NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|586500239|pdb|4L3O|B]
View 

Chain B, NAD-dependent protein deacetylase sirtuin-2

Protein Classification

SIR2 family NAD-dependent protein deacylase( domain architecture ID 10105415)

SIR2 family NAD-dependent protein deacylase such as NAD-dependent deacetylase, which catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
23-277 5.24e-152

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


:

Pssm-ID: 238699  Cd Length: 235  Bit Score: 424.74  E-value: 5.24e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       23 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLK 102
Cdd:cd01408   1 KKIVVLVGAGISTSAGIPDFRSPGTGLYANLARYNLPYPEAMFDISYFRKNPRPFYALAKELYPGQFKPSVAHYFIKLLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      103 DKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFG 182
Cdd:cd01408  81 DKGLLLRNYTQNIDTLERVAGVPDDRIIEAHGSFATAHCI--KCKHKYPGDWMREDIFNQEVPKCPRCGGLVKPDIVFFG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      183 ESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQsdpflgmimglgggmdfdSKKAYR 262
Cdd:cd01408 159 ESLPSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPSRVPSEVPRVLINREPVGH------------------LGKRPF 220
                       250
                ....*....|....*
4L3O_B      263 DVAWLGECDQGCLAL 277
Cdd:cd01408 221 DVALLGDCDDGVREL 235
 
Name Accession Description Interval E-value
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
23-277 5.24e-152

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 424.74  E-value: 5.24e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       23 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLK 102
Cdd:cd01408   1 KKIVVLVGAGISTSAGIPDFRSPGTGLYANLARYNLPYPEAMFDISYFRKNPRPFYALAKELYPGQFKPSVAHYFIKLLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      103 DKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFG 182
Cdd:cd01408  81 DKGLLLRNYTQNIDTLERVAGVPDDRIIEAHGSFATAHCI--KCKHKYPGDWMREDIFNQEVPKCPRCGGLVKPDIVFFG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      183 ESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQsdpflgmimglgggmdfdSKKAYR 262
Cdd:cd01408 159 ESLPSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPSRVPSEVPRVLINREPVGH------------------LGKRPF 220
                       250
                ....*....|....*
4L3O_B      263 DVAWLGECDQGCLAL 277
Cdd:cd01408 221 DVALLGDCDDGVREL 235
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
2-237 2.20e-80

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 247.09  E-value: 2.20e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B         2 ERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALA 81
Cdd:PTZ00410   9 EHVVGEPTFEGLARYIERNNVTKILVMVGAGISVAAGIPDFRSPHTGIYAKLGKYNLNSPTDAFSLTLLREKPEVFYSIA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        82 KE--LYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKI 159
Cdd:PTZ00410  89 REmdLWPGHFQPTAVHHFIRLLADEGRLLRCCTQNIDGLERAAGVPPSLLVEAHGSFSAASCI--ECHTPYDIEQAYLEA 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
4L3O_B       160 FSEVTPKCEDCQSLVKPDIVFFGESLPARFFScMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAG 237
Cdd:PTZ00410 167 RSGKVPHCSTCGGIVKPDVVFFGENLPDAFFN-VHHDIPEAELLLIIGTSLQVHPFALLACVVPKDVPRVLFNLERVG 243
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
30-214 2.01e-75

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 228.68  E-value: 2.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B         30 GAGISTSAGIPDFRSpSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLR 109
Cdd:pfam02146   1 GAGISTESGIPDFRS-DDGLYAKLAPEELASPEAFFSNPELVWDPEPFYNIARELLPGEAQPNPAHYFIAKLEDKGKLLR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        110 CYTQNIDTLERIAGLEQedLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARF 189
Cdd:pfam02146  80 LITQNIDGLHERAGSKK--VVELHGSFAKARCV--SCHQKYTGETLYERIRPEKVPHCPQCGGLLKPDIVFFGENLPDKF 155
                         170       180
                  ....*....|....*....|....*
4L3O_B        190 FSCMqSDFLKVDLLLVMGTSLQVQP 214
Cdd:pfam02146 156 HRAY-EDLEEADLLIVIGTSLKVYP 179
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
20-242 1.34e-53

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 174.96  E-value: 1.34e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       20 ERCRRVICLVGAGISTSAGIPDFRSPsTGLYdnlEKYHlpyPEAIFEISYFKKHPEPFFALAKE---LYPGQfKPTICHY 96
Cdd:COG0846  12 REAKRIVVLTGAGISAESGIPDFRGP-DGLW---EKYD---PEEVASPEAFRRDPELVWAFYNErrrLLRDA-EPNAAHR 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       97 FMRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKP 176
Cdd:COG0846  84 ALAELEKAGKLVFVITQNVDGLHQRAG--SKNVIELHGSLHRLRCTK--CGKRYDLEDVLEDLEGELPPRCPKCGGLLRP 159
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
4L3O_B      177 DIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRL-LINKEKAGQSDPF 242
Cdd:COG0846 160 DVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLvEINPEPTPLDSLA 226
 
Name Accession Description Interval E-value
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
23-277 5.24e-152

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 424.74  E-value: 5.24e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       23 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLK 102
Cdd:cd01408   1 KKIVVLVGAGISTSAGIPDFRSPGTGLYANLARYNLPYPEAMFDISYFRKNPRPFYALAKELYPGQFKPSVAHYFIKLLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      103 DKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFG 182
Cdd:cd01408  81 DKGLLLRNYTQNIDTLERVAGVPDDRIIEAHGSFATAHCI--KCKHKYPGDWMREDIFNQEVPKCPRCGGLVKPDIVFFG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      183 ESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQsdpflgmimglgggmdfdSKKAYR 262
Cdd:cd01408 159 ESLPSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPSRVPSEVPRVLINREPVGH------------------LGKRPF 220
                       250
                ....*....|....*
4L3O_B      263 DVAWLGECDQGCLAL 277
Cdd:cd01408 221 DVALLGDCDDGVREL 235
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
23-242 1.81e-94

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 278.30  E-value: 1.81e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       23 RRVICLVGAGISTSAGIPDFRSPStGLYDNLEKYHLPypeaiFEISYFKKHPEPFFALAKELY-PGQFKPTICHYFMRLL 101
Cdd:cd01407   1 KRIVVLTGAGISTESGIPDFRSPG-GLWARLDPEELA-----FSPEAFRRDPELFWGFYRERRyPLNAQPNPAHRALAEL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      102 KDKGLLLRCYTQNIDTLERIAGLEQedLVEAHGTFYTSHCVSasCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFF 181
Cdd:cd01407  75 ERKGKLKRVITQNVDGLHQRAGSPK--VIELHGSLFRVRCTK--CGKEYPRDELQADIDREEVPRCPKCGGLLRPDVVFF 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
4L3O_B      182 GESLPARFFSCMQSDfLKVDLLLVMGTSLQVQPFASLISKAPLS-TPRLLINKEKAGQSDPF 242
Cdd:cd01407 151 GESLPEELDEAAEAL-AKADLLLVIGTSLQVYPAAGLPLYAPERgAPVVIINLEPTPADRKA 211
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
23-241 1.95e-81

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 245.33  E-value: 1.95e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       23 RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPypeaiFEISYFKKHPEPFFALAKELY--PGQFKPTICHYFMRL 100
Cdd:cd00296   1 KRVVVFTGAGISTESGIPDFRGLGTGLWTRLDPEELA-----FSPEAFRRDPELFWLFYKERRytPLDAKPNPAHRALAE 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      101 LKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKifsEVTPKCEDCQSLVKPDIVF 180
Cdd:cd00296  76 LERKGKLKRIITQNVDGLHERAGSRRNRVIELHGSLDRVRCT--SCGKEYPRDEVLER---EKPPRCPKCGGLLRPDVVD 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
4L3O_B      181 FGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLST-PRLLINKEKAGQSDP 241
Cdd:cd00296 151 FGEALPKEWFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGaPVVIINREPTPADAL 212
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
2-237 2.20e-80

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 247.09  E-value: 2.20e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B         2 ERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALA 81
Cdd:PTZ00410   9 EHVVGEPTFEGLARYIERNNVTKILVMVGAGISVAAGIPDFRSPHTGIYAKLGKYNLNSPTDAFSLTLLREKPEVFYSIA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        82 KE--LYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKI 159
Cdd:PTZ00410  89 REmdLWPGHFQPTAVHHFIRLLADEGRLLRCCTQNIDGLERAAGVPPSLLVEAHGSFSAASCI--ECHTPYDIEQAYLEA 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
4L3O_B       160 FSEVTPKCEDCQSLVKPDIVFFGESLPARFFScMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAG 237
Cdd:PTZ00410 167 RSGKVPHCSTCGGIVKPDVVFFGENLPDAFFN-VHHDIPEAELLLIIGTSLQVHPFALLACVVPKDVPRVLFNLERVG 243
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
30-214 2.01e-75

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 228.68  E-value: 2.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B         30 GAGISTSAGIPDFRSpSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLR 109
Cdd:pfam02146   1 GAGISTESGIPDFRS-DDGLYAKLAPEELASPEAFFSNPELVWDPEPFYNIARELLPGEAQPNPAHYFIAKLEDKGKLLR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        110 CYTQNIDTLERIAGLEQedLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARF 189
Cdd:pfam02146  80 LITQNIDGLHERAGSKK--VVELHGSFAKARCV--SCHQKYTGETLYERIRPEKVPHCPQCGGLLKPDIVFFGENLPDKF 155
                         170       180
                  ....*....|....*....|....*
4L3O_B        190 FSCMqSDFLKVDLLLVMGTSLQVQP 214
Cdd:pfam02146 156 HRAY-EDLEEADLLIVIGTSLKVYP 179
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
20-242 1.34e-53

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 174.96  E-value: 1.34e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       20 ERCRRVICLVGAGISTSAGIPDFRSPsTGLYdnlEKYHlpyPEAIFEISYFKKHPEPFFALAKE---LYPGQfKPTICHY 96
Cdd:COG0846  12 REAKRIVVLTGAGISAESGIPDFRGP-DGLW---EKYD---PEEVASPEAFRRDPELVWAFYNErrrLLRDA-EPNAAHR 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       97 FMRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKP 176
Cdd:COG0846  84 ALAELEKAGKLVFVITQNVDGLHQRAG--SKNVIELHGSLHRLRCTK--CGKRYDLEDVLEDLEGELPPRCPKCGGLLRP 159
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
4L3O_B      177 DIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRL-LINKEKAGQSDPF 242
Cdd:COG0846 160 DVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLvEINPEPTPLDSLA 226
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
20-218 1.67e-51

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 169.09  E-value: 1.67e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       20 ERCRRVICLVGAGISTSAGIPDFRSPStGLYDNlekyhlPYPEAIFEISYFKKHPEPFFALAKE-LYP-GQFKPTICHYF 97
Cdd:cd01413   2 TKSRKTVVLTGAGISTESGIPDFRSPD-GLWKK------YDPEEVASIDYFYRNPEEFWRFYKEiILGlLEAQPNKAHYF 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       98 MRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLSWMKEKIFSEVtPKCEDCQSLVKPD 177
Cdd:cd01413  75 LAELEKQGIIKAIITQNIDGLHQRAG--SKNVIELHGTLQTAYCVN--CGSKYDLEEVKYAKKHEV-PRCPKCGGIIRPD 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
4L3O_B      178 IVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASL 218
Cdd:cd01413 150 VVLFGEPLPQALLREAIEAAKEADLFIVLGSSLVVYPANLL 190
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
23-242 8.20e-50

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 165.35  E-value: 8.20e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        23 RRVICLVGAGISTSAGIPDFRSPsTGLYDNLekyhlpYPEAIFEISYFKKHPEPFFALAKE----LYpgQFKPTICHYFM 98
Cdd:PRK00481  14 KRIVVLTGAGISAESGIPDFRSA-NGLWEEH------RPEDVASPEGFARDPELVWKFYNErrrqLL--DAKPNAAHRAL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        99 RLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLswmkEKIFSEVTPKCEDCQSLVKPDI 178
Cdd:PRK00481  85 AELEKLGKLVTVITQNIDGLHERAG--SKNVIELHGSLLRARCTK--CGQTYDL----DEYLKPEPPRCPKCGGILRPDV 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
4L3O_B       179 VFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRL-LINKEKAGQSDPF 242
Cdd:PRK00481 157 VLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTvEINLEPTPLDSLF 221
PRK14138 PRK14138
NAD-dependent deacetylase; Provisional
22-231 7.25e-46

NAD-dependent deacetylase; Provisional


Pssm-ID: 172627 [Multi-domain]  Cd Length: 244  Bit Score: 154.98  E-value: 7.25e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        22 CRRVICLVGAGISTSAGIPDFRSPsTGLYDNlekyhlpYPEAIFEISYFKKHPEPFFALAKE-LYP-GQFKPTICHYFMR 99
Cdd:PRK14138  11 SRLTVTLTGAGISTPSGIPDFRGP-QGIYKK-------YPQNVFDIDFFYSHPEEFYRFAKEgIFPmLEAKPNLAHVLLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       100 LLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIV 179
Cdd:PRK14138  83 KLEEKGLIEAVITQNIDRLHQKAG--SKKVIELHGNVEEYYCVR--CGKRYTVEDVIEKLEKSDVPRCDDCSGLIRPNIV 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
4L3O_B       180 FFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLI 231
Cdd:PRK14138 159 FFGEALPQDALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVI 210
SIR2H cd01411
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ...
24-234 6.07e-38

SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238702  Cd Length: 225  Bit Score: 134.03  E-value: 6.07e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       24 RVICLVGAGISTSAGIPDFRSpSTGLYDNLEKYHlpyPEAIFEISYFKKHPEPFFALAKE--LYPGQfKPTICHYFMRLL 101
Cdd:cd01411  10 RIVFFTGAGVSTASGIPDYRS-KNGLYNEIYKYS---PEYLLSHDFLEREPEKFYQFVKEnlYFPDA-KPNIIHQKMAEL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B      102 KDKGLLlRCYTQNIDTLERIAGLEQedLVEAHGTFYTSHCVSasCRHEYPlswmkeKIFSEVTPKCEDCQSLVKPDIVFF 181
Cdd:cd01411  85 EKMGLK-AVITQNIDGLHQKAGSKN--VVEFHGSLYRIYCTV--CGKTVD------WEEYLKSPYHAKCGGVIRPDIVLY 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
4L3O_B      182 GESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKE 234
Cdd:cd01411 154 EEMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQAGANLIAINKE 206
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
24-231 8.10e-36

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 127.80  E-value: 8.10e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       24 RVICLVGAGISTSAGIPDFRSPStGLYDNLE------KYHLPYPEAIfeisyfkkhpepffalakelypgqfkPTICHYF 97
Cdd:cd01410   2 HLVVFTGAGISTSAGIPDFRGPN-GVWTLLPedkgrrRFSWRFRRAE--------------------------PTLTHMA 54
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       98 MRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKIFSEVT-PKCEDCQSLVKP 176
Cdd:cd01410  55 LVELERAGLLKFVISQNVDGLHLRSGLPREKLSELHGNMFIEVCK--SCGPEYVRDDVVETRGDKETgRRCHACGGILKD 132
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
4L3O_B      177 DIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLI 231
Cdd:cd01410 133 TIVDFGERLPPENWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVI 187
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
23-234 8.59e-35

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 125.78  E-value: 8.59e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       23 RRVICLVGAGISTSAGIPDFRSPStGLYDNLEKYHLPYPEAifeisyFKKHPEP---FF------ALAKElypgqfkPTI 93
Cdd:cd01412   1 RRVVVLTGAGISAESGIPTFRDAD-GLWARFDPEELATPEA------FARDPELvweFYnwrrrkALRAQ-------PNP 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       94 CHYFMRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLswmKEKIFSEVTPKCEDCQSL 173
Cdd:cd01412  67 AHLALAELERRLPNVLLITQNVDGLHERAG--SRNVIELHGSLFRVRCSS--CGYVGEN---NEEIPEEELPRCPKCGGL 139
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
4L3O_B      174 VKPDIVFFGESLPARFFSCMQSdFLKVDLLLVMGTSLQVQPFASLISKAPLS-TPRLLINKE 234
Cdd:cd01412 140 LRPGVVWFGESLPLALLEAVEA-LAKADLFLVIGTSGVVYPAAGLPEEAKERgARVIEINPE 200
SIRT4 cd01409
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ...
19-212 1.55e-26

SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238700  Cd Length: 260  Bit Score: 104.69  E-value: 1.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       19 SERCRRVICLVGAGISTSAGIPDFRSPStGLYdnlEKYHLPypeaiFEISYFKKHPEpffalAKELY--------P--GQ 88
Cdd:cd01409   5 VARSRRLLVLTGAGISTESGIPDYRSEG-GLY---SRTFRP-----MTHQEFMRSPA-----ARQRYwarsfvgwPrfSA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       89 FKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVsaSCRHEYPLSWMKEKI------FSE 162
Cdd:cd01409  71 AQPNAAHRALAALEAAGRLHGLITQNVDGLHTKAG--SRNVVELHGSLHRVVCL--SCGFRTPRAELQDRLealnpgFAE 146
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
4L3O_B      163 VT---------------------PKCEDCQSLVKPDIVFFGESLPA--RFFSCMQsdFLKVDLLLVMGTSLQV 212
Cdd:cd01409 147 QAagqapdgdvdledeqvagfrvPECERCGGVLKPDVVFFGENVPRdrVVTAAAR--LAEADALLVLGSSLMV 217
PTZ00409 PTZ00409
Sir2 (Silent Information Regulator) protein; Provisional
1-222 3.90e-23

Sir2 (Silent Information Regulator) protein; Provisional


Pssm-ID: 173599 [Multi-domain]  Cd Length: 271  Bit Score: 96.14  E-value: 3.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B         1 KERLLDELTLEGVARYMQseRCRRVICLVGAGISTSAGIPDFRSPSTGLYdnlEKYHlpyPEAIFEISYFKKHPEPFFAL 80
Cdd:PTZ00409   9 QKKVTKSITLEDLADMIR--KCKYVVALTGSGTSAESNIPSFRGPSSSIW---SKYD---PKIYGTIWGFWKYPEKIWEV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        81 AKE-LYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCvsASCRHEYPLSWM---- 155
Cdd:PTZ00409  81 IRDiSSDYEIELNPGHVALSTLESLGYLKFVVTQNVDGLHEESG--NTKVIPLHGSVFEARC--CTCRKTIQLNKImlqk 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
4L3O_B       156 KEKIFSEVTPKCEdCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKA 222
Cdd:PTZ00409 157 TSHFMHQLPPECP-CGGIFKPNVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRA 222
PTZ00408 PTZ00408
NAD-dependent deacetylase; Provisional
21-242 3.06e-17

NAD-dependent deacetylase; Provisional


Pssm-ID: 240405  Cd Length: 242  Bit Score: 79.10  E-value: 3.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        21 RCRRVICLVGAGISTSAGIPDFRSpSTGLYDNLEKYHLPYPEAIFEISYFKKHpepFF-ALAKELYPGQFKPTICHYFMR 99
Cdd:PTZ00408   3 ACRCITILTGAGISAESGISTFRD-GNGLWENHRVEDVATPDAFLRNPALVQR---FYnERRRALLSSSVKPNKAHFALA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       100 LLKD--KGLLLRCYTQNIDTLERIAGLEQedLVEAHGTFYTSHCVSAscRHEYplSWMKEKIFSevTPKCEDCQSL--VK 175
Cdd:PTZ00408  79 KLEReyRGGKVVVVTQNVDNLHERAGSTH--VLHMHGELLKVRCTAT--GHVF--DWTEDVVHG--SSRCKCCGCVgtLR 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4L3O_B       176 PDIVFFGESlpARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLL-INKEKAGQSDPF 242
Cdd:PTZ00408 151 PHIVWFGEM--PLYMDEIESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLeLNLEEGTNYSQF 216
PRK05333 PRK05333
NAD-dependent protein deacetylase;
20-212 2.47e-16

NAD-dependent protein deacetylase;


Pssm-ID: 235415  Cd Length: 285  Bit Score: 77.41  E-value: 2.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        20 ERCRRVICLVGAGISTSAGIPDFRspstglyDNLEKYHLPYPeaifeISYfkkhpEPFF--ALAKELY--------P--G 87
Cdd:PRK05333  17 ERHPRLFVLTGAGISTDSGIPDYR-------DRNGQWKRSPP-----ITY-----QAFMgsDAARRRYwarsmvgwPvfG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B        88 QFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGleQEDLVEAHGTFYTSHCVSasCRHEYPLSWMKEKI-------- 159
Cdd:PRK05333  80 RAQPNAAHHALARLGAAGRIERLVTQNVDGLHQRAG--SRDVIELHGRLDGVRCMG--CGARHPRAEIQHVLeaanpewl 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
4L3O_B       160 ------------------FSE-VTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQV 212
Cdd:PRK05333 156 aleaapapdgdadlewaaFDHfRVPACPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMV 227
SIR2-like cd01406
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ...
24-118 9.61e-04

Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.


Pssm-ID: 238697 [Multi-domain]  Cd Length: 242  Bit Score: 40.08  E-value: 9.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4L3O_B       24 RVICLVGAGISTSAGIPDF---------RSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEP--FFALAKELYPGQFKPT 92
Cdd:cd01406   2 RVVIFVGAGVSVSSGLPDWktlldeiasELGLEIDGYSVEAKDENDYLELAELLEKEFGTIGikINAVLEEKTRPDFEPS 81
                        90       100
                ....*....|....*....|....*..
4L3O_B       93 ICHYFM-RLLKDKGLLLRCYTQNIDTL 118
Cdd:cd01406  82 PLHELLlRLFINNEGDVIIITTNYDRL 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH