEHYGY-EDADVIRGDARD-LPLADESVDAIVTDPP 101
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
569-685 9.50e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 36.34  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229889506 569 AGKRFLNLFCYTATATVH-AAKGGARSTTSVDLSKTYLDWARRNLAlngyseRNRLEQSDVMAW-LEGnrdSYDLIFidp 646
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALlAERFPGARVTGVDLSPEMLARARARLP------NVRFVVADLRDLdPPE---PFDLVV--- 68

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229889506 647 ptfSNSkrmegVFDVQRDHVQLLDLAMARLAPGGVLYFS 685
Cdd:COG4106   69 ---SNA-----ALHWLPDHAALLARLAAALAPGGVLAVQ 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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