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Conserved domains on  [gi|985483975|pdb|5CHE|D]
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Chain D, Glutamyl-tRNA reductase-binding protein, chloroplastic

Protein Classification

DUF2470 domain-containing protein; PNPOx/FlaRed_like and DUF2470 domain-containing protein( domain architecture ID 13373802)

DUF2470 domain-containing protein similar to Arabidopsis thaliana chloroplastic glutamyl-tRNA reductase-binding protein (AtGluTRBP), which is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis; PNPOx/FlaRed_like and DUF2470 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2470 pfam10615
Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron ...
 197-268 3.71e-09

Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron utilization proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.


:

Pssm-ID: 431396  Cd Length: 73  Bit Score: 52.60  E-value: 3.71e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5CHE_D        197 AEDIVNQINANNMEDIFRFCNVYVDLDfVVSETKMIWMDRLGFDLRVwspRGVYDVRIPFPMEVTDEKGAKS 268
Cdd:pfam10615   1 SARIIAHMNADHADALLLYARHYGGVP-DATAARMTDIDRDGMDLRV---TGDVTVRIPFDPPLTDREEARA 68
HugZ super family cl34030
Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and ...
 54-266 2.14e-06

Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG0748:

Pssm-ID: 440511 [Multi-domain]  Cd Length: 221  Bit Score: 47.65  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D       54 PAEVSRSIMELSSVGTLSTLTHDGWPLGVGVRFAVDKDGTPVLClnrsVSpdkRSALHVQ-LeqcgLRTPQC-------- 124
Cdd:COG0748   8 AAEEARTLLRSARSGALATLDADGYPFASYAPFALDDDGSPYIL----IS---GLAEHTRnL----LADPRAsllliede 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D      125 ------------TIQGSIGRPGDDTVLKRLSATWREKFGEevkedslyvvaVDRVLQMEDF------MEDG--------- 177
Cdd:COG0748  77 skagdplarprlTLQGRAERVEDSEEWEAARARYLARFPK-----------AALYADLPDFslfrltPERGrlvggfgra 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D      178 IWVASSDYKNASPDplrdiAEDIVNQINANNMedifrfcnvyvdLDFVVSETKMIWMDRLGFDLRVwsprGVYDVRIPFP 257
Cdd:COG0748 146 YWLSGEDLLGADAA-----EAGAVEHMNDDHA------------AGHPDAAWRMTGIDPEGFDLRA----GDRVLRLPFP 204


                ....*....
5CHE_D      258 MEVTDEKGA 266
Cdd:COG0748 205 EPVTDAGEL 213
 
Name Accession Description Interval E-value
DUF2470 pfam10615
Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron ...
 197-268 3.71e-09

Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron utilization proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.


Pssm-ID: 431396  Cd Length: 73  Bit Score: 52.60  E-value: 3.71e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5CHE_D        197 AEDIVNQINANNMEDIFRFCNVYVDLDfVVSETKMIWMDRLGFDLRVwspRGVYDVRIPFPMEVTDEKGAKS 268
Cdd:pfam10615   1 SARIIAHMNADHADALLLYARHYGGVP-DATAARMTDIDRDGMDLRV---TGDVTVRIPFDPPLTDREEARA 68
HugZ COG0748
Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and ...
 54-266 2.14e-06

Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and metabolism];


Pssm-ID: 440511 [Multi-domain]  Cd Length: 221  Bit Score: 47.65  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D       54 PAEVSRSIMELSSVGTLSTLTHDGWPLGVGVRFAVDKDGTPVLClnrsVSpdkRSALHVQ-LeqcgLRTPQC-------- 124
Cdd:COG0748   8 AAEEARTLLRSARSGALATLDADGYPFASYAPFALDDDGSPYIL----IS---GLAEHTRnL----LADPRAsllliede 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D      125 ------------TIQGSIGRPGDDTVLKRLSATWREKFGEevkedslyvvaVDRVLQMEDF------MEDG--------- 177
Cdd:COG0748  77 skagdplarprlTLQGRAERVEDSEEWEAARARYLARFPK-----------AALYADLPDFslfrltPERGrlvggfgra 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D      178 IWVASSDYKNASPDplrdiAEDIVNQINANNMedifrfcnvyvdLDFVVSETKMIWMDRLGFDLRVwsprGVYDVRIPFP 257
Cdd:COG0748 146 YWLSGEDLLGADAA-----EAGAVEHMNDDHA------------AGHPDAAWRMTGIDPEGFDLRA----GDRVLRLPFP 204


                ....*....
5CHE_D      258 MEVTDEKGA 266
Cdd:COG0748 205 EPVTDAGEL 213
 
Name Accession Description Interval E-value
DUF2470 pfam10615
Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron ...
 197-268 3.71e-09

Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron utilization proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.


Pssm-ID: 431396  Cd Length: 73  Bit Score: 52.60  E-value: 3.71e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
5CHE_D        197 AEDIVNQINANNMEDIFRFCNVYVDLDfVVSETKMIWMDRLGFDLRVwspRGVYDVRIPFPMEVTDEKGAKS 268
Cdd:pfam10615   1 SARIIAHMNADHADALLLYARHYGGVP-DATAARMTDIDRDGMDLRV---TGDVTVRIPFDPPLTDREEARA 68
HugZ COG0748
Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and ...
 54-266 2.14e-06

Putative heme iron utilization protein, contains PNPOx domain [Inorganic ion transport and metabolism];


Pssm-ID: 440511 [Multi-domain]  Cd Length: 221  Bit Score: 47.65  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D       54 PAEVSRSIMELSSVGTLSTLTHDGWPLGVGVRFAVDKDGTPVLClnrsVSpdkRSALHVQ-LeqcgLRTPQC-------- 124
Cdd:COG0748   8 AAEEARTLLRSARSGALATLDADGYPFASYAPFALDDDGSPYIL----IS---GLAEHTRnL----LADPRAsllliede 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D      125 ------------TIQGSIGRPGDDTVLKRLSATWREKFGEevkedslyvvaVDRVLQMEDF------MEDG--------- 177
Cdd:COG0748  77 skagdplarprlTLQGRAERVEDSEEWEAARARYLARFPK-----------AALYADLPDFslfrltPERGrlvggfgra 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CHE_D      178 IWVASSDYKNASPDplrdiAEDIVNQINANNMedifrfcnvyvdLDFVVSETKMIWMDRLGFDLRVwsprGVYDVRIPFP 257
Cdd:COG0748 146 YWLSGEDLLGADAA-----EAGAVEHMNDDHA------------AGHPDAAWRMTGIDPEGFDLRA----GDRVLRLPFP 204


                ....*....
5CHE_D      258 MEVTDEKGA 266
Cdd:COG0748 205 EPVTDAGEL 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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