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Conserved domains on  [gi|301598765|pdb|3NNR|A]
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Chain A, Transcriptional regulator, TetR family

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451993)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 60-204 7.92e-44

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


:

Pssm-ID: 433616  Cd Length: 143  Bit Score: 143.93  E-value: 7.92e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NNR_A         60 YEKLVDYYLDIPEDRPITLED*TFYLESVFDGLWSYRFFHRDLEYLLDSDPRLRQDYREFTNRCLAAINRIFAKLADAGI 139
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
3NNR_A        140 IQPQPEDLRsA*SLNVWLVITNW*AFLKTAHAaeePASLSLTELKQGIYQVLTLEVPYLTPEYRE 204
Cdd:pfam13972  81 LQADDEELE-ALADNIWLVATYWLSYQRTQAP---EAALTEAALRRGVYQVLSLLAPYLTPEGRE 141
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
10-56 2.67e-07

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 45.86  E-value: 2.67e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
3NNR_A         10 ILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEI 56
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 60-204 7.92e-44

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 143.93  E-value: 7.92e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NNR_A         60 YEKLVDYYLDIPEDRPITLED*TFYLESVFDGLWSYRFFHRDLEYLLDSDPRLRQDYREFTNRCLAAINRIFAKLADAGI 139
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
3NNR_A        140 IQPQPEDLRsA*SLNVWLVITNW*AFLKTAHAaeePASLSLTELKQGIYQVLTLEVPYLTPEYRE 204
Cdd:pfam13972  81 LQADDEELE-ALADNIWLVATYWLSYQRTQAP---EAALTEAALRRGVYQVLSLLAPYLTPEGRE 141
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
5-142 5.07e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 5.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NNR_A        5 KTRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEIFQEYEKLVDYYLDIPEDRPITLED*TFY 84
Cdd:COG1309   6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRAL 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
3NNR_A       85 LESVFDGLWSYRFFHRDLEYLLDSDPRLRQDYREFTNRCLAAINRIFAKLADAGIIQP 142
Cdd:COG1309  86 LRAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDP 143
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
10-56 2.67e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 45.86  E-value: 2.67e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
3NNR_A         10 ILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEI 56
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 6-56 1.83e-04

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 41.14  E-value: 1.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
3NNR_A         6 TRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEI 56
Cdd:PRK10668  12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
5-59 9.77e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 38.73  E-value: 9.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
3NNR_A         5 KTRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEIFQE 59
Cdd:NF041196   6 RTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 60-204 7.92e-44

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 143.93  E-value: 7.92e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NNR_A         60 YEKLVDYYLDIPEDRPITLED*TFYLESVFDGLWSYRFFHRDLEYLLDSDPRLRQDYREFTNRCLAAINRIFAKLADAGI 139
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
3NNR_A        140 IQPQPEDLRsA*SLNVWLVITNW*AFLKTAHAaeePASLSLTELKQGIYQVLTLEVPYLTPEYRE 204
Cdd:pfam13972  81 LQADDEELE-ALADNIWLVATYWLSYQRTQAP---EAALTEAALRRGVYQVLSLLAPYLTPEGRE 141
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
5-142 5.07e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 72.62  E-value: 5.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NNR_A        5 KTRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEIFQEYEKLVDYYLDIPEDRPITLED*TFY 84
Cdd:COG1309   6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRAL 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
3NNR_A       85 LESVFDGLWSYRFFHRDLEYLLDSDPRLRQDYREFTNRCLAAINRIFAKLADAGIIQP 142
Cdd:COG1309  86 LRAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDP 143
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
10-56 2.67e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 45.86  E-value: 2.67e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
3NNR_A         10 ILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEI 56
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
5-134 1.56e-06

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 46.86  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NNR_A        5 KTRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEIFQEY-EKLVDYYLDIPEDRPITLED*TF 83
Cdd:COG3226   8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLaEREAARLRALLAAADDLEDAAEA 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
3NNR_A       84 YLESVFDGLWSYRFFHR-DLEYLLDS--DPRLRQDYREFTNRCLAAINRIFAKL 134
Cdd:COG3226  88 LADLLAELLPADRDRLLaRYELYLEAlrDPELRALLRRWRDRLREALARLLAAL 141
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 6-56 1.83e-04

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 41.14  E-value: 1.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
3NNR_A         6 TRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEI 56
Cdd:PRK10668  12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
5-59 9.77e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 38.73  E-value: 9.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
3NNR_A         5 KTRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEIFQE 59
Cdd:NF041196   6 RTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 5-65 1.28e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 38.57  E-value: 1.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
3NNR_A         5 KTRDKILLSSLELFNDKGERNITTNHIAAHLAISPGNLYYHFRNKSDIIYEIFQEYEKLVD 65
Cdd:PRK09975  11 KTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPPLRE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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