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Conserved domains on  [gi|1524266296|pdb|6MZL|T]
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Chain T, TATA-box-binding protein

Protein Classification

TATA-box-binding protein( domain architecture ID 11476362)

TATA-box-binding protein is a general transcription factor that binds to a DNA sequence called the TATA box

CATH:  3.30.310.10
Gene Ontology:  GO:0003677|GO:0006352|GO:0006351
SCOP:  4002023

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN00062 PLN00062
TATA-box-binding protein; Provisional
162-338 8.84e-132

TATA-box-binding protein; Provisional


:

Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 372.88  E-value: 8.84e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       162 VPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       242 QKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEI 321
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160
                        170
                 ....*....|....*..
6MZL_T       322 YEAFENIYPILKGFRKT 338
Cdd:PLN00062 161 YTAFENIYPVLTEFRKR 177
 
Name Accession Description Interval E-value
PLN00062 PLN00062
TATA-box-binding protein; Provisional
162-338 8.84e-132

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 372.88  E-value: 8.84e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       162 VPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       242 QKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEI 321
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160
                        170
                 ....*....|....*..
6MZL_T       322 YEAFENIYPILKGFRKT 338
Cdd:PLN00062 161 YTAFENIYPVLTEFRKR 177
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
162-335 9.77e-131

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 370.01  E-value: 9.77e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      162 VPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      242 QKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEI 321
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160
                       170
                ....*....|....
6MZL_T      322 YEAFENIYPILKGF 335
Cdd:cd04516 161 YQAFENIYPILLQF 174
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
166-333 3.79e-61

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 193.49  E-value: 3.79e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      166 QNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLG 245
Cdd:COG2101   7 ENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLRKLG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      246 FPA-KFLDFKIQNMVGSCDVKFPIRLE----GLVLTHqqfSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAE 320
Cdd:COG2101  87 IEIpDEPEITVQNIVASADLGREINLNalaiGLGLEN---IEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEE 163
                       170
                ....*....|...
6MZL_T      321 IYEAFENIYPILK 333
Cdd:COG2101 164 AERAVDKLRERLE 176
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
252-335 1.73e-42

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 142.19  E-value: 1.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T        252 DFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPI 331
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80

                  ....
6MZL_T        332 LKGF 335
Cdd:pfam00352  81 LQKL 84
 
Name Accession Description Interval E-value
PLN00062 PLN00062
TATA-box-binding protein; Provisional
162-338 8.84e-132

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 372.88  E-value: 8.84e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       162 VPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       242 QKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEI 321
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160
                        170
                 ....*....|....*..
6MZL_T       322 YEAFENIYPILKGFRKT 338
Cdd:PLN00062 161 YTAFENIYPVLTEFRKR 177
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
162-335 9.77e-131

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 370.01  E-value: 9.77e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      162 VPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      242 QKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEI 321
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160
                       170
                ....*....|....
6MZL_T      322 YEAFENIYPILKGF 335
Cdd:cd04516 161 YQAFENIYPILLQF 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
162-333 3.89e-116

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 332.97  E-value: 3.89e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      162 VPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:cd00652   1 SPKIQNIVATVNLGCELDLRKIALAARNAEYNPKRFPGVIMRLREPKTTALIFSSGKMVITGAKSEEDAKLAARKYARIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      242 QKLGFPA-KFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAE 320
Cdd:cd00652  81 QKLGFPVeKFPEFKVQNIVASCDLGFPIRLEELALKHPENASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAKSRED 160
                       170
                ....*....|...
6MZL_T      321 IYEAFENIYPILK 333
Cdd:cd00652 161 IYEAVEKIYPILK 173
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
161-333 9.97e-65

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 202.56  E-value: 9.97e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      161 IVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPkRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV 240
Cdd:cd04517   1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNP-RYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      241 VQKLGFP-AKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRA 319
Cdd:cd04517  80 LQKLGFKvVRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGARSME 159
                       170
                ....*....|....
6MZL_T      320 EIYEAFENIYPILK 333
Cdd:cd04517 160 DVREAVEKIYPIVF 173
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
166-333 3.79e-61

