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Conserved domains on  [gi|2046389447|pdb|7ENA|s]
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Chain s, Mediator of RNA polymerase II transcription subunit 19

Protein Classification

mediator of RNA polymerase II transcription subunit 19 family protein( domain architecture ID 10563233)

mediator of RNA polymerase II transcription subunit 19 (Med19) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-233 1.34e-79

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


:

Pssm-ID: 287279  Cd Length: 178  Bit Score: 237.04  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_s         63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_s        143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDS------DHKKKKKKKEEDPDRKRKKK 216
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPLDSeglkghEKKHKKKKHEDDKERKKKKK 160

                         170
                  ....*....|....*..
7ENA_s        217 EKKKKKNRHSPDHPGMG 233
Cdd:pfam10278 161 EKKKKKKRHSPEHPGMG 177
 
Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-233 1.34e-79

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


Pssm-ID: 287279  Cd Length: 178  Bit Score: 237.04  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_s         63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_s        143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDS------DHKKKKKKKEEDPDRKRKKK 216
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPLDSeglkghEKKHKKKKHEDDKERKKKKK 160

                         170
                  ....*....|....*..
7ENA_s        217 EKKKKKNRHSPDHPGMG 233
Cdd:pfam10278 161 EKKKKKKRHSPEHPGMG 177
 
Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-233 1.34e-79

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


Pssm-ID: 287279  Cd Length: 178  Bit Score: 237.04  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_s         63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_s        143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDS------DHKKKKKKKEEDPDRKRKKK 216
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPLDSeglkghEKKHKKKKHEDDKERKKKKK 160

                         170
                  ....*....|....*..
7ENA_s        217 EKKKKKNRHSPDHPGMG 233
Cdd:pfam10278 161 EKKKKKKRHSPEHPGMG 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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