|
Name |
Accession |
Description |
Interval |
E-value |
| Biopterin_H |
pfam00351 |
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ... |
3-290 |
0e+00 |
|
Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.
Pssm-ID: 459776 Cd Length: 331 Bit Score: 641.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 3 PWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLY 82
Cdd:pfam00351 1 PWFPRKISDLDKCAHLVLKYGPELDADHPGFTDPVYRKRRKEIADIAFNYKHGDPIPRVEYTEEEIKTWGTVYKKLTSLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 83 PTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYT 162
Cdd:pfam00351 81 PTHACREYLENFPLLEKNCGYREDNIPQLEDVSNFLKERTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 163 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL 242
Cdd:pfam00351 161 PEPDCCHELLGHVPLLADPDFAQFSQEIGLASLGASDEDIEKLATCYWFTVEFGLCKQNGELKAYGAGLLSSFGELEYAL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
3HF6_A 243 SGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:pfam00351 241 SDKPEYKPFDPEVTAVQKYPITTYQPVYFVAESFEDAKEKLRKFASTI 288
|
|
| eu_TrpOH |
cd03346 |
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino ... |
3-289 |
0e+00 |
|
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tyrosine hydroxylase (TyrOH). TrpOH oxidizes L-tryptophan to 5-hydroxy-L-tryptophan, the rate-limiting step in the biosynthesis of serotonin (5-hydroxytryptamine), a widely distributed hormone and neurotransmitter.
Pssm-ID: 239462 Cd Length: 287 Bit Score: 626.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 3 PWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLY 82
Cdd:cd03346 1 PWFPKKISDLDKCANRVLMYGSELDADHPGFKDNVYRKRRKYFADVAMNYKHGDPIPRVEYTEEEIKTWGTVYRELNRLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 83 PTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYT 162
Cdd:cd03346 81 PTHACREYLKNLPLLEKHCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPFYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 163 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL 242
Cdd:cd03346 161 PEPDTCHELLGHVPLLADPSFAQFSQEIGLASLGASDEDIQKLATCYFFTVEFGLCKQDGQLKVYGAGLLSSIGELKHAL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
3HF6_A 243 SGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKT 289
Cdd:cd03346 241 SGEAKVKPFDPKVTCKQECLITTFQEAYFVSESFEEAKEKMREFAKT 287
|
|
| Trp_5_monoox |
TIGR01270 |
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a ... |
2-290 |
0e+00 |
|
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130337 [Multi-domain] Cd Length: 464 Bit Score: 617.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 2 VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKL 81
Cdd:TIGR01270 129 VPWFPKKISDLDKCANRVLMYGSELDADHPGFKDTEYRKRRMMFADLALNYKHGEPIPRVEYTEEERKTWGTIYRELRRL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 82 YPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFY 161
Cdd:TIGR01270 209 YKTHACKEFLDNLPLLEKYCGYREDNIPQLEDVSKFLKAKTGFRLRPVAGYLSARDFLSGLAFRVFHCTQYVRHSADPFY 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 162 TPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQ-DGQLRVFGAGLLSSISELKH 240
Cdd:TIGR01270 289 TPEPDTCHELLGHMPLLADPSFAQFSQEIGLASLGASEEDIKKLATLYFFTIEFGLCKQdDEQFKVYGAGLLSSVAELQH 368
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
3HF6_A 241 ALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:TIGR01270 369 ALSGSAKIKPFDPDRVCEQECLITTFQNAYFYTRSFEEAKEKMREFTNTI 418
|
|
| phhA |
PRK11913 |
phenylalanine 4-monooxygenase; Reviewed |
35-286 |
4.91e-81 |
|
phenylalanine 4-monooxygenase; Reviewed
Pssm-ID: 237020 Cd Length: 275 Bit Score: 245.93 E-value: 4.91e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 35 DNVYRKRRKYFADLAMNYKHGDPIpkVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLEDV 114
Cdd:PRK11913 1 DAAYRARRDAGMEKAADYTADQPW--IDYTAEEHAIWQTLYERQLALLPGRACDEFLEGLEAL----GLPKDRIPQLDEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 115 SNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLAS 194
Cdd:PRK11913 75 NRVLQAATGWQVVPVPGLIPFDVFFELLANRRFPVATFIRRPEELDYLQEPDIFHDVFGHVPLLTNPVFADFMQAYGKLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 195 LGAS-EEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL-SGHAKVKPFDPKITCKQECLITTFQDVYFV 272
Cdd:PRK11913 155 LRASkEGRLEFLARLYWFTVEFGLIRTPGGLRIYGAGILSSPGETLYALeSDSPNRRPFDLERVMRTPYRIDIFQPTYFV 234
|
250
....*....|....*...
