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Conserved domains on  [gi|1335514166|pdb|6EZN|B]
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Chain B, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2

Protein Classification

DAD/OST2 family dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit( domain architecture ID 10489298)

DAD/OST2 family dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit is part of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAD pfam02109
DAD family; Members of this family are thought to be integral membrane proteins. Some members ...
 24-130 5.46e-40

DAD family; Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.


:

Pssm-ID: 460448  Cd Length: 108  Bit Score: 129.16  E-value: 5.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6EZN_B         24 QETFKTSKRAYFAQIEkyPKLKLIDTFCFFLVLLGVIQCTFIILIrDNFPFNAFLAGFIICVGQFVLLMSLRLQLC---- 99
Cdd:pfam02109   1 QSILSTLWKSYSKQTP--QRLKLIDAFLLFLVLTGILQFVYCLLV-GTFPFNAFLSGFISCVGQFVLTVSLRLQLNpenk 77

                          90       100       110
                  ....*....|....*....|....*....|.
6EZN_B        100 NSFPGISKNRAFAEFIVASLILHFVCLHFIN 130
Cdd:pfam02109  78 SEFKGISPERAFADFVFASLVLHFFVINFIG 108
 
Name Accession Description Interval E-value
DAD pfam02109
DAD family; Members of this family are thought to be integral membrane proteins. Some members ...
 24-130 5.46e-40

DAD family; Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.


Pssm-ID: 460448  Cd Length: 108  Bit Score: 129.16  E-value: 5.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6EZN_B         24 QETFKTSKRAYFAQIEkyPKLKLIDTFCFFLVLLGVIQCTFIILIrDNFPFNAFLAGFIICVGQFVLLMSLRLQLC---- 99
Cdd:pfam02109   1 QSILSTLWKSYSKQTP--QRLKLIDAFLLFLVLTGILQFVYCLLV-GTFPFNAFLSGFISCVGQFVLTVSLRLQLNpenk 77

                          90       100       110
                  ....*....|....*....|....*....|.
6EZN_B        100 NSFPGISKNRAFAEFIVASLILHFVCLHFIN 130
Cdd:pfam02109  78 SEFKGISPERAFADFVFASLVLHFFVINFIG 108
 
Name Accession Description Interval E-value
DAD pfam02109
DAD family; Members of this family are thought to be integral membrane proteins. Some members ...
 24-130 5.46e-40

DAD family; Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated, these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation.


Pssm-ID: 460448  Cd Length: 108  Bit Score: 129.16  E-value: 5.46e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6EZN_B         24 QETFKTSKRAYFAQIEkyPKLKLIDTFCFFLVLLGVIQCTFIILIrDNFPFNAFLAGFIICVGQFVLLMSLRLQLC---- 99
Cdd:pfam02109   1 QSILSTLWKSYSKQTP--QRLKLIDAFLLFLVLTGILQFVYCLLV-GTFPFNAFLSGFISCVGQFVLTVSLRLQLNpenk 77

                          90       100       110
                  ....*....|....*....|....*....|.
6EZN_B        100 NSFPGISKNRAFAEFIVASLILHFVCLHFIN 130
Cdd:pfam02109  78 SEFKGISPERAFADFVFASLVLHFFVINFIG 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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