NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|160409939|sp|A2ARV4|]
View 

RecName: Full=Low-density lipoprotein receptor-related protein 2; Short=LRP-2; AltName: Full=Glycoprotein 330; Short=gp330; AltName: Full=Megalin; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1502-1544 1.36e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 1.36e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   1502 RVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHR 1544
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3761-3795 3.45e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 3.45e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3761 CTESEFRCADQQCIPSRWVCDQENDCGDNSDERDC 3795
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2908-2939 4.21e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 4.21e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDE 2939
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 863-903 6.37e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 6.37e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    863 IVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDR 903
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1110-1144 8.81e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 8.81e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1110 CPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNC 1144
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1272-1306 1.51e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 1.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1272 CSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDC 1306
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4224-4266 1.80e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.80e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   4224 VLASANLGWPNGLSIDYLNGdRIYWSDSKEDVIESIKYDGTDR 4266
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEG-RLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3360-3401 1.92e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3360 VIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHR 3401
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3723-3756 2.32e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 2.32e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 160409939 3723 PSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESC 3756
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1150-1184 4.69e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 4.69e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1150 CHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGC 1184
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 502-547 4.77e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 4.77e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 160409939    502 TLITENLGHPRGIALDPTVGYLFFSDWgslsGQPKVERAFMDGSNR 547
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW----GLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3636-3668 6.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 6.61e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3636 TCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2995-3029 1.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.06e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2995 CSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGC 3029
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4143-4178 1.54e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.54e-09
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 160409939   4143 LMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYR 4178
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 550-590 1.65e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.65e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    550 LVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQR 590
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2700-2732 2.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.36e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2700 RCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDE 2732
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 183-217 2.47e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.47e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNC 217
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 222-256 2.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  222 CGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGC 256
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3077-3111 2.81e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 2.81e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3077 CPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGC 3111
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3335-3376 3.53e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 3.53e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3335 GYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDY 3376
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1592-1633 5.14e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 5.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   1592 VIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNR 1633
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1025-1059 5.96e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 5.96e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1025 CGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQC 1059
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-142 9.25e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 9.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  108 CSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNC 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2742-2776 9.71e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 9.71e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2742 CRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGC 2776
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-62 1.07e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939   28 CGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGC 62
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1546-1590 2.28e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 160409939   1546 VLISKNVTKPRGLALDPRmgDNVMFWSDWGHhPRIERASMDGTMR 1590
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3514-3548 2.64e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 2.64e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3514 CSSTQFLCGNNeKCIPIWWKCDGQKDCSDGSDESD 3548
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3595-3627 2.83e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.83e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3595 RCEANEWQCANKRCIPEYWQCDSVDDCLDNSDE 3627
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3034-3066 3.17e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.17e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3034 CRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQ 3066
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3800-3834 4.79e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 4.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3800 CHPEHFQCTSGHCVPKALACDGRADCLDASDESAC 3834
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1065-1101 4.99e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 4.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1065 TCSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDEQNC 1101
Cdd:pfam00057    2 TCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2183-2226 5.28e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 5.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 160409939   2183 RVLLKVSVDMPRHIVVDPKHRYLFWADYGQkPKIERSFLDCTNR 2226
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4199-4240 6.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 6.73e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4199 GLMFWTDQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDY 4240
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2035-2277 6.73e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 6.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2035 LPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANG-FIYWC 2113
Cdd:COG3391     6 SLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrRLYVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2114 DfsssvRSSNGIRRIKPNGSNFTNIVTYGIGAngiRGVAVDWVAGNLYFTNafvyETLIEVIRINTTYRRVLLKVSV-DM 2192
Cdd:COG3391    86 N-----SGSGRVSVIDLATGKVVATIPVGGGP---RGLAVDPDGGRLYVAD----SGNGRVSVIDTATGKVVATIPVgAG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2193 PRHIVVDPKHRYLFWADYGQkPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDHDTGYIYWVDDSLDiiaRIHRDGGE 2268
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDGRRLYVANRGSN---TSNGGSNT 228


                  ....*....
gi 160409939 2269 SQVVRYGSR 2277
Cdd:COG3391   229 VSVIDLATL 237
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1188-1223 6.94e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 6.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDEAGC 1223
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1884-1929 9.48e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 9.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 160409939  1884 GKLYWSDHGTDsgvpAKIASANMDGTSLKILFTGNMEHLEVVTLDI 1929
Cdd:pfam00058    1 GRLYWTDSSLR----ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3930-3964 9.78e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.78e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3930 CTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGC 3964
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3844-3876 1.19e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.19e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDEE 3876
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1231-1263 1.28e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.28e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDE 1263
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3887-3917 1.94e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 1.94e-07
                            10        20        30
                    ....*....|....*....|....*....|.
gi 160409939   3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDE 3917
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2460-2501 3.17e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.17e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   2460 TILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNR 2501
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
427-576 3.65e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 54.70  E-value: 3.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  427 GVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDaPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITE 506
Cdd:COG3391    72 GADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160409939  507 NlGHPRGIALDPTVGYLFFSDWGSlsgqPKVER--AFMDGSNRKDLVTTKLG-WPAGITLDLVSKRVYWVDSR 576
Cdd:COG3391   151 G-AGPHGIAVDPDGKRLYVANSGS----NTVSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRG 218
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2865-2899 3.71e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2865 CRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDEPD 2899
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3264-3306 4.02e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 4.02e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   3264 ETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQR 3306
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2503-2543 4.61e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 4.61e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   2503 VIARVSKPRAIVLDPCRGYMYWTDWGTnAKIERATLGGNFR 2543
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2783-2818 7.43e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 2783 STTEFTCSNGRCIPLSYVCNGINNCHDNdtSDEKNC 2818
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDG--SDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3684-3716 1.87e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.87e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3684 TEFSCKtNYRCIPQWAVCNGFDDCRDNSDEQGC 3716
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3221-3262 1.95e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 1.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3221 YSLILQGLGNVVALDFDRVEERLYWIDAEKQIIERMFLNKTN 3262
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1354-1389 2.03e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 2.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1354 CLHFNGGCTHRCIQGPFGATCVCPIGYQLANDTKTC 1389
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 2.82e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 2.82e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939     67 CGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADE 99
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 837-878 3.89e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 3.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   837 GYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDW 878
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2950-2986 5.07e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.07e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 160409939   2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDE 2986
Cdd:smart00192    2 CPPGEFQC-----DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2822-2855 5.23e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.23e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   2822 TCQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDE 2855
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 775-817 5.95e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 5.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939    775 EVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSR 817
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 265-299 6.94e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 6.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  265 CYPREWACpGSGRCISMDKVCDGVPDCPEGEDENN 299
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1912-1954 1.50e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 1.50e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   1912 KILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTER 1954
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3124-3152 2.68e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 2.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 160409939  3124 CDHNCTDTITSFYCSCLPGYKLMSDKRTC 3152
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-179 2.93e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939  148 DQLTCANGACYNTSQKCDHKVDCRDSSDEANC 179
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3555-3586 5.78e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 5.78e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDE 3586
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1391-1430 8.14e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 8.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   1391 DVNECDIPGFCSQH--CVNMRGSFRCACDPEYTlesDGRTCK 1430
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 3149-3192 1.76e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 46.22  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 160409939 3149 KRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPDGKS 3192
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2656-2693 3.11e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 160409939  2656 CDQFNGGCSHICAPGPNGAECQCPHEgsWYLANDNKYC 2693
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEG--YELQDDGRTC 36
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3284-3332 3.29e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 3.29e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 160409939  3284 RKLYWLDAILDC-LFVSDLEGRQRKMLAQHCVDanntfcfeNPRGIVLHP 3332
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQ--------HPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 980-1012 3.54e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.54e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939   980 NGDCSHFCFPVPNfQRVCGCPYGMKLQRDQMTC 1012
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3471-3500 6.90e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 6.90e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 160409939  3471 CATNNGGCSHLCLIKAGGRgfTCECPDDFQ 3500
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY--TCSCPEGYE 28
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1313-1345 7.00e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.92  E-value: 7.00e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1313 CPSSQWQCPGySICVNLSALCDGVFDCPNGTDE 1345
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 662-703 9.36e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 9.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   662 CGNNNGGCAQICVlshrtdNGGLGYRCKCEFGFELDADEHHC 703
Cdd:pfam14670    1 CSVNNGGCSHLCL------NTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
4009-4049 1.17e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.17e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   4009 DINECEEFGICPQ--SCRNSKGSYECFCVDGFksmstHYGERC 4049
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY-----TDGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2347-2383 1.66e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 160409939  2347 CLQSNGGCSHFCFALPElpTPKCGCAFG-TLEDDGKNC 2383
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGyELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3406-3443 2.82e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 160409939   3406 DGTLPHPFALTIFEDTVFWTDWNTRTVEKgNKYDGSGR 3443
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEV-ANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 4340-4358 8.48e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 8.48e-03
                           10
                   ....*....|....*....
gi 160409939  4340 CSHLCLLRPGGYSCACPQG 4358
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1710-1741 9.27e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 9.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  1710 CSHLCLLSaqePRHYSCACPSGWNLSDDSVNC 1741
Cdd:pfam14670    8 CSHLCLNT---PGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2595-2626 9.77e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 9.77e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2595 HSFGLTVYGQYIYWTDFYTKKIYRANkYDGSD 2626
Cdd:smart00135   12 NGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1502-1544 1.36e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 1.36e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   1502 RVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHR 1544
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3761-3795 3.45e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 3.45e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3761 CTESEFRCADQQCIPSRWVCDQENDCGDNSDERDC 3795
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2908-2939 4.21e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 4.21e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDE 2939
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2908-2940 5.79e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 5.79e-11
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDED 2940
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 863-903 6.37e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 6.37e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    863 IVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDR 903
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1110-1144 8.81e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 8.81e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1110 CPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNC 1144
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1272-1306 1.51e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 1.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1272 CSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDC 1306
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4224-4266 1.80e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.80e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   4224 VLASANLGWPNGLSIDYLNGdRIYWSDSKEDVIESIKYDGTDR 4266
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEG-RLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3360-3401 1.92e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3360 VIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHR 3401
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3723-3756 2.32e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 2.32e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 160409939 3723 PSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESC 3756
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1270-1306 2.41e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 2.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1270 KTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDC 1306
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2908-2939 4.60e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 4.60e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDE 2939
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3760-3792 4.65e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 4.65e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3760 ECTESEFRCADQQCIPSRWVCDQENDCGDNSDE 3792
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1150-1184 4.69e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 4.69e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1150 CHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGC 1184
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 502-547 4.77e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 4.77e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 160409939    502 TLITENLGHPRGIALDPTVGYLFFSDWgslsGQPKVERAFMDGSNR 547
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW----GLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3636-3668 6.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 6.61e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3636 TCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1109-1141 1.05e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.05e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1109 TCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDE 1141
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2995-3029 1.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.06e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2995 CSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGC 3029
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3635-3668 1.53e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 1.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 160409939  3635 RTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4143-4178 1.54e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.54e-09
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 160409939   4143 LMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYR 4178
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 550-590 1.65e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.65e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    550 LVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQR 590
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3637-3668 1.75e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.75e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939 3637 CRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3721-3753 1.78e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 1.78e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3721 CHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDE 3753
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1271-1303 2.00e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.00e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1271 TCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDE 1303
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2700-2732 2.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.36e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2700 RCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDE 2732
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 183-217 2.47e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.47e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNC 217
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2701-2733 2.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 2701 CNQFQFTCLNGRCISQDWKCDNDNDCGDGSDEL 2733
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 222-256 2.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  222 CGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGC 256
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3077-3111 2.81e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 2.81e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3077 CPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGC 3111
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1149-1181 3.45e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 3.45e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1149 TCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDE 1181
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3335-3376 3.53e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 3.53e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3335 GYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDY 3376
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3076-3108 4.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 4.36e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3076 TCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDE 3108
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1592-1633 5.14e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 5.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   1592 VIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNR 1633
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3761-3795 5.85e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 5.85e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  3761 CTESEFRCADQQCIPSRWVCDQENDCGDNSDERDC 3795
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1025-1059 5.96e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 5.96e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1025 CGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQC 1059
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-142 9.25e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 9.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  108 CSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNC 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2742-2776 9.71e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 9.71e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2742 CRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGC 2776
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-62 1.07e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939   28 CGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGC 62
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 221-253 1.08e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.08e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939    221 TCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDE 253
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
183-217 1.33e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.33e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939   183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNC 217
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1024-1056 1.38e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.38e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1024 QCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDE 1056
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1546-1590 2.28e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 160409939   1546 VLISKNVTKPRGLALDPRmgDNVMFWSDWGHhPRIERASMDGTMR 1590
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1108-1144 2.30e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1108 STCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNC 1144
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3514-3548 2.64e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 2.64e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3514 CSSTQFLCGNNeKCIPIWWKCDGQKDCSDGSDESD 3548
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3595-3627 2.83e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.83e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3595 RCEANEWQCANKRCIPEYWQCDSVDDCLDNSDE 3627
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3034-3066 3.17e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.17e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3034 CRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQ 3066
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3596-3628 3.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.21e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3596 CEANEWQCANKRCIPEYWQCDSVDDCLDNSDED 3628
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3514-3546 3.27e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.27e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3514 CSSTQFLCGNNeKCIPIWWKCDGQKDCSDGSDE 3546
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
220-256 4.18e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 4.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939   220 DTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGC 256
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2993-3029 4.22e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 4.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  2993 RACSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGC 3029
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2995-3026 4.43e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 4.43e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2995 CSTGEFSCANGRCIRQSFRCDRRNDCGDYSDE 3026
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3800-3834 4.79e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 4.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3800 CHPEHFQCTSGHCVPKALACDGRADCLDASDESAC 3834
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1065-1101 4.99e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 4.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1065 TCSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDEQNC 1101
Cdd:pfam00057    2 TCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1066-1101 5.23e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 5.23e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 1066 CSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDEQNC 1101
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2183-2226 5.28e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 5.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 160409939   2183 RVLLKVSVDMPRHIVVDPKHRYLFWADYGQkPKIERSFLDCTNR 2226
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 183-214 6.18e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 6.18e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939    183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDE 214
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4199-4240 6.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 6.73e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4199 GLMFWTDQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDY 4240
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2035-2277 6.73e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 6.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2035 LPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANG-FIYWC 2113
Cdd:COG3391     6 SLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrRLYVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2114 DfsssvRSSNGIRRIKPNGSNFTNIVTYGIGAngiRGVAVDWVAGNLYFTNafvyETLIEVIRINTTYRRVLLKVSV-DM 2192
Cdd:COG3391    86 N-----SGSGRVSVIDLATGKVVATIPVGGGP---RGLAVDPDGGRLYVAD----SGNGRVSVIDTATGKVVATIPVgAG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2193 PRHIVVDPKHRYLFWADYGQkPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDHDTGYIYWVDDSLDiiaRIHRDGGE 2268
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDGRRLYVANRGSN---TSNGGSNT 228


