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Conserved domains on  [gi|532137617|pdb|3ZIQ|A]
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Chain A, Importin Subunit Alpha-2

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
44-461 8.15e-166

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 477.85  E-value: 8.15e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A       44 DIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVV 123
Cdd:COG5064  75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVV 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      124 DGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL--AVPDLSTLacgylRNLTWTLSNLC 201
Cdd:COG5064 155 DAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHISML-----RNATWTLSNLC 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      202 RNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAI 281
Cdd:COG5064 230 RGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSV 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      282 GNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEA 361
Cdd:COG5064 310 GNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEA 389

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      362 AWAITNYTSGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGL 434
Cdd:COG5064 390 CWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGM 469

                       410       420
                ....*....|....*....|....*..
3ZIQ_A      435 DKIEALQRHENESVYKASLNLIEKYFS 461
Cdd:COG5064 470 DAIHGLQDSVNRTIYDKAYSIIEKFFG 496
RNase_A super family cl00128
RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine ...
 4-25 5.54e-04

RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular endothelial cells, dendritic cells, and neurons, are cytotoxic/anti-tumoral and/or anti-pathogenic. RNase A is involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. The catalytic mechanism is a transphosphorylation of P-O 5' bonds on the 3' side of pyrimidines and subsequent hydrolysis to generate 3' phosphate groups. The RNase A family proteins have a conserved catalytic triad (two histidines and one lysine); recently some family members lacking the catalytic residues have been identified. They also share three or four disulfide bonds. The most conserved disulfide bonds are close to the N and C termini and contribute most significantly to the conformational stability. 8 RNase A homologs had initially been identified in the human genome, pancreatic RNase (RNase 1), Eosinophil Derived Neurotoxin (EDN/RNASE 2), Eosinophil Cationic Protein (ECP/RNase 3), RNase 4, Angiogenin (RNase 5), RNase 6 or k6, the skin derived RNase (RNase 7) and RNase 8. These eight human genes are all located in a cluster on chromosome 14. Recent genomic analysis has extended the family to 13 sequences. However only the first eight identified human RNases, which are refered to as "canonical" RNases, contain the catalytic residues required for RNase A activity. The new genes corresponding to RNases 9-13 are also located in the same chromosome cluster and seem to be related to male-reproductive functions. RNases 9-13 have the characteristic disulfide bridge pattern but are unlikely to share RNase activity. The RNase A family most likely started off in vertebrates as a host-defense protein, and comparative analysis in mammals and birds indicates that the family may have originated from a RNase 5-like gene. This hypothesis is supported by the fact that only RNase 5-like RNases have been reported outside the mammalian class. The RNase 5 group would therefore be the most ancient form of this family, and all other members would have arisen during mammalian evolution.


The actual alignment was detected with superfamily member smart00092:

Pssm-ID: 469623  Cd Length: 123  Bit Score: 39.58  E-value: 5.54e-04
                           10        20
                   ....*....|....*....|..
3ZIQ_A           4 KETAAAKFERQHMDSPDLGTDD 25
Cdd:smart00092   1 KETRAQKFLRQHIDSTPSSSSS 22
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
44-461 8.15e-166

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 477.85  E-value: 8.15e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A       44 DIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVV 123
Cdd:COG5064  75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVV 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      124 DGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL--AVPDLSTLacgylRNLTWTLSNLC 201
Cdd:COG5064 155 DAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHISML-----RNATWTLSNLC 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      202 RNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAI 281
Cdd:COG5064 230 RGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSV 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      282 GNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEA 361
Cdd:COG5064 310 GNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEA 389

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      362 AWAITNYTSGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGL 434
Cdd:COG5064 390 CWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGM 469

                       410       420
                ....*....|....*....|....*..
3ZIQ_A      435 DKIEALQRHENESVYKASLNLIEKYFS 461
Cdd:COG5064 470 DAIHGLQDSVNRTIYDKAYSIIEKFFG 496
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 426-461 5.43e-17

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 74.55  E-value: 5.43e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
3ZIQ_A        426 IMIEECGGLDKIEALQRHENESVYKASLNLIEKYFS 461
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFS 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 115-154 1.83e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 1.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
3ZIQ_A         115 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 42-159 4.53e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.78  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A         42 VEDIVKGINSNNLESQLQATQAARKLLsREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKA 121
Cdd:PLN03200  191 VDILVKLLSSGNSDAQANAASLLARLM-MAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKEAKQA 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
3ZIQ_A        122 VVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAGDGSA 159
Cdd:PLN03200  270 IADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICGGMSA 316
RNAse_Pc smart00092
Pancreatic ribonuclease;
4-25 5.54e-04

Pancreatic ribonuclease;


Pssm-ID: 128403  Cd Length: 123  Bit Score: 39.58  E-value: 5.54e-04
                           10        20
                   ....*....|....*....|..
3ZIQ_A           4 KETAAAKFERQHMDSPDLGTDD 25
Cdd:smart00092   1 KETRAQKFLRQHIDSTPSSSSS 22
Syo1_like cd13394
Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes ...
 108-236 9.09e-03

Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes Saccharomyces cerevisiae Ydl063c and Chaetomium thermophilum Syo1, which mediate the co-import of two ribosomal proteins, Rpl5 and Rpl11 (which both interact with 5S rRNA) into the nucleus. Import precedes their association with rRNA and subsequent ribosome assembly in the nucleolus. The primary structure of syo1 is a mixture of Armadillo- (ARM, N-terminal part of syo1) and HEAT-repeats (C-terminal part of syo1).


Pssm-ID: 240521 [Multi-domain]  Cd Length: 597  Bit Score: 38.44  E-value: 9.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      108 LTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH-ISEQAVWALGN----IAGDGSAFRDLVIKH-GAIDPLLALLAVPD 181
Cdd:cd13394 167 LWNLAEGSDEILSAVNKEDLLLFLLAILINFLTSkLPTSLFNAALQclytLSEDNPEFIDKLSSDpEILGNLLDIVSSDP 246

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
3ZIQ_A      182 LS------TLACGYLRNLTwTLSNLCRNKNPAppldAVEQILPTLVRLLHHNDPEVLADSC 236
Cdd:cd13394 247 SSsnillkVLVCGILLNIL-EVLSWLAGKDAA----ADAILLPILSAILSILALEILANIC 302
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
44-461 8.15e-166

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 477.85  E-value: 8.15e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A       44 DIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVV 123
Cdd:COG5064  75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVV 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      124 DGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL--AVPDLSTLacgylRNLTWTLSNLC 201
Cdd:COG5064 155 DAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHISML-----RNATWTLSNLC 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      202 RNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAI 281
Cdd:COG5064 230 RGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSV 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      282 GNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEA 361
Cdd:COG5064 310 GNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEA 389

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      362 AWAITNYTSGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGL 434
Cdd:COG5064 390 CWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGM 469

                       410       420
                ....*....|....*....|....*..
3ZIQ_A      435 DKIEALQRHENESVYKASLNLIEKYFS 461
Cdd:COG5064 470 DAIHGLQDSVNRTIYDKAYSIIEKFFG 496
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 426-461 5.43e-17

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 74.55  E-value: 5.43e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
3ZIQ_A        426 IMIEECGGLDKIEALQRHENESVYKASLNLIEKYFS 461
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFS 36
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 288-328 7.10e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.30  E-value: 7.10e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
3ZIQ_A        288 TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 328
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 115-154 1.18e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 50.53  E-value: 1.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
3ZIQ_A        115 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 154
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 115-154 1.83e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 1.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
3ZIQ_A         115 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 99-153 1.73e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 47.75  E-value: 1.73e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
3ZIQ_A         99 PIQFESAWALTNIASGTSEQTKAVVDGgAIPAFISLLASPHAHISEQAVWALGNI 153
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 331-370 1.82e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 1.82e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
3ZIQ_A        331 QDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTS 370
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 373-411 6.37e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 6.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
3ZIQ_A        373 TVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNI 411
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 330-370 9.23e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.11  E-value: 9.23e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
3ZIQ_A         330 RQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTS 370
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
127-284 9.66e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 9.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      127 AIPAFISLLASPHAHISEQAVWALGNIaGDGSafrdlvikhgAIDPLLALLAVPDLSTlacgyLRNLTWTLSNLcrnknp 206
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRL-GDPR----------AVPALLEALKDPDPEV-----RAAAAEALGRI------ 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3ZIQ_A      207 appldAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDgpneriemvvkKGVVPQLVKLLGATELPIVTPALRAIGNI 284
Cdd:COG1413  75 -----GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 37-62 1.43e-06

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 45.99  E-value: 1.43e-06
                          10        20
                  ....*....|....*....|....*.
3ZIQ_A         37 TVNWSVEDIVKGINSNNLESQLQATQ 62
Cdd:pfam01749  54 QLLESLPEMVQGVNSDDPELQLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 288-328 1.52e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.73  E-value: 1.52e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
3ZIQ_A         288 TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 328
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 73-113 2.97e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.98  E-value: 2.97e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
3ZIQ_A         73 QPPIDNIIRAGLIPKFVSFLGKTDCSpIQFESAWALTNIAS 113
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEE-VQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 216-244 1.83e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 1.83e-05
                          10        20
                  ....*....|....*....|....*....
3ZIQ_A        216 ILPTLVRLLHHNDPEVLADSCWAISYLTD 244
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 246-286 2.68e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 2.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
3ZIQ_A        246 PNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT 286
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 161-202 3.39e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.90  E-value: 3.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
3ZIQ_A        161 RDLVIKHGAIDPLLALLAVPDLSTlacgyLRNLTWTLSNLCR 202
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEV-----QEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 246-285 8.44e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 8.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
3ZIQ_A         246 PNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV 285
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 375-411 1.34e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
3ZIQ_A         375 EQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNI 411
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 72-113 1.35e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
3ZIQ_A          72 KQPPIDNIIRAGLIPKFVSFLGKTDcSPIQFESAWALTNIAS 113
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 214-244 1.43e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 1.43e-04
                           10        20        30
                   ....*....|....*....|....*....|.
3ZIQ_A         214 EQILPTLVRLLHHNDPEVLADSCWAISYLTD 244
Cdd:smart00185  11 AGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 195-242 3.11e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 3.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
3ZIQ_A        195 WTLSNLCrNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYL 242
Cdd:pfam13513   9 LALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 42-159 4.53e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.78  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A         42 VEDIVKGINSNNLESQLQATQAARKLLsREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKA 121
Cdd:PLN03200  191 VDILVKLLSSGNSDAQANAASLLARLM-MAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKEAKQA 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
3ZIQ_A        122 VVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAGDGSA 159
Cdd:PLN03200  270 IADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICGGMSA 316
HEAT COG1413
HEAT repeat [General function prediction only];
85-231 5.01e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 5.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A       85 IPKFVSFLGKTDcSPIQFESAWALTNIAsgtseqtkavvDGGAIPAFISLLASPHAHISEQAVWALGNIAGDgsafrdlv 164
Cdd:COG1413  18 VPALIAALADED-PDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDP-------- 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
3ZIQ_A      165 ikhGAIDPLLALLAVPDLS--TLACGYLRNLtwtlsnlcrnknpappldAVEQILPTLVRLLHHNDPEV 231
Cdd:COG1413  78 ---EAVPALIAALKDEDPEvrRAAAEALGRL------------------GDPAAVPALLEALKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
214-365 5.15e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 5.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      214 EQILPTLVRLLHHNDPEVLADSCWAISYLTDgpneriemvvkKGVVPQLVKLLGATELPIVTPALRAIGNIvtgtdeqtq 293
Cdd:COG1413  15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--------- 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3ZIQ_A      294 kvIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRqdqiqqvvnhgLVPFLVGVLSKADFKTQKEAAWAI 365
Cdd:COG1413  75 --GDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARAL 133
RNAse_Pc smart00092
Pancreatic ribonuclease;
4-25 5.54e-04

Pancreatic ribonuclease;


Pssm-ID: 128403  Cd Length: 123  Bit Score: 39.58  E-value: 5.54e-04
                           10        20
                   ....*....|....*....|..
3ZIQ_A           4 KETAAAKFERQHMDSPDLGTDD 25
Cdd:smart00092   1 KETRAQKFLRQHIDSTPSSSSS 22
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 122-412 1.05e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 41.63  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A        122 VVDGGAIPAFISLL--ASPHAHI-SEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAV-PDLSTLACGYLrnlTWTL 197
Cdd:PLN03200   95 VLLGGCIPPLLSLLksGSAEAQKaAAEAIYAVSSGGLSDHVGSKIFSTEGVVPSLWDQLQPgNKQDKVVEGLL---TGAL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A        198 SNLCRNKNP--APPLDA--VEqilpTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLG-ATELP 272
Cdd:PLN03200  172 RNLCGSTDGfwSATLEAggVD----ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGqGNEVS 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A        273 IVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP-KTNIQKE--------ATWTMSNITAGrqdqiqqvvnhglV 343
Cdd:PLN03200  248 VRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGG-------------M 314

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3ZIQ_A        344 PFLVGVLSKADFKTQKEA---------AWAITNYTSGGTVEQIVYLVHcgIIEPLMNLLSAKDTKIIQV-ILDAISNIF 412
Cdd:PLN03200  315 SALILYLGELSESPRSPApiadtlgalAYALMVFDSSAESTRAFDPTV--IEQILVKLLKPRDTKLVQErIIEALASLY 391
Syo1_like cd13394
Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes ...
 108-236 9.09e-03

Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes Saccharomyces cerevisiae Ydl063c and Chaetomium thermophilum Syo1, which mediate the co-import of two ribosomal proteins, Rpl5 and Rpl11 (which both interact with 5S rRNA) into the nucleus. Import precedes their association with rRNA and subsequent ribosome assembly in the nucleolus. The primary structure of syo1 is a mixture of Armadillo- (ARM, N-terminal part of syo1) and HEAT-repeats (C-terminal part of syo1).


Pssm-ID: 240521 [Multi-domain]  Cd Length: 597  Bit Score: 38.44  E-value: 9.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZIQ_A      108 LTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH-ISEQAVWALGN----IAGDGSAFRDLVIKH-GAIDPLLALLAVPD 181
Cdd:cd13394 167 LWNLAEGSDEILSAVNKEDLLLFLLAILINFLTSkLPTSLFNAALQclytLSEDNPEFIDKLSSDpEILGNLLDIVSSDP 246

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
3ZIQ_A      182 LS------TLACGYLRNLTwTLSNLCRNKNPAppldAVEQILPTLVRLLHHNDPEVLADSC 236
Cdd:cd13394 247 SSsnillkVLVCGILLNIL-EVLSWLAGKDAA----ADAILLPILSAILSILALEILANIC 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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