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Conserved domains on  [gi|1843802297|pdb|6SLI|G]
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Chain G, RagA protein

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 11499350)

SusC/RagA family TonB-linked outer membrane protein might act as a TonB-dependent receptor similar to Bacteroides thetaiotaomicron starch-utilization system protein C (SusC), which mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation

CATH:  1.25.40.390
Gene Ontology:  GO:0009279|GO:0016020
PubMed:  15111112|28077872|11717282|17965357

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 3-996 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 738.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G          3 RTVKGTVISsEDNEPLIGANVVVVGnTTIGAATDLDGNFTLSVPANAKmLRVSYSGMTTKEVAIA--NVMKIVLDPDSKV 80
Cdd:TIGR04056   1 ITVTGVVVD-ETGEPLIGASVVVKG-TTNGTITDIDGNFSLKVPPGAV-LVFSYIGYKTQEVKVKgqKNLNITLKEDTQE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G         81 LEQVVVLGYGTgQKLSTVSGSVAKVSSEKLAEKPVANIMDALQGQVAGMQVMTTSGDPTAVASVEIHGTGSLGASSAPLY 160
Cdd:TIGR04056  78 LDEVVVVGYGT-QKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        161 IVDGMQTSlDVVATMNPNDFESMSVLKDASATSIYGARAANGVVFIQTKKGKmSERGRITFNASYGISQILNtkpLDNMM 240
Cdd:TIGR04056 157 VIDGVPRD-NGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGK-EGKPKISYNAEFGFSTPTR---LPEML 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        241 TGDELLDFQvkagfwgnnqtvqkvKDMILAGAEDLYGNYDSLKDEYGKTLFPVDFNHDADWLKALFK-TAPTSQGDISFS 319
Cdd:TIGR04056 232 NAYEYAELY---------------NEALLNRGSSPPDIYTDEEIEAYRNGLDPDLYPNTDWQDEIFKrTAFNQRHNLSVS 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        320 GGSQGTSYYASIGYFDQEGMAREpANFKRYSGRLNFESRINEWLKVGANLSGAIANRRSADYFGKYYMGSGTFGVLTMPR 399
Cdd:TIGR04056 297 GGTEKARYYVSLGYYNEEGILKN-SDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPY 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        400 YYNPFDVNGDladvYYMYGATRPSMTEPYFAKMRPFS-SESHQANVNGFAQITPIKGLTLKAQAGVDITNTRTSsKRMPN 478
Cdd:TIGR04056 376 STPPVYSDGY----YPAYNSGNTSLQNPYALLNRGYNeNERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNK-KYYKN 450

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        479 NPYDSTPLGERRERAYRDVSKSFTNTAEYKFSIDE---KHDLTALMGHEYIEYEgdvigASSKGFESDKLMLLSQGKTGN 555
Cdd:TIGR04056 451 PYYYNATGGANNGYYSESNSRSRNYYLEATLNYNRtfgKHNVSALLGYSQQENK-----SSSYGGLLDDLPSLDAGTSDA 525

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        556 SLSLpehRVAEYAYLSFFSRFNYGFDKWMYIDFSVRNDQSSRFGSNNRSAWFYSVGGMFDIYN-KFIQE-SNWLSDLRLK 633
Cdd:TIGR04056 526 SVSG---SDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEeKFMKKlKKWLSFLKLR 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        634 MSYGTTGNSEIGN-YNHQALVTVNNY-----TEDAM---GLSISTAGNPDLSWEKQSQFNFGLAAGAFNNRLSAEVDFYV 704
Cdd:TIGR04056 603 ASYGIVGNDNIGDrYPYLSLYNLGDGgynfgTNNGTsvtGITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYY 682

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        705 RTTNDMLIDVPMPYISGFFSQYQNVGSMKNTGVDLSLKGTIYQNKDWNVYASANFNYNRQEITKLffGLNKYMLPNTGTI 784
Cdd:TIGR04056 683 KKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILEL--DEGAYLPVKYPYI 760

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        785 WEIGYP-NSFYMAEYAGIDKKTG--KQLW--YVPGQV---DADGNKVTTSqysaDLETRIDKSVTPPITGGFSLGASWKG 856
Cdd:TIGR04056 761 SKEGGPiGQIYGYIADGLFKDDDspKQTFgnVRPGDIkykDVNGDGKIDD----DDRVPIGYSNTPDLTYGFGNSFSYKG 836

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        857 LSLDADFAYIVGKWMINNDRYFTENGGGLMQLNKDKMLLNAWTEDNKETDVPKLG-------QSPQFDTHLLENASFLRL 929
Cdd:TIGR04056 837 FDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSygdsnnsNNYQASTRWLEDGSYLRL 916

                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
6SLI_G        930 KNLKLTYVLPNSLFAGQNvIGGARVYLMARNLLTVTKYKGFDPEAGGNVGkNQYPNSKQYVAGIQLS 996
Cdd:TIGR04056 917 KNLTLGYTLPKKWLKKIG-ISNLRVYFSGQNLFTFSKYKGWDPELQGNDG-GAYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 3-996 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 738.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G          3 RTVKGTVISsEDNEPLIGANVVVVGnTTIGAATDLDGNFTLSVPANAKmLRVSYSGMTTKEVAIA--NVMKIVLDPDSKV 80
Cdd:TIGR04056   1 ITVTGVVVD-ETGEPLIGASVVVKG-TTNGTITDIDGNFSLKVPPGAV-LVFSYIGYKTQEVKVKgqKNLNITLKEDTQE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G         81 LEQVVVLGYGTgQKLSTVSGSVAKVSSEKLAEKPVANIMDALQGQVAGMQVMTTSGDPTAVASVEIHGTGSLGASSAPLY 160
Cdd:TIGR04056  78 LDEVVVVGYGT-QKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        161 IVDGMQTSlDVVATMNPNDFESMSVLKDASATSIYGARAANGVVFIQTKKGKmSERGRITFNASYGISQILNtkpLDNMM 240
Cdd:TIGR04056 157 VIDGVPRD-NGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGK-EGKPKISYNAEFGFSTPTR---LPEML 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        241 TGDELLDFQvkagfwgnnqtvqkvKDMILAGAEDLYGNYDSLKDEYGKTLFPVDFNHDADWLKALFK-TAPTSQGDISFS 319
Cdd:TIGR04056 232 NAYEYAELY---------------NEALLNRGSSPPDIYTDEEIEAYRNGLDPDLYPNTDWQDEIFKrTAFNQRHNLSVS 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        320 GGSQGTSYYASIGYFDQEGMAREpANFKRYSGRLNFESRINEWLKVGANLSGAIANRRSADYFGKYYMGSGTFGVLTMPR 399
Cdd:TIGR04056 297 GGTEKARYYVSLGYYNEEGILKN-SDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPY 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        400 YYNPFDVNGDladvYYMYGATRPSMTEPYFAKMRPFS-SESHQANVNGFAQITPIKGLTLKAQAGVDITNTRTSsKRMPN 478
Cdd:TIGR04056 376 STPPVYSDGY----YPAYNSGNTSLQNPYALLNRGYNeNERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNK-KYYKN 450

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        479 NPYDSTPLGERRERAYRDVSKSFTNTAEYKFSIDE---KHDLTALMGHEYIEYEgdvigASSKGFESDKLMLLSQGKTGN 555
Cdd:TIGR04056 451 PYYYNATGGANNGYYSESNSRSRNYYLEATLNYNRtfgKHNVSALLGYSQQENK-----SSSYGGLLDDLPSLDAGTSDA 525

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        556 SLSLpehRVAEYAYLSFFSRFNYGFDKWMYIDFSVRNDQSSRFGSNNRSAWFYSVGGMFDIYN-KFIQE-SNWLSDLRLK 633
Cdd:TIGR04056 526 SVSG---SDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEeKFMKKlKKWLSFLKLR 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        634 MSYGTTGNSEIGN-YNHQALVTVNNY-----TEDAM---GLSISTAGNPDLSWEKQSQFNFGLAAGAFNNRLSAEVDFYV 704
Cdd:TIGR04056 603 ASYGIVGNDNIGDrYPYLSLYNLGDGgynfgTNNGTsvtGITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYY 682

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        705 RTTNDMLIDVPMPYISGFFSQYQNVGSMKNTGVDLSLKGTIYQNKDWNVYASANFNYNRQEITKLffGLNKYMLPNTGTI 784
Cdd:TIGR04056 683 KKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILEL--DEGAYLPVKYPYI 760

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        785 WEIGYP-NSFYMAEYAGIDKKTG--KQLW--YVPGQV---DADGNKVTTSqysaDLETRIDKSVTPPITGGFSLGASWKG 856
Cdd:TIGR04056 761 SKEGGPiGQIYGYIADGLFKDDDspKQTFgnVRPGDIkykDVNGDGKIDD----DDRVPIGYSNTPDLTYGFGNSFSYKG 836

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        857 LSLDADFAYIVGKWMINNDRYFTENGGGLMQLNKDKMLLNAWTEDNKETDVPKLG-------QSPQFDTHLLENASFLRL 929
Cdd:TIGR04056 837 FDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSygdsnnsNNYQASTRWLEDGSYLRL 916

                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
6SLI_G        930 KNLKLTYVLPNSLFAGQNvIGGARVYLMARNLLTVTKYKGFDPEAGGNVGkNQYPNSKQYVAGIQLS 996
Cdd:TIGR04056 917 KNLTLGYTLPKKWLKKIG-ISNLRVYFSGQNLFTFSKYKGWDPELQGNDG-GAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
81-763 3.95e-46

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 176.56  E-value: 3.95e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G       81 LEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVMTTSGDPTAVAsveIHGTGslGASSAPLY 160
Cdd:COG1629   1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAGQIS---IRGFG--GGGNRVLV 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      161 IVDGMQTSL-----DVVATMNPNDFESMSVLKDASATsIYGARAANGVVFIQTKKGKMSERGRITFNasygisqilntkp 235
Cdd:COG1629  75 LVDGVPLNDpsggdGGLSYIDPEDIERVEVLRGPSSA-LYGSGALGGVINIVTKKPKDGKGGEVSAS------------- 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      236 ldnmmtgdelldfqvkagfwgnnqtvqkvkdmilagaedlYGNYDslkdeygktlfpvdfnhdadwlkalfktapTSQGD 315
Cdd:COG1629 141 ----------------------------------------YGSYG------------------------------TYRAS 150

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      316 ISFSGGSQGTSYYASIGYFDQEGMaREPANFKRYSGRLNFESRINEWLKVGANLSGaianrrsadyfgkyymgsgtfgvl 395
Cdd:COG1629 151 LSLSGGNGKLAYRLSASYRDSDGY-RDNSDSDRYNLRAKLGYQLGDDTRLTLSASY------------------------ 205

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      396 tmprYYNPFDVNGDLADVYYMYGATRPSMTEPYfakmRPFSSESHQANVNGFAQITPI-KGLTLKAQAGVDITNTRTSSk 474
Cdd:COG1629 206 ----SDSDQDSPGYLTLAALRPRGAMDDGTNPY----SNDTDDNTRDRYSLSLEYEHLgDGLKLSASAYYRYDDTDLDS- 276

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      475 rmpNNPYDSTPLGERRERAYRDVSKSFTNTAEYKFSIDEKHDLTAlmGHEYIEYEGDvigasSKGFESDklmlLSQGKTG 554
Cdd:COG1629 277 ---DFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTLLV--GLDYQRQDLD-----GSGYPLD----LGSGSLP 342

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      555 NSLSLPEHRVAEYAYlSFFSRFNYGFDKWMYIDFSVRNDQSSRF------------GSNNRSAWFYSVGGMFDIYNkfiq 622
Cdd:COG1629 343 TLTSGADDDGTTTSL-ALYAQDTYKLTDKLTLTAGLRYDYVSYDvddtvtgtdsasGSRSYSAFSPSLGLTYQLSP---- 417

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      623 esnwlsDLRLKMSYGTTgnSEIGNYNHQAlvtvnnytedAMGLSISTAGNPDLSWEKQSQFNFGLAAGAFNNRLSAEVDF 702
Cdd:COG1629 418 ------NLSLYASYSRG--FRAPTFGELY----------ANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLAL 479

                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|.
6SLI_G      703 YVRTTNDMLIDVPMPYISGFFSQYQNVGSMKNTGVDLSLKGTIyqNKDWNVYASANFNYNR 763
Cdd:COG1629 480 FYSDVDNEILSVPLPNDSGFSTYYTNAGKARSYGVELELSYQL--TPGLSLNASYSYTDAK 538
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 5-86 1.27e-17

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 78.40  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G          5 VKGTVISSEDNEPLIGANVVVVGnTTIGAATDLDGNFTLS-VPANAKMLRVSYSGMTTKE--VAIANVMK----IVLDPD 77
Cdd:pfam13715   1 ISGTVVDENTGEPLPGATVYVKG-TTKGTVTDADGNFELKnLPAGTYTLVVSFVGYKTQEkkVTVSNDNTldvnFLLKED 79


                  ....*....
6SLI_G         78 SKVLEQVVV 86
Cdd:pfam13715  80 ALLLDEVVV 88
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 77-210 1.63e-08

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 58.74  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        77 DSKVLEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALqGQVAGMQVmttSGDPTAVASVEIHGTGslgaSS 156
Cdd:PRK10064  26 VDDDGETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQL---TNEGDNRKGVSIRGLD----SS 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
6SLI_G       157 APLYIVDGMQTSlDVVATMNPNDFESMSVLKDA---------SATSIYGARAANGVVFIQTKK 210
Cdd:PRK10064  98 YTLILIDGKRVN-SRNAVFRHNDFDLNWIPVDAierievvrgPMSSLYGSDALGGVVNIITKK 159
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 101-788 7.49e-08

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 56.31  E-value: 7.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      101 SVAKVSSEKLAEKPVANIMDALQgQVAGMQVmtTSGDPTAVASVEIHGTGSLGAssapLYIVDGMQTSLDVVA------T 174
Cdd:cd01347   1 SVSVITAEDIEKQPATSLADLLR-RIPGVSV--TRGGGGGGSTISIRGFGPDRT----LVLVDGLPLASSNYGrgvdlnT 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      175 MNPNDFESMSVLKDASAtSIYGARAANGVVFIQTKKGKMSERGRITfnASYGISQILNTkpldnmmtGDELLDFQVKAGF 254
Cdd:cd01347  74 IPPELIERVEVLKGPSS-ALYGSGAIGGVVNIITKRPTDEFGGSVT--AGYGSDNSGSS--------GGGGFDVSGALAD 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      255 WGnnqtvqkvkdmilAGAEDLYGNYDslkdeygktlfpvdfnhdadwlkalfktaptsqgdisfsggsQGTSYYASIGYF 334
Cdd:cd01347 143 DG-------------AFGARLYGAYR------------------------------------------DGDGTIDGDGQA 167

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      335 DQEgmarepaNFKRYSGRLNFESRINEWLKVGANLSGAIANRRSADYFG-KYYMGSGTFGVLTMPRYYNPFDVNGDLADV 413
Cdd:cd01347 168 DDS-------DEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLpANGTGSSLGGGPSSNTNGDRDWDYRDRYRK 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      414 YYMYGATRPsmtepyfakmrpFSSESHQANVNGFAQITpikgltlkaqagvdiTNTRTSSKRMPNNPYDSTPLG-ERRER 492
Cdd:cd01347 241 RASLGLEHD------------LNDTGWTLRANLSYSYT---------------DNDGDPLILNGGNNAAGGDLGrSGYSS 293

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      493 AYRDVSKSFTNTAEYKFSIDE-KHDLTAlmGHEYIEYEGDVIGASskGFESDklmllsqgktgnslslpEHRVAEYAYLS 571
Cdd:cd01347 294 ERDTTQLGFDAGLNAPFGTGPvAHTLTL--GVEYRREELDEKQTA--LYAQD-----------------TIELTDDLTLT 352

