NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|328877239|pdb|3O55|A]
View 

Chain A, Augmenter of liver regeneration

Protein Classification

Erv1/Alr family FAD-linked sulfhydryl oxidase( domain architecture ID 6790)

Erv1/Alr family FAD-linked sulfhydryl oxidase catalyzes disulfide bond formation, similar to Homo sapiens FAD-linked sulfhydryl oxidase ALR and Arabidopsis thaliana FAD-linked sulfhydryl oxidase ERV1

CATH:  1.20.120.310
EC:  1.8.3.2
Gene Ontology:  GO:0016972|GO:0050660|GO:0016971
SCOP:  4002787

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Evr1_Alr super family cl02107
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 6-121 5.20e-50

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


The actual alignment was detected with superfamily member COG5054:

Pssm-ID: 470469  Cd Length: 181  Bit Score: 156.96  E-value: 5.20e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O55_A        6 KRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLARNHPDTRTRAA 85
Cdd:COG5054  66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREA 145

                        90       100       110
                ....*....|....*....|....*....|....*.
3O55_A       86 FTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKD 121
Cdd:COG5054 146 ATTWACEVHNKVNEKLGKPKFDCDTWNERYDCGCDT 181
 
Name Accession Description Interval E-value
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 6-121 5.20e-50

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 156.96  E-value: 5.20e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O55_A        6 KRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLARNHPDTRTRAA 85
Cdd:COG5054  66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREA 145

                        90       100       110
                ....*....|....*....|....*....|....*.
3O55_A       86 FTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKD 121
Cdd:COG5054 146 ATTWACEVHNKVNEKLGKPKFDCDTWNERYDCGCDT 181
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 24-116 5.90e-49

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 151.23  E-value: 5.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O55_A         24 RHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLARNHPDTRTRAAFTQWLCHLHNEVNRKLGK 103
Cdd:pfam04777   1 RSTWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGK 80

                          90
                  ....*....|...
3O55_A        104 PDFDCSKVDERWR 116
Cdd:pfam04777  81 PEFDCSKVKERWP 93
 
Name Accession Description Interval E-value
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 6-121 5.20e-50

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 156.96  E-value: 5.20e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O55_A        6 KRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLARNHPDTRTRAA 85
Cdd:COG5054  66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREA 145

                        90       100       110
                ....*....|....*....|....*....|....*.
3O55_A       86 FTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKD 121
Cdd:COG5054 146 ATTWACEVHNKVNEKLGKPKFDCDTWNERYDCGCDT 181
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 24-116 5.90e-49

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 151.23  E-value: 5.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3O55_A         24 RHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLARNHPDTRTRAAFTQWLCHLHNEVNRKLGK 103
Cdd:pfam04777   1 RSTWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGK 80

                          90
                  ....*....|...
3O55_A        104 PDFDCSKVDERWR 116
Cdd:pfam04777  81 PEFDCSKVKERWP 93
APOBEC4 pfam18775
APOBEC4; A member of the AID/APOBEC family of cytosine deaminases. The biological function of ...
 53-100 5.07e-03

APOBEC4; A member of the AID/APOBEC family of cytosine deaminases. The biological function of APOBEC4 is poorly understood. However, it is widely conserved across vertebrates.


Pssm-ID: 436728  Cd Length: 74  Bit Score: 33.46  E-value: 5.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
3O55_A         53 IHLFSKFYPCEECAEDLRKRLARnHPDTRTRAAFTQwLCHLHNEVNRK 100
Cdd:pfam18775   1 VTLYLSWSPCNECSEKIQEFLKK-HPKVNLDIYFAQ-LYHTEEEDNRQ 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH