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Conserved domains on  [gi|378792648|pdb|4DPO|A]
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Chain A, Conserved protein

Protein Classification

putative quinol monooxygenase( domain architecture ID 10003583)

monooxygenase similar to Escherichia coli quinol monooxygenase YgiN that can oxidize menadiol to menadione, may be an antibiotic biosynthesis monooxygenase involved in the biosynthesis of antibiotics, such as Streptomyces tetracenomycin-F1 monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  16496224
SCOP:  4000637

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
26-116 1.19e-26

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 94.63  E-value: 1.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DPO_A       26 IRVVAKNQVKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFKEIFPLLSEC 105
Cdd:COG1359   1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80

                        90
                ....*....|.
4DPO_A      106 LDKETEINIYR 116
Cdd:COG1359  81 LAEPPEVRVYE 91
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
26-116 1.19e-26

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 94.63  E-value: 1.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DPO_A       26 IRVVAKNQVKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFKEIFPLLSEC 105
Cdd:COG1359   1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80

                        90
                ....*....|.
4DPO_A      106 LDKETEINIYR 116
Cdd:COG1359  81 LAEPPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 26-98 5.72e-22

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 81.93  E-value: 5.72e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
4DPO_A         26 IRVVAKNQVKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFKEI 98
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAA 73
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
34-104 8.50e-04

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 35.86  E-value: 8.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
4DPO_A        34 VKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFK----EIFPLLSE 104
Cdd:PRK10486  10 VKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKtcveKLEPLMTG 84
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
26-116 1.19e-26

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 94.63  E-value: 1.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DPO_A       26 IRVVAKNQVKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFKEIFPLLSEC 105
Cdd:COG1359   1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80

                        90
                ....*....|.
4DPO_A      106 LDKETEINIYR 116
Cdd:COG1359  81 LAEPPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 26-98 5.72e-22

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 81.93  E-value: 5.72e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
4DPO_A         26 IRVVAKNQVKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFKEI 98
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAA 73
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 26-116 3.85e-06

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 42.29  E-value: 3.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DPO_A       26 IRVVAKNQVKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFKEIFPLLSEC 105
Cdd:COG2329   2 IVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGREI 81

                        90
                ....*....|.
4DPO_A      106 LDKETEINIYR 116
Cdd:COG2329  82 LAGPPRVEHYE 92
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
34-104 8.50e-04

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 35.86  E-value: 8.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
4DPO_A        34 VKPEKVQEF*NLCKSLIEETLKEEGCIDYGVYQELENPEILT*LEEWKDEGSLDQHIRSDHFK----EIFPLLSE 104
Cdd:PRK10486  10 VKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKtcveKLEPLMTG 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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