BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       17 PECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18279   1 PECRLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
3HTM_D       97 KAPNLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18279  81 KAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       17 PECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18279   1 PECRLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
3HTM_D       97 KAPNLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18279  81 KAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
3HTM_D      132 LSVENAAEILILADLHSADQLKTQAVDFINYHATDVLETSG 172
Cdd:cd14821   1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEG 41

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D        30 ENSRFTDCCLCVA--GQEFQAHKAILAARSPVFSA*Fehe*EESKKNRVEINDVEpEVFKE**CFIYTGKAPNLDK*ADD 107
Cdd:PHA03098   5 ELQKFCDESIIIVngGGIIKVHKIILSSSSEYFKKMF---KNNFKENEINLNIDY-DSFNEVIKYIYTGKINITSNNVKD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
3HTM_D       108 LLAAADKYALERLKV*CEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 160
Cdd:PHA03098  81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYI 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       17 PECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18279   1 PECRLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
3HTM_D       97 KAPNLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18279  81 KAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       14 VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFI 93
Cdd:cd18342   2 VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
3HTM_D       94 YTGKAPNLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVENA 137
Cdd:cd18342  82 YTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       14 VKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFI 93
Cdd:cd18344   3 IKDPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFI 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
3HTM_D       94 YTGKAP--NLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVENA 137
Cdd:cd18344  83 YTGKAPhlHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D         25 LGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPNlDK* 104
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLIS-EEN 79

                          90       100
                  ....*....|....*....|....*...
3HTM_D        105 ADDLLAAADKYALERLKV*CEDALCSNL 132
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
3HTM_D      132 LSVENAAEILILADLHSADQLKTQAVDFINYHATDVLETSG 172
Cdd:cd14821   1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEG 41

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP); SPOP, also termed HIB homolog 1, or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
3HTM_D      132 LSVENAAEILILADLHSADQLKTQAVDFINYHATDVLETSG 172
Cdd:cd18518   1 LSVENAAEILILADLHSADQLKTQAVDFINYHASDVMETSG 41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       21 LADELGGLWENSRFTDCCLCV--AGQEFQAHKAILAARSPVFSA*F-EHE*EESKKNRVEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18294   1 FAADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                        90       100
                ....*....|....*....|....*...
3HTM_D       98 APNLDK*ADDLLAAADKYALERLKV*CE 125
Cdd:cd18294  81 VTLSNHTVIEVLAAAVEYGLDELRKLCE 108

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also termed HIB homolog 2, or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes containing homodimeric SPOPL or the heterodimer formed by speckle-type POZ protein (SPOP) and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
3HTM_D      132 LSVENAAEILILADLHSADQLKTQAVDFIN------------------YHATDVLETSG 172
Cdd:cd18519   1 LSVENVADTLILADLHSAEQLKAQAIDFINrcsvlrqlgckdgknwnsNHATDIMETAG 59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HTM_D       20 RLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKA 98
Cdd:cd18287   8 FLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
3HTM_D       23 DELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18259  21 DGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGK 95

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       34 FTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNR-----VEINDVEPEVFKE**CFIYTGKApnldk*addl 108
Cdd:cd18296  17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNgsipvVTLHDVSPEVFAIVLYYIYTDDT---------- 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
3HTM_D      109 laaadkyalerlkv*cedalcsNLSVENAAEILILADLHSADQLKTQA 156
Cdd:cd18296  87 ----------------------DLPPENAYDVLYVADMYLLPGLKRLC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       30 ENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPNLDK*ADDLL 109
Cdd:cd18297   8 NNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDAL 87

                        90       100       110
                ....*....|....*....|....*....|
3HTM_D      110 ---AAADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18297  88 ellRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HTM_D       28 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18256  14 LRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HTM_D       19 CRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18286   2 SRLGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGV 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       20 RLADELG---GLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18237   4 LLADFMGvmnNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
3HTM_D       97 KAPNLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18237  84 RISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       31 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPNLDK*ADDLLA 110
Cdd:cd18240  14 EGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLP 93

