ArsA family ATPase such as arsenical pump-driving ATPase GET3, which is required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
19-319
1.48e-117
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.
:
Pssm-ID: 396792 Cd Length: 302 Bit Score: 341.25 E-value: 1.48e-117
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
19-319
1.48e-117
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.
Pssm-ID: 396792 Cd Length: 302 Bit Score: 341.25 E-value: 1.48e-117
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the ...
36-314
3.87e-100
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes, respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.
Pssm-ID: 349755 [Multi-domain] Cd Length: 250 Bit Score: 295.19 E-value: 3.87e-100
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that ...
36-317
4.46e-99
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see pfam02040) for As(III) efflux. [Hypothetical proteins, Conserved]
Pssm-ID: 273027 [Multi-domain] Cd Length: 284 Bit Score: 293.61 E-value: 4.46e-99
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
33-317
1.82e-32
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.
Pssm-ID: 469308 [Multi-domain] Cd Length: 617 Bit Score: 126.92 E-value: 1.82e-32
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
7-314
1.30e-21
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.
Pssm-ID: 469308 [Multi-domain] Cd Length: 617 Bit Score: 95.33 E-value: 1.30e-21
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
19-319
1.48e-117
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.
Pssm-ID: 396792 Cd Length: 302 Bit Score: 341.25 E-value: 1.48e-117
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the ...
36-314
3.87e-100
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes, respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.
Pssm-ID: 349755 [Multi-domain] Cd Length: 250 Bit Score: 295.19 E-value: 3.87e-100
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that ...
36-317
4.46e-99
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see pfam02040) for As(III) efflux. [Hypothetical proteins, Conserved]
Pssm-ID: 273027 [Multi-domain] Cd Length: 284 Bit Score: 293.61 E-value: 4.46e-99
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
33-317
1.82e-32
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.
Pssm-ID: 469308 [Multi-domain] Cd Length: 617 Bit Score: 126.92 E-value: 1.82e-32
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
33-312
3.57e-32
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).
Pssm-ID: 275109 [Multi-domain] Cd Length: 566 Bit Score: 125.97 E-value: 3.57e-32
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
7-314
1.30e-21
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.
Pssm-ID: 469308 [Multi-domain] Cd Length: 617 Bit Score: 95.33 E-value: 1.30e-21
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
32-287
1.87e-09
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).
Pssm-ID: 275109 [Multi-domain] Cd Length: 566 Bit Score: 58.56 E-value: 1.87e-09
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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