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      572 FFSRFnygfDKWMYIDFSVRNDQSSRfgSNNRSAWFYSVGGMFDIYNkfiqesnwlsDLRLKMSYGTTgnseignYNHQA 651
Cdd:cd01347 353 LGLRY----DHYDQDSKDTIAGGTTA--KKSYSHWSPSLGLVYKLTD----------GLSLYASYSQG-------FRAPS 409

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      652 LvtvNNYTEDAMGLSISTAGNPDLSWEKQSQFNFGLAaGAFNNRLSAEVDFYVRTTNDMLIDVPMPYISGFFSQYQNVGS 731
Cdd:cd01347 410 L---GELYGGGSHGGTAAVGNPNLKPEKSKQYELGLK-YDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGK 485

                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|...
6SLI_G      732 MKNTGVDLSLKGTIyqNKDWNVYASANFNYNRQEIT------KLFFGLNKYMLpNTGTIWEIG 788
Cdd:cd01347 486 ARIRGVELEASYDL--TDGLGLTGSYTYTDTEVKRTdgattgNRLPGIPKHTA-NLGLDYELP 545
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 3-996 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 738.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G          3 RTVKGTVISsEDNEPLIGANVVVVGnTTIGAATDLDGNFTLSVPANAKmLRVSYSGMTTKEVAIA--NVMKIVLDPDSKV 80
Cdd:TIGR04056   1 ITVTGVVVD-ETGEPLIGASVVVKG-TTNGTITDIDGNFSLKVPPGAV-LVFSYIGYKTQEVKVKgqKNLNITLKEDTQE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G         81 LEQVVVLGYGTgQKLSTVSGSVAKVSSEKLAEKPVANIMDALQGQVAGMQVMTTSGDPTAVASVEIHGTGSLGASSAPLY 160
Cdd:TIGR04056  78 LDEVVVVGYGT-QKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        161 IVDGMQTSlDVVATMNPNDFESMSVLKDASATSIYGARAANGVVFIQTKKGKmSERGRITFNASYGISQILNtkpLDNMM 240
Cdd:TIGR04056 157 VIDGVPRD-NGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGK-EGKPKISYNAEFGFSTPTR---LPEML 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        241 TGDELLDFQvkagfwgnnqtvqkvKDMILAGAEDLYGNYDSLKDEYGKTLFPVDFNHDADWLKALFK-TAPTSQGDISFS 319
Cdd:TIGR04056 232 NAYEYAELY---------------NEALLNRGSSPPDIYTDEEIEAYRNGLDPDLYPNTDWQDEIFKrTAFNQRHNLSVS 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        320 GGSQGTSYYASIGYFDQEGMAREpANFKRYSGRLNFESRINEWLKVGANLSGAIANRRSADYFGKYYMGSGTFGVLTMPR 399
Cdd:TIGR04056 297 GGTEKARYYVSLGYYNEEGILKN-SDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPY 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        400 YYNPFDVNGDladvYYMYGATRPSMTEPYFAKMRPFS-SESHQANVNGFAQITPIKGLTLKAQAGVDITNTRTSsKRMPN 478
Cdd:TIGR04056 376 STPPVYSDGY----YPAYNSGNTSLQNPYALLNRGYNeNERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNK-KYYKN 450

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        479 NPYDSTPLGERRERAYRDVSKSFTNTAEYKFSIDE---KHDLTALMGHEYIEYEgdvigASSKGFESDKLMLLSQGKTGN 555
Cdd:TIGR04056 451 PYYYNATGGANNGYYSESNSRSRNYYLEATLNYNRtfgKHNVSALLGYSQQENK-----SSSYGGLLDDLPSLDAGTSDA 525

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        556 SLSLpehRVAEYAYLSFFSRFNYGFDKWMYIDFSVRNDQSSRFGSNNRSAWFYSVGGMFDIYN-KFIQE-SNWLSDLRLK 633
Cdd:TIGR04056 526 SVSG---SDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEeKFMKKlKKWLSFLKLR 602

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        634 MSYGTTGNSEIGN-YNHQALVTVNNY-----TEDAM---GLSISTAGNPDLSWEKQSQFNFGLAAGAFNNRLSAEVDFYV 704
Cdd:TIGR04056 603 ASYGIVGNDNIGDrYPYLSLYNLGDGgynfgTNNGTsvtGITESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYY 682

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        705 RTTNDMLIDVPMPYISGFFSQYQNVGSMKNTGVDLSLKGTIYQNKDWNVYASANFNYNRQEITKLffGLNKYMLPNTGTI 784
Cdd:TIGR04056 683 KKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILEL--DEGAYLPVKYPYI 760

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        785 WEIGYP-NSFYMAEYAGIDKKTG--KQLW--YVPGQV---DADGNKVTTSqysaDLETRIDKSVTPPITGGFSLGASWKG 856
Cdd:TIGR04056 761 SKEGGPiGQIYGYIADGLFKDDDspKQTFgnVRPGDIkykDVNGDGKIDD----DDRVPIGYSNTPDLTYGFGNSFSYKG 836

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        857 LSLDADFAYIVGKWMINNDRYFTENGGGLMQLNKDKMLLNAWTEDNKETDVPKLG-------QSPQFDTHLLENASFLRL 929
Cdd:TIGR04056 837 FDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSygdsnnsNNYQASTRWLEDGSYLRL 916

