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Conserved domains on  [gi|444302252|pdb|4HOU|A]
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Chain A, Interferon-induced protein with tetratricopeptide repeats 1

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
63-273 2.83e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 2.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       63 EEALKSLKEAENL*QEEHDNQANVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRYR*ECPE-------I 135
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaaL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      136 DCEEGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLAtknhkpfsLLPLRQAVRLNPDNGYIKV 215
Cdd:COG3914  81 LELAALLLQALG--RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEA--------LAALRRALALNPDFAEAYL 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
4HOU_A      216 LLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG3914 151 NLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
63-273 2.83e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 2.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       63 EEALKSLKEAENL*QEEHDNQANVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRYR*ECPE-------I 135
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaaL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      136 DCEEGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLAtknhkpfsLLPLRQAVRLNPDNGYIKV 215
Cdd:COG3914  81 LELAALLLQALG--RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEA--------LAALRRALALNPDFAEAYL 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
4HOU_A      216 LLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG3914 151 NLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
49-271 1.68e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.09  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A         49 HNLLAYVKHLKGQNEEALKSLKEAENL*QEE---HDNQANVRslvtwgnfaw*yYH*GRLAEAQTYLDKVENICKKLSNP 125
Cdd:TIGR02917 196 LLLKGDLLLSLGNIELALAAYRKAIALRPNNiavLLALATIL------------IEAGEFEEAEKHADALLKKAPNSPLA 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        126 FRYR*ecpeidceegwALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVR 205
Cdd:TIGR02917 264 HYLK------------ALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQY--------LNQILK 323
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
4HOU_A        206 LNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKA 271
Cdd:TIGR02917 324 YAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKA 389
TPR_12 pfam13424
Tetratricopeptide repeat;
48-121 3.25e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 3.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
4HOU_A         48 IHNLLAYVKHLKGQNEEALKSLKEAENL*QEEHDNQaNVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKK 121
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPD-HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
63-273 2.83e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 2.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       63 EEALKSLKEAENL*QEEHDNQANVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRYR*ECPE-------I 135
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaaL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      136 DCEEGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLAtknhkpfsLLPLRQAVRLNPDNGYIKV 215
Cdd:COG3914  81 LELAALLLQALG--RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEA--------LAALRRALALNPDFAEAYL 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
4HOU_A      216 LLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG3914 151 NLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
45-273 4.39e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 4.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       45 SVGIHNLLAYVKHLKGQNEEALKSLKEAENL*QEEHDNQANVrslvtwgnfAW*YYH*GRLAEAQTYLDKVENICKKLSN 124
Cdd:COG2956  41 TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLEL---------AQDYLKAGLLDRAEELLEKLLELDPDDAE 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      125 PFRYR*ECPEIDceegwallkcggKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAV 204
Cdd:COG2956 112 ALRLLAEIYEQE------------GDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEA--------LEKAL 171
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
4HOU_A      205 RLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG2956 172 KLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALE 240
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
149-273 1.04e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 58.28  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      149 KNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLAtknhkpfsLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEA 228
Cdd:COG4783  18 GDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEA--------IVLLHEALELDPDEPEARLNLGLALLKAGDYD 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
4HOU_A      229 EGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG4783  90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
91-273 2.53e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 2.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       91 TWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRYR*ecpeidceeGWALLKCGgkNYERAKACFEKVLEVDPENPE 170
Cdd:COG0457  10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL----------GLAYLRLG--RYEEALADYEQALELDPDDAE 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      171 SSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRY 250
Cdd:COG0457  78 ALNNLGLALQALGRYEEALED--------YDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149
                       170       180
                ....*....|....*....|...