                  ....*....
gi 160409939 2269 SQVVRYGSR 2277
Cdd:COG3391   229 VSVIDLATL 237
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1188-1223 6.94e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 6.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDEAGC 1223
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1149-1184 7.24e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 7.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1149 TCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGC 1184
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-59 8.63e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 8.63e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939     27 ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDE 59
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1884-1929 9.48e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 9.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 160409939  1884 GKLYWSDHGTDsgvpAKIASANMDGTSLKILFTGNMEHLEVVTLDI 1929
Cdd:pfam00058    1 GRLYWTDSSLR----ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3930-3964 9.78e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.78e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3930 CTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGC 3964
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2741-2773 9.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.80e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2741 TCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDE 2773
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3034-3065 1.04e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 1.04e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3034 CRDDQFTCQNGQCITKLYVCDEDNDCGDGSDE 3065
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3844-3876 1.19e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.19e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDEE 3876
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1231-1263 1.28e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.28e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDE 1263
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3799-3831 1.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.34e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3799 TCHPEHFQCTSGHCVPKALACDGRADCLDASDE 3831
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-139 1.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.37e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939    107 TCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDE 139
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2228-2268 1.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.42e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   2228 VLVSEGIVTPRGLAVDHDTGYIYWVDDSLDIIARIHRDGGE 2268
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2700-2733 1.51e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 160409939  2700 RCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDEL 2733
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1231-1265 1.83e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDEHN 1265
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3887-3917 1.94e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 1.94e-07
                            10        20        30
                    ....*....|....*....|....*....|.
gi 160409939   3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDE 3917
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3844-3875 2.43e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.43e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDE 3875
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1065-1098 2.93e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 2.93e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   1065 TCSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDE 1098
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1569-1608 3.13e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 160409939  1569 MFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDY 1608
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2460-2501 3.17e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.17e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   2460 TILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNR 2501
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
427-576 3.65e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 54.70  E-value: 3.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  427 GVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDaPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITE 506
Cdd:COG3391    72 GADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160409939  507 NlGHPRGIALDPTVGYLFFSDWGSlsgqPKVER--AFMDGSNRKDLVTTKLG-WPAGITLDLVSKRVYWVDSR 576
Cdd:COG3391   151 G-AGPHGIAVDPDGKRLYVANSGS----NTVSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRG 218
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2865-2899 3.71e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2865 CRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDEPD 2899
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3264-3306 4.02e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 4.02e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   3264 ETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQR 3306
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2864-2897 4.17e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 4.17e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   2864 TCRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDE 2897
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2503-2543 4.61e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 4.61e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   2503 VIARVSKPRAIVLDPCRGYMYWTDWGTnAKIERATLGGNFR 2543
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3033-3067 4.98e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.98e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  3033 PCRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQE 3067
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2023-2059 5.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 5.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  2023 CSNNPNACQQICLPVPGGMFsCACASGFKLSPDGRSC 2059
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2741-2776 5.49e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 5.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  2741 TCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGC 2776
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3887-3918 7.28e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.28e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939 3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEK 3918
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2783-2818 7.43e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 2783 STTEFTCSNGRCIPLSYVCNGINNCHDNdtSDEKNC 2818
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDG--SDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1024-1059 7.90e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 7.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1024 QCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQC 1059
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
28-62 7.97e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 7.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939    28 CGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGC 62
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3724-3756 8.13e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 8.13e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3724 SGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESC 3756
Cdd:pfam00057    5 PNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1859-1910 9.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 9.42e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 160409939   1859 KTLITNDgtplgVGFPVGIAVDPARGKLYWSDHGTDsgvpaKIASANMDGTS 1910
Cdd:smart00135    1 RTLLSSG-----LGHPNGLAVDWIEGRLYWTDWGLD-----VIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1522-1562 1.69e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 1.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  1522 RNIYWTDYTLE-TIEVSKIDGSHRTVLISKNVTKPRGLALDP 1562
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3684-3716 1.87e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.87e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3684 TEFSCKtNYRCIPQWAVCNGFDDCRDNSDEQGC 3716
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3221-3262 1.95e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 1.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3221 YSLILQGLGNVVALDFDRVEERLYWIDAEKQIIERMFLNKTN 3262
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1354-1389 2.03e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 2.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1354 CLHFNGGCTHRCIQGPFGATCVCPIGYQLANDTKTC 1389
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1231-1265 2.08e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDEHN 1265
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1188-1220 2.12e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.12e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDE 1220
Cdd:smart00192    2 CPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2864-2899 2.21e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.21e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  2864 TCRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDEPD 2899
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 2.82e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 2.82e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939     67 CGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADE 99
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3930-3961 3.46e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.46e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3930 CTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDE 3961
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3844-3876 3.64e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDEE 3876
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 837-878 3.89e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 3.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   837 GYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDW 878
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-142 4.30e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939   106 TTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNC 142
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2950-2986 5.07e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.07e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 160409939   2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDE 2986
Cdd:smart00192    2 CPPGEFQC-----DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 67-103 5.12e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 5.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 160409939   67 CGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADEqQNC 103
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE-ENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2822-2855 5.23e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.23e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   2822 TCQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDE 2855
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4179-4222 5.40e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 5.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 160409939   4179 KWLITTQLDQPAAIAVNPKLGLMFWTDQGkQPKIESAWMNGEHR 4222
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 775-817 5.95e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 5.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939    775 EVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSR 817
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3323-3357 6.07e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 6.07e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 160409939   3323 ENPRGIVLHPQRGYVYWADWGdHAYIARIGMDGTN 3357
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3798-3834 6.76e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 6.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  3798 KTCHPEHFQCTSGHCVPKALACDGRADCLDASDESAC 3834
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2520-2556 6.87e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 6.87e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  2520 GYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNG 2556
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNA 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 265-299 6.94e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 6.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  265 CYPREWACpGSGRCISMDKVCDGVPDCPEGEDENN 299
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 521-564 7.29e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 7.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 160409939   521 GYLFFSDWGSlsgQPKVERAFMDGSNRKDLVTTKLGWPAGITLD 564
Cdd:pfam00058    1 GRLYWTDSSL---RASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1188-1223 7.68e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.32  E-value: 7.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDEAGC 1223
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2950-2990 9.04e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 9.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 160409939 2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDElQNC 2990
Cdd:cd00112     1 CPPNEFRC-----ANGRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-500 1.06e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 1.06e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    460 ILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQR 500
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2783-2815 1.07e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 1.07e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2783 STTEFTCSNGRCIPLSYVCNGINNCHDNdtSDE 2815
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDG--SDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1912-1954 1.50e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 1.50e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   1912 KILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTER 1954
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3595-3627 1.56e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 1.56e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3595 RCEANEWQCANKRCIPEYWQCDSVDDCLDNSDE 3627
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2203-2244 1.60e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 1.60e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  2203 RYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDH 2244
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2786-2818 1.93e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 1.93e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  2786 EFTCSNGRCIPLSYVCNGINNCHDNdtSDEKNC 2818
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDG--SDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 264-297 2.02e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 2.02e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939    264 TCYPREWACpGSGRCISMDKVCDGVPDCPEGEDE 297
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3076-3111 2.17e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 2.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  3076 TCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGC 3111
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3124-3152 2.68e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 2.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 160409939  3124 CDHNCTDTITSFYCSCLPGYKLMSDKRTC 3152
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-179 2.93e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939  148 DQLTCANGACYNTSQKCDHKVDCRDSSDEANC 179
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3514-3548 3.03e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 3.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  3514 CSSTQFLCGNNEkCIPIWWKCDGQKDCSDGSDESD 3548
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3684-3713 3.90e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.90e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 160409939   3684 TEFSCKtNYRCIPQWAVCNGFDDCRDNSDE 3713
Cdd:smart00192    5 GEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3555-3586 5.78e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 5.78e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDE 3586
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2823-2856 5.89e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.96  E-value: 5.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 160409939 2823 CQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDEN 2856
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1391-1430 8.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 8.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   1391 DVNECDIPGFCSQH--CVNMRGSFRCACDPEYTlesDGRTCK 1430
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2418-2530 8.61e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 8.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2418 VEGMAIALDYDRRNNRIFFTqklNPIRGQISYVNLYSGASSPTILLSniGVTDGIAFDWINRRIYYSDFSNQTINSMaeD 2497
Cdd:COG3391    66 AVADADGADAGADGRRLYVA---NSGSGRVSVIDLATGKVVATIPVG--GGPRGLAVDPDGGRLYVADSGNGRVSVI--D 138

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 160409939 2498 GSNRAVIARVS---KPRAIVLDPCRGYMYWTDWGTN 2530
Cdd:COG3391   139 TATGKVVATIPvgaGPHGIAVDPDGKRLYVANSGSN 174
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2822-2855 1.00e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 160409939  2822 TCQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDE 2855
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3555-3587 1.03e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDED 3587
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
65-101 1.20e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.20e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939    65 RSCGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADEQQ 101
Cdd:pfam00057    1 STCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4156-4196 1.43e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 1.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4156 RHIYWSDAKSQ-RIEVATLDGRYRKWLITTQLDQPAAIAVNP 4196
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 3149-3192 1.76e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 46.22  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 160409939 3149 KRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPDGKS 3192
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
264-299 1.83e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939   264 TCYPREWACpGSGRCISMDKVCDGVPDCPEGEDENN 299
Cdd:pfam00057    2 TCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2950-2990 1.98e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 1.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 160409939  2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDElQNC 2990
Cdd:pfam00057    3 CSPNEFQC-----GSGECIPRSWVCDGDPDCGDGSDE-ENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3928-3964 2.08e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 2.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  3928 KPCTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGC 3964
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2656-2693 3.11e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 160409939  2656 CDQFNGGCSHICAPGPNGAECQCPHEgsWYLANDNKYC 2693
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEG--YELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3284-3332 3.29e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 3.29e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 160409939  3284 RKLYWLDAILDC-LFVSDLEGRQRKMLAQHCVDanntfcfeNPRGIVLHP 3332
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQ--------HPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 980-1012 3.54e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.54e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939   980 NGDCSHFCFPVPNfQRVCGCPYGMKLQRDQMTC 1012
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3154-3193 3.73e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 3.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3154 DIDECkETPQLCSQ--KCENVIGSYICKCAPGYIrepDGKSC 3193
Cdd:smart00179    1 DIDEC-ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 795-834 5.07e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 5.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   795 RNLYWTDGGSK-SVTVMKLADKSRRQIIS-NLNNPRSIVVHP 834
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3887-3919 5.89e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 5.89e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKE 3919
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4145-4251 6.11e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 4145 QPDGLAVDWVGrHIYWSDAKSQRIEVATLDGRY-RKW----LITTQLDQPAAIAVNPKlGLMFWTDQGKQpKIESAWMNG 4219
Cdd:cd14956   155 YPRGVAVDPDG-TLYVADTYNDRIQVFDNDGAFlRKWggrgTGPGQFNYPYGIAIDPD-GNVFVADFGNN-RIQKFTADG 231

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 160409939 4220 EHRSVLASAN-----LGWPNGLSIDYlNGdRIYWSDS 4251
Cdd:cd14956   232 TFLTSWGSPGtgpgqFKNPWGVVVDA-DG-TVYVADS 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3471-3500 6.90e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 6.90e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 160409939  3471 CATNNGGCSHLCLIKAGGRgfTCECPDDFQ 3500
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY--TCSCPEGYE 28
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1313-1345 7.00e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.92  E-value: 7.00e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1313 CPSSQWQCPGySICVNLSALCDGVFDCPNGTDE 1345
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 435-575 7.10e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.00  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  435 HRVfwtdpmqaKVFSTDINGLNT---QEILNVSIDAPENLAVDwINNKLYLVETRVNRIDVVNLEGNQRVTLITENLG-- 509
Cdd:cd05819   123 HRI--------QKFDPDGEFLTTfgsGGSGPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDGNFLTTFGSTGTGpg 193

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160409939  510 ---HPRGIALDPTvGYLFFSDWGSLSGQ--PKVERAFmDGSNRKDLVTTKLGWPAGITLDLvSKRVYWVDS 575
Cdd:cd05819   194 qfnYPTGIAVDSD-GNIYVADSGNNRVQvfDPDGAGF-GGNGNFLGSDGQFNRPSGLAVDS-DGNLYVADT 261
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 662-703 9.36e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 9.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   662 CGNNNGGCAQICVlshrtdNGGLGYRCKCEFGFELDADEHHC 703
Cdd:pfam14670    1 CSVNNGGCSHLCL------NTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1401-1429 1.15e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 1.15e-03
                           10        20
                   ....*....|....*....|....*....
gi 160409939  1401 CSQHCVNMRGSFRCACDPEYTLESDGRTC 1429
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
4009-4049 1.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.17e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   4009 DINECEEFGICPQ--SCRNSKGSYECFCVDGFksmstHYGERC 4049
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY-----TDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1391-1430 1.31e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 160409939 1391 DVNECDIPGFCSQH--CVNMRGSFRCACDPEYTlesdGRTCK 1430
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT----GRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 817-859 1.59e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 1.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939    817 RRQIISNLNNPRSIVVHPAAGYMFLSDWFRPaKIMRAWSDGSH 859
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2347-2383 1.66e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 160409939  2347 CLQSNGGCSHFCFALPElpTPKCGCAFG-TLEDDGKNC 2383
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGyELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3379-3419 1.67e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 1.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3379 DLLYWADAHLGYIEFS-DLEGHHRHTVYDGTLPHPFALTIFE 3419
Cdd:pfam00058    1 GRLYWTDSSLRASISSaDLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
3113-3153 2.05e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   3113 INECQDSSISHCDHNCTDTITSFYCSCLPGYklmSDKRTCV 3153
Cdd:smart00179    2 IDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 146-176 2.66e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 2.66e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 160409939    146 TCDQLTCANGACYNTSQKCDHKVDCRDSSDE 176
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3406-3443 2.82e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 160409939   3406 DGTLPHPFALTIFEDTVFWTDWNTRTVEKgNKYDGSGR 3443
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEV-ANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1313-1345 3.21e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 3.21e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 1313 CPSSQWQCpGYSICVNLSALCDGVFDCPNGTDE 1345
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4009-4038 3.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 3.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939 4009 DINECEEFGICP--QSCRNSKGSYECFCVDGF 4038
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 436-475 4.25e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 4.25e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 160409939   436 RVFWTD-PMQAKVFSTDINGLNTQEILNVSIDAPENLAVDW 475
Cdd:pfam00058    2 RLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3555-3586 4.51e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 4.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDE 3586
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4244-4283 5.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 5.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4244 DRIYWSDSKED-VIESIKYDGTDRR-LIINDAMKPFSLDIFE 4283
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKtLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3158-3193 6.13e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 6.13e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  3158 CKETPQLCSQKCENVIGSYICKCAPGYIREPDGKSC 3193
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3113-3145 6.63e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 6.63e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3113 INECQDSSISHCDHNCTDTITSFYCSCLPGYKL 3145
Cdd:cd00054     2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3241-3281 7.31e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 7.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3241 ERLYWIDA-EKQIIERMFLNKTNQETIISHRLRRAESLAVDW 3281
Cdd:pfam00058    1 GRLYWTDSsLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 4340-4358 8.48e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 8.48e-03
                           10
                   ....*....|....*....
gi 160409939  4340 CSHLCLLRPGGYSCACPQG 4358
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1710-1741 9.27e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 9.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  1710 CSHLCLLSaqePRHYSCACPSGWNLSDDSVNC 1741
Cdd:pfam14670    8 CSHLCLNT---PGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2595-2626 9.77e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 9.77e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2595 HSFGLTVYGQYIYWTDFYTKKIYRANkYDGSD 2626
Cdd:smart00135   12 NGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1502-1544 1.36e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 1.36e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   1502 RVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHR 1544
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3761-3795 3.45e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 3.45e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3761 CTESEFRCADQQCIPSRWVCDQENDCGDNSDERDC 3795
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2908-2939 4.21e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 4.21e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDE 2939
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2908-2940 5.79e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.91  E-value: 5.79e-11
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDED 2940
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 863-903 6.37e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 6.37e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    863 IVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDR 903
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1110-1144 8.81e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 8.81e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1110 CPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNC 1144
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1272-1306 1.51e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 1.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1272 CSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDC 1306
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4224-4266 1.80e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.80e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   4224 VLASANLGWPNGLSIDYLNGdRIYWSDSKEDVIESIKYDGTDR 4266
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEG-RLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3360-3401 1.92e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3360 VIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHR 3401
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3723-3756 2.32e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 2.32e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 160409939 3723 PSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESC 3756
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1270-1306 2.41e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 2.41e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1270 KTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDC 1306
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2908-2939 4.60e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 4.60e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  2908 CSANQFHCDNGRCISSSWVCDGDNDCGDMSDE 2939
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3760-3792 4.65e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 4.65e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3760 ECTESEFRCADQQCIPSRWVCDQENDCGDNSDE 3792
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1150-1184 4.69e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 4.69e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1150 CHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGC 1184
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 502-547 4.77e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 4.77e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 160409939    502 TLITENLGHPRGIALDPTVGYLFFSDWgslsGQPKVERAFMDGSNR 547
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW----GLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3636-3668 6.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 6.61e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3636 TCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1109-1141 1.05e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.05e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1109 TCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDE 1141
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2995-3029 1.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.06e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2995 CSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGC 3029
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3635-3668 1.53e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 1.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 160409939  3635 RTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4143-4178 1.54e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.54e-09
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 160409939   4143 LMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYR 4178
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 550-590 1.65e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 1.65e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    550 LVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQR 590
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3637-3668 1.75e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.75e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939 3637 CRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDE 3668
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3721-3753 1.78e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 1.78e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3721 CHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDE 3753
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1271-1303 2.00e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.00e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1271 TCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDE 1303
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2700-2732 2.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.36e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2700 RCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDE 2732
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 183-217 2.47e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.47e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNC 217
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2701-2733 2.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 2701 CNQFQFTCLNGRCISQDWKCDNDNDCGDGSDEL 2733
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 222-256 2.54e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.54e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  222 CGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGC 256
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3077-3111 2.81e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 2.81e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3077 CPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGC 3111
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1149-1181 3.45e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 3.45e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1149 TCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDE 1181
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3335-3376 3.53e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.86  E-value: 3.53e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3335 GYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDY 3376
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3076-3108 4.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 4.36e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3076 TCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDE 3108
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1592-1633 5.14e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 5.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   1592 VIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNR 1633
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3761-3795 5.85e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 5.85e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  3761 CTESEFRCADQQCIPSRWVCDQENDCGDNSDERDC 3795
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1025-1059 5.96e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 5.96e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1025 CGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQC 1059
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-142 9.25e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 9.25e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  108 CSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNC 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2742-2776 9.71e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 9.71e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2742 CRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGC 2776
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-62 1.07e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939   28 CGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGC 62
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 221-253 1.08e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.08e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939    221 TCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDE 253
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
183-217 1.33e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.33e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939   183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNC 217
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1024-1056 1.38e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.38e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1024 QCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDE 1056
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1546-1590 2.28e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 160409939   1546 VLISKNVTKPRGLALDPRmgDNVMFWSDWGHhPRIERASMDGTMR 1590
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1108-1144 2.30e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1108 STCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNC 1144
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3514-3548 2.64e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 2.64e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3514 CSSTQFLCGNNeKCIPIWWKCDGQKDCSDGSDESD 3548
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3595-3627 2.83e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.83e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3595 RCEANEWQCANKRCIPEYWQCDSVDDCLDNSDE 3627
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3034-3066 3.17e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.17e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3034 CRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQ 3066
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3596-3628 3.21e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.21e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3596 CEANEWQCANKRCIPEYWQCDSVDDCLDNSDED 3628
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3514-3546 3.27e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.27e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3514 CSSTQFLCGNNeKCIPIWWKCDGQKDCSDGSDE 3546
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
220-256 4.18e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 4.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939   220 DTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGC 256
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2993-3029 4.22e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 4.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  2993 RACSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGC 3029
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2995-3026 4.43e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 4.43e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2995 CSTGEFSCANGRCIRQSFRCDRRNDCGDYSDE 3026
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3800-3834 4.79e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 4.79e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3800 CHPEHFQCTSGHCVPKALACDGRADCLDASDESAC 3834
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1065-1101 4.99e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 4.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  1065 TCSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDEQNC 1101
Cdd:pfam00057    2 TCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1066-1101 5.23e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 5.23e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 1066 CSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDEQNC 1101
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2183-2226 5.28e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 5.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 160409939   2183 RVLLKVSVDMPRHIVVDPKHRYLFWADYGQkPKIERSFLDCTNR 2226
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 183-214 6.18e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 6.18e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939    183 CSQKEFQCGSGECILRAYVCDHDNDCEDNSDE 214
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4199-4240 6.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 6.73e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4199 GLMFWTDQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDY 4240
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2035-2277 6.73e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 6.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2035 LPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANG-FIYWC 2113
Cdd:COG3391     6 SLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrRLYVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2114 DfsssvRSSNGIRRIKPNGSNFTNIVTYGIGAngiRGVAVDWVAGNLYFTNafvyETLIEVIRINTTYRRVLLKVSV-DM 2192
Cdd:COG3391    86 N-----SGSGRVSVIDLATGKVVATIPVGGGP---RGLAVDPDGGRLYVAD----SGNGRVSVIDTATGKVVATIPVgAG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2193 PRHIVVDPKHRYLFWADYGQkPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDHDTGYIYWVDDSLDiiaRIHRDGGE 2268
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDGRRLYVANRGSN---TSNGGSNT 228


                  ....*....
gi 160409939 2269 SQVVRYGSR 2277
Cdd:COG3391   229 VSVIDLATL 237
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1188-1223 6.94e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 6.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDEAGC 1223
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1149-1184 7.24e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 7.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1149 TCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGC 1184
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-59 8.63e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 8.63e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939     27 ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDE 59
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1884-1929 9.48e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 9.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 160409939  1884 GKLYWSDHGTDsgvpAKIASANMDGTSLKILFTGNMEHLEVVTLDI 1929
Cdd:pfam00058    1 GRLYWTDSSLR----ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3930-3964 9.78e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 9.78e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 3930 CTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGC 3964
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2741-2773 9.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.80e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2741 TCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDE 2773
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3034-3065 1.04e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 1.04e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3034 CRDDQFTCQNGQCITKLYVCDEDNDCGDGSDE 3065
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3844-3876 1.19e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.67  E-value: 1.19e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDEE 3876
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1231-1263 1.28e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.28e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDE 1263
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3799-3831 1.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.34e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   3799 TCHPEHFQCTSGHCVPKALACDGRADCLDASDE 3831
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-139 1.37e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.37e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939    107 TCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDE 139
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2228-2268 1.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.42e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   2228 VLVSEGIVTPRGLAVDHDTGYIYWVDDSLDIIARIHRDGGE 2268
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2700-2733 1.51e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 160409939  2700 RCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDEL 2733
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1231-1265 1.83e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDEHN 1265
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3887-3917 1.94e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 1.94e-07
                            10        20        30
                    ....*....|....*....|....*....|.
gi 160409939   3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDE 3917
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3844-3875 2.43e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.43e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDE 3875
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1065-1098 2.93e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 2.93e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   1065 TCSSSAFTCvHGGQCIPGQWRCDKQNDCLDGSDE 1098
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1569-1608 3.13e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 160409939  1569 MFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDY 1608
Cdd:pfam00058    3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2460-2501 3.17e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.52  E-value: 3.17e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   2460 TILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNR 2501
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
427-576 3.65e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 54.70  E-value: 3.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  427 GVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDaPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITE 506
Cdd:COG3391    72 GADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160409939  507 NlGHPRGIALDPTVGYLFFSDWGSlsgqPKVER--AFMDGSNRKDLVTTKLG-WPAGITLDLVSKRVYWVDSR 576
Cdd:COG3391   151 G-AGPHGIAVDPDGKRLYVANSGS----NTVSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRG 218
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2865-2899 3.71e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939 2865 CRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDEPD 2899
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3264-3306 4.02e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 4.02e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   3264 ETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQR 3306
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2864-2897 4.17e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 4.17e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   2864 TCRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDE 2897
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2503-2543 4.61e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 4.61e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   2503 VIARVSKPRAIVLDPCRGYMYWTDWGTnAKIERATLGGNFR 2543
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3033-3067 4.98e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 4.98e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  3033 PCRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQE 3067
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2023-2059 5.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 5.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  2023 CSNNPNACQQICLPVPGGMFsCACASGFKLSPDGRSC 2059
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2741-2776 5.49e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 5.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  2741 TCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGC 2776
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3887-3918 7.28e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.28e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939 3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEK 3918
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2783-2818 7.43e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 160409939 2783 STTEFTCSNGRCIPLSYVCNGINNCHDNdtSDEKNC 2818
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDG--SDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1024-1059 7.90e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 7.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1024 QCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQC 1059
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
28-62 7.97e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 7.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939    28 CGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGC 62
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3724-3756 8.13e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 8.13e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3724 SGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESC 3756
Cdd:pfam00057    5 PNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1859-1910 9.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 9.42e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 160409939   1859 KTLITNDgtplgVGFPVGIAVDPARGKLYWSDHGTDsgvpaKIASANMDGTS 1910
Cdd:smart00135    1 RTLLSSG-----LGHPNGLAVDWIEGRLYWTDWGLD-----VIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
477-608 1.40e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.77  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  477 NNKLYLVETRVNRIDVVNLEGNQRVTLITENlGHPRGIALDPTVGYLFFSDWGSlsgqPKVerAFMDGSNRKDLVTTKLG 556
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGN----GRV--SVIDTATGKVVATIPVG 151

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 160409939  557 -WPAGITLDLVSKRVYWVDSRYDYIETVTY--DGIQRKTVARgGSLVPHPFGISL 608
Cdd:COG3391   152 aGPHGIAVDPDGKRLYVANSGSNTVSVIVSviDTATGKVVAT-IPVGGGPVGVAV 205
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1522-1562 1.69e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 1.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  1522 RNIYWTDYTLE-TIEVSKIDGSHRTVLISKNVTKPRGLALDP 1562
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3684-3716 1.87e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.87e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3684 TEFSCKtNYRCIPQWAVCNGFDDCRDNSDEQGC 3716
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3221-3262 1.95e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 1.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3221 YSLILQGLGNVVALDFDRVEERLYWIDAEKQIIERMFLNKTN 3262
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1354-1389 2.03e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.85  E-value: 2.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1354 CLHFNGGCTHRCIQGPFGATCVCPIGYQLANDTKTC 1389
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1231-1265 2.08e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  1231 CHPDEFQCqGDGTCIPNTWECDGHPDCIQGSDEHN 1265
Cdd:pfam00057    3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1188-1220 2.12e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.12e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDE 1220
Cdd:smart00192    2 CPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2864-2899 2.21e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.21e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  2864 TCRSNEFQCVSpHRCIPSYWFCDGEADCVDSSDEPD 2899
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 67-99 2.82e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 2.82e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939     67 CGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADE 99
Cdd:smart00192    2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3930-3961 3.46e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.46e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3930 CTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDE 3961
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3844-3876 3.64e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 3.64e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3844 CPAAMFECKNHVCIQSFWICDGENDCVDGSDEE 3876
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 837-878 3.89e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 3.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   837 GYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDW 878
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-142 4.30e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939   106 TTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNC 142
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2950-2986 5.07e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.07e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 160409939   2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDE 2986
Cdd:smart00192    2 CPPGEFQC-----DNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 67-103 5.12e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 5.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 160409939   67 CGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADEqQNC 103
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE-ENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2822-2855 5.23e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.23e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939   2822 TCQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDE 2855
Cdd:smart00192    1 TCPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4179-4222 5.40e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 5.40e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 160409939   4179 KWLITTQLDQPAAIAVNPKLGLMFWTDQGkQPKIESAWMNGEHR 4222
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 775-817 5.95e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 5.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939    775 EVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSR 817
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3323-3357 6.07e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 6.07e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 160409939   3323 ENPRGIVLHPQRGYVYWADWGdHAYIARIGMDGTN 3357
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3798-3834 6.76e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 6.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  3798 KTCHPEHFQCTSGHCVPKALACDGRADCLDASDESAC 3834
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2520-2556 6.87e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 6.87e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  2520 GYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNG 2556
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNA 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 265-299 6.94e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 6.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 160409939  265 CYPREWACpGSGRCISMDKVCDGVPDCPEGEDENN 299
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 521-564 7.29e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 7.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 160409939   521 GYLFFSDWGSlsgQPKVERAFMDGSNRKDLVTTKLGWPAGITLD 564
Cdd:pfam00058    1 GRLYWTDSSL---RASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1188-1223 7.68e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.32  E-value: 7.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  1188 CTSSQFKCADGSsCINSRYRCDGVYDCKDNSDEAGC 1223
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2950-2990 9.04e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 9.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 160409939 2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDElQNC 2990
Cdd:cd00112     1 CPPNEFRC-----ANGRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-500 1.06e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 1.06e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939    460 ILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQR 500
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2783-2815 1.07e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 1.07e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   2783 STTEFTCSNGRCIPLSYVCNGINNCHDNdtSDE 2815
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDG--SDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1912-1954 1.50e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 1.50e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   1912 KILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTER 1954
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3595-3627 1.56e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 1.56e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3595 RCEANEWQCANKRCIPEYWQCDSVDDCLDNSDE 3627
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2203-2244 1.60e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 1.60e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  2203 RYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDH 2244
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2786-2818 1.93e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 1.93e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  2786 EFTCSNGRCIPLSYVCNGINNCHDNdtSDEKNC 2818
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDG--SDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 264-297 2.02e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 2.02e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 160409939    264 TCYPREWACpGSGRCISMDKVCDGVPDCPEGEDE 297
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3076-3111 2.17e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.16  E-value: 2.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  3076 TCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGC 3111
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3124-3152 2.68e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 2.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 160409939  3124 CDHNCTDTITSFYCSCLPGYKLMSDKRTC 3152
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2090-2294 2.75e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 49.25  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2090 PVAGQGRNVLHADVDvANGFIYWCDFSSsvrssNGIRRIKPNGSNFTnivTYGIGAN-GIRGVAVDwVAGNLYFT----N 2164
Cdd:COG4257    11 PVPAPGSGPRDVAVD-PDGAVWFTDQGG-----GRIGRLDPATGEFT---EYPLGGGsGPHGIAVD-PDGNLWFTdngnN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2165 AfvyetlieVIRINT---TYRRVLLKVSVDMPRHIVVDPKHRYLFWADYGQKpkIERsfLDCTNRTVLVSEGIVT---PR 2238
Cdd:COG4257    81 R--------IGRIDPktgEITTFALPGGGSNPHGIAFDPDGNLWFTDQGGNR--IGR--LDPATGEVTEFPLPTGgagPY 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 160409939 2239 GLAVDHDtGYIYWVDDSLDIIARIHRDGGESQVVRYGSRYPTPYGITVFGESIIWV 2294
Cdd:COG4257   149 GIAVDPD-GNLWVTDFGANAIGRIDPDTGTLTEYALPTPGAGPRGLAVDPDGNLWV 203
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-179 2.93e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.93e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939  148 DQLTCANGACYNTSQKCDHKVDCRDSSDEANC 179
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3514-3548 3.03e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 3.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 160409939  3514 CSSTQFLCGNNEkCIPIWWKCDGQKDCSDGSDESD 3548
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEEN 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3684-3713 3.90e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.90e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 160409939   3684 TEFSCKtNYRCIPQWAVCNGFDDCRDNSDE 3713
Cdd:smart00192    5 GEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3555-3586 5.78e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 5.78e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDE 3586
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2823-2856 5.89e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.96  E-value: 5.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 160409939 2823 CQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDEN 2856
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1391-1430 8.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 8.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   1391 DVNECDIPGFCSQH--CVNMRGSFRCACDPEYTlesDGRTCK 1430
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2418-2530 8.61e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 8.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2418 VEGMAIALDYDRRNNRIFFTqklNPIRGQISYVNLYSGASSPTILLSniGVTDGIAFDWINRRIYYSDFSNQTINSMaeD 2497
Cdd:COG3391    66 AVADADGADAGADGRRLYVA---NSGSGRVSVIDLATGKVVATIPVG--GGPRGLAVDPDGGRLYVADSGNGRVSVI--D 138

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 160409939 2498 GSNRAVIARVS---KPRAIVLDPCRGYMYWTDWGTN 2530
Cdd:COG3391   139 TATGKVVATIPvgaGPHGIAVDPDGKRLYVANSGSN 174
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2822-2855 1.00e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 160409939  2822 TCQPDFAKCQTtNICVPRAFLCDGDNDCGDGSDE 2855
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3555-3587 1.03e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDED 3587
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3324-3449 1.03e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 3324 NPRGIVLHPQRGYVYWADWGDHAyIARIgmDGTNKTVIISTKI-EWPNAITIDYTNDLLYWADAHLGYI-----EFsDLE 3397
Cdd:COG3391   111 GPRGLAVDPDGGRLYVADSGNGR-VSVI--DTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSNTVsvivsVI-DTA 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 160409939 3398 -GHHRHTVYDGTLPHPFALTIFEDTVFWTDWNTRTVEKGNkydgsGRVVLVNT 3449
Cdd:COG3391   187 tGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTSNGGS-----NTVSVIDL 234
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
743-892 1.04e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  743 VGIDFDAQHSTIFYSDLSKNIIyqQKID-GTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQII 821
Cdd:COG3391    71 DGADAGADGRRLYVANSGSGRV--SVIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 160409939  822 SNLNNPRSIVVHPAAGYMFLSDWFRP--AKIMRAW--SDGSHLMPIvnTSLGWPNGLAIDWSTSRLYWVDAFFDK 892
Cdd:COG3391   149 PVGAGPHGIAVDPDGKRLYVANSGSNtvSVIVSVIdtATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRGSNT 221
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
65-101 1.20e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.20e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939    65 RSCGSGFFLCpAEGTCIPSSWVCDQDKDCSDGADEQQ 101
Cdd:pfam00057    1 STCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4156-4196 1.43e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 1.43e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4156 RHIYWSDAKSQ-RIEVATLDGRYRKWLITTQLDQPAAIAVNP 4196
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 3149-3192 1.76e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 46.22  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 160409939 3149 KRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPDGKS 3192
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
264-299 1.83e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 1.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939   264 TCYPREWACpGSGRCISMDKVCDGVPDCPEGEDENN 299
Cdd:pfam00057    2 TCSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEEN 36
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 3136-3157 1.95e-04

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 41.24  E-value: 1.95e-04
                           10        20
                   ....*....|....*....|..
gi 160409939  3136 YCSCLPGYKLMSDKRTCVDIDE 3157
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2950-2990 1.98e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 1.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 160409939  2950 CSSTEFTCinsrpPNRRCIPQHWVCDGDADCADALDElQNC 2990
Cdd:pfam00057    3 CSPNEFQC-----GSGECIPRSWVCDGDPDCGDGSDE-ENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3928-3964 2.08e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 2.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 160409939  3928 KPCTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGC 3964
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2138-2294 2.59e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.17  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2138 IVTYGIGA--NGIRGVAVDwVAGNLYFTNAFVYEtlIEVIRINTTYRRVLLKVSVDMPRHIVVDPKHRyLFWADYGQKpK 2215
Cdd:COG4257     7 ITEYPVPApgSGPRDVAVD-PDGAVWFTDQGGGR--IGRLDPATGEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNN-R 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 2216 IERsfLDCTN---RTVLVSEGIVTPRGLAVDHDtGYIYWVDDSLDIIARIHRDGGESQVVRYGSRYPTPYGITVFGESII 2292
Cdd:COG4257    82 IGR--IDPKTgeiTTFALPGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGEVTEFPLPTGGAGPYGIAVDPDGNL 158


                  ..
gi 160409939 2293 WV 2294
Cdd:COG4257   159 WV 160
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2656-2693 3.11e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 160409939  2656 CDQFNGGCSHICAPGPNGAECQCPHEgsWYLANDNKYC 2693
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEG--YELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3284-3332 3.29e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 3.29e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 160409939  3284 RKLYWLDAILDC-LFVSDLEGRQRKMLAQHCVDanntfcfeNPRGIVLHP 3332
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQ--------HPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 980-1012 3.54e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.69  E-value: 3.54e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939   980 NGDCSHFCFPVPNfQRVCGCPYGMKLQRDQMTC 1012
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3154-3193 3.73e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 3.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 160409939   3154 DIDECkETPQLCSQ--KCENVIGSYICKCAPGYIrepDGKSC 3193
Cdd:smart00179    1 DIDEC-ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 795-834 5.07e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 5.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   795 RNLYWTDGGSK-SVTVMKLADKSRRQIIS-NLNNPRSIVVHP 834
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3887-3919 5.89e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 5.89e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 160409939  3887 SPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKE 3919
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4145-4251 6.11e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 4145 QPDGLAVDWVGrHIYWSDAKSQRIEVATLDGRY-RKW----LITTQLDQPAAIAVNPKlGLMFWTDQGKQpKIESAWMNG 4219
Cdd:cd14956   155 YPRGVAVDPDG-TLYVADTYNDRIQVFDNDGAFlRKWggrgTGPGQFNYPYGIAIDPD-GNVFVADFGNN-RIQKFTADG 231

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 160409939 4220 EHRSVLASAN-----LGWPNGLSIDYlNGdRIYWSDS 4251
Cdd:cd14956   232 TFLTSWGSPGtgpgqFKNPWGVVVDA-DG-TVYVADS 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3471-3500 6.90e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 6.90e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 160409939  3471 CATNNGGCSHLCLIKAGGRgfTCECPDDFQ 3500
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY--TCSCPEGYE 28
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1313-1345 7.00e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.92  E-value: 7.00e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 160409939   1313 CPSSQWQCPGySICVNLSALCDGVFDCPNGTDE 1345
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 435-575 7.10e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.00  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  435 HRVfwtdpmqaKVFSTDINGLNT---QEILNVSIDAPENLAVDwINNKLYLVETRVNRIDVVNLEGNQRVTLITENLG-- 509
Cdd:cd05819   123 HRI--------QKFDPDGEFLTTfgsGGSGPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDGNFLTTFGSTGTGpg 193

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160409939  510 ---HPRGIALDPTvGYLFFSDWGSLSGQ--PKVERAFmDGSNRKDLVTTKLGWPAGITLDLvSKRVYWVDS 575
Cdd:cd05819   194 qfnYPTGIAVDSD-GNIYVADSGNNRVQvfDPDGAGF-GGNGNFLGSDGQFNRPSGLAVDS-DGNLYVADT 261
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 468-618 8.26e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  468 PENLAVDwINNKLYLVETRVNRIDVVNLEGNQRVTLIT-----ENLGHPRGIALDPTvGYLFFSDWG-------SLSGQp 535
Cdd:cd05819    10 PQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSfgsgdGQFNEPAGVAVDSD-GNLYVADTGnhriqkfDPDGN- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  536 kveraFMDGSNRKDLVTTKLGWPAGITLDLvSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVP---HPFGISLF-EE 611
Cdd:cd05819    87 -----FLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFLTTFGSGGSGPGqfnGPTGVAVDsDG 160


                  ....*..
gi 160409939  612 HVFFTDW 618
Cdd:cd05819   161 NIYVADT 167
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 489-518 8.98e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 8.98e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 160409939   489 RIDVVNLEGNQRVTLITENLGHPRGIALDP 518
Cdd:pfam00058   13 SISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 662-703 9.36e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 9.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939   662 CGNNNGGCAQICVlshrtdNGGLGYRCKCEFGFELDADEHHC 703
Cdd:pfam14670    1 CSVNNGGCSHLCL------NTPGGYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 397-576 1.13e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.20  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  397 FSNGRdLLVGDLHGRNFRILAESKNR-GIVMGVDFHYQKHRVFWTD--PMQAKVFstDINGlntQEILNVS--------I 465
Cdd:cd14963    74 LYNGR-IQVFDPDGKFLKYFPEKKDRvKLISPAGLAIDDGKLYVSDvkKHKVIVF--DLEG---KLLLEFGkpgsepgeL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939  466 DAPENLAVDwINNKLYLVETRVNRIDVVNLEGN-----QRVTLITENLGHPRGIALDPTvGYLFFSDwgSLSGQ-----P 535
Cdd:cd14963   148 SYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKfikelNGSPDGKSGFVNPRGIAVDPD-GNLYVVD--NLSHRvyvfdE 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 160409939  536 KVERAFMDGSNRKDLVTTKLgwPAGITLDlVSKRVY---WVDSR 576
Cdd:cd14963   224 QGKELFTFGGRGKDDGQFNL--PNGLFID-DDGRLYvtdRENNR 264
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1401-1429 1.15e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 1.15e-03
                           10        20
                   ....*....|....*....|....*....
gi 160409939  1401 CSQHCVNMRGSFRCACDPEYTLESDGRTC 1429
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
4009-4049 1.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.17e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939   4009 DINECEEFGICPQ--SCRNSKGSYECFCVDGFksmstHYGERC 4049
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY-----TDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1391-1430 1.31e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 160409939 1391 DVNECDIPGFCSQH--CVNMRGSFRCACDPEYTlesdGRTCK 1430
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT----GRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 817-859 1.59e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 1.59e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 160409939    817 RRQIISNLNNPRSIVVHPAAGYMFLSDWFRPaKIMRAWSDGSH 859
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2347-2383 1.66e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 160409939  2347 CLQSNGGCSHFCFALPElpTPKCGCAFG-TLEDDGKNC 2383
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGyELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3379-3419 1.67e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 1.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3379 DLLYWADAHLGYIEFS-DLEGHHRHTVYDGTLPHPFALTIFE 3419
Cdd:pfam00058    1 GRLYWTDSSLRASISSaDLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
3113-3153 2.05e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 160409939   3113 INECQDSSISHCDHNCTDTITSFYCSCLPGYklmSDKRTCV 3153
Cdd:smart00179    2 IDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 146-176 2.66e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 2.66e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 160409939    146 TCDQLTCANGACYNTSQKCDHKVDCRDSSDE 176
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3406-3443 2.82e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.82e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 160409939   3406 DGTLPHPFALTIFEDTVFWTDWNTRTVEKgNKYDGSGR 3443
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLDVIEV-ANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1313-1345 3.21e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 3.21e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 1313 CPSSQWQCpGYSICVNLSALCDGVFDCPNGTDE 1345
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4009-4038 3.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 3.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 160409939 4009 DINECEEFGICP--QSCRNSKGSYECFCVDGF 4038
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 436-475 4.25e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 4.25e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 160409939   436 RVFWTD-PMQAKVFSTDINGLNTQEILNVSIDAPENLAVDW 475
Cdd:pfam00058    2 RLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4146-4324 4.35e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 4146 PDGLAVDWVGRhIYWSDAKSQRIEVATLDGRYRKWL----ITTQLDQPAAIAVnpKLGLMFWTDQGKQpKIESAWMNGEh 4221
Cdd:cd14963    58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAI--DDGKLYVSDVKKH-KVIVFDLEGK- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409939 4222 rSVLASANLG-------WPNGLSIDylNGDRIYWSDSkedviesikydGTDRrliindamkpfsLDIFEDQLYWVAKEKG 4294
Cdd:cd14963   133 -LLLEFGKPGsepgelsYPNGIAVD--EDGNIYVADS-----------GNGR------------IQVFDKNGKFIKELNG 186

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 160409939 4295 EVWRQNKF------GKGNKEKLLVVNPWLTQVRIFH 4324
Cdd:cd14963   187 SPDGKSGFvnprgiAVDPDGNLYVVDNLSHRVYVFD 222
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3555-3586 4.51e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 4.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  3555 CRLGQFQCRDGNCTSPQALCNARQDCADGSDE 3586
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4244-4283 5.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 5.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  4244 DRIYWSDSKED-VIESIKYDGTDRR-LIINDAMKPFSLDIFE 4283
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKtLFTDDLQHPNAIAVDP 42
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1373-1394 5.04e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 37.00  E-value: 5.04e-03
                           10        20
                   ....*....|....*....|..
gi 160409939  1373 TCVCPIGYQLANDTKTCEDVNE 1394
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3154-3193 5.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 5.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 160409939 3154 DIDECkETPQLCS--QKCENVIGSYICKCAPGYIrepdGKSC 3193
Cdd:cd00054     1 DIDEC-ASGNPCQngGTCVNTVGSYRCSCPPGYT----GRNC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3158-3193 6.13e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 6.13e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 160409939  3158 CKETPQLCSQKCENVIGSYICKCAPGYIREPDGKSC 3193
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3113-3145 6.63e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 6.63e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 160409939 3113 INECQDSSISHCDHNCTDTITSFYCSCLPGYKL 3145
Cdd:cd00054     2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3241-3281 7.31e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 7.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 160409939  3241 ERLYWIDA-EKQIIERMFLNKTNQETIISHRLRRAESLAVDW 3281
Cdd:pfam00058    1 GRLYWTDSsLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 4340-4358 8.48e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 8.48e-03
                           10
                   ....*....|....*....
gi 160409939  4340 CSHLCLLRPGGYSCACPQG 4358
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1710-1741 9.27e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 9.27e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 160409939  1710 CSHLCLLSaqePRHYSCACPSGWNLSDDSVNC 1741
Cdd:pfam14670    8 CSHLCLNT---PGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2595-2626 9.77e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 36.81  E-value: 9.77e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 160409939   2595 HSFGLTVYGQYIYWTDFYTKKIYRANkYDGSD 2626
Cdd:smart00135   12 NGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH