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Conserved domains on  [gi|226737157|sp|A2C5L7|]
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RecName: Full=Protein GrpE; AltName: Full=HSP-70 cofactor

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793976)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 6-219 5.13e-122

heat shock protein GrpE; Provisional


:

Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 346.33  E-value: 5.13e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   6 PTPAHDPAAEGLEASVPLESVASMN------------------------SDEGQPSAQSAPLADNEARLQQLEQEHSSLR 61
Cdd:PRK14143   1 STPEQDPLEVKLAVISESEAEDNSPesseevteqeaeltnpegdaaeaeSSPDSGSAASETAADNAARLAQLEQELESLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  62 EEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGEEAQALHRSYQGLYKQLVE 141
Cdd:PRK14143  81 QELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVD 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226737157 142 VLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSMGPGPQSGASPSSAQSN 219
Cdd:PRK14143 161 VLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGPGPSSPAEEDQATPA 238
 
Name Accession Description Interval E-value
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 6-219 5.13e-122

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 346.33  E-value: 5.13e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   6 PTPAHDPAAEGLEASVPLESVASMN------------------------SDEGQPSAQSAPLADNEARLQQLEQEHSSLR 61
Cdd:PRK14143   1 STPEQDPLEVKLAVISESEAEDNSPesseevteqeaeltnpegdaaeaeSSPDSGSAASETAADNAARLAQLEQELESLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  62 EEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGEEAQALHRSYQGLYKQLVE 141
Cdd:PRK14143  81 QELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVD 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226737157 142 VLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSMGPGPQSGASPSSAQSN 219
Cdd:PRK14143 161 VLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGPGPSSPAEEDQATPA 238
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 58-204 1.19e-55

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 174.57  E-value: 1.19e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  58 SSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQlEPQGEEAQALHRSYQGLYK 137
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAA-AEEDEDVKSLLEGVEMTLK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226737157 138 QLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSMG 204
Cdd:COG0576   81 QLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 65-201 2.70e-51

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 163.06  E-value: 2.70e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  65 ETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQlEPQGEEAQALHRSYQGLYKQLVEVLK 144
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEA-APKEEELKNLLEGVEMTLKQLLKVLE 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 226737157 145 QLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKV 201
Cdd:cd00446   80 KHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
43-202 7.31e-46

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 150.45  E-value: 7.31e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   43 LADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQqLEPQG 122
Cdd:pfam01025   6 EEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALN-SAPEN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  123 EEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:pfam01025  85 EDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
 
Name Accession Description Interval E-value
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 6-219 5.13e-122

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 346.33  E-value: 5.13e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   6 PTPAHDPAAEGLEASVPLESVASMN------------------------SDEGQPSAQSAPLADNEARLQQLEQEHSSLR 61
Cdd:PRK14143   1 STPEQDPLEVKLAVISESEAEDNSPesseevteqeaeltnpegdaaeaeSSPDSGSAASETAADNAARLAQLEQELESLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  62 EEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGEEAQALHRSYQGLYKQLVE 141
Cdd:PRK14143  81 QELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVD 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226737157 142 VLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSMGPGPQSGASPSSAQSN 219
Cdd:PRK14143 161 VLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGPGPSSPAEEDQATPA 238
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 58-204 1.19e-55

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 174.57  E-value: 1.19e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  58 SSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQlEPQGEEAQALHRSYQGLYK 137
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAA-AEEDEDVKSLLEGVEMTLK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226737157 138 QLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSMG 204
Cdd:COG0576   81 QLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 65-201 2.70e-51

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 163.06  E-value: 2.70e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  65 ETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQlEPQGEEAQALHRSYQGLYKQLVEVLK 144
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEA-APKEEELKNLLEGVEMTLKQLLKVLE 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 226737157 145 QLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKV 201
Cdd:cd00446   80 KHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
43-202 7.31e-46

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 150.45  E-value: 7.31e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   43 LADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQqLEPQG 122
Cdd:pfam01025   6 EEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALN-SAPEN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  123 EEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:pfam01025  85 EDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 27-202 2.68e-38

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 131.66  E-value: 2.68e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  27 ASMNSDEGQPSAQSAPLADNEARLQQLEQEHSSLREehetlrsQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILP 106
Cdd:PRK14140  23 DEVEEETVEEESEAELLDEEQAKIAELEAKLDELEE-------RYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 107 VVDNFERARQQlEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRG 186
Cdd:PRK14140  96 ALDNFERALQI-EADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKG 174

                        170
                 ....*....|....*.
gi 226737157 187 YHLNGRVLRHALVKVS 202
Cdd:PRK14140 175 YKLKDRVIRPSMVKVN 190
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 30-205 1.14e-30

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 112.24  E-value: 1.14e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  30 NSDEGQPSAQSAPLADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVD 109
Cdd:PRK14153  15 EARNSGSSAEEAEELKEEPEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 110 NFERARQQLEpQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHL 189
Cdd:PRK14153  95 NFERALESAR-TAEDMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNTIVDVCKPGYAL 173

                        170
                 ....*....|....*.
gi 226737157 190 NGRVLRHALVKVSMGP 205
Cdd:PRK14153 174 NSKVIRPAMVSVARNP 189
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 29-202 6.96e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 99.61  E-value: 6.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  29 MNSDEGQPSAQSAPLADNE-----ARLQQLEQE-HSSLREEHETLrsqyMRIAADFDNFRKRQSRDQDDLRLQLICTTLS 102
Cdd:PRK14150  17 IEAEVEQQEEADEAELEDEldeadARIAELEAQlAEAQAEERDSV----LRARAEVENIRRRAEQDVEKAHKFALEKFAN 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 103 EILPVVDNFERARQQLEPQGEEAQALhrsYQGL---YKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVV 179
Cdd:PRK14150  93 ELLPVIDNLERALQAADKENEALKAL---IEGVeltLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNTV 169

                        170       180
                 ....*....|....*....|...
gi 226737157 180 TEELQRGYHLNGRVLRHALVKVS 202
Cdd:PRK14150 170 MMVMQKGYTLNGRLLRPAMVMVS 192
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 18-202 5.35e-24

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 94.90  E-value: 5.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  18 EASVPLESVASMNSDEGQPSAQSApladnEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLI 97
Cdd:PRK14162  14 QEETTDEAPKKEAKEAPKEEDQEK-----QNPVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYES 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  98 CTTLSEILPVVDNFERARQqLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSE-EHPE 176
Cdd:PRK14162  89 QSLAKDVLPAMDNLERALA-VKADDEAAKQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAEnDDQK 167

                        170       180
                 ....*....|....*....|....*.
gi 226737157 177 DVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:PRK14162 168 DHVVQVLQKGYQYKDRTLRPAMVVVA 193
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 16-202 1.38e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 94.05  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  16 GLEASVPLESVASMNSDEGQPSAQSAPLADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQ 95
Cdd:PRK14160  29 GKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDENNKLKEENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSD 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  96 LICTTLSEILPVVDNFERArqqLEPQGEeAQALHRSYQGLYKQLVEVLKQLGVASMRVVGqAFDPTLHEAVSREPSEEHP 175
Cdd:PRK14160 109 ACEDVLKELLPVLDNLERA---AAVEGS-VEDLKKGIEMTVKQFKTSLEKLGVEEISTEG-EFDPNLHNAVMHVEDENYG 183

                        170       180
                 ....*....|....*....|....*..
gi 226737157 176 EDVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:PRK14160 184 ENEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 24-202 1.09e-22

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 91.52  E-value: 1.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  24 ESVASMNSDEGQPSAQSAPLADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSE 103
Cdd:PRK14145  21 SNEQMEGPPEDEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 104 ILPVVDNFERArqqLEPQGEEAqALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEEL 183
Cdd:PRK14145 101 LLPVMDNFERA---LASSGDYN-SLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEIIEVF 176

                        170
                 ....*....|....*....
gi 226737157 184 QRGYHLNGRVLRHALVKVS 202
Cdd:PRK14145 177 QKGYYLKDKVIRPSLVKVA 195
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 18-201 1.15e-22

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 91.35  E-value: 1.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  18 EASVPLESVASMNSDEGQPSAQSAPLADNEarlqQLEQEHSSLREEHET---LRSQYMRIAADFDNFRKRQSRDQDDLRL 94
Cdd:PRK14148  11 DKSLDIETAAQVETAQESASGALEELSVEE----QLERAKDTIKELEDScdqFKDEALRAKAEMENIRKRAERDVSNARK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  95 QLICTTLSEILPVVDNFERARQQlEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEH 174
Cdd:PRK14148  87 FGIEKFAKELLPVIDSIEQALKH-EVKLEEAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEF 165

                        170       180
                 ....*....|....*....|....*..
gi 226737157 175 PEDVVTEELQRGYHLNGRVLRHALVKV 201
Cdd:PRK14148 166 EDNTIFDVFQKGYMLNGRIVRAAKVVI 192
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 24-202 5.33e-22

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 89.07  E-value: 5.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  24 ESVASMNSDEgQPSAQSAPLADNEARLQQLEqehsslrEEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSE 103
Cdd:PRK14151   4 EQTLDLQAPE-AAQAEAAAGDDLTARVQELE-------EQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 104 ILPVVDNFERARQQLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEEL 183
Cdd:PRK14151  76 LLPVVDSLERGLELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVF 155

                        170
                 ....*....|....*....
gi 226737157 184 QRGYHLNGRVLRHALVKVS 202
Cdd:PRK14151 156 QKGYLLNGRLLRPAMVVVS 174
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 29-202 7.12e-22

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 88.47  E-value: 7.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  29 MNSDegQPSAQSAPLADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVV 108
Cdd:PRK14147   1 MNQD--HPEFDSEDLAQNPPETDPLKAEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 109 DNFERArqqLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYH 188
Cdd:PRK14147  79 DSLDAG---LTAAGTEPSPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYL 155

                        170
                 ....*....|....
gi 226737157 189 LNGRVLRHALVKVS 202
Cdd:PRK14147 156 LNERLLRPALVVVA 169
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 33-202 7.91e-22

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 7.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  33 EGQPSAQSAPLAdnEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFE 112
Cdd:PRK14158  27 QGKPEAAQPVAA--ADRIKELEEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNME 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 113 RArqqLEPQGEE-AQALHRSYQGLYKQLVEVLKQLGVASMRV-VGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLN 190
Cdd:PRK14158 105 RA---LDHADEEsMSAIIEGIRMTLSMLLSTLKKFGVTPVEAeKGTPFDPAYHQAMCQVESAEQEPNTVVAVFQKGYLLN 181

                        170
                 ....*....|..
gi 226737157 191 GRVLRHALVKVS 202
Cdd:PRK14158 182 ERLLRPAMVSVA 193
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 29-221 1.42e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 86.26  E-value: 1.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  29 MNSDEGQPSAQSAPLADNEARLQQLEQEHS-----SLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSE 103
Cdd:PRK14141   7 KNGNPADAARDANNPVDREAKPYEMEDDPEpdpleALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 104 ILPVVDNFERArqqLEPQGEEAQALHRSyqGLyKQLVE-----------VLKQLGVASMRVVGQAFDPTLHEAVSREPSE 172
Cdd:PRK14141  87 MLSVSDNLRRA---LDAIPAEARAAADA--GL-KALIEgvemteramlnALERHGVKKLDPEGQKFDPNFHQAMFEVPNP 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 226737157 173 EHPEDVVTEELQRGYHLNGRVLRHALVKVSMGpGPQSGASPSSAQSNDD 221
Cdd:PRK14141 161 DVPNNTVVQVVQAGYTIGERVLRPAMVGVAKG-GPKAAAEAGASTSEDD 208
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 7-217 2.62e-19

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 82.87  E-value: 2.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   7 TPAHDPAAEGLEASVPLESVASMNSDEGqpSAQSAPLADNEARLQQLEQEHSSLREEHETLRsqymRIAADFDNFRKRQS 86
Cdd:PRK14163   5 TPGFEEKPDVPSGATPDDAEPKAASEEG--AAPAGDAAATAGLTAQLDQVRTALGERTADLQ----RLQAEYQNYRRRVE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  87 RDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGeeaqalhrSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAV 166
Cdd:PRK14163  79 RDRVTVKEIAVANLLSELLPVLDDVGRAREHGELVG--------GFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEAL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 226737157 167 SREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSMgpgPQSGASPSSAQ 217
Cdd:PRK14163 151 MHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAE---PQPGAQTAKAK 198
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 7-209 3.04e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 82.86  E-value: 3.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   7 TPAHDPAAEGLEASVPLE--SVASMNSDEGQPS-----AQSAPLADNEARLQQleqEHSSLREEHETLRSQYMRIAADFD 79
Cdd:PRK14146   9 TSEEAKANEKKSQSQTLEesKLENMNSEESQTIteetqEQAVEGAETETSLQK---ELDNAKKEIESLKDSWARERAEFQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  80 NFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERArQQLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFD 159
Cdd:PRK14146  86 NFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERV-GATQNQSEELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFD 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 226737157 160 PTLHEAVSREPSEEHPEDVVTEELQRGYHL----NGRVLRHALVKVSMgpgPQS 209
Cdd:PRK14146 165 PMSMEALSSEEGDQYSEETVIDVYQAGYYYkeneDKFTLRPARVRIGK---PKS 215
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 45-202 1.20e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 78.23  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  45 DNEARLQQLEQEHSSLR--EEHETLRSQY--------MRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERA 114
Cdd:PRK14144  32 DEESQHQEPALGHPSYTalEEQLTLAEQKahenweksVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 115 RQqLEPQGEEAqALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVL 194
Cdd:PRK14144 112 LQ-LADKNSDP-SMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQKGYKLSDRVI 189


                 ....*...
gi 226737157 195 RHALVKVS 202
Cdd:PRK14144 190 RPARVIVS 197
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 31-230 3.38e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 76.93  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  31 SDEGQPsAQSAPLADNEArlqqlEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDN 110
Cdd:PRK14155   2 TDEQTP-AEDGPFEADDA-----AQEIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 111 FERARQQlEPQGEEAQALHRSYQGL---YKQLVEVLKQLGVASMR-VVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRG 186
Cdd:PRK14155  76 LGRATAA-SPKDSADPAVKNFIIGVemtEKELLGAFERNGLKKIDpAKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAG 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 226737157 187 YHLNGRVLRHALVKV----SMGPG----PQSGASP--SSAQSNDDSTATFQGEA 230
Cdd:PRK14155 155 YELMGRLVRPAMVAVaakgSTGPAapaePAAGANPyaSAAADGDGSGGSFDTKA 208
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 10-201 1.16e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 75.29  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  10 HDPAAEGLEASVPLESVASMNSDEGQPS-AQSAPLADNEARlQQLEQEHSSLREehetlrsQYMRIAADFDNFRKRQSRD 88
Cdd:PRK14149   5 HNQEHDHLSQKEPESEEKACACKEQQGEeKQEASEKEGEIK-EDFELKYKEMHE-------KYLRVHADFENVKKRLERD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  89 QDDLRLQLICTTLSEILPVVDNFERARQQLEPQGEEAqALHRSYQGLYKQLVEVLKQLGVASMRVVGQaFDPTLHEAVSR 168
Cdd:PRK14149  77 KSMALEYAYEKIALDLLPVIDALLGALKSAAEVDKES-ALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQ 154

                        170       180       190
                 ....*....|....*....|....*....|...
gi 226737157 169 EPSEEHPEDVVTEELQRGYHLNGRVLRHALVKV 201
Cdd:PRK14149 155 VKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 187
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 18-206 2.06e-16

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 74.71  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  18 EASVPLESVASMNSD-EGQPSAQSAPLADneARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQL 96
Cdd:PRK10325  10 EGQAPEEIIMDQHEEiEAVEPEASAEQVD--PRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  97 ICTTLSEILPVVDNFERARQQLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPE 176
Cdd:PRK10325  88 LEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAP 167

                        170       180       190
                 ....*....|....*....|....*....|
gi 226737157 177 DVVTEELQRGYHLNGRVLRHALVKVSMGPG 206
Cdd:PRK10325 168 GNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 67-236 4.34e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 74.27  E-value: 4.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  67 LRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGEEAQALHrsyqglyKQLVEVLKQL 146
Cdd:PRK14142  52 LTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGPLKSVA-------DKLDSALTGL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 147 GVASMRVVGQAFDPTLHEAVSRE-PSEEHPEDVVTEELQRGYHLNGRVLRHALVKVsMGPGPQSGASPSSAqsNDDSTAT 225
Cdd:PRK14142 125 GLVAFGAEGEDFDPVLHEAVQHEgDGGQGSKPVIGTVMRQGYQLGEQVLRHALVGV-VDTVVVDAAELESV--DDGTAVA 201

                        170
                 ....*....|.
gi 226737157 226 FQGEADPAEPG 236
Cdd:PRK14142 202 DTAENDQADQG 212
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 33-202 4.49e-16

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 73.18  E-value: 4.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  33 EGQPSAQSAPLADNEarlqqlEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFE 112
Cdd:PRK14159  14 ENSEHLQDENLQNIE------DVEQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 113 RArQQLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQaFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGR 192
Cdd:PRK14159  88 AA-VNVECHDEISLKIKEGVQNTLDLFLKKLEKHGVALIKEEKE-FDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIADR 165

                        170
                 ....*....|
gi 226737157 193 VLRHALVKVS 202
Cdd:PRK14159 166 VIRPTKVSVA 175
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 31-202 1.92e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 71.93  E-value: 1.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  31 SDEGQPSAQSAPLADNEarLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDN 110
Cdd:PRK14139  17 GAAAQAAAAAAAAAEDA--APALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLLPVKDS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 111 FERArqqLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRVVGQAFDPTLHEAVSREPSEEHPEDVVTeELQRGYHLN 190
Cdd:PRK14139  95 LEAA---LADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPAEQEPNTVVA-VLQKGYTIA 170