3HF6_A 273 SESFED----AKEKMREF 286
Cdd:PRK11913 235 IDSFEQlfdiAEPDFMAL 252
|
|
| PhhA |
COG3186 |
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism]; |
33-278 |
7.66e-79 |
|
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];
Pssm-ID: 442419 Cd Length: 279 Bit Score: 240.48 E-value: 7.66e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 33 FKDNVYRKRRKYFAdlamnyKHGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLE 112
Cdd:COG3186 2 ETNAQLARDPAYLA------RYTDPQGYIDYTAEEHAVWRRLYRRQVALLPGRACDEYLDGLEKL----GLPADRIPQLD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 113 DVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGL 192
Cdd:COG3186 72 EVNERLKALTGWRVVAVPGLIPPDAFFELLANRRFPVATFIRTPEEIDYLPEPDIFHEVFGHVPLLTNPVFADFLQAYGE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 193 ASLGASE--EAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL-SGHAKVKPFDPKITCKQECLITTFQDV 269
Cdd:COG3186 152 AGLKASKldSELALLARLYWFTVEFGLIGTPEGLRIYGAGILSSPGESEYALeSDEPNRIPFDLERVMRTPYRIDIYQPT 231
|
....*....
3HF6_A 270 YFVSESFED 278
Cdd:COG3186 232 YFVIDSFDQ 240
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Biopterin_H |
pfam00351 |
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ... |
3-290 |
0e+00 |
|
Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.
Pssm-ID: 459776 Cd Length: 331 Bit Score: 641.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 3 PWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLY 82
Cdd:pfam00351 1 PWFPRKISDLDKCAHLVLKYGPELDADHPGFTDPVYRKRRKEIADIAFNYKHGDPIPRVEYTEEEIKTWGTVYKKLTSLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 83 PTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYT 162
Cdd:pfam00351 81 PTHACREYLENFPLLEKNCGYREDNIPQLEDVSNFLKERTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 163 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL 242
Cdd:pfam00351 161 PEPDCCHELLGHVPLLADPDFAQFSQEIGLASLGASDEDIEKLATCYWFTVEFGLCKQNGELKAYGAGLLSSFGELEYAL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
3HF6_A 243 SGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:pfam00351 241 SDKPEYKPFDPEVTAVQKYPITTYQPVYFVAESFEDAKEKLRKFASTI 288
|
|
| eu_TrpOH |
cd03346 |
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino ... |
3-289 |
0e+00 |
|
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tyrosine hydroxylase (TyrOH). TrpOH oxidizes L-tryptophan to 5-hydroxy-L-tryptophan, the rate-limiting step in the biosynthesis of serotonin (5-hydroxytryptamine), a widely distributed hormone and neurotransmitter.
Pssm-ID: 239462 Cd Length: 287 Bit Score: 626.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 3 PWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLY 82
Cdd:cd03346 1 PWFPKKISDLDKCANRVLMYGSELDADHPGFKDNVYRKRRKYFADVAMNYKHGDPIPRVEYTEEEIKTWGTVYRELNRLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 83 PTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYT 162
Cdd:cd03346 81 PTHACREYLKNLPLLEKHCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPFYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 163 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL 242
Cdd:cd03346 161 PEPDTCHELLGHVPLLADPSFAQFSQEIGLASLGASDEDIQKLATCYFFTVEFGLCKQDGQLKVYGAGLLSSIGELKHAL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
3HF6_A 243 SGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKT 289
Cdd:cd03346 241 SGEAKVKPFDPKVTCKQECLITTFQEAYFVSESFEEAKEKMREFAKT 287
|
|
| Trp_5_monoox |
TIGR01270 |
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a ... |
2-290 |
0e+00 |
|
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130337 [Multi-domain] Cd Length: 464 Bit Score: 617.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 2 VPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKL 81
Cdd:TIGR01270 129 VPWFPKKISDLDKCANRVLMYGSELDADHPGFKDTEYRKRRMMFADLALNYKHGEPIPRVEYTEEERKTWGTIYRELRRL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 82 YPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFY 161
Cdd:TIGR01270 209 YKTHACKEFLDNLPLLEKYCGYREDNIPQLEDVSKFLKAKTGFRLRPVAGYLSARDFLSGLAFRVFHCTQYVRHSADPFY 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 162 TPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQ-DGQLRVFGAGLLSSISELKH 240
Cdd:TIGR01270 289 TPEPDTCHELLGHMPLLADPSFAQFSQEIGLASLGASEEDIKKLATLYFFTIEFGLCKQdDEQFKVYGAGLLSSVAELQH 368
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
3HF6_A 241 ALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:TIGR01270 369 ALSGSAKIKPFDPDRVCEQECLITTFQNAYFYTRSFEEAKEKMREFTNTI 418
|
|
| eu_PheOH |
cd03347 |
Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent ... |
3-290 |
0e+00 |
|
Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic phenylalanine-4-hydroxylase (pro_PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH catalyzes the first and rate-limiting step in the metabolism of the amino acid L-phenylalanine (L-Phe), the hydroxylation of L-Phe to L-tyrosine (L-Tyr). It uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as the physiological electron donor. The catalytic activity of the tetrameric enzyme is tightly regulated by the binding of L-Phe and BH4 as well as by phosphorylation. Mutations in the human enzyme are linked to a severe variant of phenylketonuria.
Pssm-ID: 239463 Cd Length: 306 Bit Score: 511.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 3 PWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLY 82
Cdd:cd03347 1 PWFPRTIQDLDRFANQILSYGAELDADHPGFKDPVYRARRKEFADIAYNYKHGQPIPRVEYTEEEKKTWGTVFRELKSLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 83 PTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYT 162
Cdd:cd03347 81 PTHACYEYNHVFPLLEKNCGFSEDNIPQLEDVSNFLQTCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 163 PEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL 242
Cdd:cd03347 161 PEPDICHELLGHVPLFADPSFAQFSQEIGLASLGAPDEYIEKLATVYWFTVEFGLCKQGGSIKAYGAGLLSSFGELQYCL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
3HF6_A 243 SGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:cd03347 241 SDKPELLPFEPEKTAVTKYPITEFQPLYYVAESFEDAKEKLRNFAATI 288
|
|
| Phe4hydrox_tetr |
TIGR01268 |
phenylalanine-4-hydroxylase, tetrameric form; This model describes the larger, tetrameric form ... |
1-290 |
5.30e-178 |
|
phenylalanine-4-hydroxylase, tetrameric form; This model describes the larger, tetrameric form of phenylalanine-4-hydroxylase, as found in metazoans. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. It is closely related to metazoan tyrosine 3-monooxygenase and tryptophan 5-monoxygenase, and more distantly to monomeric phenylalanine-4-hydroxylases of some Gram-negative bacteria. The member of this family from Drosophila has been described as having both phenylalanine-4-hydroxylase and tryptophan 5-monoxygenase activity (. However, a Drosophila member of the tryptophan 5-monoxygenase clade has subsequently been discovered.
Pssm-ID: 130335 [Multi-domain] Cd Length: 436 Bit Score: 498.21 E-value: 5.30e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 1 SVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNK 80
Cdd:TIGR01268 101 SVPWFPRKINDIDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAFNYKHGQPIPRVEYTDEEIATWRTVFNNLTV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 81 LYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPF 160
Cdd:TIGR01268 181 LYPTHACQEYNHIFPLLQQNCGFREDNIPQLEDVSQFLQDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSKPM 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 161 YTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKH 240
Cdd:TIGR01268 261 YTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDYIEKLATLYWFTIEFGLCKQDGEKKAYGAGLLSSFGELQY 340
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
3HF6_A 241 ALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:TIGR01268 341 CLSDKPEVVDFDPEVTCVTKYPITEFQPLYFLAESFEDAKEKLKSFAATI 390
|
|
| eu_TyrOH |
cd03345 |
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino ... |
4-290 |
2.50e-167 |
|
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tryptophan hydroxylase (TrpOH). TyrOH catalyzes the conversion of tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.
