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Conserved domains on  [gi|1756477778|pdb|6E16|A]
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Chain A, Transcription initiation factor TFIID subunit 1,Myc proto-oncogene protein,TATA-box-binding protein

Protein Classification

TATA-box-binding protein( domain architecture ID 11476362)

TATA-box-binding protein is a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 91-266 4.20e-130

TATA-box-binding protein; Provisional


:

Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 365.56  E-value: 4.20e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        91 VPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       171 QKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEI 250
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160

                        170
                 ....*....|....*.
6E16_A       251 YQAFEAIYPVLSEFRK 266
Cdd:PLN00062 161 YTAFENIYPVLTEFRK 176
Myc_N super family cl03082
Myc amino-terminal region; The myc family belongs to the basic helix-loop-helix leucine zipper ...
 45-74 1.29e-12

Myc amino-terminal region; The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.


The actual alignment was detected with superfamily member pfam01056:

Pssm-ID: 460045  Cd Length: 339  Bit Score: 66.73  E-value: 1.29e-12
                          10        20        30
                  ....*....|....*....|....*....|.
6E16_A         45 ADQLEMVTELLGGDMVNQSFICDPD-DETFI 74
Cdd:pfam01056  71 ADQLEMVTELLGADLVNQSFICDPDeDDSFL 101
 
Name Accession Description Interval E-value
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 91-266 4.20e-130

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 365.56  E-value: 4.20e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        91 VPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       171 QKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEI 250
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160

                        170
                 ....*....|....*.
6E16_A       251 YQAFEAIYPVLSEFRK 266
Cdd:PLN00062 161 YTAFENIYPVLTEFRK 176
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 91-264 7.81e-129

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 362.31  E-value: 7.81e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       91 VPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      171 QKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEI 250
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160

                       170
                ....*....|....
6E16_A      251 YQAFEAIYPVLSEF 264
Cdd:cd04516 161 YQAFENIYPILLQF 174
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
92-264 8.03e-60

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 187.33  E-value: 8.03e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       92 PTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQ 171
Cdd:COG2101   4 IEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      172 KIGFAA-KFTDFKIQNIVGSCDVKFPIRLEGLAFSHG-TFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREE 249
Cdd:COG2101  84 KLGIEIpDEPEITVQNIVASADLGREINLNALAIGLGlENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEE 163

                       170
                ....*....|....*
6E16_A      250 IYQAFEAIYPVLSEF 264
Cdd:COG2101 164 AERAVDKLRERLEEL 178
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
181-264 4.49e-43

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 141.42  E-value: 4.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        181 DFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPV 260
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
6E16_A        261 LSEF 264
Cdd:pfam00352  81 LQKL 84
Myc_N pfam01056
Myc amino-terminal region; The myc family belongs to the basic helix-loop-helix leucine zipper ...
 45-74 1.29e-12

Myc amino-terminal region; The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.


Pssm-ID: 460045  Cd Length: 339  Bit Score: 66.73  E-value: 1.29e-12
                          10        20        30
                  ....*....|....*....|....*....|.
6E16_A         45 ADQLEMVTELLGGDMVNQSFICDPD-DETFI 74
Cdd:pfam01056  71 ADQLEMVTELLGADLVNQSFICDPDeDDSFL 101
 
Name Accession Description Interval E-value
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 91-266 4.20e-130

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 365.56  E-value: 4.20e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        91 VPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       171 QKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEI 250
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREEI 160

                        170
                 ....*....|....*.
6E16_A       251 YQAFEAIYPVLSEFRK 266
Cdd:PLN00062 161 YTAFENIYPVLTEFRK 176
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 91-264 7.81e-129

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 362.31  E-value: 7.81e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       91 VPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      171 QKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEI 250
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREEI 160

                       170
                ....*....|....
6E16_A      251 YQAFEAIYPVLSEF 264
Cdd:cd04516 161 YQAFENIYPILLQF 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 91-263 3.15e-113

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 322.96  E-value: 3.15e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       91 VPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:cd00652   1 SPKIQNIVATVNLGCELDLRKIALAARNAEYNPKRFPGVIMRLREPKTTALIFSSGKMVITGAKSEEDAKLAARKYARIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      171 QKIGFAA-KFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREE 249
Cdd:cd00652  81 QKLGFPVeKFPEFKVQNIVASCDLGFPIRLEELALKHPENASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAKSRED 160

                       170
                ....*....|....
6E16_A      250 IYQAFEAIYPVLSE 263
Cdd:cd00652 161 IYEAVEKIYPILKE 174
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 90-263 4.71e-63

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 195.63  E-value: 4.71e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       90 IVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPkRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARI 169
Cdd:cd04517   1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNP-RYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      170 IQKIGF-AAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQRE 248
Cdd:cd04517  80 LQKLGFkVVRFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGARSME 159

                       170
                ....*....|....*
6E16_A      249 EIYQAFEAIYPVLSE 263
Cdd:cd04517 160 DVREAVEKIYPIVFE 174
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
92-264 8.03e-60

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 187.33  E-value: 8.03e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       92 PTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQ 171
Cdd:COG2101   4 IEIENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      172 KIGFAA-KFTDFKIQNIVGSCDVKFPIRLEGLAFSHG-TFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREE 249
Cdd:COG2101  84 KLGIEIpDEPEITVQNIVASADLGREINLNALAIGLGlENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEE 163

                       170
                ....*....|....*
6E16_A      250 IYQAFEAIYPVLSEF 264
Cdd:COG2101 164 AERAVDKLRERLEEL 178
PRK00394 PRK00394
transcription factor; Reviewed
 93-264 5.09e-57

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 180.43  E-value: 5.09e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        93 TLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQK 172
Cdd:PRK00394   2 KIENIVASTDLGQELDLEKVAEDLPNAEYNPEQFPGLVYRLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKLKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       173 IGFaaKFTD---FKIQNIVGSCDVKFPIRLEGLAFSHGTFSS-YEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQRE 248
Cdd:PRK00394  82 LGI--KVIDepeIKVQNIVASADLGVELNLNAIAIGLGLENIeYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEE 159

                        170
                 ....*....|....*.
6E16_A       249 EIYQAFEAIYPVLSEF 264
Cdd:PRK00394 160 DAEKAVEKILEKLEEL 175
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 92-263 1.38e-55

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 176.67  E-value: 1.38e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       92 PTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQ 171
Cdd:cd04518   2 LKIENIVASVDLGQELDLEKVAAELPNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKLK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A      172 KIGFAAKF-TDFKIQNIVGSCDVKFPIRLEGLAFSHGTfSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEI 250
Cdd:cd04518  82 DYGIKVIEkPEIKVQNIVASADLGREVNLDAIAIGLPN-AEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEEDA 160

                       170
                ....*....|...
6E16_A      251 YQAFEAIYPVLSE 263
Cdd:cd04518 161 KRAVEKLLSRLKE 173
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
181-264 4.49e-43

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 141.42  E-value: 4.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        181 DFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPV 260
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80


                  ....
6E16_A        261 LSEF 264
Cdd:pfam00352  81 LQKL 84
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
92-173 8.54e-40

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 132.95  E-value: 8.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A         92 PTLQNIVATVTLGCRLDLKTVAL-HARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:pfam00352   2 IKIQNVVASADLGFPIDLEKLALkLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPIL 81


                  ...
6E16_A        171 QKI 173
Cdd:pfam00352  82 QKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
92-175 1.68e-22

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 91.03  E-value: 1.68e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       92 PTLQNIVATVTLGCRLDLKTVA--LHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARI 169
Cdd:COG2101  95 ITVQNIVASADLGREINLNALAigLGLENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAERAVDKLRER 174


                ....*.
6E16_A      170 IQKIGF 175
Cdd:COG2101 175 LEELGL 180
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 92-173 2.55e-22

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 90.39  E-value: 2.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A       92 PTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQ 171
Cdd:cd04518  93 IKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEEDAKRAVEKLLSRLK 172


                ..
6E16_A      172 KI 173
Cdd:cd04518 173 EL 174
PRK00394 PRK00394
transcription factor; Reviewed
 93-174 1.10e-21

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 89.14  E-value: 1.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6E16_A        93 TLQNIVATVTLGCRLDLKTVA--LHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARII 170
Cdd:PRK00394  93 KVQNIVASADLGVELNLNAIAigLGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDAEKAVEKILEKL 172


                 ....
6E16_A       171 QKIG 174
Cdd:PRK00394 173 EELG 176
Myc_N pfam01056
Myc amino-terminal region; The myc family belongs to the basic helix-loop-helix leucine zipper ...
 45-74 1.29e-12

Myc amino-terminal region; The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.


Pssm-ID: 460045  Cd Length: 339  Bit Score: 66.73  E-value: 1.29e-12
                          10        20        30
                  ....*....|....*....|....*....|.
6E16_A         45 ADQLEMVTELLGGDMVNQSFICDPD-DETFI 74
Cdd:pfam01056  71 ADQLEMVTELLGADLVNQSFICDPDeDDSFL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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