4HOU_A      251 AAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG0457 150 LGIALEKLGRYEEALELLEKLEA 172
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
18-248 4.39e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 4.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       18 ELSIDDDE*PDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQNEEALKSLKEAENL*QEEHDNQANVRSLVTWgnFAW 97
Cdd:COG3914   9 LAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL--AAL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       98 *YYH*GRLAEAQTYLDKVENIckklsNPfryr*ECPEIDCEEGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAI 177
Cdd:COG3914  87 LLQALGRYEEALALYRRALAL-----NP-----DNAEALFNLGNLLLALG--RLEEALAALRRALALNPDFAEAYLNLGE 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
4HOU_A      178 SAYRLDGFKLATKNhkpfsllpLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVF 248
Cdd:COG3914 155 ALRRLGRLEEAIAA--------LRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-272 5.81e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.09  E-value: 5.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       49 HNLLAYVKHLKGQNEEALKSLKEAENL*QEEHDnqanvrslvTWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRY 128
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE---------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      129 R*ecpeidceeGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVRLNP 208
Cdd:COG0457  82 L----------GLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEA--------YERALELDP 141
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
4HOU_A      209 DNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKAL 272
Cdd:COG0457 142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
48-273 1.04e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       48 IHNLLAYVKHLKGQNEEALKSLKEAENL*QEehdnqaNVRSLVTWGNFaw*YYH*GRLAEAQTYLDKVENIckklsnpfr 127
Cdd:COG2956  78 ALLELAQDYLKAGLLDRAEELLEKLLELDPD------DAEALRLLAEI---YEQEGDWEKAIEVLERLLKL--------- 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      128 yR*ECPEIDCEEGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVRLN 207
Cdd:COG2956 140 -GPENAHAYCELAELYLEQG--DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAA--------LERALEQD 208
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
4HOU_A      208 PDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYaAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG2956 209 PDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALALLERQLR 273
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
153-273 2.24e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 2.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      153 RAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEK 232
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAA--------YEKALRLDPDNADALLDLAEALLAAGDTEEAEE 72
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
4HOU_A      233 YIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG4235  73 LLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLA 113
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
140-239 2.81e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 2.81e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      140 GWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVRLNPDNGYIKVLLAL 219
Cdd:COG4235  24 GRAYLRLG--RYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEEL--------LERALALDPDNPEALYLLGL 93
                        90       100
                ....*....|....*....|
4HOU_A      220 KLQDEGQEAEGEKYIEEALA 239
Cdd:COG4235  94 AAFQQGDYAEAIAAWQKLLA 113
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
49-271 1.68e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.09  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A         49 HNLLAYVKHLKGQNEEALKSLKEAENL*QEE---HDNQANVRslvtwgnfaw*yYH*GRLAEAQTYLDKVENICKKLSNP 125
Cdd:TIGR02917 196 LLLKGDLLLSLGNIELALAAYRKAIALRPNNiavLLALATIL------------IEAGEFEEAEKHADALLKKAPNSPLA 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        126 FRYR*ecpeidceegwALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVR 205
Cdd:TIGR02917 264 HYLK------------ALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQY--------LNQILK 323
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
4HOU_A        206 LNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKA 271
Cdd:TIGR02917 324 YAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKA 389
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
149-243 3.42e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.17  E-value: 3.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      149 KNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLAtknhkpfslLPLRQAVRLNPDNGYIKVLLALKLQDEGQEA 228
Cdd:COG3063   6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA---------IALEKALKLDPNNAEALLNLAELLLELGDYD 76
                        90
                ....*....|....*
4HOU_A      229 EGEKYIEEALAN*SS 243
Cdd:COG3063  77 EALAYLERALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
150-273 5.10e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      150 NYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKpfsllplrQAVRLNPDNGYIKVLLALKLQDEGQEAE 229
Cdd:COG2956  23 QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQ--------KLLERDPDRAEALLELAQDYLKAGLLDR 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
4HOU_A      230 GEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG2956  95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLK 138
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
140-272 6.07e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.47  E-value: 6.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        140 GWALLKCGgkNYERAKACFEKVLEVDPENpessagyAISAYRLDGFKLATKNHKPfSLLPLRQAVRLNPDNGYIKVLLAL 219
Cdd:TIGR02917 370 GEAYLALG--DFEKAAEYLAKATELDPEN-------AAARTQLGISKLSQGDPSE-AIADLETAAQLDPELGRADLLLIL 439
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
4HOU_A        220 KLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKAL 272
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKAL 492
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-272 9.58e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 9.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       49 HNLLAYVKHLKGQNEEALKSLKEAENL*qeehdnqaNVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRY 128
Cdd:COG0457  45 LYNLGLAYLRLGRYEEALADYEQALEL---------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      129 R*ecpeidceeGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKpfSLLPLRQAVRLNP 208
Cdd:COG0457 116 L----------GLALLELG--RYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE--KLEAAALAALLAA 181
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
4HOU_A      209 DNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKAL 272
Cdd:COG0457 182 ALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
149-240 1.76e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.88  E-value: 1.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      149 KNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNhkpfsllpLRQAVRLNPDNGYIKVLLALKLQDEGQEA 228
Cdd:COG5010  68 GDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEY--------YEKALALSPDNPNAYSNLAALLLSLGQDD 139
                        90
                ....*....|..
4HOU_A      229 EGEKYIEEALAN 240
Cdd:COG5010 140 EAKAALQRALGT 151
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
48-248 6.47e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 6.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       48 IHNLLAYVKHLKGQNEEALKSLKEAenl*qeehdNQANVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENIckklsNPfr 127
Cdd:COG3914  80 LLELAALLLQALGRYEEALALYRRA---------LALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL-----NP-- 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      128 yr*ECPEIDCEEGWALLKCGgkNYERAKACFEKVLEVDPENPEssagyaisAYRLDGFKLATKNHKPFSLLPLRQAVRLN 207
Cdd:COG3914 144 ---DFAEAYLNLGEALRRLG--RLEEAIAALRRALELDPDNAE--------ALNNLGNALQDLGRLEEAIAAYRRALELD 210
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
4HOU_A      208 PDNGYIK--VLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVF 248
Cdd:COG3914 211 PDNADAHsnLLFALRQACDWEVYDRFEELLAALARGPSELSPF 253
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
200-273 1.77e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 1.77e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
4HOU_A      200 LRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYiEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG3063  15 YEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87
TPR_12 pfam13424
Tetratricopeptide repeat;
48-121 3.25e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 3.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
4HOU_A         48 IHNLLAYVKHLKGQNEEALKSLKEAENL*QEEHDNQaNVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKK 121
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPD-HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
200-273 5.14e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 5.14e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
4HOU_A      200 LRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG5010  77 LEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
45-273 6.25e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A         45 SVGIHNLLAYVKHLKGQNEEALKSLKEAENL*qeehDNQANVRSLvtwgNFAW*YYH*GRLAEAQTYLDKVENICKKlsn 124
Cdd:TIGR02917 532 NLRAILALAGLYLRTGNEEEAVAWLEKAAEL-----NPQEIEPAL----ALAQYYLGKGQLKKALAILNEAADAAPD--- 599
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        125 pfryr*eCPEIDCEEGWALLKcgGKNYERAKACFEKVLEVDPENPEssagyaisAYRLDGFKLATKNHKPFSLLPLRQAV 204
Cdd:TIGR02917 600 -------SPEAWLMLGRAQLA--AGDLNKAVSSFKKLLALQPDSAL--------ALLLLADAYAVMKNYAKAITSLKRAL 662
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
4HOU_A        205 RLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:TIGR02917 663 ELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALK 731
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
99-273 2.01e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.44  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       99 YYH*GRLAEAQTYLDKVENICKKLSNPFRYR*ecpeidceeGWALLKCGgkNYERAKACFEKVLEVDPENPESSAGYAIS 178
Cdd:COG4785  83 YDSLGDYDLAIADFDQALELDPDLAEAYNNR----------GLAYLLLG--DYDAALEDFDRALELDPDYAYAYLNRGIA 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A      179 AYRLDGFKLATKNhkpfsllpLRQAVRLNPDNGYIKVLLALklqdegqeAEGEKYIEEALAN*SSQTyvfryaAKFYRRK 258
Cdd:COG4785 151 LYYLGRYELAIAD--------LEKALELDPNDPERALWLYL--------AERKLDPEKALALLLEDW------ATAYLLQ 208
                       170
                ....*....|....*
4HOU_A      259 GSVDKALELLKKALQ 273
Cdd:COG4785 209 GDTEEARELFKLALA 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
140-273 5.59e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        140 GWALLKCGGKNYERAKACFEKVLEVDPENpessagyaISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLAL 219
Cdd:TIGR02917 164 GLAQLALAENRFDEARALIDEVLTADPGN--------VDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALAT 235
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
4HOU_A        220 KLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:TIGR02917 236 ILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALK 289
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
45-168 5.89e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 5.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A       45 SVGIHNLLAYVKHLKGQNEEALKSLKEAENL*QEEHDnqanvrslvTWGNFAW*YYH*GRLAEAQTYLDKVenickklsn 124
Cdd:COG4783  37 NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE---------ARLNLGLALLKAGDYDEALALLEKA--------- 98
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
4HOU_A      125 pFRYR*ECPEIDCEEGWALLKCGgkNYERAKACFEKVLEVDPEN 168
Cdd:COG4783  99 -LKLDPEHPEAYLRLARAYRALG--RPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
217-273 1.88e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 1.88e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
4HOU_A      217 LALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:COG4783  10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE 66
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
61-273 4.50e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 38.43  E-value: 4.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A         61 QNEEALKSL--KEAENL*QEE-HDNQANVRSLVTWGNFAW*YYH*GRLAEAQTYLDKVENICKKLSNPFRyr*ECPEIDC 137
Cdd:TIGR00990 230 QSAQAVERLlkKFAESKAKEIlETKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNELDEETGNGQLQLGL---KSPESKA 306
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        138 EEGwallkcggknYERAKACFEKVLEVDPENPessagYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNP--DNGYIKv 215
Cdd:TIGR00990 307 DES----------YEEAARAFEKALDLGKLGE-----KEAIALNLRGTFKCLKGKHLEALADLSKSIELDPrvTQSYIK- 370
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
4HOU_A        216 lLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALELLKKALQ 273
Cdd:TIGR00990 371 -RASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSID 427
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
30-273 9.03e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.37  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A         30 ENRVLDQIEFLDTKY--SVGIHNLLAYVKHLKGQNEEALKSLKEAENL*qeehdNQANVRSLVtwgNFAW*YYH*GRLAE 107
Cdd:TIGR02917 447 FDKALAAAKKLEKKQpdNASLHNLLGAIYLGKGDLAKAREAFEKALSI------EPDFFPAAA---NLARIDIQEGNPDD 517
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        108 AQTYLDKVENICKKlsnpfryr*ecpEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAiSAYRLDG-FK 186
Cdd:TIGR02917 518 AIQRFEKVLTIDPK------------NLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALA-QYYLGKGqLK 584
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HOU_A        187 LAtknhkpfsLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALAN*SSQTYVFRYAAKFYRRKGSVDKALE 266
Cdd:TIGR02917 585 KA--------LAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAIT 656

                  ....*..
4HOU_A        267 LLKKALQ 273
Cdd:TIGR02917 657 SLKRALE 663
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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