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Conserved domains on  [gi|292630784|sp|A4RS24|]
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RecName: Full=Anamorsin homolog; AltName: Full=Fe-S cluster assembly protein DRE2 homolog

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5636 super family cl35031
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
158-257 5.37e-19

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


The actual alignment was detected with superfamily member COG5636:

Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 84.04  E-value: 5.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630784 158 ELIDESALLTElDVNTAPVKYDDC--DVGAGKKACKNCTCG-----------------RAEAEAAEEATTAASEETFVSA 218
Cdd:COG5636  162 RTIMEDELLDE-DSEDKAIQRSECppSKTKKKRACKDCTCGlkeeeeneivrtrqdkvVKFTEDELTEIDFTIDGKKVSA 240

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 292630784 219 CGNCALGDAFRCAGCPYLGQPAFKdqPGTKVELD-------LGDDL 257
Cdd:COG5636  241 CGNCYLGDAFRCSGCPYLGLPAFE--PGDVVSFSmnldnefQGDDA 284
 
Name Accession Description Interval E-value
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
158-257 5.37e-19

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 84.04  E-value: 5.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630784 158 ELIDESALLTElDVNTAPVKYDDC--DVGAGKKACKNCTCG-----------------RAEAEAAEEATTAASEETFVSA 218
Cdd:COG5636  162 RTIMEDELLDE-DSEDKAIQRSECppSKTKKKRACKDCTCGlkeeeeneivrtrqdkvVKFTEDELTEIDFTIDGKKVSA 240

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 292630784 219 CGNCALGDAFRCAGCPYLGQPAFKdqPGTKVELD-------LGDDL 257
Cdd:COG5636  241 CGNCYLGDAFRCSGCPYLGLPAFE--PGDVVSFSmnldnefQGDDA 284
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 180-251 1.21e-18

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 78.47  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630784  180 DCDVGAGK--KACKNCTCGRAEAEAAEEATTAASEET---------------------FVSACGNCALGDAFRCAGCPYL 236
Cdd:pfam05093   7 ECEPNGKKrrKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgKTGSCGSCALGDAFRCSGCPYL 86

                          90
                  ....*....|....*
gi 292630784  237 GQPAFKdqPGTKVEL 251
Cdd:pfam05093  87 GLPAFK--PGEEVTI 99
 
Name Accession Description Interval E-value
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
158-257 5.37e-19

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 84.04  E-value: 5.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630784 158 ELIDESALLTElDVNTAPVKYDDC--DVGAGKKACKNCTCG-----------------RAEAEAAEEATTAASEETFVSA 218
Cdd:COG5636  162 RTIMEDELLDE-DSEDKAIQRSECppSKTKKKRACKDCTCGlkeeeeneivrtrqdkvVKFTEDELTEIDFTIDGKKVSA 240

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 292630784 219 CGNCALGDAFRCAGCPYLGQPAFKdqPGTKVELD-------LGDDL 257
Cdd:COG5636  241 CGNCYLGDAFRCSGCPYLGLPAFE--PGDVVSFSmnldnefQGDDA 284
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 180-251 1.21e-18

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 78.47  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292630784  180 DCDVGAGK--KACKNCTCGRAEAEAAEEATTAASEET---------------------FVSACGNCALGDAFRCAGCPYL 236
Cdd:pfam05093   7 ECEPNGKKrrKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgKTGSCGSCALGDAFRCSGCPYL 86

                          90
                  ....*....|....*
gi 292630784  237 GQPAFKdqPGTKVEL 251
Cdd:pfam05093  87 GLPAFK--PGEEVTI 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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