Pssm-ID: 239461 Cd Length: 298 Bit Score: 465.76 E-value: 2.50e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 4 WFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNKLYP 83
Cdd:cd03345 1 WFPRHISELDKCHHLVTKYEPDLDLDHPGFSDKVYRERRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYKTLKDLHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 84 THACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTP 163
Cdd:cd03345 81 THACKEYLDAFQLLEKECGYSEDRIPQLEDVSEFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 164 EPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALS 243
Cdd:cd03345 161 EPDCCHELLGHVPMLADPTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKENGELKAYGAGLLSSYGELLHALS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
3HF6_A 244 GHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:cd03345 241 DEPEHRPFDPAATAVQPYQDQTYQPIYFVSESFSDAKDKLRNYASTM 287
|
|
| Tyr_3_monoox |
TIGR01269 |
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member ... |
1-290 |
1.47e-148 |
|
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria.
Pssm-ID: 130336 [Multi-domain] Cd Length: 457 Bit Score: 424.34 E-value: 1.47e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 1 SVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFRELNK 80
Cdd:TIGR01269 122 KEDWFPKHISELDKCQHLLTKFQPDLDTDHPGFHDKVYRQRREAIAEIAFQYKYGDPIPEVEYTKEEIETWRLVFTTMKD 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 81 LYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPF 160
Cdd:TIGR01269 202 LHASHACREYIDAFQLLEKYCNYNSESIPQLQTISEFLHRTTGFRLRPVAGLLSARDFLASLAFRVFQCTQYIRHHSSPM 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 161 YTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKH 240
Cdd:TIGR01269 282 HTPEPDCIHELLGHMPMLADRQFAQFSQEIGLASLGASEEEIEKLSTLYWFTVEFGLCKENGETKAYGAGLLSSYGELEH 361
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
3HF6_A 241 ALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTI 290
Cdd:TIGR01269 362 AFSDLSEKRPFNPNDAAVQPYQDQGYQKIYFVTESFEDAKRKLRNYINTS 411
|
|
| arom_aa_hydroxylase |
cd00361 |
Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent ... |
59-282 |
2.37e-138 |
|
Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH converts L-phenylalanine to L-tyrosine, an important step in phenylalanine catabolism and neurotransmitter biosynthesis, and is linked to a severe variant of phenylketonuria in humans. TyrOH and TrpOH are involved in the biosynthesis of catecholamine and serotonin, respectively. The eukaryotic enzymes are all homotetramers.
Pssm-ID: 238215 Cd Length: 221 Bit Score: 389.22 E-value: 2.37e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 59 PKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDF 138
Cdd:cd00361 1 PRVDYTEEEHATWRTLYRRLKKLLPTHACREYLEGLELL----GLPEDRIPQLEDVSEFLKALTGWTLVPVAGLISPRDF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 139 LSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASE-EAVQKLATCYFFTVEFGL 217
Cdd:cd00361 77 FALLAFRVFPVTQYIRHPEEPDYTPEPDIFHELFGHVPLLADPSFADFSQEYGLASLGASDlEEIEKLARLYWFTVEFGL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
3HF6_A 218 CKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEK 282
Cdd:cd00361 157 IKEDGELKAYGAGLLSSYGELQHALSDKPKRIPFDPERVARTPYDITSFQPTYFVIESFEQLKEK 221
|
|
| phhA |
PRK11913 |
phenylalanine 4-monooxygenase; Reviewed |
35-286 |
4.91e-81 |
|
phenylalanine 4-monooxygenase; Reviewed
Pssm-ID: 237020 Cd Length: 275 Bit Score: 245.93 E-value: 4.91e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 35 DNVYRKRRKYFADLAMNYKHGDPIpkVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLEDV 114
Cdd:PRK11913 1 DAAYRARRDAGMEKAADYTADQPW--IDYTAEEHAIWQTLYERQLALLPGRACDEFLEGLEAL----GLPKDRIPQLDEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 115 SNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLAS 194
Cdd:PRK11913 75 NRVLQAATGWQVVPVPGLIPFDVFFELLANRRFPVATFIRRPEELDYLQEPDIFHDVFGHVPLLTNPVFADFMQAYGKLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 195 LGAS-EEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL-SGHAKVKPFDPKITCKQECLITTFQDVYFV 272
Cdd:PRK11913 155 LRASkEGRLEFLARLYWFTVEFGLIRTPGGLRIYGAGILSSPGETLYALeSDSPNRRPFDLERVMRTPYRIDIFQPTYFV 234
|
250
....*....|....*...
