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Conserved domains on  [gi|1787098779|pdb|6IB6|A]
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Chain A, Ly6/PLAUR domain-containing protein 6

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 2-89 1.86e-49

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467145  Cd Length: 89  Bit Score: 151.09  E-value: 1.86e-49
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNI 81
Cdd:cd23625  2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEKCLSTGCRDSEHEGHKVCTSCCEGNI 81


               ....*...
6IB6_A      82 CNLPLPRN 89
Cdd:cd23625 82 CNLPLPRN 89
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 2-89 1.86e-49

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467145  Cd Length: 89  Bit Score: 151.09  E-value: 1.86e-49
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNI 81
Cdd:cd23625  2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEKCLSTGCRDSEHEGHKVCTSCCEGNI 81


               ....*...
6IB6_A      82 CNLPLPRN 89
Cdd:cd23625 82 CNLPLPRN 89
UPAR_LY6_2 pfam16975
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ...
 2-96 3.67e-44

Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.


Pssm-ID: 435685  Cd Length: 106  Bit Score: 138.25  E-value: 3.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A          2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNI 81
Cdd:pfam16975   8 FKCFTCEAADDNYCCNRWAPDWCCPRTTYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCSSCCEGNI 87

                          90
                  ....*....|....*
6IB6_A         82 CNLPLPRNETDATFA 96
Cdd:pfam16975  88 CNVVLPNNTTAAVFA 102
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD6 cd23625
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar ...
 2-89 1.86e-49

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6 (LYPD6) and similar proteins; LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467145  Cd Length: 89  Bit Score: 151.09  E-value: 1.86e-49
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNI 81
Cdd:cd23625  2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEKCLSTGCRDSEHEGHKVCTSCCEGNI 81


               ....*...
6IB6_A      82 CNLPLPRN 89
Cdd:cd23625 82 CNLPLPRN 89
UPAR_LY6_2 pfam16975
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ...
 2-96 3.67e-44

Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6.


Pssm-ID: 435685  Cd Length: 106  Bit Score: 138.25  E-value: 3.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A          2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNI 81
Cdd:pfam16975   8 FKCFTCEAADDNYCCNRWAPDWCCPRTTYYCTTHHFMSHGGSSVSVTKRCATEEECLVGGCHHRDDGGHEVCSSCCEGNI 87

                          90
                  ....*....|....*
6IB6_A         82 CNLPLPRNETDATFA 96
Cdd:pfam16975  88 CNVVLPNNTTAAVFA 102
TFP_LU_ECD_LYPD6_like cd23567
extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like ...
 2-87 4.31e-35

extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like family; The LYPD6-like family includes LYPD6 and LYPD6B. LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6B (also called LYPD7) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it acts on nAChRs in a subtype- and stoichiometry-dependent manner. LYPD6B modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398, but not its wild-type sequence. LYPD6B also activates AP1 (PMA)-mediated transcriptional activation. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467097  Cd Length: 88  Bit Score: 114.76  E-value: 4.31e-35
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECL--STGCRDSEHEGHKVCTSCCEG 79
Cdd:cd23567  1 ITCFTCENKTDNYECNRWAIDRPCPQGTSYCYTVHVMDSRGRSVSVTKKCATPSECTpnTVGCRDSTDTGHTVCISCCDG 80


               ....*...
6IB6_A      80 NICNLPLP 87
Cdd:cd23567 81 SYCNVEVP 88
TFP_LU_ECD_LYPD6B cd23626
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6B (LYPD6B) and ...
 2-89 2.32e-28

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 6B (LYPD6B) and similar proteins; LYPD6B (also called LYPD7) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it acts on nAChRs in a subtype- and stoichiometry-dependent manner. LYPD6B modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398, but not its wild-type sequence. LYPD6B also activates AP1 (PMA)-mediated transcriptional activation. LYPD6B contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467146  Cd Length: 88  Bit Score: 98.02  E-value: 2.32e-28
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNI 81
Cdd:cd23626  1 FKCFTCENAPDNYNCNRWAEDKWCPQNTQYCLTIHHFTSHGKSKSVTKKCASREECHFVGCHHHRDSGHTECVSCCEGMI 80


               ....*...
6IB6_A      82 CNLPLPRN 89
Cdd:cd23626 81 CNVEVPTN 88
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 3-83 6.31e-06

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 40.55  E-value: 6.31e-06
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       3 KCFTCEKAADNYECNRWAPDIYCPRETRYCYTQhTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNIC 82
Cdd:cd00117  2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKI-VGKVGGGETLVIRGCATECECGCTECCSGTGTSGTTCTSCCDTDLC 80


               .
6IB6_A      83 N 83
Cdd:cd00117 81 N 81
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 2-83 7.18e-04

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 35.02  E-value: 7.18e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECnrWAPDIyCPRETRYCYTQHTMEVTGNS--ISVTKRCVPleECLSTGcrdSEHEGHKVCTSCCEG 79
Cdd:cd23543  3 LYCYTCENQSSNWNC--LKPTK-CSDNDKYCVTTVASGGTGSSsgVRITKKCSP--KCPETN---VNIGIASVSTSCCQS 74


               ....
6IB6_A      80 NICN 83
Cdd:cd23543 75 SLCN 78
TFP_LU_ECD_CinHb4_like cd23539
extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; ...
 2-83 9.26e-03

extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; Four distinct globin genes have been identified in the Ciona genome. CinHb4 is encoded by the fourth globin gene. It shows an unusual extension at its N-terminus, which reveals a conserved region with similarity to the extracellular domain (ECD) of the TGF-beta receptor type I/II protein family involved in signal transduction. The functional relevance of these matches is currently unknown. The ECD belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467069  Cd Length: 91  Bit Score: 32.39  E-value: 9.26e-03
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6IB6_A       2 FKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEvTGNSISVTKRCVPLEECL------------STGCRDSEHeg 69
Cdd:cd23539  1 LSCWTCDNASSNEECLANGTLVTCQSNEESCQTEVRRR-GGGVYLISKGCKQRQACEnnkkqnfkaawnPTQCNPESP-- 77

                       90
               ....*....|....
6IB6_A      70 HKVCTSCCEGNICN 83
Cdd:cd23539 78 NSVCRCCCSTDLCN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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