                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
6SLI_G        930 KNLKLTYVLPNSLFAGQNvIGGARVYLMARNLLTVTKYKGFDPEAGGNVGkNQYPNSKQYVAGIQLS 996
Cdd:TIGR04056 917 KNLTLGYTLPKKWLKKIG-ISNLRVYFSGQNLFTFSKYKGWDPELQGNDG-GAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
81-763 3.95e-46

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 176.56  E-value: 3.95e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G       81 LEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVMTTSGDPTAVAsveIHGTGslGASSAPLY 160
Cdd:COG1629   1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAGQIS---IRGFG--GGGNRVLV 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      161 IVDGMQTSL-----DVVATMNPNDFESMSVLKDASATsIYGARAANGVVFIQTKKGKMSERGRITFNasygisqilntkp 235
Cdd:COG1629  75 LVDGVPLNDpsggdGGLSYIDPEDIERVEVLRGPSSA-LYGSGALGGVINIVTKKPKDGKGGEVSAS------------- 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      236 ldnmmtgdelldfqvkagfwgnnqtvqkvkdmilagaedlYGNYDslkdeygktlfpvdfnhdadwlkalfktapTSQGD 315
Cdd:COG1629 141 ----------------------------------------YGSYG------------------------------TYRAS 150

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      316 ISFSGGSQGTSYYASIGYFDQEGMaREPANFKRYSGRLNFESRINEWLKVGANLSGaianrrsadyfgkyymgsgtfgvl 395
Cdd:COG1629 151 LSLSGGNGKLAYRLSASYRDSDGY-RDNSDSDRYNLRAKLGYQLGDDTRLTLSASY------------------------ 205

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      396 tmprYYNPFDVNGDLADVYYMYGATRPSMTEPYfakmRPFSSESHQANVNGFAQITPI-KGLTLKAQAGVDITNTRTSSk 474
Cdd:COG1629 206 ----SDSDQDSPGYLTLAALRPRGAMDDGTNPY----SNDTDDNTRDRYSLSLEYEHLgDGLKLSASAYYRYDDTDLDS- 276

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      475 rmpNNPYDSTPLGERRERAYRDVSKSFTNTAEYKFSIDEKHDLTAlmGHEYIEYEGDvigasSKGFESDklmlLSQGKTG 554
Cdd:COG1629 277 ---DFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTLLV--GLDYQRQDLD-----GSGYPLD----LGSGSLP 342

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      555 NSLSLPEHRVAEYAYlSFFSRFNYGFDKWMYIDFSVRNDQSSRF------------GSNNRSAWFYSVGGMFDIYNkfiq 622
Cdd:COG1629 343 TLTSGADDDGTTTSL-ALYAQDTYKLTDKLTLTAGLRYDYVSYDvddtvtgtdsasGSRSYSAFSPSLGLTYQLSP---- 417

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      623 esnwlsDLRLKMSYGTTgnSEIGNYNHQAlvtvnnytedAMGLSISTAGNPDLSWEKQSQFNFGLAAGAFNNRLSAEVDF 702
Cdd:COG1629 418 ------NLSLYASYSRG--FRAPTFGELY----------ANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLAL 479

                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|.
6SLI_G      703 YVRTTNDMLIDVPMPYISGFFSQYQNVGSMKNTGVDLSLKGTIyqNKDWNVYASANFNYNR 763
Cdd:COG1629 480 FYSDVDNEILSVPLPNDSGFSTYYTNAGKARSYGVELELSYQL--TPGLSLNASYSYTDAK 538
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 61-781 1.09e-35

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 144.23  E-value: 1.09e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G       61 TKEVAIANVMKIVLDPDSKVLEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVmTTSGDPTA 140
Cdd:COG4771   7 LLLLALAAQAADALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSV-TRSGGRGG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      141 VASVEIHGtgslGASSAPLYIVDGM------QTSLDVVATMNPNDFESMSVLKDAsATSIYGARAANGVVFIQTKKGKMS 214
Cdd:COG4771  85 SSGISIRG----LGGDRVLVLIDGVpvnnpaLGGGGDLSYIPPDDIERIEVIRGP-ASALYGSDAIGGVINIITKKPTDE 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      215 ERGRITFNasygisqilntkpldnmmtgdelldfqvkagfwgnnqtvqkvkdmilagaedlYGNYDSLkdeygktlfpvd 294
Cdd:COG4771 160 LEGSVSLG-----------------------------------------------------YGSNGNG------------ 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      295 fnhdadwlkalfktapTSQGDISFSGGSQGTSYYASIGYFDQEGM-------AREPANFKRYSGRLNFESRINEWLKVGA 367
Cdd:COG4771 175 ----------------TYSGSLSLGGPGDKLSFLLSGSYRDRDGYldyrnggFVGNSGYERYNLNAKLGYRLSDNHRLSL 238

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      368 NLSGAIANRRSADYFGKYYMGSGTFGVlTMPRYYNPFDVNGDLADVYymygatrpsmtepyfakmrpfsseshqanvngf 447
Cdd:COG4771 239 SGGYSRQDRDGGPPTLGDTEISSDNAG-DRDTTTDRGNYSLRYNGDL--------------------------------- 284

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      448 aqitpikGLTLKAQAGVDITNTRTSSKRMPNNPYDSTPLGERrerayrdvskSFTNTAEYKFSIDEKHDLTALMGHEYIE 527
Cdd:COG4771 285 -------GDNLDLSLYYSRTDRDSTNGSLGGSTGSFSDSDDT----------TYGLELDLTYPLGGNHTLTLGAEYRYDD 347