3HF6_A 273 SESFED----AKEKMREF 286
Cdd:PRK11913 235 IDSFEQlfdiAEPDFMAL 252
|
|
| PhhA |
COG3186 |
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism]; |
33-278 |
7.66e-79 |
|
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];
Pssm-ID: 442419 Cd Length: 279 Bit Score: 240.48 E-value: 7.66e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 33 FKDNVYRKRRKYFAdlamnyKHGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLE 112
Cdd:COG3186 2 ETNAQLARDPAYLA------RYTDPQGYIDYTAEEHAVWRRLYRRQVALLPGRACDEYLDGLEKL----GLPADRIPQLD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 113 DVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGL 192
Cdd:COG3186 72 EVNERLKALTGWRVVAVPGLIPPDAFFELLANRRFPVATFIRTPEEIDYLPEPDIFHEVFGHVPLLTNPVFADFLQAYGE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 193 ASLGASE--EAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHAL-SGHAKVKPFDPKITCKQECLITTFQDV 269
Cdd:COG3186 152 AGLKASKldSELALLARLYWFTVEFGLIGTPEGLRIYGAGILSSPGESEYALeSDEPNRIPFDLERVMRTPYRIDIYQPT 231
|
....*....
3HF6_A 270 YFVSESFED 278
Cdd:COG3186 232 YFVIDSFDQ 240
|
|
| pro_PheOH |
cd03348 |
Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent ... |
53-278 |
3.97e-63 |
|
Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH), tyrosine hydroxylase (TyrOH) and tryptophan hydroxylase (TrpOH). PheOH catalyzes the hydroxylation of L-Phe to L-tyrosine (L-Tyr). It uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as the physiological electron donor.
Pssm-ID: 239464 Cd Length: 228 Bit Score: 198.65 E-value: 3.97e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 53 KHGDPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLEDVSNFLKERTGFSIRPVAGY 132
Cdd:cd03348 1 DVPDEQGQIDYTPEEHAVWRTLYERQAKLLPGRACDAFLEGLEKL----GLPTDRIPDFADVSERLKAATGWTVVAVPGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 133 LSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASE-EAVQKLATCYFF 211
Cdd:cd03348 77 IPDDEFFEHLANRRFPVTNFIRRPEELDYLQEPDIFHDIFGHVPMLTNPVFADFMQAYGKGGLKATGlEDRALLARLYWY 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
3HF6_A 212 TVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHA-KVKPFDPKITCKQECLITTFQDVYFVSESFED 278
Cdd:cd03348 157 TVEFGLIQEPGGLRIYGAGILSSPGETLYALESPDpNRIPFDLERVMRTPYRIDSFQPTYFVIDSFEQ 224
|
|
| Phe4hydrox_mono |
TIGR01267 |
phenylalanine-4-hydroxylase, monomeric form; This model describes the smaller, monomeric form ... |
56-277 |
4.16e-45 |
|
phenylalanine-4-hydroxylase, monomeric form; This model describes the smaller, monomeric form of phenylalanine-4-hydroxylase, as found in a small number of Gram-negative bacteria. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. This family is of biopterin and metal-dependent hydroxylases is related to a family of longer, multimeric aromatic amino acid hydroxylases that have additional N-terminal regulatory sequences. These include tyrosine 3-monooxygenase, phenylalanine-4-hydroxylase, and tryptophan 5-monoxygenase. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130334 Cd Length: 248 Bit Score: 153.10 E-value: 4.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 56 DPIPKVEFTEEEIKTWGTVFRELNKLYPTHACREYLKNLPLLskycGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSP 135
Cdd:TIGR01267 4 DDQGFDHYSEEEHAVWNTLITRQLKLIEGRACQEYLDGIEQL----GLPHDRIPDFDEINRKLQATTGWRIAAVPGLIPF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 136 RDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGAS-EEAVQKLATCYFFTVE 214
Cdd:TIGR01267 80 QTFFEHLANRRFPVTTWLRTPEELDYLQEPDIFHDIFGHVPLLTNPVFADFTHTYGKLGLKASaLGRVEMLARLYWYTIE 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
3HF6_A 215 FGLCKQDGQLRVFGAGLLSSISELKHALSG-HAKVKPFDPKITCKQECLITTFQDVYFVSESFE 277
Cdd:TIGR01267 160 FGLVETDQGKRIYGAGILSSPKETVYSLESdEPLHVAFDLLEAMRTPYRIDIFQPLYFVLPSFK 223
|
|
| PRK14056 |
PRK14056 |
aromatic amino acid hydroxylase; |
71-289 |
2.46e-20 |
|
aromatic amino acid hydroxylase;
Pssm-ID: 237598 Cd Length: 578 Bit Score: 90.50 E-value: 2.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 71 WGTVFRELNKLYPTHACREYLKNLpllsKYCGYREDNIPQLEDVSNFLKeRTGFSIRPVAGYLSPRDFLSGLAFRVFHCT 150
Cdd:PRK14056 29 WRYVMRQNHSFLKDVAHPAYLNGL----QSTGINIERIPKVEEMNECLA-EIGWGAVAVDGFIPPVAFFEFQGHGVLPIA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 151 QYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQ---EIGLASLGASE-----EAVQKL----------------- 205
Cdd:PRK14056 104 TDIRKVENIEYTPAPDIIHEAAGHAPILADPTYAEYLRrfgEIGAKAISSKEdhdvfEAVRTLsivkesptstpeevaaa 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 206 --------------------ATCYFFTVEFGLCkqdGQL---RVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECL 262
Cdd:PRK14056 184 enrviekqnlvsglseaeqiSRLFWWTVEYGLI---GTLdnpKIYGAGLLSSVGESKHCLTDAVEKVPFSIEACTSTTYD 260
|
250 260
....*....|....*....|....*..
3HF6_A 263 ITTFQDVYFVSESFEDAKEKMREFTKT 289
Cdd:PRK14056 261 ITKMQPQLFVCPDFEELSEVLEEFAET 287
|
|
| PRK14055 |
PRK14055 |
aromatic amino acid hydroxylase; Provisional |
89-281 |
2.02e-18 |
|
aromatic amino acid hydroxylase; Provisional
Pssm-ID: 172547 [Multi-domain] Cd Length: 362 Bit Score: 83.95 E-value: 2.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 89 EYLKNLPLLSKYCGYREdnipqledVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTC 168
Cdd:PRK14055 128 DYLEAFGLLSDFLDHQA--------VIKFFELETHFSYYPVSGFVAPHQYLSLLQDRYFPIASVMRTLDKDNFSLTPDLI 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HF6_A 169 HELLGHVPLLAEPSFAQFSQEIG---------LASLGASEEAVQKLAT-------CYFFTVEFGLCKQDGQLRVFGAGLL 232
Cdd:PRK14055 200 HDLLGHVPWLLHPSFSEFFINMGrlftkviekVQALPSKKQRIQTLQSnliaivrCFWFTVESGLIENHEGRKAYGAVLI 279
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
3HF6_A 233 SSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKE 281
Cdd:PRK14055 280 SSPQELGHAFIDNVRVLPLELDQIIRLPFNTSTPQETLFSIRHFDELVE 328
|
|
| |