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 193.49  E-value: 3.79e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      166 QNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLG 245
Cdd:COG2101   7 ENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLRKLG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      246 FPA-KFLDFKIQNMVGSCDVKFPIRLE----GLVLTHqqfSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAE 320
Cdd:COG2101  87 IEIpDEPEITVQNIVASADLGREINLNalaiGLGLEN---IEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEE 163
                       170
                ....*....|...
6MZL_T      321 IYEAFENIYPILK 333
Cdd:COG2101 164 AERAVDKLRERLE 176
PRK00394 PRK00394
transcription factor; Reviewed
164-335 1.08e-57

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 184.67  E-value: 1.08e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       164 QLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQK 243
Cdd:PRK00394   2 KIENIVASTDLGQELDLEKVAEDLPNAEYNPEQFPGLVYRLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKLKE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       244 LGFPAKF-LDFKIQNMVGSCDVKFPIRLEGLVLT-HQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEI 321
Cdd:PRK00394  82 LGIKVIDePEIKVQNIVASADLGVELNLNAIAIGlGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDA 161
                        170
                 ....*....|....
6MZL_T       322 YEAFENIYPILKGF 335
Cdd:PRK00394 162 EKAVEKILEKLEEL 175
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
163-333 3.35e-53

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 172.82  E-value: 3.35e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      163 PQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQ 242
Cdd:cd04518   2 LKIENIVASVDLGQELDLEKVAAELPNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKLK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      243 KLGfpAKFLD---FKIQNMVGSCDVKFPIRLEGLVLTHQQfSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRA 319
Cdd:cd04518  82 DYG--IKVIEkpeIKVQNIVASADLGREVNLDAIAIGLPN-AEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEE 158
                       170
                ....*....|....
6MZL_T      320 EIYEAFENIYPILK 333
Cdd:cd04518 159 DAKRAVEKLLSRLK 172
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
252-335 1.73e-42

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 142.19  E-value: 1.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T        252 DFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPI 331
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80

                  ....
6MZL_T        332 LKGF 335
Cdd:pfam00352  81 LQKL 84
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
163-244 3.06e-41

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 138.72  E-value: 3.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T        163 PQLQNIVSTVNLGCKLDLKTIALRA-RNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:pfam00352   2 IKIQNVVASADLGFPIDLEKLALKLlENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPIL 81

                  ...
6MZL_T        242 QKL 244
Cdd:pfam00352  82 QKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
163-246 1.43e-24

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 98.35  E-value: 1.43e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      163 PQLQNIVSTVNLGCKLDLKTIA--LRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV 240
Cdd:COG2101  95 ITVQNIVASADLGREINLNALAigLGLENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAERAVDKLRER 174

                ....*.
6MZL_T      241 VQKLGF 246
Cdd:COG2101 175 LEELGL 180
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
163-244 3.51e-24

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 96.93  E-value: 3.51e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      163 PQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQ 242
Cdd:cd04518  93 IKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEEDAKRAVEKLLSRLK 172

                ..
6MZL_T      243 KL 244
Cdd:cd04518 173 EL 174
PRK00394 PRK00394
transcription factor; Reviewed
164-245 1.57e-23

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 95.30  E-value: 1.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T       164 QLQNIVSTVNLGCKLDLKTIA--LRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV 241
Cdd:PRK00394  93 KVQNIVASADLGVELNLNAIAigLGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDAEKAVEKILEKL 172

                 ....
6MZL_T       242 QKLG 245
Cdd:PRK00394 173 EELG 176
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
254-333 8.67e-17

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 77.16  E-value: 8.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6MZL_T      254 KIQNMVGSCDVKFPIRLEGLVLTHQQfSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILK 333
Cdd:COG2101   5 EIENIVASGSLGQELDLEKLAEDLPN-AEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLR 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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