                        90       100
                ....*....|....*....|....*.
3HTM_D      111 AADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18240  94 AADQFNIMGIVKACCDFLEDQLCPEN 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       28 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18238   9 FYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGK 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
3HTM_D       39 LCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPN 100
Cdd:cd01165   3 LVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDL 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
3HTM_D       28 LWENSRFTDCCLCVAGQ----EFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18248  15 LRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTA 87

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3HTM_D       20 RLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*F-EHE*EESKKNRVEINDVEPEVFKE**CFIYT 95
Cdd:cd18285   1 HLSQDLLRLLREELHTDVTFYVGSTLFKAHKAILLARVPEFFSHIiGKLSSLEDQEPINIENLEASEFKTFLRQVYT 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       25 LGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPNLDK* 104
Cdd:cd18255   9 LNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDC 88

                        90       100       110
                ....*....|....*....|....*....|..
3HTM_D      105 ADDLLAAADKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18255  89 IQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HTM_D       28 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18242  15 LRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       21 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPN 100
Cdd:cd18270  13 LLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAI 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
3HTM_D      101 LDK*ADDLLAAADKYALERLKV*CEDALCSNLSVENAAEIL 141
Cdd:cd18270  93 NDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|...
3HTM_D       35 TDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGR 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       21 LADELGGLWENSRFTDCCLCVA--------GQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CF 92
Cdd:cd18273  13 LLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDY 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
3HTM_D       93 IYTGKAPNLDK*ADDLLAAADKYALERLKV*CEDALCSNLSVENAAEIL 141
Cdd:cd18273  93 CYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       34 FTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAP-NLDK*ADDLLAAA 112
Cdd:cd18300   9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPiLEDGDCVGLIVLA 88

                        90
                ....*....|...
3HTM_D      113 DKYALERLKV*CE 125
Cdd:cd18300  89 NRLCLPRLVALCE 101

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       17 PECRLADELGGLWENSRFTDCCLCVA--GQEFQAHKAILAARSP---------------VFSA*FEHE*EE--------- 70
Cdd:cd18308   6 PKCTLHDDFGRLLESRQFCDVEFIVGeeEERIPAHIAFVAARSKwlrnkilqarerqkqKAEQEVEDEGSEadsssaskn 85

                        90       100
                ....*....|....*....|....*...
3HTM_D       71 -SKKNRVEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18308  86 dSPMLEVRLPEADPEAFELILSFIYTDK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       34 FTDCCL-CVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNRVEINDVEPEVFKE**CFIYTGKAPNLDK*ADDLLAAA 112
Cdd:cd18252  21 FTDITLqCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAA 100

                        90       100
                ....*....|....*....|....
3HTM_D      113 DKYALERLKV*CEDALCSNLSVEN 136
Cdd:cd18252 101 DLLQFISVKKACEQFLVRHLDIDN 124

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       41 VAGQEFQAHKAILAARSPVFSA*FEHE*EESKKN----RVEINDVEPEVFKE**CFIYTG 96
Cdd:cd18301  25 VGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HTM_D       23 DELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*-EESKKNRVEINdvEPE----VFKE**CFIYTGK 97
Cdd:cd18292   6 QDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwSESKQSEIELV--EDPecaaVFEKFLRYLYTGQ 83

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3HTM_D       23 DELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSA*Fehe*eESK-KNRVEIN----DVEPEVFKE**CFIYTG 96
Cdd:cd18295   8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMF-----ETKwKDKREINlkhpLVNPDAFRALLQYLYTG 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3HTM_D       33 RFTDCCLCVAGQEFQAHKAILAARSPVFSA*FEHE*EESKKNR-VEINDVEPEVFKE**CFIYTGK 97
Cdd:cd18207  26 RFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPReLEMHTISSKVFGDILDFAYTSR 91