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      528 YEGDVIGASSKgfesdklmllsqgktgnslslpehrvAEYAYLSFFSRFNYGFDKWMYIDFSVRNDQSSRFGSNNRSAWF 607
Cdd:COG4771 348 LDSSSFLGGAD--------------------------ASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFS 401

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      608 YSVGGMFDIYNkfiqesnwlsDLRLKMSYGTTGnseignynhQALVTVNNYTEDAMGLSISTAGNPDLSWEKQSQFNFGL 687
Cdd:COG4771 402 PRLGLRYDLSD----------NLTLRASYGRGF---------RAPSLAELYGSGTGTPGRYVLGNPDLKPETSDNYELGL 462

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      688 AAGAFNNRLSAEVDFYVRTTNDMLIDVPMPYISGFFSQYQNVGSMKNTGVDLSLKGTIyqNKDWNVyaSANFNYNRQEIT 767
Cdd:COG4771 463 EYRLGNGGLSLSLTGFYTDIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRL--GKGLTL--TASYTYLDSKID 538

                       730
                ....*....|....
6SLI_G      768 KlffGLNKYMLPNT 781
Cdd:COG4771 539 D---GDTGEPLPNV 549
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
84-229 6.13e-29

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 117.28  E-value: 6.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G       84 VVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVmTTSGDPTAVASVEIHGTGSlgasSAPLYIVD 163
Cdd:COG4206   1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQV-SSSGGPGSAASISIRGLGS----NQTLVLID 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
6SLI_G      164 GM-----QTSLDVVATMNPNDFESMSVLKDASAtSIYGARAANGVVFIQTKKGKMSERGRITFNA-SYGISQ 229
Cdd:COG4206  75 GVplndpSLGGVDLSLIPPDDIERIEVLKGAAS-ALYGSDAIGGVINITTKKGKKGFKGSVSASYgSFGTRR 145
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 5-86 1.27e-17

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 78.40  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G          5 VKGTVISSEDNEPLIGANVVVVGnTTIGAATDLDGNFTLS-VPANAKMLRVSYSGMTTKE--VAIANVMK----IVLDPD 77
Cdd:pfam13715   1 ISGTVVDENTGEPLPGATVYVKG-TTKGTVTDADGNFELKnLPAGTYTLVVSFVGYKTQEkkVTVSNDNTldvnFLLKED 79


                  ....*....
6SLI_G         78 SKVLEQVVV 86
Cdd:pfam13715  80 ALLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 94-203 6.17e-14

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 68.83  E-value: 6.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G         94 KLSTVSGSVAKVSSEKLAEKPVANIMDALQGqVAGMQVmtTSGDPTAVASVEIHGTGslgaSSAPLYIVDGM-----QTS 168
Cdd:pfam07715   1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSV--SSGGGGGGSSISIRGFG----SNRVLVLVDGVplnsgGGG 73

                          90       100       110
                  ....*....|....*....|....*....|....*
6SLI_G        169 LDVVATMNPNDFESMSVLKDAsATSIYGARAANGV 203
Cdd:pfam07715  74 SVDLNSIDPEDIERVEVLKGP-ASALYGSGAIGGV 107
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 179-209 4.52e-12

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 61.06  E-value: 4.52e-12
                          10        20        30
                  ....*....|....*....|....*....|.
6SLI_G        179 DFESMSVLKDASATSIYGARAANGVVFIQTK 209
Cdd:TIGR04057   1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 382-785 3.98e-10

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 63.25  E-value: 3.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        382 FGKYYMGSGTFGVLTMPRYYNPFDVNGDLADVY-YMYGATRPSMTEPYFAKMRPFSSESHQANVNGFAQITPIKGLTLKA 460
Cdd:pfam00593   2 WQLSLDLLGDDTLLTLGYDYSRYTDGLDLGLTLdGYGNDGGYLGDRPLYYGRDYSDTDRKRLSLGYDYDLGDGLSWLSTL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        461 QAGVDITNTRTSSKrmpNNPYDSTPLGERRERAYRDVSKSFTNTAEYKFSIDekhdLTALMGHEYIEYEGDVIGASSKGF 540
Cdd:pfam00593  82 RLGLRYSSLDGDYT---SNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLS----HDLLLGVELRTAGLDYRRLDDDAY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        541 ESdklmllSQGKTGNSLSLPEHRVAEYAylsFFSRFNYGFDKWMYIDFSVRNDQSSRFGSNNR----------SAWFYSV 610
Cdd:pfam00593 155 DP------YDPANPSSSSYSDTTTDSYG---LYLQDNIKLTDRLTLTLGLRYDHYSTDGDDGNgggdnfsrsySAFSPRL 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        611 GGMFDIYNkfiqesnwlsDLRLKMSYGTTgnseignYNHQALVTVNNYTEDAMGLSIsTAGNPDLSWEKQSQFNFGLAAg 690
Cdd:pfam00593 226 GLVYKPTD----------NLSLYASYSRG-------FRAPSLGELYGSGSGGGGGAV-AGGNPDLKPETSDNYELGLKY- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        691 aFNNRLSAEVDFYVRTTNDMLIDVP-MPYISGFFSQYQNVGSMKNTGVDLSLKGTIyqnkdWNVYASAN-FNYNRQEITK 768
Cdd:pfam00593 287 -DDGRLSLSLALFYIDIKNLITSDPdGPGLGGTVYTYTNVGKARIRGVELELSGRL-----WGLGLSGGgYTYTDADDDA 360

                         410       420
                  ....*....|....*....|
6SLI_G        769 LFFGLNKYML---PNTGTIW 785
Cdd:pfam00593 361 DADDTGNPLPnvpRHTANLG 380
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 77-210 1.63e-08

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 58.74  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        77 DSKVLEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALqGQVAGMQVmttSGDPTAVASVEIHGTGslgaSS 156
Cdd:PRK10064  26 VDDDGETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQL---TNEGDNRKGVSIRGLD----SS 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
6SLI_G       157 APLYIVDGMQTSlDVVATMNPNDFESMSVLKDA---------SATSIYGARAANGVVFIQTKK 210
Cdd:PRK10064  98 YTLILIDGKRVN-SRNAVFRHNDFDLNWIPVDAierievvrgPMSSLYGSDALGGVVNIITKK 159
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 101-788 7.49e-08

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 56.31  E-value: 7.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      101 SVAKVSSEKLAEKPVANIMDALQgQVAGMQVmtTSGDPTAVASVEIHGTGSLGAssapLYIVDGMQTSLDVVA------T 174
Cdd:cd01347   1 SVSVITAEDIEKQPATSLADLLR-RIPGVSV--TRGGGGGGSTISIRGFGPDRT----LVLVDGLPLASSNYGrgvdlnT 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      175 MNPNDFESMSVLKDASAtSIYGARAANGVVFIQTKKGKMSERGRITfnASYGISQILNTkpldnmmtGDELLDFQVKAGF 254
Cdd:cd01347  74 IPPELIERVEVLKGPSS-ALYGSGAIGGVVNIITKRPTDEFGGSVT--AGYGSDNSGSS--------GGGGFDVSGALAD 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      255 WGnnqtvqkvkdmilAGAEDLYGNYDslkdeygktlfpvdfnhdadwlkalfktaptsqgdisfsggsQGTSYYASIGYF 334
Cdd:cd01347 143 DG-------------AFGARLYGAYR------------------------------------------DGDGTIDGDGQA 167

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      335 DQEgmarepaNFKRYSGRLNFESRINEWLKVGANLSGAIANRRSADYFG-KYYMGSGTFGVLTMPRYYNPFDVNGDLADV 413
Cdd:cd01347 168 DDS-------DEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLpANGTGSSLGGGPSSNTNGDRDWDYRDRYRK 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      414 YYMYGATRPsmtepyfakmrpFSSESHQANVNGFAQITpikgltlkaqagvdiTNTRTSSKRMPNNPYDSTPLG-ERRER 492
Cdd:cd01347 241 RASLGLEHD------------LNDTGWTLRANLSYSYT---------------DNDGDPLILNGGNNAAGGDLGrSGYSS 293

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      493 AYRDVSKSFTNTAEYKFSIDE-KHDLTAlmGHEYIEYEGDVIGASskGFESDklmllsqgktgnslslpEHRVAEYAYLS 571
Cdd:cd01347 294 ERDTTQLGFDAGLNAPFGTGPvAHTLTL--GVEYRREELDEKQTA--LYAQD-----------------TIELTDDLTLT 352

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      572 FFSRFnygfDKWMYIDFSVRNDQSSRfgSNNRSAWFYSVGGMFDIYNkfiqesnwlsDLRLKMSYGTTgnseignYNHQA 651
Cdd:cd01347 353 LGLRY----DHYDQDSKDTIAGGTTA--KKSYSHWSPSLGLVYKLTD----------GLSLYASYSQG-------FRAPS 409

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G      652 LvtvNNYTEDAMGLSISTAGNPDLSWEKQSQFNFGLAaGAFNNRLSAEVDFYVRTTNDMLIDVPMPYISGFFSQYQNVGS 731
Cdd:cd01347 410 L---GELYGGGSHGGTAAVGNPNLKPEKSKQYELGLK-YDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGK 485

                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|...
6SLI_G      732 MKNTGVDLSLKGTIyqNKDWNVYASANFNYNRQEIT------KLFFGLNKYMLpNTGTIWEIG 788
Cdd:cd01347 486 ARIRGVELEASYDL--TDGLGLTGSYTYTDTEVKRTdgattgNRLPGIPKHTA-NLGLDYELP 545
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
4-69 1.65e-06

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 46.89  E-value: 1.65e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G          4 TVKGTVISSeDNEPLIGANVVVV---GNTTIGAATDLDGNFTL-SVPANAKMLRVSYSGMTTKEVAIANV 69
Cdd:pfam13620   1 TISGTVTDP-SGAPVPGATVTVTntdTGTVRTTTTDADGRYRFpGLPPGTYTVTVSAPGFKTATRTGVTV 69
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 81-382 5.64e-06

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 50.47  E-value: 5.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G         81 LEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVmTTSGDPTAVaSVEIHGTGSlgasSAPLY 160
Cdd:TIGR01785   1 LDTVTVTATRTRQVLSEAPASVSVISGEQIESKQANNLADALN-TVPGVDV-TGGGRPPGQ-SINIRGLQD----NRVLV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        161 IVDGMQTSLDV------VATMNPNDFESMSVLKDASATsIYGARAANGVVFIQTKkgkmsergritfnasygisqilntK 234
Cdd:TIGR01785  74 VVDGARQNYQRggahngSLFVDPELLKRIEIVKGPSSS-LYGSGALGGVVAFRTK------------------------D 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        235 PLDnMMTGDELLDFQVKAGFWGNNQTVQkvKDMILAGAEDLygNYDSLKdEYGKTlfpvdfnhDADWLKALFKTAPTSQG 314
Cdd:TIGR01785 129 AAD-LLRPGQLFGGLAKLSYGSNNNSFG--GSVAVAGRLDD--NLDALV-AATYR--------DGGNYRNGNKEEATNSA 194

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
6SLI_G        315 DISFSGGSQGTSYYASI-----GYFDQEGMAREPANFKrysgrLNFESRINEWLKVGAnlSGAIANRRSADYF 382
Cdd:TIGR01785 195 YVQKNLLAKLGWQLDDAqrlefSYFTTEGSLDEAQNSG-----PGTEYVLGSSSTLLA--SSTRDRSATLTYN 260
OMP_b-brl_3 pfam14905
Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB ...
 671-766 2.64e-05

Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.


Pssm-ID: 434300 [Multi-domain]  Cd Length: 407  Bit Score: 47.65  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        671 GNPDLSWEKQSQFNFGLAagaFNNRLSAEVdFYVRTTNDMLIDVPMPYISG-FFSQYQNVGSMKNTGVDLSLKGTIyqNK 749
Cdd:pfam14905 208 GNPNLKPEYTNSFELGYT---YKWKLSLSL-SYRYTNDVIQQTFITDDNDNvTYTTYENLGKSNSYGLELSASFNP--TK 281

                          90
                  ....*....|....*..
6SLI_G        750 DWNVYASANFNYNRQEI 766
Cdd:pfam14905 282 WWSLNGNLNGYYNKYKI 298
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
81-226 4.37e-04

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 44.15  E-value: 4.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G       81 LEQVVVLGYGTGQ-KLSTVSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVMTTSGdpTAVAS-VEIHGTGSLGASSAP 158
Cdd:COG4772  23 LETVVVTGSRAAEaRLKDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDG--FGLRPnIGIRGLGPRRSRGIT 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
6SLI_G      159 LYiVDGMQTSLDVVA------TMNPNDFESMSVLKDASATsIYGARAANGVVFIQTKKGKMSERGRITFNA-SYG 226
Cdd:COG4772 100 LL-EDGIPIAPAPYGdpaayyFPDLERMERIEVLRGAAAL-RYGPQTVGGAINFVTRTIPTAFGGELRVTGgSFG 172
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 98-327 5.99e-04

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 43.56  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G         98 VSGSVAKVSSEKLAEKPVANIMDALQgQVAGMQVMTTSGDpTAVASVEIHGTGSLGasSAPLYIVDGM-QTSLDVVATMN 176
Cdd:TIGR01783   2 IPQSVSVITRQELEDQQAGSLSEALQ-RVPGVVVGGSGGT-TQFGNITIRGFGLEV--DIDNVYLDGVpLLSRGNLAIVD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        177 PNDFESMSVLKDASATsIYGARAANGVVFIQTKKGKMSERGRITFNASYGiSQILNTKPLDNMMTGDELLDFQVKAGFWG 256
Cdd:TIGR01783  78 PAMVERVEVLRGPASL-LYGGSAPGGVINIVTKRPQDEPKGSVTFGAGTR-SGYRTAFDLGGPLGADGTFRGRLNGARQD 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
6SLI_G        257 NNQtvqkvkDMILAGAE--DLYGNYDSLKDEYGKTLFPVDFNHDADwlkalfktaPTSQGDISFSGGSQGTSY 327
Cdd:TIGR01783 156 GDS------FYDGAGEEtrLGATATDWQLDDRTLLRLGAYYQKERD---------RGGYGGLPASGGTSGRDL 213
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
77-228 2.05e-03

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 41.92  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        77 DSKVlEQVVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQGqVAGMQVMTTSGDPtavasvEIHGTGSLGASS 156
Cdd:PRK13484  27 DKKE-DTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKD-VEGISITGGNEKP------DISIRGLSGDYT 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G       157 apLYIVDGMQTSldvVATMNPND--------------FESMSVLKdASATSIYGARAANGVVFIQTK-------KGKMSE 215
Cdd:PRK13484  99 --LILVDGRRQS---GRESRPNGsggfeagfippveaIERIEVIR-GPMSSLYGSDAIGGVINIITKpvnnqtwDGVLGL 172

                        170
                 ....*....|...
6SLI_G       216 RGRITFNASYGIS 228
Cdd:PRK13484 173 GGIIQEHGKFGNS 185
PRK13486 PRK13486
TonB-dependent receptor;
84-210 6.24e-03

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 40.39  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6SLI_G        84 VVVLGYGTGQKLSTVSGSVAKVSSEKLAEKPVANIMDALQGqVAGMQVMTTSGDpTAVASVEIHGTgslgASSAPLYIVD 163
Cdd:PRK13486  28 MIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGK-TGGLEISIRGM----PASYTLILID 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
6SLI_G       164 GMQT--SLDVVatmnPNDFESM--SVLKDASA-----------TSIYGARAANGVVFIQTKK 210
Cdd:PRK13486 102 GVRQggSSDVT----PNGFSAMntGFMPPLAAierievirgpmSTLYGSDAMGGVVNIITRK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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