                        170
                 ....*....|..
gi 226737157 191 GRVLRHALVKVS 202
Cdd:PRK14139 171 DRVLRPALVTVA 182
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 4-202 8.25e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 70.61  E-value: 8.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   4 DAPTPAHDPAAEGLEASVPLESVASMNSDEGQPSAQSAPLADNEarlqQLEQEHSSLREEHETLRSQYMRIAADFDNFRK 83
Cdd:PRK14154  12 ESETKAKNKWEKVMEAEEEQEEGGGDGSQEMEPHREGLEFPSRE----KLEGQLTRMERKVDEYKTQYLRAQAEMDNLRK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  84 RQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGEEAQALHRSYQGLYKQLVEVLKQLGVASMRV-VGQAFDPTL 162
Cdd:PRK14154  88 RIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPAL 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 226737157 163 HEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:PRK14154 168 HEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 2-202 2.56e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 69.60  E-value: 2.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   2 SGDAPTPAHDPAAEGLEASVPLESVASMNSDEGQPSA-----------QSAPLADNEARLQQLEQEHSSLREEHETLRsq 70
Cdd:PRK14157  24 QAAQASSGADASAESGEQQDSAAQADANAGADAAPAAaegeakaaaekTGEAQSDSDDTLTPLGQAKKEAAEYLEALQ-- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  71 ymRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEpqgeeaqaLHRSYQGLYKQLVEVLKQLGVAS 150
Cdd:PRK14157 102 --RERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDRIREHSE--------MDDSFKAVAAKIDKAFEKFGVEK 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 226737157 151 MRVVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:PRK14157 172 FGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 2-199 1.67e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 67.13  E-value: 1.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   2 SGDAPTPAHDPAAEGlEASVPLESVASMNSDEGQPSAQSAPLADNEARLQqleqehsslreehetlrsqymRIAADFDNF 81
Cdd:PRK14164  46 FGDAVEGEIDPDLEA-DLEDLLDDVDPELADDGEASTVEAQLAERTEDLQ---------------------RVTAEYANY 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  82 RKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQlepqGEEAQALHRSYQglyKQLVEVLKQLGVASMRVVGQAFDPT 161
Cdd:PRK14164 104 RRRTERERQAIIETAKAGVATDLLPILDDLDLAEQH----GDLNEGPLKAFS---DKLTNVLAGLKVEKFGEEGDAFDPE 176

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 226737157 162 LHEAVSREPSEEhpEDVVTEELQRGYHLNGRVLRHALV 199
Cdd:PRK14164 177 IHEAVQDLSSGD--EKVLGTVLRKGYRMGDRVLRTAMV 212
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 46-205 2.09e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 60.76  E-value: 2.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  46 NEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQGE-E 124
Cdd:PRK14161  17 AEEIVETANPEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPANSDvE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157 125 AQALHRSYQGLYKQLVEVLKQLGVASMR-VVGQAFDPTLHEAVSREPSEEHPEDVVTEELQRGYHLNGRVLRHALVKVSM 203
Cdd:PRK14161  97 VTNIIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVK 176


                 ..
gi 226737157 204 GP 205
Cdd:PRK14161 177 KP 178
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 62-202 3.06e-09

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 54.45  E-value: 3.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  62 EEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERArqqLEPQGEeAQALHRSYQGLYKQLVE 141
Cdd:PRK14156  41 ERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERA---LAVEGL-TDDVKKGLEMVQESLIQ 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226737157 142 VLKQLGVAsmRVVGQAFDPTLHEAVSREPS-EEHPEDVVTEELQRGYHLNGRVLRHALVKVS 202
Cdd:PRK14156 117 ALKEEGVE--EVAVDSFDHNLHMAVQTLPAdDEHPADSIAQVFQKGYKLHERLLRPAMVVVY 176
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
43-149 5.20e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157  43 LADNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQSRDQDDLRLQLICTTLSEILPVVDNFERARQQLEPQG 122
Cdd:COG4717   83 AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELE 162

                         90       100
                 ....*....|....*....|....*..
gi 226737157 123 EEAQALHRSYQGLYKQLVEVLKQLGVA 149
Cdd:COG4717  163 EELEELEAELAELQEELEELLEQLSLA 189
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
45-147 1.51e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.51  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226737157   45 DNEARLQQLEQEHSSLREEHETLRSQYMRIAADFDNFRKRQS-------RDQDDLRLQLICTTLSEILPVVDNFERARQQ 117
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREalqrlaeYSWDEIDVASAEREIAELEAELERLDASSDD 686

                          90       100       110
                  ....*....|....*....|....*....|
gi 226737157  118 LEPQGEEAQALHRSYQGLYKQLVEVLKQLG 147
Cdd:COG4913   687 LAALEEQLEELEAELEELEEELDELKGEIG 716
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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